Basic Information

Gene Symbol
ZEB2
Assembly
GCA_033807575.1
Location
CM066370.1:63587-88619[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 22 0.53 44 6.0 4.5 2 23 1292 1314 1291 1314 0.91
2 22 0.085 7.1 8.5 2.8 2 21 1321 1340 1320 1342 0.93
3 22 0.13 11 8.0 0.5 2 19 1348 1365 1347 1365 0.94
4 22 0.085 7.1 8.5 2.8 2 21 1375 1394 1374 1396 0.93
5 22 0.085 7.1 8.5 2.8 2 21 1402 1421 1401 1423 0.93
6 22 0.085 7.1 8.5 2.8 2 21 1429 1448 1428 1450 0.93
7 22 0.085 7.1 8.5 2.8 2 21 1456 1475 1455 1477 0.93
8 22 0.085 7.1 8.5 2.8 2 21 1483 1502 1482 1504 0.93
9 22 0.085 7.1 8.5 2.8 2 21 1510 1529 1509 1531 0.93
10 22 0.085 7.1 8.5 2.8 2 21 1537 1556 1536 1558 0.93
11 22 0.085 7.1 8.5 2.8 2 21 1564 1583 1563 1585 0.93
12 22 0.31 26 6.8 2.2 2 21 1591 1610 1590 1612 0.93
13 22 0.15 13 7.7 0.2 3 23 1625 1647 1625 1647 0.92
14 22 0.15 13 7.7 0.2 3 23 1672 1694 1672 1694 0.92
15 22 0.15 13 7.7 0.2 3 23 1719 1741 1719 1741 0.92
16 22 0.15 13 7.7 0.2 3 23 1766 1788 1766 1788 0.92
17 22 0.15 13 7.7 0.2 3 23 1813 1835 1813 1835 0.92
18 22 0.15 13 7.7 0.2 3 23 1860 1882 1860 1882 0.92
19 22 0.0023 0.19 13.5 1.4 1 23 1890 1913 1890 1913 0.92
20 22 0.013 1.1 11.1 0.7 1 23 1919 1942 1919 1942 0.96
21 22 3.5e-05 0.003 19.2 1.2 1 23 1952 1974 1952 1974 0.97
22 22 1.3 1.1e+02 4.9 0.3 1 23 1980 2005 1980 2005 0.88

Sequence Information

Coding Sequence
ATGAAGCATATTTGTGTAATTTGCACACTCCAGAAACCGCCGCTGACGCCGCTGGCCACGGAGCATAGGGAATTACTCGAGGCTATTGTATCTCCAGCTATTACCATGGCAGACCTCAGCGCTTGTGAAATCTTGCTGTGTATGGATTGCCAGGAGAAGCTGCAGTCCATACAGCAGTTCCAGAAGATGGCGCTGAACGGCCTCACAGTACTCAAGTCTGTGCTTTCTAAAGTGAACAATGCACCCACGGTACAGGATCAGAAAATACAAACACTAATAGAAATGAAAGATGGCCGGAAACTACTTGTGAATCCAATATCTGTTGTGGAAACAATTATAACCGAACCAGAACTGGAAGAACCAGCCAGCTTAGAACTTTCTGCGACTTCACCCAGACACCCACACCCCCTTGCAGAGGAGATGGATATTAAATCGGAGCAACCTGCGTTCCCAGAGCAGCCCTGCTTAGACGTTGAATTGAAGCTCGAAGTACAATCCAAACATGAGACTGGAACTGAATTCGAACCTGAAATAGAGTTAAAATCGGAGCACTATGAATTTGACTCTGAGTCTGAATTTGATAATGCTTCTTTGAGTCGCTCTGTGGCTCAGTGTGACTCGGACTCGAAGATGAAAACAGAGGAATGTGATTTCACCAGAGTACAGAACATTGCGTTTCATACACGAATTATGAGCCCCTTGCAAACGAATCACGTTTATAAGGTCCCGCTCCTAGAGTGTCCAATTTGTTACGACCATAAGCTGTACAAAGGCCAGCGGGGCCTAAAAATACATTGCGTTCGTGCCCACAGTCCCCGTATTGATAAGTCATGTTTCCCAATATCAGCCGAGGGTTTGACTGATGGTGGCACTGATCCTAGTCCGGCTCCTGCGTCGCTAGCTCAATTGTTGGCTAGCCTTAAGTCAGGCTCTAAGTTAACAAAAAGAATCCCGAAAGGGGCACGAGCTTTGGCGGCGCGAAGTTTATCGGAGTCCATATCCAAAGTGGTGTCAGAAAACAGTTTCACAGCTTGGGAAAATCTTCTTTCGTTTGCGTACAAAAATTTCCATATACCACATACAAAATCAAGCATCAGCCTAACCGCCATAATTAAGGGAAACTTATCTCATCCTTCTATTCCTAATTTGGATTCTAGCGATACACCGTCCGTGACAGACCAAACTGCCCAAACCAATAATGATAAGTATAAGTGCAGGCAAATTGAGCAAAAGGTGTCCGATGGTAACATAAAGGGAGCAACGAGGTTACTTTTTTCTAGCGACTCTTTGGCTTCATATTCCCCTGCCGTGCTCAGTGCGTTATTGGATAAACATCCCTCCGTTTCATCGTCCTCACTTCCACCCCATGCGCTGAGGCCGCCAGCAGCCTCAAACCAGCCGCTTCAGGTATCAAAAGATGCAATTCGTCAGGCTGTGCTCTCTTTTCCGGCTGGCTCAGCTGGTGGCTTAGACGGTATCACACCGCAACATTTAAAAGACTTGATTAGCCCTCTTGCTGGGGATGCCGGTGAAACTTTACTAGAGGAGCTTACCGCTTTGACAAACTTAATGCTCGCGGGCAAAGTTTGCCAAGAGATTGTTCCTACTTTATACGGAGCTAATCTTATTGCCTTGAAGAAAAGAGATGGGGGTATTCGGCCCATTGCCGTTGGTAACACTTTTCGACGTCTTACGTCTAAAGTTTGTTGTCGCCAGTTCCATTCCCGTTTAACAGATAAGTTCAAGCCCGTCCAGCTGGGTTTTGGCCTTAAAGGGGGTTGTGAGGGGGCAGTGCATGCAGCCCGATCATTCCTTGATAGCCAAAATTTTGAAATTCTAGTGAAGATTGACGTTCGCAATGCTTTTAACTCTATAGACCGGGGCGTCCTTCTGGCTCAAATCGAGAATGAACTTCCTGAAATTTACGGCTACCTATGGCAGTGTTATGGTTCAGCATCAAGCCTCATGTATAAAGATAATGAAATTCCTTCTTGCGTGGGCTGCCAGCAGGGAGATCCGCTGGGTCCTGTAATTTTCAGTCTGGCAATCCATCCGATCATCACCCAGCTCACTTCTGAATTAAATTGTTGGTACCTCGACGACGGCACTATCGGTGGTGATAAGTCAAAGgttttagccgatttaaaaaCTTTGGTCGATCGGTTTGCAGAGGTTGGTCTATCAGTGAACTACAATAAGTGCGAGTTGTTTATTTCGGACGCCATTCCTCCTGACACCCGGTCGTCTTTGATAAACGAGATAAACCAGCTCACACCAAACATATCAATCTTGTCTCGCGCCACCCTCACGCTTCTAGGAGCTCCGATTTTTGAGGAATCTATACCGGAGTCTATAGACTCTAAGATCGAACATTTTAATAGGTGTTCAGACCTATTGTTCAAAATTAATCCGCACATGGCAATTTACATTCTACGCCTTTGCTTGTTCTCACCGCGTTTGATGTATATTCTCCGCTGTGCCCCCGTTTGGAAATTTCCCATGATTACATCAAACGTTGACCGTATTCTGAAAGAGGCggttagtaaaattttaaatgtaagttTTACTCCGTCGAGTTGGTCTCAAGCTTCCCTCCCGATAAAGTTTGGTGGACTCGGTATCCGTTTGGCGGGAGATCTAGCACTCCCGGCGTTTTTGTCGTCTGCCTACAGCACAGTCACTCTCGTCAGCGGTATTCTCCGTATCTCTTCAACCGCTGACGTGACGGTGTCGTGCCTGGCGGAGGCAGAAGCTGCTTGGAGAGCAGATCATTCCGTCGATCTGGTCCCGGAGGAAAAGTCAAGCCAAGCGGCGTGGGACGTTATTAACGTTAAACTGCGACACCAGCTCCTCGTGCGGGAAGCCCGTGACCACCATGAGCGAGCTAGACTCCTGGCTGTGTCAGAGAAGGAGTCGGGCTATTGGCTACACGCGCTCCCTTCGCGCAACCTTGGCACCGCACTAGAACCGAATGCTCTGCAGATCGCGATTTGCCTTCGTCTGGGCATGAAGATCTGTGAGGCCCATGCCTGTAGTCGCTGCGCCCAGCCAGTGGACGCTCTAGGACGACATGGCCTGCACTGCAAGTTGAGCGCTGGCCGTCTTTATAGGCATTCCTCCCTGAACGACTTAGTCCGCCGCGCCCTCAGCACCGCCTCTCTTCCCGCGACTTTGGAGCCATCAGGCCTCTCCGCGGCTGACGGTAAAAGACCTGATGGCTGCACTCTCGTGCCATGGAGCCTGGGTCACCCCTTAGCGTGGGACGCCACCTGCGTCGATACGCTGGCCCCGTCCCACGTTGAGGGATCTGCTCGAAAGCCTGGGACGGCCGCGGACCAGGCACAGACACTCAAGCGCCGCAAGTATGCATTCTTAACGAACGAATacgagtttgcggcgcttgcaatGGAAACATTGGGTCCTTGGTCGACCGACACCAAAAAATTTATTAAGGAAGTGTCGGTTCGACTGacGATTGAAAACAAATATAAGCCTGCAATTTTAAAACAAGCACACAGACCACCAAAGGAACCTAGAGCAGCAAAAGTGGGTATAATAGCTAGAGCATACGCTGCCAAACAAGCTAAAGCAGCTTTAAAAGCTAGCGCAAACGCAGCTAAACAGGTTAACGTAGCTTCAGAAGGAGCACATGGAATTATAGAAGCAAATGTAGCTTCAGAAGAAGCACAAACAGTTGAAGAAGTAAACATAGCTTCAGTAGCTAGTGATAATGCATTTGTAGAAATGACTGTCGCTTGTACAACTGAAATGGCAAACGAAGCTGAGAAAGCGAACGCTACAAATATTACTACAGAAGCAAACGCAGCAGTTGAAAAGGAAAAGGAAAGAGAGAGTAAGAAGTCGGAGCGCGTGCAGTGTGCACTCTGTGACAAAGTCCTGTGCCACAAGCGGAGTTTTCGGCAACATTACTATCTACGGCACGCCGAGGCAAACCCAGTCAAGTGCGAGTTGTGCCACAAACAGTTCCGCAACGCAGGTGTGCTCCGCTACCACCAGTGTCCGCACAAAAAGGTAACAGTCAAGTGCGAGTTGTGCCACAAACAGTTCCGCAACGCAGGTGTGCTCCGCTACCACCCGTGTCCGCACAAAAAGGTAACAGTCAAGTGCGAGTTGTGCCACAAACAGTTCCGCAACGCAGGTGTGCTCCGCTACCACCAGTGTCCGCACAAAAAGGTAACAGTCAAGTGCGAGTTGTGCCACAAACAGTTCCGCAACGCAGGTGTGCTCCGCTACCACCAGTGTCCGCACAAAAAGGTAACAGTCAAGTGCGAGTTGTGCCACAAACAGTTCCGCAACGCAGGTGTGCTCCGCTACCACCAGTGTCCGCACAAAAAGGTAACAGTCAAGTGCGAGTTGTGCCACAAACAGTTCCGCAACGCAGGTGTGCTCCGCTACCACCAGTGTCCGCACAAAAAGGTAACAGTCAAGTGCGAGTTGTGCCACAAACAGTTCCGCAACGCAGGTGTGCTCCGCTACCACCAGTGTCCGCACAAAAAGGTAACAGTCAAGTGCGAGTTGTGCCACAAACAGTTCCGCAACGCAGGTGTGCTCCGCTACCACCAGTGTCCGCACAAAAAGGTAACAGTCAAGTGCGAGTTGTGCCACAAACAGTTCCGCAACGCAGGTGTGCTCCGCTACCACCAGTGTCCGCACAAAAAGGTAACAGTCAAGTGCGAGTTGTGCCACAAACAGTTCCGCAACGCAGGTGTGCTCCGCTACCACCAGTGTCCGCACAAAAAGGTAACAGTCAAGTGCGAGTTGTGCCACAAACAGTACCGCGACGCAGGTGTGCTTCGCTACCACCAGTGTCCGCACAAAAAGgcCGCCCCGAGGCCGGCGCCGCGGACGTGGTGCGCGGAGTGCGCGCGGCAGTTCCCGACCCGCGCGCAGTACCGCGCGCACCTCCTCACCCTCAAGCACACGCCGCGGGCCCTCTACAAGTACGTATACGGCCTCGTCGCAGGCCCCCCGAGGCCGGCGCCGCGGACGTGGTGCGCGGAGTGCGCGCGGCAGTTCCCGACCCGCGCGCAGTACCGCGCGCACCTCCTCACCCTCAAGCACACGCCGCGGGCCCTCTACAAGTACGTATACGGCCTCGTCGCAGGCCCCCCGAGGCCGGCGCCGCGGACGTGGTGCGCGGAGTGCGCGCGGCAGTTCCCGACCCGCGCGCAGTACCGCGCGCACCTCCTCACCCTCAAGCACACGCCGCGGGCCCTCTACAAGTACGTATACGGCCTCGTCGCAGGCCCCCCGAGGCCGGCGCCGCGGACGTGGTGCGCGGAGTGCGCGCGGCAGTTCCCGACCCGCGCGCAGTACCGCGCGCACCTCCTCACCCTCAAGCACACGCCGCGGGCCCTCTACAAGTACGTATACGGCCTCGTCGCAGGCCCCCCGAGGCCGGCGCCGCGGACGTGGTGCGCGGAGTGCGCGCGGCAGTTCCCGACCCGCGCGCAGTACCGCGCGCACCTCCTCACCCTCAAGCACACGCCGCGGGCCCTCTACAAGTACGTATACGGCCTCGTCGCAGGCCCCCCGAGGCCGGCGCCGCGGACGTGGTGCGCGGAGTGCGCGCGGCAGTTCCCGACCCGCGCGCAGTACCGCGCGCACCTCCTCACCCTCAAGCACACGCCGCGCGCCCTCTACAAATTCGAGTGTGAAGTGTGCAAGAAGCGGTTCCGGCACCGGCGCTGGATGCGCGACCACCTCGACGCCGCGCACCGCGGCCTGAAAAAGTACTCGTGCGACAGATGCGACTCTTCGTTCGGCTCGTTCACGTCCCTGCGGCGCCACGTCGCGCGCGACCACGACAAGGTAGTCGCGCCGCGGGCAACGCACGTGTGCGACCTCTGCGGGAAGACGTTCAAGGTTAAAAAGTCGCTGGAGGAGCACCTGTTGTCGCACTACGGGCTGCGGCCCTTCACGTGCGCGGCGCCGGCGTGTCCGGCCGCCTTCTGCTACCGCGCCGCGCTCTACACGCACACGCGCCTCAAGCACGCGCCCGACAAGCAGGGACGGAAGGAACAGGAACATGACGAACAAATGGATGACGGGGAAAGGCCTGAATACTTGGAATTACAATTTGATGACTGA
Protein Sequence
