Basic Information

Insect: Cyclargus thomasi
Gene Symbol: topi
Assembly: GCA_026546445.1
Location: JAOTAV010041377.1:6149-11581[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 12 0.0039 0.28 12.0 1.8 2 23 71 92 70 92 0.96

2 12 0.028 2 9.3 0.3 3 23 100 121 98 121 0.94

3 12 0.4 29 5.7 0.1 2 23 129 151 128 151 0.88

4 12 3.9e-06 0.00028 21.5 1.8 1 23 157 179 157 179 0.97

5 12 1.6e-05 0.0011 19.6 4.7 1 23 185 207 185 207 0.98

6 12 0.00018 0.013 16.3 2.3 1 21 213 233 213 234 0.96

7 12 0.23 17 6.5 1.7 3 19 254 270 253 275 0.92

8 12 1.4e-07 1e-05 26.0 1.8 1 23 573 595 573 595 0.98

9 12 0.00056 0.04 14.7 0.3 1 23 602 625 602 625 0.91

10 12 0.0056 0.4 11.6 0.1 1 20 633 652 633 653 0.94

11 12 0.0013 0.096 13.5 3.6 1 23 662 686 662 686 0.96

12 12 3.6e-05 0.0026 18.4 0.2 1 20 692 711 692 713 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	12	0.0039	0.28	12.0	1.8	2	23	71	92	70	92	0.96
2	12	0.028	2	9.3	0.3	3	23	100	121	98	121	0.94
3	12	0.4	29	5.7	0.1	2	23	129	151	128	151	0.88
4	12	3.9e-06	0.00028	21.5	1.8	1	23	157	179	157	179	0.97
5	12	1.6e-05	0.0011	19.6	4.7	1	23	185	207	185	207	0.98
6	12	0.00018	0.013	16.3	2.3	1	21	213	233	213	234	0.96
7	12	0.23	17	6.5	1.7	3	19	254	270	253	275	0.92
8	12	1.4e-07	1e-05	26.0	1.8	1	23	573	595	573	595	0.98
9	12	0.00056	0.04	14.7	0.3	1	23	602	625	602	625	0.91
10	12	0.0056	0.4	11.6	0.1	1	20	633	652	633	653	0.94
11	12	0.0013	0.096	13.5	3.6	1	23	662	686	662	686	0.96
12	12	3.6e-05	0.0026	18.4	0.2	1	20	692	711	692	713	0.95

