Csor006535.1
Basic Information
- Insect
- Cosmopolites sordidus
- Gene Symbol
- Runx1
- Assembly
- GCA_031761425.1
- Location
- JARFXV010000149.1:1104317-1107865[-]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 7.7e-54 8e-50 169.2 0.0 4 95 34 125 31 132 0.96 2 2 0.0077 80 4.3 0.0 83 104 131 152 126 156 0.88
Sequence Information
- Coding Sequence
- ATGCATTTGGCGGGCGAGGTCAGCTCCACCACCGGCCACTATGACCGCAACTACACCAACCTGACCGCGGAGATGTTGGCGGAAAGGACCATTGACGGCCTGTTGGCCGAACATCCTGGCGAGTTGGTGCGCACTGGAAGTCCACACGTGGTGTGTACTGTTTTGCCACCGCACTGGAGGTCAAACAAGACGCTACCGGTTGCTTTTAAGGTCGTTGCTTTGGGTGAAGTCGGGGATGGGACTGTGGTGACCGTGAGGGCGGGCAATGATGAAAACTATTGTGCGGAGTTGAGAAATGCGACTGCCATCATGAAGAATCAAGTGGCCAAGTTCAATGATTTGCGGTTCGTCGGAAGAAGTGGAAGAGGTAAGGGCGAGGGGCGAGCTATTGATATAAAACAAATAGGAGTAAGTTATCGTGAAAAAACGATCCGCTTAGACATTGCTGTTTCTAGTGTCATGGGAATATGGGTACGATGA
- Protein Sequence
- MHLAGEVSSTTGHYDRNYTNLTAEMLAERTIDGLLAEHPGELVRTGSPHVVCTVLPPHWRSNKTLPVAFKVVALGEVGDGTVVTVRAGNDENYCAELRNATAIMKNQVAKFNDLRFVGRSGRGKGEGRAIDIKQIGVSYREKTIRLDIAVSSVMGIWVR
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01023619; iTF_00764452; iTF_01209995; iTF_00394060; iTF_01289524; iTF_00001749; iTF_00641173; iTF_00845653;
- 90% Identity
- -
- 80% Identity
- -