Basic Information

Gene Symbol
-
Assembly
GCA_947568885.1
Location
OX387701.1:1074893-1090256[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 19 0.00034 0.021 15.9 4.2 3 23 277 298 275 298 0.96
2 19 5.5 3.4e+02 2.6 0.8 1 23 306 329 306 329 0.90
3 19 0.00015 0.0091 17.0 0.8 1 23 334 356 334 356 0.98
4 19 0.0008 0.05 14.7 5.8 2 23 385 406 384 406 0.97
5 19 0.025 1.5 10.0 5.7 1 23 414 436 414 436 0.98
6 19 0.019 1.2 10.3 9.0 2 23 443 464 442 464 0.97
7 19 0.25 16 6.8 9.3 1 23 470 492 470 492 0.98
8 19 0.0011 0.069 14.2 6.8 1 23 498 520 498 520 0.99
9 19 6.5e-05 0.004 18.1 4.9 1 23 526 548 526 548 0.98
10 19 0.00023 0.014 16.4 6.2 1 23 554 576 554 576 0.99
11 19 0.0018 0.11 13.6 8.2 1 23 582 604 582 604 0.99
12 19 3.5e-06 0.00021 22.1 2.0 1 23 610 632 610 632 0.98
13 19 0.00047 0.029 15.4 3.5 1 23 638 660 638 660 0.98
14 19 0.044 2.7 9.2 5.7 1 23 666 688 666 688 0.95
15 19 4.9e-05 0.003 18.5 4.7 1 23 694 716 694 716 0.99
16 19 6.4e-05 0.004 18.1 4.8 1 23 722 744 722 744 0.95
17 19 0.00022 0.013 16.5 5.2 1 23 750 772 750 772 0.99
18 19 0.00021 0.013 16.5 5.0 1 23 778 800 778 800 0.98
19 19 5.2e-05 0.0032 18.4 4.5 1 23 806 828 806 828 0.99

