Cmes037319.1


Basic Information
Transcription Factor Domain
Sequence Information
Similar Transcription Factors

Basic Information

Insect
Cybosia mesomella
Gene Symbol
Hr96_1
Assembly
GCA_946251875.1
Location
CAMIUH010001277.1:359925-365752[-]

Transcription Factor Domain

TF Family
THR-like
Domain
zf-C4|THR-like
PFAM
AnimalTFDB
TF Group
Zinc-Coordinating Group
Description
DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. TR interacts with the thyroid response element, which is a DNA site with direct repeats of the consensus sequence 5'-AGGTCA-3' separated by one to five base pairs, upstream of target genes and modulates the rate of transcriptional initiation. Thyroid hormone receptor (TR) mediates the actions of thyroid hormones, which play critical roles in growth, development, and homeostasis in mammals. They regulate overall metabolic rate, cholesterol and triglyceride levels, and heart rate, and affect mood. TRs are expressed from two separate genes (alpha and beta) in human and each gene generates two isoforms of the receptor through differential promoter usage or splicing. TRalpha functions in the heart to regulate heart rate and rhythm and TRbeta is active in the liver and other tissues. The unliganded TRs function as transcription repressors, by binding to thyroid hormone response elements (TRE) predominantly as homodimers, or as heterodimers with retinoid X-receptors (RXR), and being associated with a complex of proteins containing corepressor proteins. Ligand binding promotes corepressor dissociation and binding of a coactivator to activate transcription. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, TR has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [4, 3, 5, 2, 7, 1, 6]
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 32 6.4 1.9e+04 -3.1 0.0 113 140 40 66 37 69 0.86
2 32 0.11 3.3e+02 2.6 0.0 112 140 81 108 77 114 0.87
3 32 0.31 9.3e+02 1.2 0.0 113 140 124 150 120 156 0.86
4 32 0.13 4.1e+02 2.3 0.0 112 140 165 192 161 198 0.87
5 32 0.11 3.3e+02 2.6 0.0 112 140 207 234 203 240 0.87
6 32 0.31 9.3e+02 1.2 0.0 113 140 250 276 246 282 0.86
7 32 0.11 3.4e+02 2.6 0.0 112 140 291 318 287 323 0.87
8 32 0.37 1.1e+03 0.9 0.0 113 140 334 360 329 365 0.86
9 32 0.11 3.3e+02 2.6 0.0 112 140 375 402 371 408 0.87
10 32 0.028 84 4.6 0.0 112 140 417 444 413 450 0.88
11 32 0.11 3.4e+02 2.6 0.0 112 140 459 486 455 491 0.87
12 32 0.11 3.2e+02 2.7 0.0 112 140 501 528 496 534 0.87
13 32 0.11 3.4e+02 2.6 0.0 112 140 543 570 539 575 0.87
14 32 1.4 4.3e+03 -1.0 0.0 112 140 585 612 582 617 0.87
15 32 6.4 1.9e+04 -3.1 0.0 113 140 628 654 625 657 0.86
16 32 0.11 3.3e+02 2.6 0.0 112 140 669 696 665 702 0.87
17 32 0.13 4.1e+02 2.3 0.0 112 140 711 738 707 744 0.87
18 32 0.11 3.3e+02 2.6 0.0 112 140 753 780 749 786 0.87
19 32 0.087 2.6e+02 3.0 0.0 112 140 795 822 791 828 0.88
20 32 0.38 1.2e+03 0.9 0.0 113 140 838 864 834 869 0.86
21 32 0.028 84 4.6 0.0 112 140 879 906 875 912 0.88
22 32 0.11 3.3e+02 2.6 0.0 112 140 921 948 917 954 0.87
23 32 0.11 3.4e+02 2.6 0.0 112 140 963 990 959 995 0.87
24 32 0.12 3.7e+02 2.5 0.0 112 140 1005 1032 1000 1037 0.88
25 32 6.4 1.9e+04 -3.1 0.0 113 140 1048 1074 1045 1077 0.86
26 32 0.11 3.3e+02 2.6 0.0 112 140 1089 1116 1085 1122 0.87
27 32 0.11 3.3e+02 2.6 0.0 112 140 1131 1158 1127 1164 0.87
28 32 0.31 9.3e+02 1.2 0.0 113 140 1174 1200 1170 1206 0.86
29 32 0.11 3.4e+02 2.6 0.0 112 140 1215 1242 1211 1247 0.87
30 32 1.4 4.3e+03 -1.0 0.0 112 140 1257 1284 1254 1289 0.87
31 32 6.4 1.9e+04 -3.1 0.0 113 140 1300 1326 1297 1329 0.86
32 32 4.6e-13 1.4e-09 39.8 0.0 112 182 1341 1410 1336 1424 0.93

