Basic Information

Gene Symbol
-
Assembly
GCA_958336395.1
Location
OY284493.1:19664349-19669543[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 22 0.0017 0.19 13.9 1.4 1 23 264 286 264 286 0.99
2 22 0.00083 0.092 14.9 0.7 2 23 297 318 296 318 0.98
3 22 0.068 7.6 8.8 1.0 1 18 324 341 324 341 0.95
4 22 0.022 2.4 10.4 0.6 1 23 352 374 352 374 0.98
5 22 0.27 31 6.9 0.0 2 23 456 478 455 478 0.94
6 22 4.6 5.2e+02 3.1 0.4 1 23 484 506 484 506 0.97
7 22 0.12 14 8.0 2.6 1 23 512 534 512 534 0.98
8 22 0.0014 0.15 14.2 0.7 1 23 540 562 540 562 0.98
9 22 1.4 1.6e+02 4.7 0.5 2 21 589 608 588 609 0.93
10 22 0.0046 0.51 12.5 5.1 1 23 694 716 694 716 0.98
11 22 4e-05 0.0045 19.0 3.9 1 23 722 744 722 744 0.99
12 22 0.3 34 6.8 4.5 1 23 750 772 750 772 0.97
13 22 0.00019 0.021 16.9 0.1 1 23 778 800 778 800 0.98
14 22 0.078 8.7 8.6 2.1 1 23 806 829 806 829 0.75
15 22 9.3e-07 0.0001 24.1 1.1 1 23 835 857 835 857 0.98
16 22 0.00021 0.023 16.8 0.6 1 23 863 887 863 887 0.96
17 22 3.6e-05 0.004 19.1 2.6 1 23 983 1005 983 1005 0.99
18 22 2e-05 0.0022 20.0 3.4 1 23 1011 1033 1011 1033 0.98
19 22 3.1e-05 0.0035 19.3 2.3 1 23 1039 1061 1039 1061 0.98
20 22 0.16 18 7.7 0.7 1 23 1067 1089 1067 1089 0.95
21 22 1.2e-05 0.0013 20.7 0.6 1 23 1095 1117 1095 1117 0.98
22 22 0.00038 0.043 15.9 0.8 1 23 1123 1147 1123 1147 0.97

Sequence Information

Coding Sequence
ATGAGTGGGTTTGACAAATTCCTTCACACCAGTATTAAAGTTGAACCCTCAGACCATCTAGATatatctgaaataaaaatagaagcAAACACACTTGAAACTGATTatgaatttgaaattaaaatcgaAGAAAATTGTATTAAGCAGGAGGCGTATGATGGTGACCACAATTATGCCTGTGTTAGCAACATTGAGCACAATTATGCCTGTGTTTACAACATTGAGCTTGAGCACAGTTACGCCAAAAGACGCGAACTAAACTTGCAGGATGCTGAAAGTATTGAAGAGTCAATTAAGAATCAGAAAAGCGTCCGTTTacgaattaaaaatgaaattgaagaaACATCTTTTGCTAGTAGCAAAAACAATCTTAAACTTGTTGATATTAATGAGTTTGTAGACAGCCACAAAGAAATACCACCTGAAGATGATCCTGATTGTGTTGAAGCCACTGAGGatgctaaaaaaaatcaactagAAGtgacacaaaattttgaaaacaaaaataaacggcAAATACATTTAGAAACTCTTTTAcgagaaatttgtttaaaggaCAGtgCTTTGGTGAACaaagattttcctgaaaaaTCCTCCAAACCAGTTCCAGATCTATTAAGTGATGGTAGTGACGGTGGGGCTGTTACGGCTAGTGAAAATACATTTGTTGAAATAGTGAAAGTACCAGGACAAGCCGAAGAAATTAAAGTTTCACAATCACACACCAACATAAcctttaaatTttacaaaaagattttaaatcaACACATGAGGACCCACATTCAGCCATACGAGTGCAGTGACTGCACTTTCAAAACCCCTAACAAATGGAAGTTATATgaacacatgaaaactcatattaGGGTTGAACCGAGGCAAGAACTAAACAAATGCGTCTACTGTGAATACAAAACTGTATATAAAGTTGCCTTAAATAAACACATGAGAATGCACAATTGGGAAAAGCCATACACTTGCAGCAAATGCGATTACAGCGGCAAGCAGAAGCACCATCTGATCAGGGATTTAGAATCACACACCGATGTCATGCCTTTTGTGTGCAAAGTTTGTCTTTACAGAACTAAAGACGAAAAATCATTAATAGAGCACACAAAAATACACGAAAGTACACTTAATTGTCGTCTTTGTGGTCTTAAGCCTGATAGaactttcattattaaaagtCATATGGTTAAACACAGAAGCAACAAGAGTTACAGGTGTTATCAGTGTGATTTTGTCGCTTGGCATTATAATGAGTTGATTTTGCATAAACAGTGTCATTTAAAGACTGTTAAATCTGATGTGTGCAGTGAAAATATCTTTGAAAAGGTTTTTGAGACACATAGCAAAAATCATGCAGTTGAGTGCAACAAATGTGATTTTGTAGCAGCCAATGATGAGGCTTTAAAGGTGCATATTATAAATGTTCACAATATTAAGAAGACTTTTAGGTGTGCTGCTTGTGAATACTTTACAATGAAAAAGAACGAGCTGGACTTACACATAGATACACACACTGAGGAAAAGCCATTCAAATGCATGAAGTGCAGTTACAGTGCTATGACAATCTCTCATGTTCGTGTTCACATGAAATCGCATAGAAATAATATTCCTTATAAGTGCAATAAGTGTTCATATATAACTGTTTCCAGTTTTGATTTACTCGCTCACATGGACCGCCATACAGGGAAGTTTACAAATAATCACAGTTTAAGTTTACACAAATATAAATCGAAGCAATCGGCAGTTAAAGTGATGCAGAAATGTCGAAAATGTGACTATTCCTCTGAAGATCGACTTGAAATGCGCAATCATTGGAAGATGTACATGTTTGAGAAACCAGACAAGTTTAGAATTTACGACTGCGTTGTCAAAGAAGAAATCATTCCATCCACAATTAACTTTCTAGAACCGAAAGCTGAATGTGACAATTTAGAAATGAAGTGCAACGATATTTGTATCACATCACAACCTTTCTTAAGTGTCGAACTTGATATAAAGGATGAAGATGAAACTCACGTCAGCAAAAAGTCTTTGAAGTGTTATACTAAGGGCAAAAGCGTTGAGAAGAACCTTTTTAAATGTGAAGTGTGTAGCCTTGTTACTTTCAAGAAATCCCATTTTAGAAAACATATGAAACTTCACAGTGAATATAAACCTTTCCAATGTAAATTATGCGGTCATAGGACTGCTCACAAATCTAATTTAGCACAGCATATGAAAATTCACATTGGAGAGAAAACCTTTGAGTGTACACAATGCGAGtacaaaacatttcttaaatgcAAATTAGTGCGTCACATGAAGATTCACagtggagaaaaacctttcaagTGTGCAATTTGTGGTCTTGAAACTACTTACAAACCTAATTTGGTACAGCACATGATGATTCACATGGAAGAGAAACCGTTTGAGTGTGAAATTTGTGGTTTCAAAACTGCTCACAAATCGTATTTAATGCAAAAGCACATGAAACttcatactggtgagaaacccTTCGAGTGCGAAATATGTGGCCTCAAAACTCCACACAAATCTAATTTAATACGGCACATGAGAAGTCACactggagagaaaccttttGAATGTGCAATGTCTGGATGTGGATACAGAAGTAGTCAGAAATCAGATGTCAGAAagcacatgaaaactcataatagagaaaagaaaaaatttaaaaatagggaTATTTTTTCCTACAATAATCAGAGTATAAAACAAGAATTCCCCAATGaggatttaatttcttttactgTTACCAACGAAGTAGAACAACAGCAAACCACCGTGGTTGGACAACCCAGCATAAAAAGTGAGTGCAACTTCTCAGATATAGAATACAACGAAGTTTTTATCAAGGCAGAACCTTCAATGGACGaagaattttgtataaaagctGATATACTGAATGAAACGATGCAAAACTCCACAGAAACACGTTTTCAATGCTCAGATTGCAATTATAAAACCGAATATAACAGCAATTTTTTGCGACATATAAGAACTCACACTGGGGAAAAGCCTTACAGTTGCGAAAATTGTGATCATAAAACTTCCAGTCAATCTGATTTAACAAGACACATGAAAAGTCACACTGGGGAGAAGCCCTTCGAGTGCAAAACGTGTGGGCACAAAACTATTCGGAAATACGATTTAATAAACCACATGAGAATTCATACAGGAGAGAAGCCCTTCAAGTGCAACTTATGCGAATTTAAAACATTCGTGAAGGCTTCTTTAGTTGGACATCAGAAAGTTCACACGGGAGAGAAACCTTTTGAGTGTGAAGTGTGTGGTTTGAAAGTATCTCATAGGTCCAATTTAGTACAGCACATGAAAATTCAcactggggaaaaacctttCATGTGTAAAATTAATGGATGTGAGTATAGAAGCATTCGGAAGTCTGATTTAGTGaagcatatgaaaactcataatGAGAAACTTTTTAAGTACAGAACTCAGATACAAAAAGTAGAATAtgaaaatttgtcaaatttcTACTTTGCAGAAGCACCTGAAACTTCACAGTGA
Protein Sequence
MSGFDKFLHTSIKVEPSDHLDISEIKIEANTLETDYEFEIKIEENCIKQEAYDGDHNYACVSNIEHNYACVYNIELEHSYAKRRELNLQDAESIEESIKNQKSVRLRIKNEIEETSFASSKNNLKLVDINEFVDSHKEIPPEDDPDCVEATEDAKKNQLEVTQNFENKNKRQIHLETLLREICLKDSALVNKDFPEKSSKPVPDLLSDGSDGGAVTASENTFVEIVKVPGQAEEIKVSQSHTNITFKFYKKILNQHMRTHIQPYECSDCTFKTPNKWKLYEHMKTHIRVEPRQELNKCVYCEYKTVYKVALNKHMRMHNWEKPYTCSKCDYSGKQKHHLIRDLESHTDVMPFVCKVCLYRTKDEKSLIEHTKIHESTLNCRLCGLKPDRTFIIKSHMVKHRSNKSYRCYQCDFVAWHYNELILHKQCHLKTVKSDVCSENIFEKVFETHSKNHAVECNKCDFVAANDEALKVHIINVHNIKKTFRCAACEYFTMKKNELDLHIDTHTEEKPFKCMKCSYSAMTISHVRVHMKSHRNNIPYKCNKCSYITVSSFDLLAHMDRHTGKFTNNHSLSLHKYKSKQSAVKVMQKCRKCDYSSEDRLEMRNHWKMYMFEKPDKFRIYDCVVKEEIIPSTINFLEPKAECDNLEMKCNDICITSQPFLSVELDIKDEDETHVSKKSLKCYTKGKSVEKNLFKCEVCSLVTFKKSHFRKHMKLHSEYKPFQCKLCGHRTAHKSNLAQHMKIHIGEKTFECTQCEYKTFLKCKLVRHMKIHSGEKPFKCAICGLETTYKPNLVQHMMIHMEEKPFECEICGFKTAHKSYLMQKHMKLHTGEKPFECEICGLKTPHKSNLIRHMRSHTGEKPFECAMSGCGYRSSQKSDVRKHMKTHNREKKKFKNRDIFSYNNQSIKQEFPNEDLISFTVTNEVEQQQTTVVGQPSIKSECNFSDIEYNEVFIKAEPSMDEEFCIKADILNETMQNSTETRFQCSDCNYKTEYNSNFLRHIRTHTGEKPYSCENCDHKTSSQSDLTRHMKSHTGEKPFECKTCGHKTIRKYDLINHMRIHTGEKPFKCNLCEFKTFVKASLVGHQKVHTGEKPFECEVCGLKVSHRSNLVQHMKIHTGEKPFMCKINGCEYRSIRKSDLVKHMKTHNEKLFKYRTQIQKVEYENLSNFYFAEAPETSQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-