Basic Information

Gene Symbol
Bcl11a
Assembly
GCA_033807575.1
Location
CM066368.1:5253091-5261787[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 0.94 78 5.3 4.4 1 14 172 185 172 197 0.82
2 15 5.9e-06 0.00049 21.6 3.1 1 23 203 225 203 225 0.96
3 15 2.3e-05 0.002 19.7 0.4 1 23 231 253 231 253 0.98
4 15 1.5e-07 1.3e-05 26.6 3.9 1 23 259 281 259 281 0.99
5 15 7.9e-05 0.0066 18.1 2.4 1 23 307 329 307 329 0.98
6 15 0.00069 0.058 15.1 1.2 1 23 335 357 335 357 0.92
7 15 6.6e-06 0.00055 21.5 0.7 1 23 363 385 363 385 0.98
8 15 0.0001 0.0084 17.8 0.9 1 23 391 413 391 413 0.96
9 15 0.00049 0.041 15.6 2.7 1 23 419 442 419 442 0.95
10 15 5.4e-06 0.00045 21.8 1.9 1 23 450 472 450 472 0.97
11 15 0.00016 0.014 17.1 1.2 1 23 492 514 492 514 0.98
12 15 5.3e-06 0.00044 21.8 3.2 1 23 520 542 520 542 0.98
13 15 5.7e-06 0.00048 21.7 2.0 1 23 548 571 548 571 0.97
14 15 5e-05 0.0042 18.7 0.5 1 23 577 599 577 599 0.98
15 15 2e-05 0.0017 19.9 0.5 1 23 605 628 605 628 0.97

Sequence Information

Coding Sequence
ATGGAGAAAATGCACTCGTGTAGCTGCTGCCTGGTGCGGCCGCCGGAGAAGGGACTGAAGACAATGTATAAACATCTCGGAAAAACTGAGATTTATTACGACATGCTGAAAGCCTGCTTCgatattaatCTCGGTATAAGAAATGAAGAGTGCGGAATCTGTGAAGTATGCGTGGGGCGGCTGCGGGACGCGAGTGACTTCAAGCTGCAAGTGCAGCGCAGCCAGTCAGAGCTGAATGCGCGGTTCAAGGGCGTACTCTCTACCAGTGACAAGTTCAAAATTAAGTTGGAGAAAGCGGGTGGAGATGAGGCCATCAAATgcGATATCAAGCTGGAGAAGTCCGAGGCGGAGATGACTGATGGCGAGGTCATATCAGTGGCTATATACGGCGGGCATCCAGGGCCTTCAGCAAAACCCGTTTCTAATAAAACTAACCGCGACACTTCACCGGCAGATAGCGTCACCGATCTCGACGATTCCAAGCCGGCTCGCGCTTCTGGCCGCAGTAAGGTGCACGAGTGCGACATATGCCATAAAAAGTTCGAGAATTCAAACGCAAAAACCAGACTCGTGATCCATCGCCGCTCCCACACTGGAGAGAAGCCTTACTCGTGCAATGTATGCGACAAAAAATTCGCACAAAGGAGCCACTTAAACACACATTACGCATATCACATCGGGAAGTTCAAATTCTCCTGCGAAGTATGTGGCACGCGATTCATTCAAAGAAATCAATATGTTGTGCATATGCGTGGGCACACAGGCGCAAGACCGTATTCGTGTGAATTATGCAACAAAACTTTCAGACAAAAAGGCCACTTAACCGTTCATATGAGAAAACATTTGAAATATGATCCTAGTAGCGTAGAGCCGGGAGAGATTACATGCAAAACAGAATTTGCTGATGAAACTGAAGATTTTACATGTGATATATGCAAAAAACAATTTGCAGACGAAAGCGCCTTAAACACTCATAAAAAACATCATTCGGGTGATTATCCATTCATTTGCGATATTTGTGAAAGGAAGTTTAATACGCAGTTTGCCTTGAATAATCATAAATTTGACCATTCGGGAGGGAAACCTTTTAAGTGTGAAAAATGCAATAAGGGCTACACATCGAAAGGTGCTTTAAATCTACATTTGAAAGTTCACACTGAGGATTACAAACACGCATGTCTTCTGTGTAGTAAACGGTTCATAATAAAAGAGAATCTAAATGTACATATGCGCGTACACACGGGGGAAAAGCCTTATACCTGTGCAACTTGTGAAACTAAGTTCCGCTATCGATATAGCCTGAAGAAACATTTATTGGAAAAGCACAACCAAGTTATGGACAAACAGTTCTGTTGCGACATTTGTGGGAAACGATTTGCACTACAGGGGACATTAACTAAACACATGGAAAAGCATGCTGAGCAAAAAAGGGAGGAAGAAGCCAAAAAGGAAGGGCGGATAGAAGACAGGCCATTTATGTGTGAAATATGTAGCAAACGTTTTTCAACAAAAGGTATCTTAAGAAATCACCGAGAAACGCACTCCGAAGAAAGACCTTTCGAATGTGaaatatgtcataaaaactTCAGAATGAAAAAGAGCTTGCAAGATCACATGAAAGTGCATGAGGACTTTAAGCGACACTCCTGTGAAGTCTGCGGTCAGcaatttaaacataaatctgCCTTAGCAGTTCATATCCGACGAATGCATTCAAAAAGTATGCCTCATACTTGCGATGTGTGCGACAAGTCGTATCCAGTTATCGCTGAATTGAAGAAGCATTATCGTGTGCACACTGGGGAGAGACCATTTGCTTGTGAAATATGCTATAAGAGGTTTCCTCGGCAAGATGGAGTAAGGAGACACCTTAGAAAAGTTCACCAAGAGAAACCTtcgaaatatattaaattaaaagaattTAATAAtccttacaataaataa
Protein Sequence
MEKMHSCSCCLVRPPEKGLKTMYKHLGKTEIYYDMLKACFDINLGIRNEECGICEVCVGRLRDASDFKLQVQRSQSELNARFKGVLSTSDKFKIKLEKAGGDEAIKCDIKLEKSEAEMTDGEVISVAIYGGHPGPSAKPVSNKTNRDTSPADSVTDLDDSKPARASGRSKVHECDICHKKFENSNAKTRLVIHRRSHTGEKPYSCNVCDKKFAQRSHLNTHYAYHIGKFKFSCEVCGTRFIQRNQYVVHMRGHTGARPYSCELCNKTFRQKGHLTVHMRKHLKYDPSSVEPGEITCKTEFADETEDFTCDICKKQFADESALNTHKKHHSGDYPFICDICERKFNTQFALNNHKFDHSGGKPFKCEKCNKGYTSKGALNLHLKVHTEDYKHACLLCSKRFIIKENLNVHMRVHTGEKPYTCATCETKFRYRYSLKKHLLEKHNQVMDKQFCCDICGKRFALQGTLTKHMEKHAEQKREEEAKKEGRIEDRPFMCEICSKRFSTKGILRNHRETHSEERPFECEICHKNFRMKKSLQDHMKVHEDFKRHSCEVCGQQFKHKSALAVHIRRMHSKSMPHTCDVCDKSYPVIAELKKHYRVHTGERPFACEICYKRFPRQDGVRRHLRKVHQEKPSKYIKLKEFNNPYNK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-