MKHICVICTLQKPPLTPLATEHRELLEAIVSPAITMADLSACEILLCMDCQEKLQSIQQFQKMALNGLTVLKSVLSKVNNAPTVQDQKIQTLIEMKDGRKLLVNPISVVETIITEPELEEPASLELSATSPRHPHPLAEEMDIKSEQPAFPEQPCLDVELKLEVQSKHETGTEFEPEIELKSEHYEFDSESEFDNASLSRSVAQCDSDSKMKTEECDFTRVQNIAFHTRIMSPLQTNHVYKVPLLECPICYDHKLYKGQRGLKIHCVRAHSPRIDKSCFPISAEGLTDGGTDPSPAPASLAQLLASLKSGSKLTKRIPKGARALAARSLSESISKVVSENSFTAWENLLSFAYKNFHIPHTKSSISLTAIIKGNLSHPSIPNLDSSDTPSVTDQTAQTNNDKYKCRQIEQKVSDGNIKGATRLLFSSDSLASYSPAVLSALLDKHPSVSSSSLPPHALRPPAASNQPLQVSKDAIRQAVLSFPAGSAGGLDGITPQHLKDLISPLAGDAGETLLEELTALTNLMLAGKVCQEIVPTLYGANLIALKKRDGGIRPIAVGNTFRRLTSKVCCRQFHSRLTDKFKPVQLGFGLKGGCEGAVHAARSFLDSQNFEILVKIDVRNAFNSIDRGVLLAQIENELPEIYGYLWQCYGSASSLMYKDNEIPSCVGCQQGDPLGPVIFSLAIHPIITQLTSELNCWYLDDGTIGGDKSKVLADLKTLVDRFAEVGLSVNYNKCELFISDAIPPDTRSSLINEINQLTPNISILSRATLTLLGAPIFEESIPESIDSKIEHFNRCSDLLFKINPHMAIYILRLCLFSPRLMYILRCAPVWKFPMITSNVDRILKEAVSKILNVSFTPSSWSQASLPIKFGGLGIRLAGDLALPAFLSSAYSTVTLVSGILRISSTADVTVSCLAEAEAAWRADHSVDLVPEEKSSQAAWDVINVKLRHQLLVREARDHHERARLLAVSEKESGYWLHALPSRNLGTALEPNALQIAICLRLGMKICEAHACSRCAQPVDALGRHGLHCKLSAGRLYRHSSLNDLVRRALSTASLPATLEPSGLSAADGKRPDGCTLVPWSLGHPLAWDATCVDTLAPSHVEGSARKPGTAADQAQTLKRRKYAFLTNEYEFAALAMETLGPWSTDTKKFIKEVSVRLTIENKYKPAILKQAHRPPKEPRAAKVGIIARAYAAKQAKAALKASANAAKQVNVASEGAHGIIEANVASEEAQTVEEVNIASVASDNAFVEMTVACTTEMANEAEKANATNITTEANAAVEKEKERESKKSERVQCALCDKVLCHKRSFRQHYYLRHAEANPVKCELCHKQFRNAGVLRYHQCPHKKVTVKCELCHKQFRNAGVLRYHPCPHKKVTVKCELCHKQFRNAGVLRYHQCPHKKVTVKCELCHKQFRNAGVLRYHQCPHKKVTVKCELCHKQFRNAGVLRYHQCPHKKVTVKCELCHKQFRNAGVLRYHQCPHKKVTVKCELCHKQFRNAGVLRYHQCPHKKVTVKCELCHKQFRNAGVLRYHQCPHKKVTVKCELCHKQFRNAGVLRYHQCPHKKVTVKCELCHKQFRNAGVLRYHQCPHKKVTVKCELCHKQYRDAGVLRYHQCPHKKAAPRPAPRTWCAECARQFPTRAQYRAHLLTLKHTPRALYKYVYGLVAGPPRPAPRTWCAECARQFPTRAQYRAHLLTLKHTPRALYKYVYGLVAGPPRPAPRTWCAECARQFPTRAQYRAHLLTLKHTPRALYKYVYGLVAGPPRPAPRTWCAECARQFPTRAQYRAHLLTLKHTPRALYKYVYGLVAGPPRPAPRTWCAECARQFPTRAQYRAHLLTLKHTPRALYKYVYGLVAGPPRPAPRTWCAECARQFPTRAQYRAHLLTLKHTPRALYKFECEVCKKRFRHRRWMRDHLDAAHRGLKKYSCDRCDSSFGSFTSLRRHVARDHDKVVAPRATHVCDLCGKTFKVKKSLEEHLLSHYGLRPFTCAAPACPAAFCYRAALYTHTRLKHAPDKQGRKEQEHDEQMDDGERPEYLELQFDD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-