Basic Information

Insect: Cosmia pyralina
Gene Symbol: -
Assembly: GCA_946251865.1
Location: CAMIUE010002627.1:1-4574[+]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 18 0.016 1.3e+02 3.6 0.1 4 31 14 40 11 49 0.78

2 18 0.026 2.1e+02 2.9 0.0 5 27 39 61 35 69 0.82

3 18 0.025 2e+02 3.0 0.0 4 27 62 85 59 93 0.82

4 18 0.026 2.1e+02 2.9 0.0 4 27 86 109 83 116 0.83

5 18 0.019 1.5e+02 3.3 0.0 4 28 110 134 107 147 0.79

6 18 0.024 1.9e+02 3.0 0.0 4 27 158 181 155 188 0.81

7 18 0.016 1.3e+02 3.6 0.1 4 28 182 206 179 217 0.78

8 18 0.019 1.5e+02 3.3 0.0 4 28 206 230 203 238 0.79

9 18 0.024 1.9e+02 3.0 0.0 4 27 230 253 227 260 0.81

10 18 0.015 1.2e+02 3.6 0.1 4 30 254 279 251 290 0.78

11 18 0.019 1.5e+02 3.3 0.0 4 28 278 302 275 310 0.79

12 18 0.018 1.4e+02 3.4 0.0 4 28 302 326 299 335 0.79

13 18 0.015 1.2e+02 3.6 0.1 4 30 326 351 323 362 0.78

14 18 0.021 1.7e+02 3.2 0.0 4 28 350 374 347 381 0.80

15 18 0.019 1.5e+02 3.3 0.0 4 28 374 398 371 406 0.79

16 18 0.028 2.2e+02 2.8 0.0 4 27 398 421 395 428 0.83

17 18 0.031 2.5e+02 2.6 0.0 4 27 422 445 419 450 0.84

18 18 0.022 1.7e+02 3.1 0.0 4 27 446 469 443 479 0.81

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	18	0.016	1.3e+02	3.6	0.1	4	31	14	40	11	49	0.78
2	18	0.026	2.1e+02	2.9	0.0	5	27	39	61	35	69	0.82
3	18	0.025	2e+02	3.0	0.0	4	27	62	85	59	93	0.82
4	18	0.026	2.1e+02	2.9	0.0	4	27	86	109	83	116	0.83
5	18	0.019	1.5e+02	3.3	0.0	4	28	110	134	107	147	0.79
6	18	0.024	1.9e+02	3.0	0.0	4	27	158	181	155	188	0.81
7	18	0.016	1.3e+02	3.6	0.1	4	28	182	206	179	217	0.78
8	18	0.019	1.5e+02	3.3	0.0	4	28	206	230	203	238	0.79
9	18	0.024	1.9e+02	3.0	0.0	4	27	230	253	227	260	0.81
10	18	0.015	1.2e+02	3.6	0.1	4	30	254	279	251	290	0.78
11	18	0.019	1.5e+02	3.3	0.0	4	28	278	302	275	310	0.79
12	18	0.018	1.4e+02	3.4	0.0	4	28	302	326	299	335	0.79
13	18	0.015	1.2e+02	3.6	0.1	4	30	326	351	323	362	0.78
14	18	0.021	1.7e+02	3.2	0.0	4	28	350	374	347	381	0.80
15	18	0.019	1.5e+02	3.3	0.0	4	28	374	398	371	406	0.79
16	18	0.028	2.2e+02	2.8	0.0	4	27	398	421	395	428	0.83
17	18	0.031	2.5e+02	2.6	0.0	4	27	422	445	419	450	0.84
18	18	0.022	1.7e+02	3.1	0.0	4	27	446	469	443	479	0.81

