Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.53 82 5.5 0.1 1 23 54 77 54 77 0.92

2 6 0.00013 0.02 16.9 0.9 1 23 88 111 88 111 0.94

3 6 0.0002 0.03 16.3 2.5 1 23 121 143 121 143 0.97

4 6 1.6e-06 0.00025 22.8 2.1 1 23 269 291 269 291 0.97

5 6 2e-06 0.00031 22.5 0.2 1 23 297 319 297 319 0.98

6 6 2e-06 0.0003 22.6 4.1 1 23 325 347 325 347 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.53	82	5.5	0.1	1	23	54	77	54	77	0.92
2	6	0.00013	0.02	16.9	0.9	1	23	88	111	88	111	0.94
3	6	0.0002	0.03	16.3	2.5	1	23	121	143	121	143	0.97
4	6	1.6e-06	0.00025	22.8	2.1	1	23	269	291	269	291	0.97
5	6	2e-06	0.00031	22.5	0.2	1	23	297	319	297	319	0.98
6	6	2e-06	0.0003	22.6	4.1	1	23	325	347	325	347	0.98

Coding Sequence: ATGGAGACTGAGCGTTGCATCGGTTCTCCAGTGCCAGATCGGCCGTCCAGCACGCAGAGCAGTCGCTCCTCCACACCCTTTGCCCTTCCATTCCCCACACTACCCACCTCGCTGCTGGAGGTCGGGATGATGCATCATGCTCTTCTCGGCGAAGAAATGTTCAGATGTTCATCGTGCATGGCCGCCTTTCCTTCTTTGTGGCTTCTGGAACAGCACACCGCCTTGCAGCACATTGGTACTTCTGGATCACTGGATAAGCCTTTCGTTTGCGAACAATGCGGACAAAGCTATCGATAcaggTCAGCATACGTGAAGCACAGAGAACAAAATCACCGAGCCCGACTGCCAGCCGATAAACTTTTCTCGTGTGACGTTTGTGGAATGCAATTCAGATATTTGAAGTCATTCAAGAAGCACAGACTTAACCACGCCTTGGAAAAACTGCACGGCAAGAGTGGGGACATACCCAAGGAGGTGAAGTACAATGCCGAAGAGGAAAATTCAAGAGGCGTCCATGAGAATAGTAGCGATCACGTGTCCAGCTCGAATGAAACGATCAACATCGAAGAAGAAAGTAGCCCCATTGCGGTTAAAAAGGAGAATGTTGCCGATGATATTGCAGCTGAAGGCACCTCATCGGACGCCGAAAAGACCGAAACCGAGCAGGATGATACAGTCGATTCCATGGCGTACACCTTTCGCAGTGGTGGCCCCTCCAATGAGCTGCTTCCCACCACACCGGAATCTTCATCCTTGGTGAACTTTCTGCGCAGCGATGCCGCCGATCGACAGCGAGAACGCCGCTTCGCTTGTCCCTTTTGCGGCAAGTGTGTTCGCAGCAAGGAGAATCTCAAGCTGCACGTGCGCAAGCATACTGGGGAACGTCCATTCGTATGTCTGTTCTGTGGTCGTGCGTTCGGCGGCAAAAGCGACTTGACAAGGCACTTACGCATTCACACGGGCGAAAGACCGTACCATTGTGATATGTGTGGCAAGTGCTTTGCCAGGGCAGATTATCTTTCAAAGCATCTAACGACACATATTAATACGCCACGTTGA
Protein Sequence: METERCIGSPVPDRPSSTQSSRSSTPFALPFPTLPTSLLEVGMMHHALLGEEMFRCSSCMAAFPSLWLLEQHTALQHIGTSGSLDKPFVCEQCGQSYRYRSAYVKHREQNHRARLPADKLFSCDVCGMQFRYLKSFKKHRLNHALEKLHGKSGDIPKEVKYNAEEENSRGVHENSSDHVSSSNETINIEEESSPIAVKKENVADDIAAEGTSSDAEKTETEQDDTVDSMAYTFRSGGPSNELLPTTPESSSLVNFLRSDAADRQRERRFACPFCGKCVRSKENLKLHVRKHTGERPFVCLFCGRAFGGKSDLTRHLRIHTGERPYHCDMCGKCFARADYLSKHLTTHINTPR

Sequence clustering based on sequence similarity using MMseqs2