Basic Information

Gene Symbol
DGCR8
Assembly
None
Location
scaffold:29290-38620[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 20 0.00042 0.042 14.3 2.4 1 23 120 142 120 142 0.98
2 20 3.9e-05 0.0039 17.6 0.5 1 23 147 169 147 169 0.98
3 20 0.028 2.8 8.6 0.4 1 23 175 197 175 197 0.98
4 20 0.00028 0.028 14.9 0.5 1 23 203 225 203 225 0.97
5 20 1.8e-06 0.00018 21.7 2.7 1 23 231 253 231 253 0.98
6 20 5.2e-06 0.00052 20.3 1.6 1 23 259 281 259 281 0.98
7 20 6e-06 0.0006 20.1 3.2 1 23 298 320 298 320 0.99
8 20 0.00016 0.016 15.7 1.5 1 23 326 348 326 348 0.97
9 20 0.00089 0.089 13.3 3.3 1 23 926 948 926 948 0.98
10 20 1.9e-05 0.0019 18.5 6.8 1 23 954 976 954 976 0.99
11 20 0.0011 0.11 13.1 1.8 1 23 982 1004 982 1004 0.99
12 20 0.0003 0.029 14.8 1.9 1 23 1010 1032 1010 1032 0.98
13 20 1.1e-05 0.0011 19.3 1.8 1 23 1038 1060 1038 1060 0.97
14 20 5.2e-06 0.00052 20.3 0.1 1 23 1066 1088 1066 1088 0.99
15 20 0.0066 0.66 10.6 0.1 3 23 1096 1116 1094 1116 0.97
16 20 2.7e-05 0.0027 18.1 0.8 1 23 1122 1144 1122 1144 0.98
17 20 0.00076 0.076 13.5 2.0 1 23 1149 1172 1149 1172 0.94
18 20 0.65 65 4.3 1.6 1 23 1177 1199 1177 1199 0.98
19 20 0.0012 0.12 12.9 0.7 1 23 1205 1227 1205 1227 0.95
20 20 0.063 6.3 7.5 0.5 1 23 1233 1255 1233 1255 0.97

Sequence Information

Coding Sequence
ATGAATGTAAATTATTCATTTGAAAAAGTTATTATTAAAGTTGAAAAAGATGAAGAGGATTTTCAAGAGAATCAATCAATTTTTAATTGTGAAGATCATAATTTAGGTCAAGATTATCCTGTTGATGTTGAGGATATTAAAATTGAAGAACCTGATATTAAATACGAAAATGAAGAGAATCCTCAGTATGATCCCTTGTTAATTGAAAAAAATTTCCTACCGCCTATGGTAACGATTAAAACACGTGAAATAAATTTTGGAACAGTTTATGTTGAAGATACAAAGCCTTTTTTTGATAAAGATAATTTCCAAGAAGAATTAAAAAAATCAAAAGTCCAAAAAAAAAGATCAAAAAAGTACGAGTGTGATTTTTGCAAGTTAAAATTTTCTCATAAAAACGCTCTACTTGTTCACGTCAATAAACATTTGACCACAAAATATAAATGTGAGATCTGTTCAAAAACTTACATCTCAAAAGAAGGCCTGACCCTTCACACAGCAAGGCATACAGGCGACATGCCCTACGAGTGTGAAATTTGTGCTTCTAAATTCGGGGTAAAATTTACTTACGACAATCACATGCGAATCCACAACGGCGAAAAGCCCTTTGCTTGTGAGGTTTGTTTCTCGAAATTCCGCGAAAAAAGCCAGCTGGCCGTTCACCAGAGGATTCACTCAGGGGACAAGCCCTACGCTTGTCACATTTGTTCTGTCAAGTTTCGTCACAAAGGGAACTTGAAGGCTCACATTAGAATTCACACCGATGAGCGGCCTTTCAGTTGCGAAGAATGCTCCGCGAAATTCCGGGATTCTTCGACGCTAAAGCGGCACAAGCGAGTTCACACTGGAGAAAAAAGAGAAAAAAGAGAAAAAAGAGAAAAAGAAAAACGGTACTCTTGTAAAATTTGCTCCTACAAATTTAGAGATAATTACTTCTTGAATATTCACATGCGCAAACATACTGGAGAACGGCCTTTTGCTTGTCAAGTTTGCTTCTCGAAATTCAAGGAAAAAGGCTCGTTGAACAGGCACATGAATACTCATCAGAAGAAAATTAAGGGAGAAAATTTTGATAAATTAGAACAAGAAAATGAAAATGAAAATGAAAAATTGTCAAGCTTGGAAATTGAGGAGGCTTTTCATGATGATTTGAGACAGTTTGATGTTCTTGATGATCTAGATCATCACTCGGATCAAGATGACTCGGGAAGTGATTCTGACAGTATTTATAGTGTTGATTCTGATATTCCTGATGAGGAAGTTCATGCTATGCTCGAAGAAGGTCTGTCGGAAGAATTAAAAAATAAGCGGAAAAATCTAGATGATTGTATGCCTTATGAAGAAAAAGAGAAGCTAGTTTTACAAGAAATCGGACATAATCACTTTGACGCATTACCTGAGGGCTGGGTCCAGGTTACACATAACAGCGGGATGCCTCTGTACCTGCACAAGCAATCCCGAGTGTGTACTCTGGCGAAGCCGTACTTTCTGGGCCCTGGAAGTGTTCGCAAGCATGAAGTCCCGGTGAGCGCAGTTCCTTGCTTGCAGTACAGACGCGCGCTCGAGGAGGAGAATGAAGAAAAGAGAAAAGAAACCGAACGCGAGTCAAGCGGAATTGGAGCCTCAAATCTGCCCAGTGCTAGAATCGAGACTATTCAAGAAAATTTGGCCAACCATTCGCTTGACAGTGAGCGGTTGAGGAATTACTGTCAGAAGATTTTTAGATTTAAAAAAATCAAGCAACTAGAGCGTCCAACCTTGCCTGGAGGTACTAAACTGATAACATTCCCTATCGGAACTGGTACCGGATCCGGAAGCGGAAGTTCTGGAGCTGGAGATGACAGCTCCAACCAACGGCCTCCCAAGCACTGGATAATGAACCCTTCGGGCAAGAGTTTTGTCTGTATTTTGCACGAATACGTTCAACACGCTTTAAAAAAGCAACCGACTTATAAATTCAAGGAATTAGAAAATGCGGCGACACCCTACTCCGCAATAGTCTGTATCAACGACATGGAGTACGGAGTCGGGTTTGGCAGCAGCAAGAAGCAAGCCAAGGCCGATGCAGCGCGCAAAACTTTGGAAATTTTGATCCCTCAGATGCGAGACAAGATTTTAGGAGAAATGGCTACGGACAGCTCGACTAATGCGGAGAGAATTAAAGCCTCGCGGGGTGATACTGATGCTGACTTGTCATTTTTTGATGACATTTCTATTACTGATCCACGGGTAGCTGAATTTTGTGCCAAGACTACTGAACCCTCGCCTCATGCTATTTTAGTTACTTGCTTGCAGAGAAATTTTGGACTTGGTGATGTTCAAATTAATTACTCGGTTAATACGTTAAAGCATCAGCAAAATGAATTTACTATGAGAGTTGGTAAACATGAGGCTAAAGTTGTTTGCAGAAATAAAAAAGAAGGCAAACAACAAGCGGCCCAGGCAATTTTAAAACTCCTCCATCCAAGTATCCCCAGTTGGGGATCTCTGCTCCGCTTGTACGGATCGCGCAGTGTCAAGTCTTTCAAGGAGAAAAAACAACAGGAACAAGAGATTACTTTGCTCCAGGGAAAGGCTGCTGTTAATCAGCCAAATCACGCTATTTTAAACAAACTGCGCCATGAAATGAAAAAATTGTCCGAGCAGCGGCAAGCTGTTCAACCAATCGATACCTGTCAAGATTACCCCATAGACATCGAAGAAGTGAAAATAGAATCCAAAGATCCACCAAATGTATCTCCAAAAAAATCCAAAAACCTCAGCGAGAAGAGACCATTTACATGTGACAGCTGTTCGATGAGATTCCTGACAAAAGGCCACTTAAAGCGGCACATGCAAGTGCACACAGACGAGAAGCAATTCACCTGCGACACATGTTCCAAGCAGTTCCGGCAAAAATGTAACCTAAAATTGCACATGCGAAAGCACTCAAAAGAAAAACCTTACAAGTGCAAAGAGTGTTCGGCAAAGTTCGGGTACCGAAAGTCGTTCGAGTACCACATGTTGGTGCACAACGACGTAAGGCCGTACGAGTGTGAGTTCTGCAGCTCGACATTTCGTACAAGGACATTGTTTAACAACCACATGCTGATCCACAAGGGAGAGAAGCCGTTTGCTTGTAAAGTATGTTCCATGAAGTACCGGAACAAGTATTATTTAAAAATACACATGCGTGTGCACACCGGCGAGCGGCCGTACGAGTGCGACATCTGTCCGGCCAAGTTCGCGATCTTGAGCAACCTGTCACGGCACATGCGCGTCCACACCGGCGAGAAGCCGTTCGGCTGCGATGTTTGTTCCGCGAGGTTCGGCCAGAAGGTGGCGCTGCAGGAACATCAGCTGATCCACAAAGATGAAAAGCCGTTCGAGTGCGACCTCTGCACCGCCAAGTTCCGCGTGAAAAGAGGCCTGAAGATTCACATGCGCACGCACAGAAAAAAACCATTTACTTGCGAGGTTTGTTCCCAAAAATTCCGCGACCAAATTTCCCTGAATCAGCACGTGCATCTGCGGCACAACACTGTTCCTTATCAGTGCAATGTCTGCTGTCAGCTGTTCAGGGATATTTTAAAACTAAACACACACTTGCTGGTCCACCGTCCTGAACAACTTTTTCTCTGTGACACTTGTTCCGCGCAATTTTATTCCAAGGAACAGCTGATCAAGCACCAGGCTAGGCATCTAGTGAAAAAAGCTTATATTTGTAGGGTTTGTTCGGCTACTTACCAGATTAAGAGTGAGTTCTTGAAACACGTGATGAGCCATCAGGAAATTAATTCAAGCTCCGAGTCCGCGGTTGTTAAAGTTCTTAGCAAGAGACATTTTTATGTCTACAATCAAATTAATGTTCAAAATAAGTCCGAGTCCGATGATGGCGCTAGTTGTTCTGAACATGAAGACAAAGATCCTTTGGAGATTGTTGGACACCAGAAAGAGGCTAAAAGT
Protein Sequence
MNVNYSFEKVIIKVEKDEEDFQENQSIFNCEDHNLGQDYPVDVEDIKIEEPDIKYENEENPQYDPLLIEKNFLPPMVTIKTREINFGTVYVEDTKPFFDKDNFQEELKKSKVQKKRSKKYECDFCKLKFSHKNALLVHVNKHLTTKYKCEICSKTYISKEGLTLHTARHTGDMPYECEICASKFGVKFTYDNHMRIHNGEKPFACEVCFSKFREKSQLAVHQRIHSGDKPYACHICSVKFRHKGNLKAHIRIHTDERPFSCEECSAKFRDSSTLKRHKRVHTGEKREKREKREKEKRYSCKICSYKFRDNYFLNIHMRKHTGERPFACQVCFSKFKEKGSLNRHMNTHQKKIKGENFDKLEQENENENEKLSSLEIEEAFHDDLRQFDVLDDLDHHSDQDDSGSDSDSIYSVDSDIPDEEVHAMLEEGLSEELKNKRKNLDDCMPYEEKEKLVLQEIGHNHFDALPEGWVQVTHNSGMPLYLHKQSRVCTLAKPYFLGPGSVRKHEVPVSAVPCLQYRRALEEENEEKRKETERESSGIGASNLPSARIETIQENLANHSLDSERLRNYCQKIFRFKKIKQLERPTLPGGTKLITFPIGTGTGSGSGSSGAGDDSSNQRPPKHWIMNPSGKSFVCILHEYVQHALKKQPTYKFKELENAATPYSAIVCINDMEYGVGFGSSKKQAKADAARKTLEILIPQMRDKILGEMATDSSTNAERIKASRGDTDADLSFFDDISITDPRVAEFCAKTTEPSPHAILVTCLQRNFGLGDVQINYSVNTLKHQQNEFTMRVGKHEAKVVCRNKKEGKQQAAQAILKLLHPSIPSWGSLLRLYGSRSVKSFKEKKQQEQEITLLQGKAAVNQPNHAILNKLRHEMKKLSEQRQAVQPIDTCQDYPIDIEEVKIESKDPPNVSPKKSKNLSEKRPFTCDSCSMRFLTKGHLKRHMQVHTDEKQFTCDTCSKQFRQKCNLKLHMRKHSKEKPYKCKECSAKFGYRKSFEYHMLVHNDVRPYECEFCSSTFRTRTLFNNHMLIHKGEKPFACKVCSMKYRNKYYLKIHMRVHTGERPYECDICPAKFAILSNLSRHMRVHTGEKPFGCDVCSARFGQKVALQEHQLIHKDEKPFECDLCTAKFRVKRGLKIHMRTHRKKPFTCEVCSQKFRDQISLNQHVHLRHNTVPYQCNVCCQLFRDILKLNTHLLVHRPEQLFLCDTCSAQFYSKEQLIKHQARHLVKKAYICRVCSATYQIKSEFLKHVMSHQEINSSSESAVVKVLSKRHFYVYNQINVQNKSESDDGASCSEHEDKDPLEIVGHQKEAKS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00382231;
90% Identity
iTF_00382231;
80% Identity
iTF_00382231;