Basic Information

Gene Symbol
Zfx
Assembly
GCA_963556715.1
Location
OY750816.1:10782587-10794046[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 8 0.0068 0.44 12.1 1.9 2 23 190 212 189 212 0.95
2 8 4e-05 0.0026 19.1 0.6 2 23 234 256 234 256 0.96
3 8 2.8e-05 0.0018 19.6 0.3 1 23 262 284 262 284 0.98
4 8 0.0049 0.32 12.6 0.4 2 22 293 313 292 317 0.92
5 8 3.5e-05 0.0022 19.3 0.4 1 23 325 348 325 348 0.91
6 8 0.17 11 7.7 5.2 1 23 354 377 354 377 0.96
7 8 0.001 0.066 14.7 0.4 3 23 387 408 386 408 0.91
8 8 0.0064 0.41 12.2 0.0 1 23 414 437 414 437 0.97

Sequence Information

Coding Sequence
ATGCTGAAATATGATGGAGactgtacccacaacacaagcattattgagcttactAGCACCCCAAAATACGCACTGTGCCAACCGCCTCGGTTGAGTATTCAACCCGTGCACACCATCAGTTACCCGCTAGATGTGAAAGCCGAGCCCACGGACACAACCAATGTGGAGATTATTGACAACATAAAGGTGGAAGTAGATGACACCGTAGAGCATTGTGAACCGGAGACGTTTGTGAATGACCTGGATTTGAAGAAAACTGAGGATCTCGAGAAGAGTGAGGATTTAAAGAAGCCAAGcaagaaaaagaagaaaaagCTAAAAGGGAacaaaaagaagaaaaagaaactAGAGGAACCATTGTCAGATGGATTCAGCGACAGAGACTGTGATTACAAAATTGACATTGTTGACAATTTTGAGAATATCGCTAACAATGTTGACAACTTTGACAATGTGGGTGCAGATGTTGACAACTTTGACAATGGTGACAATTTTGACAATGGTGACAATGGTGACAATGGTGACAAAGTTGACAAAGCTGGGGAGAATGTGATAGAAGCTAAATGTATGTGTTCTGAGTGCGGTCTTACCTTTGATACCAGAAGGCAGATGGACTTACATGTTAAAAAGGAACATTTAAAGGAGGGTGTGACGGGGAAAGTTAGGACCCGGAGTAAAGAGGTGTTGGCGGAGAAACCCACGTGCGCGGAGTGTGGAAAGGTGTTCAGCTCTAGAAAGACCTACAGGTACCATCTAAATGTGCTACACAAAGGACAGAACCGATACCCGTGTCCGCGATGCGGTAAAGTGTACCAGTGGAAGTCCAATCTCGGCCGCCATCTCAGAACACATAAGGCTCGAGATGACGGCGAGCTGTACTGCGCGCTGTGCGACAAGCGGTTCGCGTCCGTCGCGACATACCGACAACATCTGCGCGTGTCGCGGCGACACGTGCCCGAGAGCGAGTTCAGtttcgtaTGCAACGAGTGCGGTAAGAAGTTCGTGAATAAGACCCGGCTGAGAGACCACGTGGACTGGGAGCATCTCAAGAAGATCAAGTTCCGGTGCCAGCTCTGTAACAAGCCCTTCAAGTGCCACACATCGCTGTACGTGCACCTACAGAACGTGCACCGAAATAAGGAGAAGAAAGACAACTTGTGTCACGTCTGCGGGAAATCTTATCAGAACGCAGCCAAACTTAAGTACCACATAGTGGCGATGCACACACGTGAGACGCCGTACGAGTGTGGACAGTGTGGGGCGGCCTTTGGGTGGTACTCGAGCTTATACAGACACATCCGCGAGGTGCATTATAAGATGAAAGTGCAACCGAAGAAGTCGAAGAAGGGAAAGAAGATAGAAGATATGGACGTGATGCCGCCGCTGCCCGGGCCCGCTTAA
Protein Sequence
MLKYDGDCTHNTSIIELTSTPKYALCQPPRLSIQPVHTISYPLDVKAEPTDTTNVEIIDNIKVEVDDTVEHCEPETFVNDLDLKKTEDLEKSEDLKKPSKKKKKKLKGNKKKKKKLEEPLSDGFSDRDCDYKIDIVDNFENIANNVDNFDNVGADVDNFDNGDNFDNGDNGDNGDKVDKAGENVIEAKCMCSECGLTFDTRRQMDLHVKKEHLKEGVTGKVRTRSKEVLAEKPTCAECGKVFSSRKTYRYHLNVLHKGQNRYPCPRCGKVYQWKSNLGRHLRTHKARDDGELYCALCDKRFASVATYRQHLRVSRRHVPESEFSFVCNECGKKFVNKTRLRDHVDWEHLKKIKFRCQLCNKPFKCHTSLYVHLQNVHRNKEKKDNLCHVCGKSYQNAAKLKYHIVAMHTRETPYECGQCGAAFGWYSSLYRHIREVHYKMKVQPKKSKKGKKIEDMDVMPPLPGPA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_00409644;
80% Identity
-