Sequence Information

Coding Sequence
ATGTGCGCCATCCTGCTGTTCGCGCCCAACCGCGCGCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTTCACCCGTGGCCCACCTACAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCGCCCTACCGCGCGCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTACACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCGCCCGACCGCGCGCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTACACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATTTGCGCCATCCTGCTGTTCGCGCCCGACCGCGCGCGCGTGGTGCACAGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTACACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCGCCCGACCGCGCGCACGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTACACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCGCCCGACCGCGCGCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTACACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATTTGCGCCATCCTGCTGTTCGCGCCCGACCGCGCGCGCGTGGTGCACAGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTACACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCGCCCGACCGCGCGCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTTCACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATTTGCGCCATCCTGCTGTTCGCGCCCGACCGCGCGCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTACACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCGCCCGACCGCGCGCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTACACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATGTGCGCCGTCCTGCTGTTCGCGCCCGACCGCGCGCGCGTGGTGCAGCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTACACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCGCCCGACCGCGCGCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTTCACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCACCCGACCGCGCCCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTACACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCGCCCGACCGCGCGCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTTCACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCGCCCCACCGCGCCCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTTCACCCGTGGCCCACCTACAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCGCCCTACCGCGCGCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTACACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCGCCCGACCGCGCGCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTATACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCGCCCGACCGCGCGCACGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTACACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCGCCCGACCGCGCGCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTACACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATGTGCGCCGTCCTGCTGTTCGCGCCCGACCGCGCGCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTACACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATTTGCGCCATCCTGCTGTTCGCGCCCGACCGCGCGCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTACACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATGTGCGCCGTCCTGCTGTTCGCGCCCGACCGCGCGCGCGTGGTGCAGCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTACACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCGCCCGACCGCGCCCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTACACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCGCCCGACCGCGCGCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTTCACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCGCCCGACCGCGCCCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGTTAACTAGCTGGGAGGGTTCACCCGTGGCCCACCTACAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCGCCCTACCGCGCGCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTACACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCGCCCGACCGCGCGCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTACACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCGCCCGACCGCGCGCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTACACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATTTGCGCCATCCTGCTGTTCGCGCCCGACCGCGCGCGCGTGGTGCACAGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTACACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCGCCCGACCGCGCGCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTTCACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCGCCCCACCGCGCCCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTTCACCCGTGGCCCACCTACAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCGCCCTACCGCGCGCGCGTGGTGCACCGCGACGTCATCAAGCTGGAGCAGGTAACTAGCTGGGAGGGTTCACCCGTGGCCCACCTCCAGGGGACGCTCCTCATCATGTGCGCCATCCTGCTGTTCGCGCCCGACCGCGCGCGCGTGGTGCACAGCGACGTCATCAAGCTGGAGCAGAACTCGTATTACTACCTACTGCGACGTTACCTCGAAAGCGTATATCCTGGCTGCGAAGCGAAATCCACCTTCCTAAAGCTCATTCAGAAGATTCTAGAACTTCGTAAATTGGCCGAAGAAGTGACGGGAGTCTACCTCGACGTGAACCCCATAGAACCATTGCTAATGGAAATATTTGACTTGAAACATCACGCCGCATGA
Protein Sequence
MCAILLFAPNRARVVHRDVIKLEQVTSWEGSPVAHLQGTLLIMCAILLFAPYRARVVHRDVIKLEQVTSWEGTPVAHLQGTLLIMCAILLFAPDRARVVHRDVIKLEQVTSWEGTPVAHLQGTLLIICAILLFAPDRARVVHSDVIKLEQVTSWEGTPVAHLQGTLLIMCAILLFAPDRAHVVHRDVIKLEQVTSWEGTPVAHLQGTLLIMCAILLFAPDRARVVHRDVIKLEQVTSWEGTPVAHLQGTLLIICAILLFAPDRARVVHSDVIKLEQVTSWEGTPVAHLQGTLLIMCAILLFAPDRARVVHRDVIKLEQVTSWEGSPVAHLQGTLLIICAILLFAPDRARVVHRDVIKLEQVTSWEGTPVAHLQGTLLIMCAILLFAPDRARVVHRDVIKLEQVTSWEGTPVAHLQGTLLIMCAVLLFAPDRARVVQRDVIKLEQVTSWEGTPVAHLQGTLLIMCAILLFAPDRARVVHRDVIKLEQVTSWEGSPVAHLQGTLLIMCAILLFAPDRARVVHRDVIKLEQVTSWEGTPVAHLQGTLLIMCAILLFAPDRARVVHRDVIKLEQVTSWEGSPVAHLQGTLLIMCAILLFAPHRARVVHRDVIKLEQVTSWEGSPVAHLQGTLLIMCAILLFAPYRARVVHRDVIKLEQVTSWEGTPVAHLQGTLLIMCAILLFAPDRARVVHRDVIKLEQVTSWEGIPVAHLQGTLLIMCAILLFAPDRAHVVHRDVIKLEQVTSWEGTPVAHLQGTLLIMCAILLFAPDRARVVHRDVIKLEQVTSWEGTPVAHLQGTLLIMCAVLLFAPDRARVVHRDVIKLEQVTSWEGTPVAHLQGTLLIICAILLFAPDRARVVHRDVIKLEQVTSWEGTPVAHLQGTLLIMCAVLLFAPDRARVVQRDVIKLEQVTSWEGTPVAHLQGTLLIMCAILLFAPDRARVVHRDVIKLEQVTSWEGTPVAHLQGTLLIMCAILLFAPDRARVVHRDVIKLEQVTSWEGSPVAHLQGTLLIMCAILLFAPDRARVVHRDVIKLEQLTSWEGSPVAHLQGTLLIMCAILLFAPYRARVVHRDVIKLEQVTSWEGTPVAHLQGTLLIMCAILLFAPDRARVVHRDVIKLEQVTSWEGTPVAHLQGTLLIMCAILLFAPDRARVVHRDVIKLEQVTSWEGTPVAHLQGTLLIICAILLFAPDRARVVHSDVIKLEQVTSWEGTPVAHLQGTLLIMCAILLFAPDRARVVHRDVIKLEQVTSWEGSPVAHLQGTLLIMCAILLFAPHRARVVHRDVIKLEQVTSWEGSPVAHLQGTLLIMCAILLFAPYRARVVHRDVIKLEQVTSWEGSPVAHLQGTLLIMCAILLFAPDRARVVHSDVIKLEQNSYYYLLRRYLESVYPGCEAKSTFLKLIQKILELRKLAEEVTGVYLDVNPIEPLLMEIFDLKHHAA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-