Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.0032 0.18 12.8 1.5 2 23 49 71 48 71 0.95

2 7 1e-05 0.00057 20.7 0.6 2 23 75 97 74 97 0.97

3 7 0.21 11 7.1 0.1 3 23 110 131 109 131 0.93

4 7 0.0026 0.14 13.1 0.4 2 23 140 162 139 162 0.91

5 7 6.6e-05 0.0036 18.1 7.1 1 23 168 190 168 190 0.99

6 7 0.0014 0.076 14.0 1.4 3 23 201 221 200 221 0.96

7 7 0.00025 0.014 16.3 0.1 1 23 227 250 227 250 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.0032	0.18	12.8	1.5	2	23	49	71	48	71	0.95
2	7	1e-05	0.00057	20.7	0.6	2	23	75	97	74	97	0.97
3	7	0.21	11	7.1	0.1	3	23	110	131	109	131	0.93
4	7	0.0026	0.14	13.1	0.4	2	23	140	162	139	162	0.91
5	7	6.6e-05	0.0036	18.1	7.1	1	23	168	190	168	190	0.99
6	7	0.0014	0.076	14.0	1.4	3	23	201	221	200	221	0.96
7	7	0.00025	0.014	16.3	0.1	1	23	227	250	227	250	0.97

Coding Sequence: ATGCTACGGAAGGAGCACACACAGTCAAACCTGCACGAGCACCACCGGCACAAGTACCAGTGCCTGGGCTGCAGATGGTCGGAGGCTTTCTTCTGGAACAAAGAAGACCATTCGTACCACTGGCAGACAGTGCACGCGACGCTTGTGTGCGACATCTGCCGGCAGACAAGGCGCAACACGCACGACATGGAGCGCCACATGAGAGCCAGTCACCTCCCAATAAAATGTCCGCAGTGTCCGCGCGTGTACTCCAAGTGGAAGTATTACCGCCAGCACCAGAAGATGGCGCACCCGGTGCTTGCGCTGGAGCCGCCCGAATCCAGGTACTGCGTGGAGTGCGACATGCAGTTCCCGTCCATCATGGCGTATAAGATGCATGTCATGAACCAACACCGGAACACGCCCAAAAAGAGATGGCCGTGCCCGGCGTGCAACAAGACACTCAACAACAAGGACACCATGAAGAAACACTACGCCCTGTTCCACAGCGACAGGACCAGCTACCAGTGCCCCCACTGCGGCAAGTACTTGTCTTCGAAGTGCTCGCTACAGCACCACCTCAACTCGCACCTCAACATCAAACTACCCAAGGATAAGCTGTGCTCCATATGCGGCCGCGGTTTCTCGACGAAGCGCATGCTCCGTTTCCACACGTACACGCACACGGGCGAGCGGCCGTACGCGTGCGCGCACTGCCCCGCCGCCTTCACGCAGCCCAACCCGCTGCGCGTGCACGCCAGGAAACTGCACCCGCATCTGCCGCTCAACGTGCAGCCGAAGAAAGTTCAGCAATAA
Protein Sequence: MLRKEHTQSNLHEHHRHKYQCLGCRWSEAFFWNKEDHSYHWQTVHATLVCDICRQTRRNTHDMERHMRASHLPIKCPQCPRVYSKWKYYRQHQKMAHPVLALEPPESRYCVECDMQFPSIMAYKMHVMNQHRNTPKKRWPCPACNKTLNNKDTMKKHYALFHSDRTSYQCPHCGKYLSSKCSLQHHLNSHLNIKLPKDKLCSICGRGFSTKRMLRFHTYTHTGERPYACAHCPAAFTQPNPLRVHARKLHPHLPLNVQPKKVQQ

Sequence clustering based on sequence similarity using MMseqs2