Basic Information

Gene Symbol
ZEB2
Assembly
GCA_963082685.1
Location
OY720117.1:10908532-10913964[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.0048 0.37 11.8 2.4 1 19 490 508 490 512 0.98
2 11 0.0027 0.2 12.6 2.4 1 23 528 551 528 551 0.97
3 11 0.12 9.1 7.4 1.1 3 23 558 580 556 580 0.90
4 11 0.078 5.9 8.0 0.1 2 21 631 650 630 651 0.93
5 11 1.9e-05 0.0014 19.4 0.9 1 23 710 731 710 731 0.98
6 11 0.00011 0.0081 17.0 1.1 1 23 737 760 737 760 0.95
7 11 0.0035 0.26 12.2 3.7 2 20 778 796 777 798 0.92
8 11 0.079 6 8.0 0.3 2 23 807 830 807 830 0.96
9 11 0.00017 0.013 16.3 6.4 1 23 838 860 838 860 0.96
10 11 0.097 7.4 7.7 3.1 1 21 866 886 866 891 0.91
11 11 0.053 4 8.5 2.3 1 23 897 920 897 920 0.90

Sequence Information

Coding Sequence
ATGCTCTCCCCACGAGAAGACGAAGATGACGATACTCACCTCTGCATCAAATGTAACGCCACTCTGGTTGGGCTCGACAACTACATCAAGCATCGAAAGGAGAGATGCGGCAAAAATAAAGGCGACCCTAAACCAGACCTCTCTACTATCGACTCTTTGGATCCAACGTACAGTTTGGGAGCAGACGTGTTCTTCCAGTCTTTAGAACTTCAGAGCAGTGTGAAGAAAACTTCACTATCAAGACTAACGCCTCCAATACCGATAAGCAAATCGAACTTAGAAAGAAAATCTTTAATCGCAACGACGTCACAGCCTCGCATGAGTCCTTTAGAAACTAATCTTAGAGGAGAAGACTGGATTGGAGGTCATACGCTAAGAATTAGTGGGAATGAAGACAATCAGACTAAACTAATTAATGCCGTTGCTAGTATAAGTGGCAATGTTAAGAAAGAAACCAGTACATCCTACACTATTGGATACAATGATTATAAAGGGGTTGAAGAAAGTGAAGAATCAGAGGTATCTGAGGATGACGAAGAAGAAGAGCATACAAGTGGGAAGTGGAAACCACCCCCAAATTATACAGGAGGGAAATGGCGTCCAGATTCCCCTGAACACGACTGGGATGACCAAGAACAGGAACAACCACCTTCTTGGAAGTCGTTACTCCCTGAAGTTGATCGCGATGATGACTACGACGCGCCTCCTCCGGGGCATACTAAAGGAAAATGGGTTCCTGGAGCCAATGAAAAGACTCAGATCATGCAGCCAACTATACAAACCAAAGGCTTCGTACAATACTGGTGTGGTCCTTGCAACAGAAGACTCGGTTCCAGAGCTATATATGACAAGCATCTAAGATCTAGTCTACACTTGAAGAAAGTACTCCCAGAACATGAGCTAGAATTCTCAGGACACCTAGAACCCATCAAAATGACAGAAAAACGTGTTACAAGACCTTCCAAATTCGTAGACGGCGATATCTATTCCCAAGTTGAAAGAAAAAAGCGACAGAAGAAAGACGATAAGGAAGTCAATCAGGTTAAGAAAAGGAAaagaaaatctatttttattaattgccCTGGATGCAAGTCTCGTGTCAGAGAACATTTGATGGGAAAGCATTTAATATCACATTACCACTTCAGAAAGGCTGCTGGAGTAACGAACTCAGTCTACCAACAGCTGATCTTAGACAATATCGACGCCATAGTCCATCAGTCACCGTTCCAATGCAGTCCATGCAAATACTACACTAATTGGATCCCAAATTTTATGCAGCATTGGAAATCAGAAGAGCATAAAGCTATAGTCGATTCCATTGAAGGTGTTTTCTGGTGTTCGTTTTGTAAATTCGATTGTGAATCTTGTGAAGAAATGATAACTCATCTGTCAAGTTCAGATCACAACGAAGTCGTGGCTGTGATGAATAGATCCATGCCAATTATCATTAGAAAGAAGACTATCTTCAAATGTGAGACATGTTCTGAAGTTTTCAGATATAACATGGAACTGAAGAAACATTGTGAGAAGACTGGACATGCTATAGGTTATACGGCAACTGATAACTATCAGGAACTTCATAAATGCCAGCTCTGCAGAGCTAAGTTCAAAACTTCTATCACATTAGCGGCACACTTGAAGTCTAGACATAGGCATAAGTCACATCTGTGCATGGTTTGCTCCTTGACCTTCAAGTCAGCTGAAGAAGCGAAGCAGCACAGACAGACAACAGAACACATGATAAAACGAATAGAGATGTTGAATGAAAAGGGGATAAAGTCGAAGGATTTGAGGAAGAAATGCCCGTATTGTCCAGGGAATGTGATGTTGAAGAACATTTTGGTTTTGAAAGAACATATTAGAGCGCGCCATCCTGATATTAAAAAGACgtGTCCCAAATGTGGCATGGAGTTCGTGCTCTCCCAAGAAGTGTCAAGCCACATCAAGTACAACGCCTGCCAGTTCCAAGGGTCCAGTAGGATCAACAGCTCCGTATTCTGGAGCTGCAGCCAATGTCTCTTCGCCACCGACTCCAAAGCCGAATGCTTCTTCCACGAAGTTTTACACAAAGCACCAAAAAGTGTGATCATCCAAGTCGGTGACACCAAAAAGGTTATACAGCAATACTCATGCCCTATTTGTGAGAAGATGTTTAAGAAGAGTTCTTTACGAGAACATTTACGATTGCACACCTTTGAGAGGCCCTTTACTTGTCATATTTGTTCGGCTAACTTTACTAGGCAGACTAGTTTGGCCAATCACGTGAAGGCAGAACACGGAGATGATGTCCAGAAGTTGCCGAAATTGTCTAGTGAGATTGATGAGTGGAGCTGCGAGAAGTGTTTGAAGAGTTTTACTAGCAAGAGTTTATTTACCCGCCATTCCTGCAAGACTGTTTTACCTAATGAGGATAGAAAGTGCGATGTACTTGACTGTTCGTTTGTAGCTGCAACACCTTTACAACTGACAAGgCATAAAAGAAAACATGGAATCTACGGGGAACAAAGACATAAATGCCCGTATTGCGATTTTAAATGCAGTCAATCAAGTAATATGAAACGACACATGGTTTATCATAAAGGGGAGAAACCGTACTTATGTCCACATTGTACATTCTTTTGTTCAGGCTTGGAAAATCTCCGGAAGCACGTTCTCAAGACTGGCCGCCACAAAGATGTCTTCCTATACCTTTGTAAACATTGTgactataaaacaaatatggcTAAAGATTTAAGAAGCCATTTGACTGACACCCATTCTGACTTGTATAACCCAAAGAGTGCAATGGAAGCagtaaaaaatcatttaatgAACATTTAA
Protein Sequence
MLSPREDEDDDTHLCIKCNATLVGLDNYIKHRKERCGKNKGDPKPDLSTIDSLDPTYSLGADVFFQSLELQSSVKKTSLSRLTPPIPISKSNLERKSLIATTSQPRMSPLETNLRGEDWIGGHTLRISGNEDNQTKLINAVASISGNVKKETSTSYTIGYNDYKGVEESEESEVSEDDEEEEHTSGKWKPPPNYTGGKWRPDSPEHDWDDQEQEQPPSWKSLLPEVDRDDDYDAPPPGHTKGKWVPGANEKTQIMQPTIQTKGFVQYWCGPCNRRLGSRAIYDKHLRSSLHLKKVLPEHELEFSGHLEPIKMTEKRVTRPSKFVDGDIYSQVERKKRQKKDDKEVNQVKKRKRKSIFINCPGCKSRVREHLMGKHLISHYHFRKAAGVTNSVYQQLILDNIDAIVHQSPFQCSPCKYYTNWIPNFMQHWKSEEHKAIVDSIEGVFWCSFCKFDCESCEEMITHLSSSDHNEVVAVMNRSMPIIIRKKTIFKCETCSEVFRYNMELKKHCEKTGHAIGYTATDNYQELHKCQLCRAKFKTSITLAAHLKSRHRHKSHLCMVCSLTFKSAEEAKQHRQTTEHMIKRIEMLNEKGIKSKDLRKKCPYCPGNVMLKNILVLKEHIRARHPDIKKTCPKCGMEFVLSQEVSSHIKYNACQFQGSSRINSSVFWSCSQCLFATDSKAECFFHEVLHKAPKSVIIQVGDTKKVIQQYSCPICEKMFKKSSLREHLRLHTFERPFTCHICSANFTRQTSLANHVKAEHGDDVQKLPKLSSEIDEWSCEKCLKSFTSKSLFTRHSCKTVLPNEDRKCDVLDCSFVAATPLQLTRHKRKHGIYGEQRHKCPYCDFKCSQSSNMKRHMVYHKGEKPYLCPHCTFFCSGLENLRKHVLKTGRHKDVFLYLCKHCDYKTNMAKDLRSHLTDTHSDLYNPKSAMEAVKNHLMNI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00407980;
90% Identity
iTF_00407980;
80% Identity
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