Sequence Information

Coding Sequence: GAAGATCAAAAGTTAACAATAATCTCTACCTTGAGCAACGCTAGAGTGAGACAGGAAACAGAAGTGTTGCAGACGCAGTCCCCTCGTACAATAATCTCTACCTTGAGCCACGCTAGAGTGAGACAGGAAACAGAAGTGTTGCAGACGCAGTCCCCTCGTACAATAATCTCCACCTTGAGCAACGCTAGAGTGAGACAGGAAACAGAAGTGTTGCAGACGCAGTCCCCTCGTACAATAATCTCTACCTTGAGCAACGCTAGAGTGAGACAGGAAACAGAAGTGTTGCAGACGCAGTCCCCTCGTACAATAATCTCTACCTTGAGCAACGCTAGAGTGAGACAAGAAACAGAAGTGTTGCAGACGCAGTCCCCTCGTACAATAATCTCTACCTTGAGCAACGCTAGAAGTGAGACAGGAAACAGAAGTTTGCAGACGCAGTCCCCTCGTACAATAATCTCTACCTTGAGCAACGCTAGAGTGAGAAAGGAAACAGAAGTGTTGCAGACGCAGTCCCCTCGTACAATAATCTCCACCTTGAGCAACGCTAGAGTAAGAAAGGAAACAGAAGTGTTGCAGACGCAGTCCCCTCGTACAATAATCTCCACCTTGAGCAACGCTAGAGTAAGAAAGGAAACAGAAGTGTTGCAGACGCAGTCCCCTCGTACAATAATCTCTACCTTGAGCAACGCTAGAGTGAGAAAGGAAACAGAAGTGTTGCAGACGCAGTCCCCTCGTACAATAATCTCTACCTTGAGCAACGCTAGAGTGAGAAAGGAAACAGAAGTGTTGCAGACGCAGTCCCCTCGTACAATAATCTCCACCTTGAGCAACGCTAGAGTAAGAAAGGAAACAGAAGTGTTGCAGACGCAGTCCCCTCGTACAATAATCTCTACCTTGAGCAACGCTAGAGTGAGAAAGGAAACAGAAGTGTTGCAGACGCAGTCCCCTCGTACAATAATCTCTACCTTGAGCAACGCTAGAGTGAGAAAGGAAACAGAAGTGTTGCAGACGCAGTCCCCTCGTACAATAATCTCTACCTTGAGCAACGCTAGAGTGAGAAAGGAAACAGAAGTGTTGCAGACGCAGTCCCCTCGTACAATAATCTCCACCTTGAGCAACGCTAGAGTAAGAAAGGAAACAGAAGTGTTGCAGACGCAGTCCCCTCGTACAATAATCTCTACCTTGAGCAACGCTAGAGTGAGAAAGGAAACAGAAGTGTTGCAGACGCAGTCCCCTCGTACAATAATCTCTACCTTGAGCAACGCTAGAGTGAGACAGGAAACAGAAGTATTGCAGACGCAGTCCCCTCGTACAATAATCTCTACCTTGAGCAACGCTAGAGTGAGACAGGAAACAGAAGTGTTGCAGACGCAGTCCCCTCGTACAATAATCTCTACCTTGAGCAACGCTAGAGTGAGACAGGAAACAGAAGTTTGCAGACGCAGTCCCCTCGTACAATAA
Protein Sequence: EDQKLTIISTLSNARVRQETEVLQTQSPRTIISTLSHARVRQETEVLQTQSPRTIISTLSNARVRQETEVLQTQSPRTIISTLSNARVRQETEVLQTQSPRTIISTLSNARVRQETEVLQTQSPRTIISTLSNARSETGNRSLQTQSPRTIISTLSNARVRKETEVLQTQSPRTIISTLSNARVRKETEVLQTQSPRTIISTLSNARVRKETEVLQTQSPRTIISTLSNARVRKETEVLQTQSPRTIISTLSNARVRKETEVLQTQSPRTIISTLSNARVRKETEVLQTQSPRTIISTLSNARVRKETEVLQTQSPRTIISTLSNARVRKETEVLQTQSPRTIISTLSNARVRKETEVLQTQSPRTIISTLSNARVRKETEVLQTQSPRTIISTLSNARVRKETEVLQTQSPRTIISTLSNARVRQETEVLQTQSPRTIISTLSNARVRQETEVLQTQSPRTIISTLSNARVRQETEVCRRSPLVQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -