Basic Information

Gene Symbol
ZFHX3
Assembly
GCA_031894815.1
Location
JAVIWC010000891.1:807418-817855[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 0.056 9 8.2 0.2 2 23 84 106 83 106 0.96
2 15 0.014 2.2 10.2 0.1 2 23 115 137 114 137 0.94
3 15 0.0034 0.55 12.1 2.8 2 22 186 206 186 209 0.91
4 15 0.66 1.1e+02 4.9 1.2 3 23 223 246 221 246 0.88
5 15 0.01 1.6 10.6 1.7 1 23 264 286 264 286 0.97
6 15 0.0046 0.74 11.7 0.7 2 23 293 315 292 315 0.96
7 15 0.00059 0.095 14.5 3.9 1 23 417 441 417 441 0.92
8 15 0.007 1.1 11.1 0.6 1 22 461 482 461 485 0.89
9 15 0.00096 0.16 13.8 0.2 1 23 541 565 541 565 0.93
10 15 0.054 8.8 8.3 0.1 2 21 672 691 671 692 0.94
11 15 0.21 34 6.4 2.0 2 19 833 850 832 855 0.91
12 15 0.00015 0.024 16.3 2.5 1 23 1481 1503 1481 1503 0.99
13 15 0.00047 0.076 14.8 0.8 1 23 1588 1610 1588 1610 0.98
14 15 0.0081 1.3 10.9 0.4 2 23 1786 1808 1785 1808 0.96
15 15 1.1 1.9e+02 4.1 4.0 3 23 2045 2067 2044 2067 0.90

Sequence Information

Coding Sequence
ATGGATGATAGCCCTGAAAGCGTCGTCGGGACACATCAGGGCGCTTCGGCGAGCCCTATAACTGTTATGACCAGGTGTCTATTACCCCGTCCCGTTAGCCCAACACCTGATGCGGGAAGTGAAAAGTCTGAGAGTAAAGAAGTAGCAGTAGAGAAAAAAGGTAGCCCTTCTCCGTCCTTGCAAATGCCATCTCAACTGACCGAACAAGCCCAACATTCTTCCTCGCAAGAGGAGGTTAAGTCAGAAATTCAATGCGGCCAATGTAATTTTACCGCGATCAGTGAAAGCAAGTTGCAGGAGCACATTCAAAGCTCTCATCAGTCAGAGCAAGCTGCTGAAGTTCAATGCCCATTGTGCCAAGATAGTTTCAGTGATAGGCCATCCCTTGAGAGCCACGTAATGCAAATCCATTCTGTCAATTCCGAGGGGTTGCAGAGGTTGTTGTTACTGGTAAATCAGTCCCATTGGCTCAACCAGAGTAAAACACCGAGTACGtctgaaaataaggaaaaatcggAGGAAGAGAAAGATGAGGTAGAGGAGAccgatgatgaaaaatgtcaGACGTGCAATAGGAGCTTCAAAACCATTGACGAACTTTGCTCACATCAAAATGAAACCGGTCATTTGGAATTGAAGCAAACTCCGAGTGGCCCTGGTTATCTTTGCTGGAAAAAAGGTTGCAATCAATACTTCCAAACCGCACATGCTCTTCAAATGCATTTCCGAGAGATTCATGCTCGTGGTGCTGGCCAGAACATGGCAGTATCGGAAAAACATGTGTACAAATATCGTTGTAACCAATGCAGCCTTGCTTTCAAAACCATGGAGAAACTTCAACTACATTCTCAGTACCACGTTATCAGAGATGCTACGAAATGCGTTTTGTGTGGGAGGAGCTTCAGATCTGTTCTTGCACTCCACAAGCATGTAGAAACCGCTCATACTGACCTCTCAGAAGATGAGATGAATGCATATAAGCAAAGTTTGTTGAATAACCCTCTGCTTATCGCCGGTTTCAGTGGACAAGTACTTGATTCTTCTACCAATGAATTGCTCAAGCgagaatccatgaaaatggaCGAAGAATCGGAAGCTGATGAAACTAAAGAAACGGACGATTCAACTGCTCCACAAGAAGGTGAGAATAGTGATGATTCCATTGTGTACAAGGAGCAACAGTTTTTGGAGGACTATCTCAACAGCCAAGCCATTGCTGAAGATTCATACAATGATCCTGCAAGAAAATACAAATGTCATAGATGCAAGGTGGCTTTCACTCGTCAATCTTATCTGACAAGCCATAATAAAACCTTGCTGCATCGAAAGGGTGAGAAATTGTCATATCCCATGGAGAAATACTTGGACCCTAATCGCCCTTATaaatgtgatgtatgcaaggaaTCATTCACACAGAAAAACATCCTCTTGGTTCATTACAATTCTGTGAGCCATTTGCATAAATTGAAACGAGCCATGCAAGAACAACAGCAGttgcaacaaaataataacaataacaacgcTCTTTCACCCCAAGTTGCTGCTGCTGCAGCTCTAGCTGCTCAACTGGGTGTACCCACTCCTTTGAAGCAGTCTCAAGAAGAAGATGACAAGAAACCTTACAAATGCAACATTTGTAAAGTGGCCTATACCCAGGGCTCAACCTTGGATATACATATGCGCTCAGTTCTTCATCAGACGAGGGCCTCTAAACTTCAAGACCTCGCAATTACTGGTCAAATTGACCTGAGTAAGCCTTTGATTGAACAGCCAGAGCCTCAAAAAGCTCAGGATCAACATAAAAAGTTGATTCAAGATATTTTGGGTAGCTCACCTAAACAATTGCTTTCCTCGCCACCGTCCTCTGGTAGCTCTCAGCTCACCGGGTCCTCGCCGAGCTCGTCTGCTCCGCCTCCAGCGGCGTCAACTCCTAACTCGGCAACTTCAGTTCCTACTAGCTTAACTAACACATCGAACTCTGTGATAAACACATCTCCCAACGCAGGTATGTTGACCTGTGGGCGGTGTAATGCTCTTTTTGTCAATCAAGAACAGCTGACGACGCATCAGCAACTCTATTGCTTGTTTAGCAATCATATGTCCATGTTTCCGCCTTTGCCGACTCCCCCTTCCTCATCGGCCAACTTGTCATCTCCCCAGCCTAACAGCAGTAAGACGCCGCCTCCGATTCCACTGACCCCAATTACTCCGGGTAACGATGAATCATTCCCAAGGATCACGATTCCTACCAAGAAATCGTCTCAGATGTATAAAACTCTACTTGAAAGCTTTGGCTTTGATCTTGTCATGCAGTTTAATGAAAATCATCAACGAAGACAGCGGAAAGAAAAGGAAGAGGCTGAAAAATTGCTATCCGAAATTTCATCTACAACGCAACCAGTTGAGGAAGCCATCCCACCAGTAgaagaagagaaggaaaaaGTGGAGGTCAAAGTCGAGGAAGAACTCGTTGATCTTCCAGAAGTAGCGAAGTCTACATGTCAACATTGTAATAAGGAATTTTCCAGTGTATGGGTGTTGAAAGCTCATTGTGAGGAGGTTCACAAAGATTTAGTACCTCTCGATTTCTTGGAAAAGTACGCACAGCAAATTAAGTgtgaaattgagaagaaagtgGTCCCATCTCCCGTAGTTTCTTCAACCACTGGAACTGAGACAACTCCTGAGAAAGAGGAGGACAACAAAGAAGCCATTCAAGCTAAAATCGCTTTAcagcagcaacaacaacaaacaccTCCTAATGCTGAAAACGTTACTGCGCCTTCTACACCCACGGCGTCCTCTACTCCTGCTTCCTCAACTGATTCATTGCCAGCAACTTTGAGTCACTCGTTGGCTGCTGCAGTGGCTGGTATGAGTGGGAATGCTGCAAACATGGCACTTGCTCAACAGATGACTGAAATGCAAGCGGCTCTCAATGTCATGGCCGCCTCGCAAATCCAACAGCAGCTGCAACAGTTCAATCCTATGATGATGGGTATGGCTGGACTAGGAATGGGGCTCCCGTTGGGTCTGAATATGCCTGCTCTTGCTGCGATGAACCTGCAGCCGCCTCTCGTCCCGATGATGATGCCTCCGCCATCGTTCGACTCCATGGTTGGGATGAGCCAAAACCAGCCCAATCTATTCAACCCTCAGGGGATGGATCCTGCTGCCATGCTCGCCAAGCAGCAAGCCCTAATTCAACAACAACAGCAAGTGgCTAATGCATCTCAACAAAAACGAGCCAGAACGAGAATAACTGACGATCAATTGAAAATACTGAGAGCACATTTCGATATCAACAATTCCCCTTCGGAAGAACAGATAAATGATATGGCCGCTCAAAGTGGACTACCACCTAAGGTTATAAAGCATTGGTTCAGAAACACCCTTTTCAAAGAAAGACAACGAAATAAAGACTCTCCTTATAATTTCAACAACCCGCCATCAACCACTCTGAATCTTGAGGAGTATGAGAAAACGGGTGAGGCGAAAGTCACTCAGTTGGTGCCTGATGAGAACAGGGAACAATCTAAGACCCCAACTCAGAAACCATCACCTTCTCCAATACCTCCATCTCCGCAACCTCCTTCAATCACGCAACCATCCAGCTTACAGCAACAGTCGCTCCAACAACAGCAAGAGCAACAACAAGAACACCATCAACAACAGTTGCAACAGCAATTGCAGCAGCAACAACAGCAACAGCAGCAACAGCAGCAgcaacaacaacagcaacagCAGCAGCAACAACAACACATGCAACAACAATTAATGCAGCAGGGATTTGGTCACAGTAATATGATCAAAACAGAACCTAGGGAACACGAGACTGAACAACACCATCATAATGAGAAACCAGCTCCTCAGTTCAATCATCACCCTCTGCAACAATCACCAATGAGTCCAAGTGATCGAATGAATCTCTTGGGTACAAGAAATAGCTCACCTGAAAATCTCACGTTGACATCTATTATATCTTCCCAGTTGTCTAATATGACTCCAACATCAATGTCTTCGCCTCACCCAAACATGTTACCGCCGCCCAAGCTGACCCCGCCTTCTGGTTTTTCAACACCAAACCATCAGCAGATGCCTATGAGCAACGCTCAGGACTGCTTCTCTCACGCGATGTTGGGCAACAATGGCGGGAACACGGGCAGCTCCACAACTGGGAAAAGAGCCAACAGAACTCGATTCACAGACTATCAAATCAAAGTACTCCAAGAGTTCTTCGAAAACAACGCTTACCCAAAAGACGACGATTTGGAATACCTTTCAAAGCTTCTGAGCCTGAGTCCTAGGGTAATTGTTGTTTGGTTCCAGAATGCCCGTCAAAAGGCTAGGAAAGTATACGAAAATCAACCACCTGTCGAACTGTCTCCTGGTGTTGATGAAACTGGTGCTGGAAGGTTCCAACGTACTCCAGGGTTGAACTATCagtgtaaaaaatgtttgttggtgTTCCAGAGGTATTACGAACTCATTCGTCATCAAAAGACTCATTGTTTCAAAGAAGAAGATGCCAAACGTTCTGCCCAGGCTCAGGCTGCGGCTGCCCAAATTGCTGCTGTTCTTTCATCTGAAGACTCAAATTCGAGTACCCACTTGGATCAGTCAAGCCAACCGAACCATTCTGTGATGACTTGCAGTAATCCTTCTACTCCAGCTGCAGCGGTCACACCTACTCCTTCCCAAAACATGTTTTCTCCTTCTCCTGCTCCAACGACTACTCCTACTCCTGACAGCAAAGACAATTTCCAATGCGACCACTGCAATCTCGTTTTCCCCAGATTTGATCTATGGCGTGAACACCAGCTCGTTCACATCATGAATCCCAATCTTTTCCCTACATATCCTCCTGATAGCCCTTTTGGCATCTTACAGCAGCATGCTCAGTTGCAACAACAACAGCAGCAACAACAACAGCAGCAACAACAACAGCAGCAAGCTCAACAGCAACACCAACAGCAACATCAACAGGCTCAACACCAACAATCTCCTCAAACACCCCAACAAAAAATGGGTCCTGATCTCCTGAATCCCAATACTCCTCATCCGTTAATTTCCATGCTAGCTGGTCATAAAAGAAAGTTTGACGAATTTGAGGATAACCAAGATAAAGAGGGTGAGCAACCAAAAGATAAGAGACTGCGAACCACGATTCTTCCTGAACAGTTGGATTATTTATATCAGAAATACCAAATTGAGAGCAATCCCTCCCGAAAAATGCTAGAGAATATTGCCCATGAAGTTGGGCTTAAGAAAAGAGTGGTTCAAGTTTGGTTCCAGAATACGAGAGCAAGGGAAAGAAAGGGACAGTTTAGAGCACATTCTCAGGTGATCAACAAGCGTTGTCCGTTTTGCCCAGCTCTTTTCAAAGTGAAATCAGCTTTAGAGAGCCATCTGACGACGAAACACGCTGATCAATGTTCGAGGGGAGAAATAAACATCGATGCATTACCTGATGAAGACACCAATGCAAATGAGAATTCCAGCTCAAACGTGCAAGATAAATTTAACAGCATGATGCCCCCAGTATTTAACCAATTCAGTAATGACGTAGATGGAACCTTGAAAAAATACTACGAAGAGTCAATGAAAAGATACATGGCTGAAGCGATGAATGGTAAGGATGTTTCAGATATGACTGTGAAAAAGGAGGGAGAGACTGGTGATTCGCCCTTGGACCTTAGCAAACCAGTAGATTTGAGTAGACCTATGAAGCTCAGTTTAGAGCATATGATGATGGACCAAGGACCTTTGACGGATCTCAGTGAAAAGAGCATTTGTGATGAAGACAGTTTCTCTGAATGTACAGATAACATGGAAGATGAGTCGAACCCAACATCACCTGCCTCAAGCACGCAAAGTCAACACCAGCACGGAAAAGCTAAGAGATTTAGAACGCCTATGTCAACGTTGCAAGTCAAGTTGatgaaaactttgtttaatGATTATAAAACTCCCACCATGGCAGAGTGTGAGATGCTCGGTAGGGAAATTGGTTTACAAAAGAGGGTGATACAAGTTTGGTTCCAAAATGCTCGAGcgaaagaaaagaaatacaaatctGCCATTCAAAGTATGGGAGGGCAAATCGGAGAGCAAGAGAGGCTTCCAGAAGACTGCAAGTTCTGTCAATTCAAGTACTCCCACAAATATTCCGTGCAAGACCACATTTTCACCAAAAAGCACATAGATATGGTGAAAACTTATTTGGAGAGTTCACTGGCCAAAGAAAACGAAGGGGATTTCACTGTGCCTCCAGTACCCGGAGCTTCGGGCGAGAGCAACAACAACCACACGACCCAACAGCAGCAAATGGCTCAGCTGCAGATGCTCCAAATGGCCGGTCTGTCGCTACCTCAGGCGCAGGCGATGGCAATGGCTGTGAAGATCGAGGGCAAAGAGAGCACGCCGGGTCAGCAACCGAGCGCTGAAGACCTCGCGCTCCTTCAGCAGCTCTACGGAGTCACGAACTACCCGCAGGGCTTCATCCACCCCGCCCTCCTCTCCGCTACTGGTGAGTGTCCCATCATTTTCTATTCATTGTTACATTCTCGTACTTACAAGTTAGCCTGA
Protein Sequence
MDDSPESVVGTHQGASASPITVMTRCLLPRPVSPTPDAGSEKSESKEVAVEKKGSPSPSLQMPSQLTEQAQHSSSQEEVKSEIQCGQCNFTAISESKLQEHIQSSHQSEQAAEVQCPLCQDSFSDRPSLESHVMQIHSVNSEGLQRLLLLVNQSHWLNQSKTPSTSENKEKSEEEKDEVEETDDEKCQTCNRSFKTIDELCSHQNETGHLELKQTPSGPGYLCWKKGCNQYFQTAHALQMHFREIHARGAGQNMAVSEKHVYKYRCNQCSLAFKTMEKLQLHSQYHVIRDATKCVLCGRSFRSVLALHKHVETAHTDLSEDEMNAYKQSLLNNPLLIAGFSGQVLDSSTNELLKRESMKMDEESEADETKETDDSTAPQEGENSDDSIVYKEQQFLEDYLNSQAIAEDSYNDPARKYKCHRCKVAFTRQSYLTSHNKTLLHRKGEKLSYPMEKYLDPNRPYKCDVCKESFTQKNILLVHYNSVSHLHKLKRAMQEQQQLQQNNNNNNALSPQVAAAAALAAQLGVPTPLKQSQEEDDKKPYKCNICKVAYTQGSTLDIHMRSVLHQTRASKLQDLAITGQIDLSKPLIEQPEPQKAQDQHKKLIQDILGSSPKQLLSSPPSSGSSQLTGSSPSSSAPPPAASTPNSATSVPTSLTNTSNSVINTSPNAGMLTCGRCNALFVNQEQLTTHQQLYCLFSNHMSMFPPLPTPPSSSANLSSPQPNSSKTPPPIPLTPITPGNDESFPRITIPTKKSSQMYKTLLESFGFDLVMQFNENHQRRQRKEKEEAEKLLSEISSTTQPVEEAIPPVEEEKEKVEVKVEEELVDLPEVAKSTCQHCNKEFSSVWVLKAHCEEVHKDLVPLDFLEKYAQQIKCEIEKKVVPSPVVSSTTGTETTPEKEEDNKEAIQAKIALQQQQQQTPPNAENVTAPSTPTASSTPASSTDSLPATLSHSLAAAVAGMSGNAANMALAQQMTEMQAALNVMAASQIQQQLQQFNPMMMGMAGLGMGLPLGLNMPALAAMNLQPPLVPMMMPPPSFDSMVGMSQNQPNLFNPQGMDPAAMLAKQQALIQQQQQVANASQQKRARTRITDDQLKILRAHFDINNSPSEEQINDMAAQSGLPPKVIKHWFRNTLFKERQRNKDSPYNFNNPPSTTLNLEEYEKTGEAKVTQLVPDENREQSKTPTQKPSPSPIPPSPQPPSITQPSSLQQQSLQQQQEQQQEHHQQQLQQQLQQQQQQQQQQQQQQQQQQQQQQQHMQQQLMQQGFGHSNMIKTEPREHETEQHHHNEKPAPQFNHHPLQQSPMSPSDRMNLLGTRNSSPENLTLTSIISSQLSNMTPTSMSSPHPNMLPPPKLTPPSGFSTPNHQQMPMSNAQDCFSHAMLGNNGGNTGSSTTGKRANRTRFTDYQIKVLQEFFENNAYPKDDDLEYLSKLLSLSPRVIVVWFQNARQKARKVYENQPPVELSPGVDETGAGRFQRTPGLNYQCKKCLLVFQRYYELIRHQKTHCFKEEDAKRSAQAQAAAAQIAAVLSSEDSNSSTHLDQSSQPNHSVMTCSNPSTPAAAVTPTPSQNMFSPSPAPTTTPTPDSKDNFQCDHCNLVFPRFDLWREHQLVHIMNPNLFPTYPPDSPFGILQQHAQLQQQQQQQQQQQQQQQQAQQQHQQQHQQAQHQQSPQTPQQKMGPDLLNPNTPHPLISMLAGHKRKFDEFEDNQDKEGEQPKDKRLRTTILPEQLDYLYQKYQIESNPSRKMLENIAHEVGLKKRVVQVWFQNTRARERKGQFRAHSQVINKRCPFCPALFKVKSALESHLTTKHADQCSRGEINIDALPDEDTNANENSSSNVQDKFNSMMPPVFNQFSNDVDGTLKKYYEESMKRYMAEAMNGKDVSDMTVKKEGETGDSPLDLSKPVDLSRPMKLSLEHMMMDQGPLTDLSEKSICDEDSFSECTDNMEDESNPTSPASSTQSQHQHGKAKRFRTPMSTLQVKLMKTLFNDYKTPTMAECEMLGREIGLQKRVIQVWFQNARAKEKKYKSAIQSMGGQIGEQERLPEDCKFCQFKYSHKYSVQDHIFTKKHIDMVKTYLESSLAKENEGDFTVPPVPGASGESNNNHTTQQQQMAQLQMLQMAGLSLPQAQAMAMAVKIEGKESTPGQQPSAEDLALLQQLYGVTNYPQGFIHPALLSATGECPIIFYSLLHSRTYKLA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00386120;
90% Identity
iTF_00930141;
80% Identity
iTF_00386120;