Basic Information

Insect: Culicoides brevitarsis
Gene Symbol: ZNF646
Assembly: GCA_036172545.2
Location: CM070086.1:2832690-2837417[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 18 0.00043 0.017 15.4 0.6 1 20 192 211 192 213 0.94

2 18 0.0018 0.07 13.4 0.2 1 23 283 306 283 306 0.95

3 18 9.9 3.8e+02 1.7 0.4 2 20 314 332 314 334 0.87

4 18 0.068 2.6 8.5 0.2 2 23 345 367 344 367 0.93

5 18 9.1e-06 0.00035 20.7 2.9 1 23 378 401 378 401 0.98

6 18 0.045 1.7 9.1 1.0 2 23 410 432 409 432 0.96

7 18 3.7 1.4e+02 3.0 0.2 3 23 441 464 440 464 0.87

8 18 4.1 1.6e+02 2.9 0.6 2 12 626 636 625 650 0.83

9 18 0.19 7.4 7.1 0.2 3 19 659 675 658 677 0.91

10 18 0.61 23 5.5 0.2 3 23 690 711 689 711 0.95

11 18 0.22 8.3 6.9 0.2 2 23 724 744 724 744 0.95

12 18 0.00086 0.033 14.5 0.2 1 23 750 773 750 773 0.95

13 18 4.6 1.8e+02 2.7 1.2 1 23 780 805 780 805 0.92

14 18 2 77 3.8 3.7 5 23 823 841 822 841 0.73

15 18 0.00026 0.01 16.1 2.2 2 23 855 876 854 876 0.97

16 18 0.025 0.95 9.9 0.4 1 23 884 906 884 906 0.97

17 18 7.7e-05 0.003 17.7 0.5 2 23 913 934 912 934 0.97

18 18 0.00014 0.0053 16.9 5.0 1 23 939 961 939 961 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	18	0.00043	0.017	15.4	0.6	1	20	192	211	192	213	0.94
2	18	0.0018	0.07	13.4	0.2	1	23	283	306	283	306	0.95
3	18	9.9	3.8e+02	1.7	0.4	2	20	314	332	314	334	0.87
4	18	0.068	2.6	8.5	0.2	2	23	345	367	344	367	0.93
5	18	9.1e-06	0.00035	20.7	2.9	1	23	378	401	378	401	0.98
6	18	0.045	1.7	9.1	1.0	2	23	410	432	409	432	0.96
7	18	3.7	1.4e+02	3.0	0.2	3	23	441	464	440	464	0.87
8	18	4.1	1.6e+02	2.9	0.6	2	12	626	636	625	650	0.83
9	18	0.19	7.4	7.1	0.2	3	19	659	675	658	677	0.91
10	18	0.61	23	5.5	0.2	3	23	690	711	689	711	0.95
11	18	0.22	8.3	6.9	0.2	2	23	724	744	724	744	0.95
12	18	0.00086	0.033	14.5	0.2	1	23	750	773	750	773	0.95
13	18	4.6	1.8e+02	2.7	1.2	1	23	780	805	780	805	0.92
14	18	2	77	3.8	3.7	5	23	823	841	822	841	0.73
15	18	0.00026	0.01	16.1	2.2	2	23	855	876	854	876	0.97
16	18	0.025	0.95	9.9	0.4	1	23	884	906	884	906	0.97
17	18	7.7e-05	0.003	17.7	0.5	2	23	913	934	912	934	0.97
18	18	0.00014	0.0053	16.9	5.0	1	23	939	961	939	961	0.99