Sequence Information

Coding Sequence
ATGGACGTGACGCGCGCGTGTCGCTGCTGTCTGCGGTGTCCCCCGGACAAGGACCTGACGACGCCGTACACACATCTCGGCAACACAGAGATTTATGCCGACATGATCAAACAGTGCTTTGACATAAATCTGGCAGGGGGCGGCCCGGGCTCGTGCGGCATCTGCTCGGCGTGCGTGGGCCGCCTGCGAGACGCGAGCGACTTCAAGCTGCAAGTGCAGCGCAGCCAGGAGGAGCTGCAGGCGCGCTCGCAGGGAGCGAGTGGTGTTAAAGAGGAGGAATCTACAGTCGAGCCAGAGAATCCAGAAATTCAGGATAGAGATGGCACCAGGGAGCCTGTATCGGGGGAAGAGCCCCCGGTCAAGCCGGAGATGCCGGAAGATGATGGGACACCTGATGAGATATTGTTCCCGGTTACTGCGCGGAACATGGGGTTTAATATAGTATTGGTTGCTCTAGATGACATGCTCTGGTTAAACATGGCGGCCGGAGACGAGGCGAGCGACGAGGGGGACCCGCTGTTGGATGTAGAGCTCCTAATCAAGCCGGAGCTGGCGGATGATGATGACACAAATGATGAGATGTCACCGGAGGAGCGGGCGGTCAAGTCGGAGGTGTCGGACGAGGCGAGTGACGAGGACTGCGTGTCGGCGGAGGAGCGGGCGGTCAAGTCGGAGGTGTCGGACGAGGCGAGTGACGAGGACTGCGTGTCGGTGTGTTCGGACGGCAACGCCGCCCGCGCCAGGGAACAGCTCTCGATGGCTTGTTCCGTGGTGCTCGAGCGCCTCCGTGACGACGCGACTGTTCACAGTGGAGGCAAGCCGTATGGCTGCGATCACTGTGGAAAACATTTTACAAATAAGTCTATTTTACGAAAACACATACAATATACTCACTTATCGTTTGGGTACAAGAAATTTAATTGTGATTTTTGTAGTTCTACATTTCAAAGTAAATTGCTTGTATTAGAGCATGAAAAAAGTGAACACGGTGTTACAAATTTCATGTGTGCTGAATGTGAGTATTCAACAAGTTCCAAGAAGAGTTTGCGGATCCATATAAAGAGTCACTCTGTGGAGAATCTGTTTGATGGTAGTCAGTATAAAAGTGAAATACACAAataccaaaacatacacgttggggaaaagcctcttcagtgtacgaaatgtggtttcaaatgcagtgttgaatcaaacctgcggcatcaccagaagatgcacaacagaagacaccaagagccgtacacatgtagtcattgtgattacaagtgcagtgataaatcatactcacaaatacaccagatgatacatactggggcgaagccattacaatgtactcactgcgagtacaggtgtaggcataaaagagactttctagttcaccagaggacacacaccggggagaagccttttcagtgttgtcactgtgatttcaaatgcagtaaaaaatcaattctaaaaacacacatgatgatacacactgaggcgaagccatttcaatgtagcaactgcgagtacaggtgcaggcataaaagagacttgctagttcaccagaggacacacaccggggagaagccttttcagtgtagtcaatgcgattacaaatgcagcctaaaaaaaaacctaaaaagacacatgatgatacacactgaggcgaagctatttcagtgtagccactgcgagtacaggtgcaggcggaaaggagacttgctattacaccagaggacacacaccggggaaaagccttttcagtgtggccactgcgagtacaggtgcaggcataaaagagacttgctagttcaccagaggacacacaccggggagaagccttttcagtgtagtcaatgcgatgacaaattcagtaataaatcaagcctaagaaaacacatgatgatacactctggggccaagccatttcaatgtagctactgcgactacaggtgcaggcagcaaagagacttgctagtacacgagagcacacacaccggggagaagccttttctatgtagtcactgtgattacaaatgcagtaaaaaatatattctaaaaagacacataatgatacacactgaggcgaagccatttcaatgtagcaactgcgactacaggtgcacgcggaaaagagacttgctaatacaccagaggacacacaccagggaaaagccttttctgtgtggccactgcggttacaaatgcagtctaaaatcaaacctaaaaagacacatgatgatacacactgaggcgaagctatttcaatgtagccactgcgagtacaggtgcaggcggaaaggagacttgctagtacaccagatgacacacaccggggagaagccttttcagtgcagtcactgtgattacaaatgcattaaaaaatcagatctaaaaagacacgtgattatacacactggggcgaagccatttcagtgtagcaactgcgactacaggtgcaggcggaaaggatacttgctagtacaccagaggacacacaccggggagaagccttttCAGGCGGTTCCCTGA
Protein Sequence
MDVTRACRCCLRCPPDKDLTTPYTHLGNTEIYADMIKQCFDINLAGGGPGSCGICSACVGRLRDASDFKLQVQRSQEELQARSQGASGVKEEESTVEPENPEIQDRDGTREPVSGEEPPVKPEMPEDDGTPDEILFPVTARNMGFNIVLVALDDMLWLNMAAGDEASDEGDPLLDVELLIKPELADDDDTNDEMSPEERAVKSEVSDEASDEDCVSAEERAVKSEVSDEASDEDCVSVCSDGNAARAREQLSMACSVVLERLRDDATVHSGGKPYGCDHCGKHFTNKSILRKHIQYTHLSFGYKKFNCDFCSSTFQSKLLVLEHEKSEHGVTNFMCAECEYSTSSKKSLRIHIKSHSVENLFDGSQYKSEIHKYQNIHVGEKPLQCTKCGFKCSVESNLRHHQKMHNRRHQEPYTCSHCDYKCSDKSYSQIHQMIHTGAKPLQCTHCEYRCRHKRDFLVHQRTHTGEKPFQCCHCDFKCSKKSILKTHMMIHTEAKPFQCSNCEYRCRHKRDLLVHQRTHTGEKPFQCSQCDYKCSLKKNLKRHMMIHTEAKLFQCSHCEYRCRRKGDLLLHQRTHTGEKPFQCGHCEYRCRHKRDLLVHQRTHTGEKPFQCSQCDDKFSNKSSLRKHMMIHSGAKPFQCSYCDYRCRQQRDLLVHESTHTGEKPFLCSHCDYKCSKKYILKRHIMIHTEAKPFQCSNCDYRCTRKRDLLIHQRTHTREKPFLCGHCGYKCSLKSNLKRHMMIHTEAKLFQCSHCEYRCRRKGDLLVHQMTHTGEKPFQCSHCDYKCIKKSDLKRHVIIHTGAKPFQCSNCDYRCRRKGYLLVHQRTHTGEKPFQAVP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-