Sequence Information

Coding Sequence: ATGGAGTCAAGCTTGACATACTTTAGTTTGTCTTTTGTAGATGCTGAACTGCCTGACCTACTGCAGAAGAAACCACAGGATTGCGATTATGGTCTTCACAACTCTCTTTCTTCCCAAGGCAATCTCTTGGGTGGTGATGATGTATTGGCTCAGTTTTTGACTGCCGATGGACCTCTCGAGGAGCCAGATTTAAACGGTCCAACTACTTTGCACTGTGAGATATGTAGCAAGAAATTTGACAATGCAAAGAAGTACTATGGCCATCTGAGAATTCACTCCAAACAAAATGTTTGGATCTGTGACAAATGCCCAAATGAAAGATTTCCAAACAAGCAGGACTTAATGAAACACAGCTTGACTCATAAGCCCCTGGCCAAAGTGTGGAAGTGTCCCCAATGTACTCTGGCTTTTGAAGCACTTTGGCGGCTCCAGCAACACTTGTTTGCCAAACACTTGAACAACAGACCTCATAAATGTGACCAATGTGACAAAGCATTCCAAAAACCATCAGATTTGAAAAAACATCAAGATGTTCACAATGATGTTAAGAAGTACTGCTGCGGCCAATGCAAGAAAAGTTTTTTAGACCGATCAAACTTAAAAAGGCACATGATGACACATACCAGCGAGAAACCTTACAAATGTCAAGGGTGTAGGGCCTGTTTTAAGCAGCTAGCTTCACTGAATCGCCACCAAAAGAACTGTGTGATGTATAACCAACTGGCTATCATTCAAGAGAAAGGTGTCAAGAAGAACCACTGTCGAGTATGTGGAGCTACATTTCAATACAAAAGCGCTTTGCTAGAACATTGTGTGAGGGCACATGTAAATAATAATGTTGAACCAGAAAAAGATAATAAAGTAAACGAAACTAACATGGACACAAATAAAACTGTTGATAACATTGTGGACGATATTTTGTCAGCTGAAGATGACTACTGCATCGCTACATCGTCTCAAAACACGATGTTGAATAGTTACAACTACACCAATCACGATGACAATCTCAATCAAATTGAGTTTTTAAAGGAAATCAATACTTTACATATATTGGACGATGAATTACTTTGTAACGATCTAGACTTAGACACGCTACAGAATAATCATTTCTTTAATATGAACGACGATTATATCGATAAACAATTTCTATTGGACTTCAACGACGGCGATCGGAGTGTTGATCAAGATTTAATGAACGCTCTATATCAGGTGAAGTCGGAACATTTACCGGAGGAATTCCTAAATCTACCAGCACCCAGCCAGAATGCTCCAGTCCCTGAAAAACCACCCGATATAGAAGCTGCAGTCTCTGTCAATGATTGTTCTACTATATTCGAAAGTGACGTTGATTTAGAAGCCAGCACCAATTTAGCGGCTAACCTAAATCAGCTCATTGGTGAAAATAATGTTCAATACATATCTACGGAGGACGATGATATGTTCATAATTAGTTTAAATAGCGAAATAGACGCCGCACAACTTACTGATATGTTAAACATCGGAGTTGTAGACGCAAATACAAAAAAAATAAATGATCAAGACAATTATGATGATTATCAGAGTATGGATGATAAACACAAAAAAATGCTTGACAACATCCAACCAGTTGTTATGAAAATAAGTGAACCTTGTGATAATAAAGCTGCTGAAGTAACAATTGATAAAAACGCCAAATCAGACCTTAAAACAAAATCTAAAGATAAAAAACCAAACATTTTTACTTGTGGCAAGTGTGGAAAAGTGTTTAAGAGGAAAGATAACTACAAATCACATCTTGCGACCCACGAGCCGTCTCTACGTCGTCATTCGTGTGCGATCTGCGGCGCGCGTTTCGGTTACCGCTCCACGCTGAACAAACACCGCGCCGCAGCGCACGAGCCGCGCGTCCGCACGCCGCACCGCTGCGATCTGTGCGACAAGGTGTACCGCGCCGCTTGGATGCTGAAGAACCACGTAGAGTGCGAGCACGTCGGTCTCAAGCCGTACGCGTGTGAGCACGCTGGCTGCGGCAAGCGGTTCTACAAGAAGTGCGATCTGAAGATACACGAGAGGTACCACACCGGCGAGCGGCCGTTCGTGTGCGATATCTGTGGGCGCGGCTTCCCGCACGTTTCGCACCTCATACGGCACACCGCCTACGTCGACTGTACACGACGGAAGGTGAAAAAGCCTGAGAAATGA
Protein Sequence: MESSLTYFSLSFVDAELPDLLQKKPQDCDYGLHNSLSSQGNLLGGDDVLAQFLTADGPLEEPDLNGPTTLHCEICSKKFDNAKKYYGHLRIHSKQNVWICDKCPNERFPNKQDLMKHSLTHKPLAKVWKCPQCTLAFEALWRLQQHLFAKHLNNRPHKCDQCDKAFQKPSDLKKHQDVHNDVKKYCCGQCKKSFLDRSNLKRHMMTHTSEKPYKCQGCRACFKQLASLNRHQKNCVMYNQLAIIQEKGVKKNHCRVCGATFQYKSALLEHCVRAHVNNNVEPEKDNKVNETNMDTNKTVDNIVDDILSAEDDYCIATSSQNTMLNSYNYTNHDDNLNQIEFLKEINTLHILDDELLCNDLDLDTLQNNHFFNMNDDYIDKQFLLDFNDGDRSVDQDLMNALYQVKSEHLPEEFLNLPAPSQNAPVPEKPPDIEAAVSVNDCSTIFESDVDLEASTNLAANLNQLIGENNVQYISTEDDDMFIISLNSEIDAAQLTDMLNIGVVDANTKKINDQDNYDDYQSMDDKHKKMLDNIQPVVMKISEPCDNKAAEVTIDKNAKSDLKTKSKDKKPNIFTCGKCGKVFKRKDNYKSHLATHEPSLRRHSCAICGARFGYRSTLNKHRAAAHEPRVRTPHRCDLCDKVYRAAWMLKNHVECEHVGLKPYACEHAGCGKRFYKKCDLKIHERYHTGERPFVCDICGRGFPHVSHLIRHTAYVDCTRRKVKKPEK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00744967;
90% Identity: iTF_01248403;
80% Identity: -