Sequence Information

Coding Sequence: atgtctgaaacaataaacattttccTCGAATTTGACGCTTCTGACGGTTACATCTTCAGCGTTCTCTCGGAGGAAAACCTGAAAAGGCGAATCGTTCGCAGTAAAGAACGAATTTTGGTTGTCAAGGAAAATCCCGCTGTTCCCAAAACCAATGTTCGAGTCTATTGTGAGGTTCGGCGGATGCCTTTGCCCTTGGAAAGCATATTTTTGAACGAAGATCCTGTTATTACGGAAGATATCAAGCCAGAATTTCCTGAAGAACTTGAATTAGGAGAAATTCCAAAATTGCCGTCTTGTTTGACAGTCAAAATCAAGCCTCTTGAAGTTTCGAAGCCTCTTGAGCCAAAACGAGGTCCTATTATCTtaacaaaagtaaaaagtttgaaaaatgctCCTCCGCCGAGCTTTTTGAAGgatcttcaaataaaattacctcGAATCGATCAAGTTTtctccttaaaaaattcaagtttgagCCTTGAAGCaccaaaaaatgttgaaaaaccgCCGGTTTTTGAAGTTCCAACGCCCGTTATCATCAAAAGTACGCCCGAAAAGCCtaataacaagaaattttcttgcCCGAATTGCCCGATGTTCTTTACCACGAAACACGCTTTGATGACTCACACCGCGCGAAAAACTTGCTTCGTTCGAATGCTCaacggagagaaaaaaatggttCGTCGTGTTAAGGAATACATCCCGCCTGACTTGGTTCTTCCGGATTTAAACACTATTCCGTGTCCGTATGAAAAATCTTTCCTTCAACCCGATGGAACAACAGCTTACGTGTATCACGTGAGTGAATCTAGTCTCCGAATCAGCAATTTTGACTTACAAAATTTCGTTTGCGGTATTTGTGGCGAGAATTCACGTGATTCGAAGAACCTTTTGATGCATCGCTTGCAACAACACTTCTTTCCGGGCAACAAAAGGACCTGCAATGGCTGCGAAAAGTACGTTGAAACGCACAAAGAACGTCGTGATCATGTACTTTATTGCTTGAAACACACGGAAATTGATCCGAACAAGTGTTACATCTGCAATTCGGTGTTTGCGGAGCTAACTTCGTTGAAAGTTCACCTGTATCAAGAACATCCGTACCAAAATGACCCCGTCGAGTACACATTTGAGTGCAAAATCTGcaataaattcttcaaatcgCGCGATAATCGTAAAAGTCACATTCGTCGGGTGCATCAAAAGTACAAAGAACCGAGAGTTTATTGCGCGCATTGTCCGTACGAAGCGAGAAACAAGAAAACTTTGTACAATCATCTCATTACGAGACACTTCCCGAACTTGGCAGCCGAAATTTGTGAGGTTTGTCGCCCAACGAGGTATTTTGTGTCGAACTCCAAATACGTGCAACACATGTCTGCCATGCATCGCGGCTTGAAATTCAATCCTGACACAACTTTGGAAGCTTTGCGGaaacaaaacatgaaaataatcCAAAGAAAACCGCTTCGGATGCAAAAATATCGCTTCGAGGATGTTCGAGTTCCCAAACGAGCTGACAATTTTTACGTCGAAGACATGGAAATTATTGAAGAACTTCCCGTTTTAGAGCCAAAAGTCGCTGAAAAGGCCCCTGAAGAGGAAGAAAAGGGAAATAATTACATGAAAGTTGAGCTAATCCCGTCGGATTcgacaaaaattacgaaaaatctcACCAAATTCGATTTGCAACTCAATCGGAAGTCAACTTTGGATTATTTGCCGGAAGGAGTTTTGATCCCGAGCAACTTTAAAACGTTCAAACATCCCATTCATGTGAGTGTTGATCAGCCGGATGGCACAACAGTGTACATTTATCAGTCCTCGGAGACGTCAATTCtgtttatttcgaattttgaCTTGCGTTGTAATCGTTGCGAGCTCTGCGGACAAGATTTTTCCAACGGATTTTACACTTCTTTCATCAAACATCGTcagaatttccattttttccccGGAGATCGAGAAGAATGCGTTGCTTGCGGAAAATCCTTCGATTCGGCGGATAAACGACAACGTCACTCGTTGTTTTGCAcggaaaaagacaaaatggACATCGGCTTGTGCTACATTTGCAACATCCAATACGACGACTTTTACATGTATCGCCAACATTTGATGGCAATGCATCCGAGACTTTCGCACGGAGCGAAATCCAACATGCGAACATGTCCGATTTGCAGTAAAACCGTGTCGGCGAATGTCATAAGGGATCACATGCGACGTCACGACAACCCGAAGCCATACAAATGCAACGAGTGTGGCAATGTTTATGCCATCAAGCGAAGTCTCCGGAATCATTTGTTGGAAGTTCATTTTCAAGACTTGTGTTCGCACAAATGCGAAGAATGCAATCCGGTGAGGTACTTTGAAATGTTGTCGGCGTACTTGACTCATCGGAAGAACATGCACAATTTGATGGTTGATCCGAAAAATGTCTTGAGGAAACAGCcagagcgaaaaaaatgccCAAAATGCGGAAAACATGTCGTTTGTCTTCAAGATCATTTGCAAACGCATGCTGATGCGGAGGCAATGTTTGTGACGAATCAGGGAAAATCTTGCGAAATTTGTGGAAAGTTGTTTAAAAAGACATCCTCGTTGATGAATCATAAGAAATCGCATTTGCCGGAGCACGAGAGACCGTTCAAGTGTGCGCATTGTGCAAAGGGATTTAATTCCATGGCAGCTGTGACGGAACATGAAAGACTTCATACaggtgaaaAACCCCTCGTTTGCCCATTTTGTCAAAAAGCCTTTGCCCGTCAACAAACATACACGGATCACGTAAAAACTCACACAGGTCAAGGTTACAAATGTGAACATTGCGACAGAGTCCTGAACGATCACAGCAGTTTCCGGAAACACTTGAAGGTACACGAAAAGGAGCTTGGCATAAAACTTACTTACACAAAAGACGAACGACGCTGGAAAGACATGGGCTTGTACGAAAAAGCAAAAGATTTCAtctaa
Protein Sequence: MSETINIFLEFDASDGYIFSVLSEENLKRRIVRSKERILVVKENPAVPKTNVRVYCEVRRMPLPLESIFLNEDPVITEDIKPEFPEELELGEIPKLPSCLTVKIKPLEVSKPLEPKRGPIILTKVKSLKNAPPPSFLKDLQIKLPRIDQVFSLKNSSLSLEAPKNVEKPPVFEVPTPVIIKSTPEKPNNKKFSCPNCPMFFTTKHALMTHTARKTCFVRMLNGEKKMVRRVKEYIPPDLVLPDLNTIPCPYEKSFLQPDGTTAYVYHVSESSLRISNFDLQNFVCGICGENSRDSKNLLMHRLQQHFFPGNKRTCNGCEKYVETHKERRDHVLYCLKHTEIDPNKCYICNSVFAELTSLKVHLYQEHPYQNDPVEYTFECKICNKFFKSRDNRKSHIRRVHQKYKEPRVYCAHCPYEARNKKTLYNHLITRHFPNLAAEICEVCRPTRYFVSNSKYVQHMSAMHRGLKFNPDTTLEALRKQNMKIIQRKPLRMQKYRFEDVRVPKRADNFYVEDMEIIEELPVLEPKVAEKAPEEEEKGNNYMKVELIPSDSTKITKNLTKFDLQLNRKSTLDYLPEGVLIPSNFKTFKHPIHVSVDQPDGTTVYIYQSSETSILFISNFDLRCNRCELCGQDFSNGFYTSFIKHRQNFHFFPGDREECVACGKSFDSADKRQRHSLFCTEKDKMDIGLCYICNIQYDDFYMYRQHLMAMHPRLSHGAKSNMRTCPICSKTVSANVIRDHMRRHDNPKPYKCNECGNVYAIKRSLRNHLLEVHFQDLCSHKCEECNPVRYFEMLSAYLTHRKNMHNLMVDPKNVLRKQPERKKCPKCGKHVVCLQDHLQTHADAEAMFVTNQGKSCEICGKLFKKTSSLMNHKKSHLPEHERPFKCAHCAKGFNSMAAVTEHERLHTGEKPLVCPFCQKAFARQQTYTDHVKTHTGQGYKCEHCDRVLNDHSSFRKHLKVHEKELGIKLTYTKDERRWKDMGLYEKAKDFI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -