Basic Information

Gene Symbol
TFAP2A
Assembly
GCA_949710035.1
Location
OX453313.1:11541956-11578326[-]

Transcription Factor Domain

TF Family
AP-2
Domain
TF_AP-2 domain
PFAM
PF03299
TF Group
Basic Domians group
Description
Activator protein-2 (AP-2) transcription factors constitute a family of closely related and evolutionarily conserved proteins that bind to the DNA consensus sequence GCCNNNGGC and stimulate target gene transcription [PMID: 2010091, PMID: 1998122]. Four different isoforms of AP-2 have been identified in mammals, termed AP-2 alpha, beta, gamma and delta. Each family member shares a common structure, possessing a proline/glutamine-rich domain in the N-terminal region, which is responsible for transcriptional activation [PMID: 2010091], and a helix-span-helix domain in the C-terminal region, which mediates dimerisation and site-specific DNA binding [PMID: 199812]. http://www.ebi.ac.uk/interpro/entry/IPR013854
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 7e-79 4.5e-74 250.4 0.0 1 191 188 375 188 381 0.97
2 9 0.011 7.3e+02 1.7 0.1 139 186 377 424 373 431 0.80
3 9 0.046 3e+03 -0.3 0.0 152 183 816 847 805 859 0.79
4 9 1.5e-08 0.00097 20.9 0.0 158 191 1312 1345 1296 1351 0.86
5 9 3.4e-09 0.00022 23.0 0.1 139 191 1347 1399 1343 1405 0.86
6 9 3e-09 0.00019 23.1 0.1 139 191 1401 1453 1396 1459 0.87
7 9 3e-09 0.00019 23.1 0.1 139 191 1455 1507 1450 1513 0.87
8 9 3e-09 0.00019 23.1 0.1 139 191 1509 1561 1504 1567 0.87
9 9 3.6e-10 2.3e-05 26.2 0.1 140 196 1564 1620 1559 1621 0.84

Sequence Information

Coding Sequence
atgtacaGATACTCTGCCGAAGACAGTATTACCCATGAGCGCCTGGGCGGTGGCGGGCTTGGGCTGGGCGGCGGCGGCTTCCGCGGCGGCGCGCAGCCCTCGCTCGCCGACTTCCAGCCGCCGTACTTCCCGCCGCCGTTCGCGCCCGCGCCGCATCCGGCCAGCCCACACCACCAGCAGCAGAGTCATGGCATGGAATACGGCGGCGGAGGTGGCGGTGGGGCGGAGTACGCACAACACTACGCGCCACAGCAGCTCCTGCCGCGCCACCACCACCACGAGCCGCACGCGCACCTGCGCCATCACCGCGACCACCACGACCCTATTCACGCGCACCACCTGTCACATGGTGGCTTCAGTTATGGCGGCGGCGAGCGGCGCGCGGACTACGGTGCCAGAGAGCAGCACGAGCTCGCGTTGCACCACGCACTGCACTCCGCGGAGGAAGCGCCGAATGCGGGTATGGATGATACGACAGGGTTTATGACAGATCTTCCTTTATTAAaaaCCATGAAAGGGCGCGACGGCCTCGGCGGCGGGTCCTGCGCACCCAACGATGTCTTCTGCTCCGTGCCGGGCAGACTATCTCTCCTCTCCTCCACGTCGAAATACAAGgtgACGGTGGCGGAGGTCCAGAGGCGGCTATCACCGCCGGAGTGCCTCAACGCGTCGCTACTCGGAGGCGTGCTCAGGAGAGCAAAAAGCAAAAATGGCGGGCGACTACTCCGCGAGAAGTTGGAGAAGATTGGCCTAAACCTGCCGGCGGGCAGGAGAAAAGCCGCCAACGTCACTCTACTCACTTCTTTAGTGGAAGCTGAGGCGGTCCATCTCGCGCGTGACTTCGGCTACGTCTGTGAGACGGAGTTCCCCGCGCGAGCGCTAGCGGAGTACCTCGCGCGGCAGTACGCGGAGCACgacgcgcgccgccgccgagaCCTGCTCCAAGCCACCAAACAGGTGACGAAGGAGCTGATGGACTTATTAAACCAGGACCGGTCGCCGCTGTGCAACACGCGGCCGCCGCACCTACTGGAGCCGGCCATACAGCGGCATCTGACGCACTTCTCGCTCATCTCGCACGGGTTCGGCGGGCCTGCCATAGTCGCTGCACTCACCGCGATACAGGTGAATCTCGCCTCCACTATACATCACTATCGATCACGTGTATCACTATACACAGTGATACAGCTACTAGAGCCGGCCATACAGCGGCATCTGACGCACTTCTCGCTCATCTCTGAAAATCTATCACCTGAAAATAAAATGCTTCATGCCTCCGCGCGTGCAAAAGCCAAGGAACTTCATTACAAACATGTTTGGGTTCGCGGCGGTCGTATTTATATGCGCAAAACGGACACATCCGAACGCGACCGTGAGACAAGCGGTTTTGCTAGAACTAAATTGGGTGGCGGTGTGCTCATCGCCGTGAACAAACGCTTAAATTCTCGCAGGATGCCTGATCATGAAAGTGAGTGTGAGGATGTCTGGGTTGAATTGGATTTTAACGGGAAGGATACTGAGAAATTATTAATATGTGGTGTTTATCTCCCATCCCCCATCAAAAAGCATATTTTAGATCATTTCCTTGATAACAGCAATCGAGTTTTGGAATCTCAATCTCACAAGAGAACTTTAATTCTGggtgattttaatttaagtgGCATTGCTTGGAACGTTAACATGAATATGGCATCTGATGGAATTGCTTCTAAGAGTTTATTTGAACGAAGTGTATTGGATTTTCTGGCCTTAAATAACCTCACTCAgtgtaattacatacttaatgaCAAGGGCACTATTTTGGATCTCATTATTTCTAGTGCTGAATTATCTGAAGTATCGCGCAGTTTTTCACCTTTGAGTAATGTCGTCTCTTACCATCCACCCTTGGAATTTGTGATAAATAATGGCAAGCCTTCTTACTCGCGAAAACCAGTTGTAGCCGAAAGATTTAACTTCTTCAAAGCAGACTACGAAAAGATTATATCTGATTTAGACTCTGTATCATGGGAGAACTGTTTAACATCTTGTACTTCGACCGATGCTATGGTTGATAGATTCTATGAAATTCTTAGGAGCACTATAGAAAAACACGTACCAAAATGCAAACCGACATCGAATAAGTATCCAGTCTGGTACACTAAAGAGTTAATTCATCTCCTAAATGAAAGGAATAAACTCAGGAAAAGGTATGCCAAATACTCAAACCCACTTGACGAAATTGctctaaaaacaattaaaaagagATGTTCCGAATTGACCTCTGCCTGTTATATCAACTATCTCGATAACATCGAAAGATCACTGTCTAAAAATCCCAAATTATTTTGGTCGTATGTCAAAAAGAAAAAACGGAATGCAAGCACTTACCCCTCGACAATGTCTTCTGATAATGGTGAGGCCACGGGTGATGACAAAATATGTAATCTCTTTGCTTCCTCTTTTGCCTCTGTTTATAAAAGTCCTTCTGATCCAACCAATTTACAAGAATCCGCAAATGAATGCTGTCTCACCTCCCACTCTATCGGTGAGGTCCAGTTCACGTCGGATGAGGTGCTACAGGCTTTAAAACGTTTAGATAGGTCTAAAGGTGCTGGGCCAGATGGCATTACCtctttatttgttattcaatgcAGCAAAGCTCTCTCTTTACCTCTTTCTGTTATCTTCAACCATTCCATTAAGTCTGGCATATTTCCGAAAGTTTGGAAGGAGGCCAGAATAGTCCCAATATTTAAATCTGGTAGTTGCTCGTCAGTAAAAAACTATAGACCGATTTCAATATTATCTGTATTTTCTAAGGTTTTTGAATCCCTTTTATGCCCTGTTCTATGCTGGCAAGTAAATCGGGTTATGTCGTCACAGCAAGCTGGATTTTTTTCGGCCCGTTCTTCAACATCAAACCTGGTCTCTTTTCTCACCCACGTGACAGATGCACTTGACTCCCGTGGTACTGTAGATGCCATTTATACTGATATTAGTAAAGCCTTCGACACAGTTGACCATCACATTCTGCTGAGGAAGATGTCCCGATTCGGTATTACTGGCAAACTTTTCGACTGGTTCACCTCATATTTGAGTCAGCGCTTTTCAAAAGTGGTGGTGAATGGTTGTTCCTCTGAGGCATACCAGGCTACATCTGGAGTTCCACAAGGTTCTCATCTCGGCCCCATTCTCTTCAATATCTTCATCGATGATGTTGTCTCTGTCTTTGAACATGCTACTTGTTTTCTATATGCTGATGATATGAAGCTTAGTTTGCCaattacttcaatacatgactgcGATTTGTTGCAGAAGGATTTGGACCGACTTGCTCAGTGGTGTACTGATAACAAATTGTCTTTAAACATTAACAAATGCAAGCACATTCGGTTTACAAGATGCAAGGGTACCGTGGCTCCGAATTACACAATTAATGGTCGAGTTTTGGAGGAGGTTAACACCATCCGTGATCTGGGGgtaactcttgacaagaaactACTATTCCATCGTCACATTGACGACATTGTCACAAAGGCTTTTCAAATGCTCGGATTTGTAATCCGTAACACTAAAGATTTTAAGAGGCCTTCGACGAAACTTTTACTCTATTCGTCACTAGTGCGTTCACGCTTGGAATACTGTAGTCAAGTTTGGACCCCCCAATATGATGTACATGTCAAACGAATTGAGCGCGTTCAGAAGCGATTTATGTGGCATCTCACCTATCAGACCCATAAAGCCAAAGAACTATCCACGTACGAGAAacgtctttctttctttcagttACTAAGTTTGGAGGATAGGAGATTGCTACTGGACCACATGTTGTTATATAAAATAGTCAACGGAGTTGTGGATTGTCCTTTCTTGCTCAGCAAGATTAACTTGAAGGTGCCCATAAAACTTCCTCGCTCGATAAGCCACGTTCCATTCTCGGTAAGAGTGATACAGCTACTAGAGCCGGCCATACAGCGGCATCTGACGCACTTCTCGCTCATCTCGCACGGGTTCGGCGGGCCTGCCATAGTCGCTGCACTCACCGCGATACAGGTGAATCTCGCCTCCACTATACATCACTATCGATCACGTGTATCACTATACACAGTGATACAGCTACTAGAGCCGGCCATACAGCGGCATCTGACGCACTTCTCGCTCATCTCGCACGGGTTCGGCGGGCCTGCCATAGTCGCTGCACTCACCGCGATACAGGTGAATCTCGCCTCCACTATACATCACTATCGATCACGTGTATCACTATACACAGTGATACAGCTACTAGAGCCGGCCATACAGCGGCATCTGACGCACTTCTCGCTCATCTCGCACGGGTTCGGCGGGCCTGCCATAGTCGCTGCACTCACCGCGATACAGGTGAATCTCGCCTCCACTATACATCACTATCGATCACGTGTATCACTATACACAGTGATACAGCTACTAGAGCCGGCCATACAGCGGCATCTGACGCACTTCTCGCTCATCTCGCACGGGTTCGGCGGGCCTGCCATTGTCGCTGCACTCACCGCGATACAGGTGAATCTCGCCTCCACTATACATCACTATCGATCACGTGTATCACTATACACAGTGATACAGCTACTAGAGCCGGCCATACAGCGGCATCTGACGCACTTCTCGCTCATCTCGCACGGGTTCGGCGGGCCTGCCATTGTCGCTGCACTCACCGCGATACAGGTGAATCTCGCCTCCACTATACATCACTATCCATCACGTGTATCACTATACACAGTGATACAGCTACTGGAGCCGGCCATACAGCGGCATCTGACGCACTTCTCGCTCATCTCGCACGGGTTCGGCGGGCCTGCCATTGTCGCTGCACTCACCGCGATACAGAATTTCCTAAACGAATCATTAAAACACCTAGACAAATTATATCCACAAAGCGGCATGGTGTCCTCATCGATGGACAAAACGAAAATGGACCCCGACATCAAGAAGTAA
Protein Sequence
MYRYSAEDSITHERLGGGGLGLGGGGFRGGAQPSLADFQPPYFPPPFAPAPHPASPHHQQQSHGMEYGGGGGGGAEYAQHYAPQQLLPRHHHHEPHAHLRHHRDHHDPIHAHHLSHGGFSYGGGERRADYGAREQHELALHHALHSAEEAPNAGMDDTTGFMTDLPLLKTMKGRDGLGGGSCAPNDVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEAEAVHLARDFGYVCETEFPARALAEYLARQYAEHDARRRRDLLQATKQVTKELMDLLNQDRSPLCNTRPPHLLEPAIQRHLTHFSLISHGFGGPAIVAALTAIQVNLASTIHHYRSRVSLYTVIQLLEPAIQRHLTHFSLISENLSPENKMLHASARAKAKELHYKHVWVRGGRIYMRKTDTSERDRETSGFARTKLGGGVLIAVNKRLNSRRMPDHESECEDVWVELDFNGKDTEKLLICGVYLPSPIKKHILDHFLDNSNRVLESQSHKRTLILGDFNLSGIAWNVNMNMASDGIASKSLFERSVLDFLALNNLTQCNYILNDKGTILDLIISSAELSEVSRSFSPLSNVVSYHPPLEFVINNGKPSYSRKPVVAERFNFFKADYEKIISDLDSVSWENCLTSCTSTDAMVDRFYEILRSTIEKHVPKCKPTSNKYPVWYTKELIHLLNERNKLRKRYAKYSNPLDEIALKTIKKRCSELTSACYINYLDNIERSLSKNPKLFWSYVKKKKRNASTYPSTMSSDNGEATGDDKICNLFASSFASVYKSPSDPTNLQESANECCLTSHSIGEVQFTSDEVLQALKRLDRSKGAGPDGITSLFVIQCSKALSLPLSVIFNHSIKSGIFPKVWKEARIVPIFKSGSCSSVKNYRPISILSVFSKVFESLLCPVLCWQVNRVMSSQQAGFFSARSSTSNLVSFLTHVTDALDSRGTVDAIYTDISKAFDTVDHHILLRKMSRFGITGKLFDWFTSYLSQRFSKVVVNGCSSEAYQATSGVPQGSHLGPILFNIFIDDVVSVFEHATCFLYADDMKLSLPITSIHDCDLLQKDLDRLAQWCTDNKLSLNINKCKHIRFTRCKGTVAPNYTINGRVLEEVNTIRDLGVTLDKKLLFHRHIDDIVTKAFQMLGFVIRNTKDFKRPSTKLLLYSSLVRSRLEYCSQVWTPQYDVHVKRIERVQKRFMWHLTYQTHKAKELSTYEKRLSFFQLLSLEDRRLLLDHMLLYKIVNGVVDCPFLLSKINLKVPIKLPRSISHVPFSVRVIQLLEPAIQRHLTHFSLISHGFGGPAIVAALTAIQVNLASTIHHYRSRVSLYTVIQLLEPAIQRHLTHFSLISHGFGGPAIVAALTAIQVNLASTIHHYRSRVSLYTVIQLLEPAIQRHLTHFSLISHGFGGPAIVAALTAIQVNLASTIHHYRSRVSLYTVIQLLEPAIQRHLTHFSLISHGFGGPAIVAALTAIQVNLASTIHHYRSRVSLYTVIQLLEPAIQRHLTHFSLISHGFGGPAIVAALTAIQVNLASTIHHYPSRVSLYTVIQLLEPAIQRHLTHFSLISHGFGGPAIVAALTAIQNFLNESLKHLDKLYPQSGMVSSSMDKTKMDPDIKK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-