Cpom012111.2
Basic Information
- Insect
- Cydia pomonella
- Gene Symbol
- ewg
- Assembly
- GCA_033807575.1
- Location
- CM066349.1:21328994-21330067[-]
Transcription Factor Domain
- TF Family
- Nrf1
- Domain
- Nrf1_DNA-bind domain
- PFAM
- PF10491
- TF Group
- Basic Domians group
- Description
- In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 6 5e-13 3.7e-09 37.9 0.0 186 212 1 27 1 28 0.95 2 6 1.2e-06 0.009 17.0 0.0 184 212 41 68 31 69 0.76 3 6 1.8e-06 0.013 16.4 0.0 186 212 84 109 72 110 0.74 4 6 1.2e-06 0.009 17.0 0.0 184 212 123 150 113 151 0.76 5 6 1.2e-06 0.009 17.0 0.0 184 212 164 191 154 192 0.76 6 6 1.2e-06 0.009 17.0 0.0 184 212 205 232 195 233 0.76
Sequence Information
- Coding Sequence
- ATGTCGTGGACGCACGCGCTTCGTCAGATCGTGATCAACTGCTACAAGTACCACGGCCGCGAGGACCTGCTGCCCGCCTTCACCGAGGACGACGATCAGAAACCTACGCAGCCCGTGAGTACAACTGTAAACCTTACTCCAAACATAAGGCTCACTATCAACTGCTACAAGTACCACGGCCGCGAGGACCTGCTGCCCGCCTTCACCGAGGACGACGATCAGAAACCTACGCAGCCCGTGAGTACAACTATAAACCTTACTCCAAACATAAGGCTCACTATCAACTGCTACAAGTACCACGGCCGCGAGGACCTGCTGCCCGCCTTCACCGAGGACGACGATCAGAAACCTACGCAGCCCGTGAGTACAACTGTAAACCTTACTCCAAACATAAGGCTCACTATCAACTGCTACAAGTACCACGGCCGCGAGGACCTGCTGCCCGCCTTCACCGAGGACGACGATCAGAAACCTACGCAGCCCGTGAGTACAACTGTAAACCTTACTCCAAACATAAGGCTCACTATCAACTGCTACAAGTACCACGGCCGCGAGGACCTGCTGCCCGCCTTCACCGAGGACGACGATCAGAAACCTACGCAGCCCGTGAGTACAACTGTAAACCTTACTCCAAACATAAGGCTCACTATCAACTGCTACAAGTACCACGGCCGCGAGGACCTGCTGCCCGCCTTCACCGAGGACGACGATCAGAAACCCACGCAGCCCGAGAGACAAAACCGAACCTTCTGCCGAATCATGATTTTTACGTCGAAACCATCACCGAAACTTCGATCGGACACTATTCTCAAGTCTTTGTTCCTAATTCACTTTGTGTGGGAACACAACATTTATATAGAACTAGCAATGAACTCGCCAGGAGTAGTGGTTCTTAACTTTTCAGTGATAAACGATGAAATTTCTTTTGGTCCATCACCAACTGCTTGGTGTGGTAAGTATTTAACCTATGACGAATTAAGTCAACAAAAGATGGACCACTTCAGACGCTTCCAGGGATTATATCGGTTAAGAACCACATCACAGAAGATTTTTTGTAACTCCTACGAATACTAA
- Protein Sequence
- MSWTHALRQIVINCYKYHGREDLLPAFTEDDDQKPTQPVSTTVNLTPNIRLTINCYKYHGREDLLPAFTEDDDQKPTQPVSTTINLTPNIRLTINCYKYHGREDLLPAFTEDDDQKPTQPVSTTVNLTPNIRLTINCYKYHGREDLLPAFTEDDDQKPTQPVSTTVNLTPNIRLTINCYKYHGREDLLPAFTEDDDQKPTQPVSTTVNLTPNIRLTINCYKYHGREDLLPAFTEDDDQKPTQPERQNRTFCRIMIFTSKPSPKLRSDTILKSLFLIHFVWEHNIYIELAMNSPGVVVLNFSVINDEISFGPSPTAWCGKYLTYDELSQQKMDHFRRFQGLYRLRTTSQKIFCNSYEY
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -