Basic Information

Gene Symbol
wfs1
Assembly
GCA_032883995.1
Location
CM065052.1:67466788-67494191[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.0028 0.76 11.9 1.5 1 23 260 282 260 282 0.99
2 9 0.002 0.54 12.3 1.8 1 23 289 311 289 311 0.97
3 9 0.024 6.6 8.9 1.7 2 23 457 479 456 479 0.91
4 9 0.0035 0.96 11.5 4.2 1 23 562 584 562 584 0.98
5 9 2.2e-06 0.00061 21.6 0.7 1 23 590 612 590 612 0.98
6 9 8.9e-06 0.0024 19.7 1.2 1 23 618 641 618 641 0.97
7 9 1.6e-06 0.00045 22.0 0.8 1 23 647 669 647 669 0.99
8 9 4.6e-06 0.0013 20.6 1.0 1 23 675 697 675 697 0.98
9 9 7.7e-07 0.00021 23.0 3.3 1 23 832 854 832 854 0.98

Sequence Information

Coding Sequence
ATGGCTTCTGGAAATCATAGCATACAGCTGGTAGCACTTAATCCAAATGTAGATGATGATTCTTCTGAGAATCTGGTTGAACCTGAATATATCATTCACCGCCCTGCCGAATTGACTAAAGACTTAACGATAAGTTCGTTTTCAACAGAATTATTATCGCAAAATATCATTGAATTAACTTCTACTACAAATTTTGCTCCACATGCGCTTACGACGACTCAGTATTATGATACTGATTTTCTAACGCAGACATTTACAGATGAAGATCGCAAGTTAGCGGCTGCTTTAGTAGCTGTTCAGTTAAGTCACAATCGTGCGAATGTATCTGTAGGTTCAGAATTAATCAATACTAAACTTAACACGTCTTCGCAACAACTTTCTTTAATTCAGAATGAAAAACCGGTTACCACGTCTATCGTTACAAATTATATACCCTCAATTGAACAAACGCAAATTAAAACCGAACACGCGATGGATCTTCCAATACAAgatcaaaataatatttcggaCGATCAGAGTGAACATTGTGAAGTAGAAcaagttacgttaaaattatatCATCCGTTACGAGAACatGCGCCAGATTCTGACATAGAAGACAACGCGGAACACATAAGTTTAAATGAAACGGATGGCGTTGTTGGCCACGAATTTGAAACGGAATATGATAATGAAATGCAAACATCTCGAAGAAGTTTGCCACATAAAAAAAGGATTCCCAATAAACTTAAACGATCTCAGCCGTTAACTAGTGGGCGCTACTTTCATTCTAAATGttataaatgtacaaaatgCGGAGAACAGTTTCTAAGCCAAACGTCACTTTCGgAACATAAATTAACGCATAGTATAAAACGGAATGATTTCTCTTGCGAACTTTGCggaaatacatttaataatcagttgaattttttcgaacatCTGAAATTTCATTACGAGCCACAACCTCGTATTGTGGATACTATAACTTTATCCGAGGATGAGACGAAGAATATTAAAGCTGAATCACCGCATCATGAACAAGAGAAACAAGAAATTCCATATGAAAATGACCATATCTCGATTGCGACGGATGAAATGAATGATGATAGAAGTTCGAATTCGATTAAAGACAGTCAAATCAAGTCAGTGACTTTACGAGGAAGTGATCCAGGTTTTGCGATACGTTTGTTCCCACCTTCAGAGTTCCATACCGTGGAAGGTACGGGGGAACTAGACCGCCCATGCCTGATACACCCTTTCGAGCATATCCCACGGGTGCAGCATATTTATAGTTATCTTGCGACGTACCAGACTTTTAGTgaacagAAAACTTCCGTCGACGTAGTAAGAGAACCCCGTGAACACGTGGCAGAAGTGAATCCTATCACTTGCGGAATTTGTAGAAAAGTATTTCGACGTAAGAAAGCTTTCGACTGTCATATGTCTGTAATTCATCCTAAAAAAGAAGATATCGAAGAATTTTCAGAGCCGGAAGACATGATGGAAGGTATCCGACATGTAGTAAACCTGGTACCTTCTTACGACGATGAAGATCGGTCTGATATCGAGTGGCATCCTGATAACAGGAACGAGTTCAAAATTGTTCCAAATATGTCCGATTCGACGGTGTCATCTACAAATCATTCGATATTAACGCCGAGGGGACCGTGTAATATTCTAGAAGGAAAGCCGAAGAAGCAGTTTAATTGTACCGAATGCGATCGTACATTTTTACATAGAAATTCTTTGTTCTATCATATTCGATCTCATACGGGAAATCGACCATTTCAGTGTCAGACGTGTGGTAAAAGTTTCTACGCGCAAGGCGCTTTAAAAATCCATATGCGTTACCACTCTGGTGAGAGACCTTATAAATGTGAATTTTGCGAAAAACGATTCAGACAATGGGGCGATTTAAAATATCACATAACATCACTCCATACCGATACGAAAATGTTTCAATGCGAATTCTGCGGGAAAGACTTTGCTAGAAAATATTCTTTGGTCGTGCATCGTAGAATTCATACGGGGGAAAAGAATTACATATGCGAATATTGTTCGAAGACTTTCAGAGCAGCTTCGTATTTGCAGAATCATCGAAGAATTCATACCGTTGTAAACGATCTACAAAGTACAGTAATAAACCAAATCAATAATATATTACCCCTTAAAATAATACGCGAACTCATCAGTAAAAGAAGAAATGCTCGCAAGGAATGGCAACATTATAGATACCCTTCAAATCATCAAATATACAATAAACTAAGTAAACGATTACGAGAAGCAATCGCGGCTTACCATAATGCGTGTCATGATTATTATTTGTCGACTTTAAACAGTACCGACTGTTCGGTGTGGAAAGCagcaaattatttaatgaaaaaatctatTACACCCTATCATATCAAAAAACCTGACGGAAGTTGGTCAAAGACAGAAAACCAAAAGGAGGATACTTTCGCAGAATACCTTGAAAATGTATTTCAACCTCACAGCATTGGGGAAAAACCGCATACTTGCGAAGTATGTAAAAAACCGTTTAGAGTGCGATCCGATTTGAAACGTCACATGAAAACGCACGGTGAAATTAGCAACGCAATGATAAAATCTATACAAGTTATAAACGGTCAATCCGACAGCGGCCAATTAACCAACTGTAAGAACGAATTAGTTAAAACGTccaacaataacaacaacaacgtcGTCGGTAGCGATAGTCGTAATTCGGCCGAACAGATGAAATTGGAAGAAAATAGCGACTCGGCTATTCGAGAAGAAGACGAAGATGATCCTCCGCCAGCTGTTATCTGTAACGAAATAATCAGCAATAATCCGAATACCACCACCGTTATTAGTAGGACACCTTCCGAAACGATtccgttaaatttacatatgAAACCGGAAAACGATAACGACCTAGTCGTTACCGTTACTACTACAAGTACTGAAAATACGACTGATATTGTTACTATTAATACTACTAATCCTAATACCGATATTACTACCGATACTAATACTACTAGCGTATCTACCGAAAATATATATCAAGCTTATAGGCAAGCCGTTTCGAATGCTGAACGCAAGTCGTCAGTTCCGTTCCACAGAAATGGCAGTCATTTAGCAGAAGATGGGTGTCCAGAGTCCCAGGTGCTTTTGGCTAAACAGTTGCTCGAACAGAATGATTCTTCTGATTTGGATGCAGAAGAAAATGCTCAACAGGGTGTTTACTGGTTAATAAAAGCTTCCAAGCAAGGTTATTCAGAAGCTACGGAACTGTTAAGACAATGTGTGGAATCCGGACGAGGGATTAATGATCATAATTATCCTGATGTACAAGAATGTTTAGAAACACCTGATGATGAAAAACAAGCTGTGAAGATAGCACGTGATATATTCTCAGTATTGAGTGCCGACGACGATTTCATTACCACCGATCAATTACGTAATGCACTCAAATTAGCAGATCGTGTGACTGCCGGTTTATCCGAAGAAActtcgaagaaattaaaaagggACTTATTGGCCGGGAGTGTTGGTAATTCtgGGCATAATTATCGATTCGACGAGTGCGGTTCAAAAATAACCGAAGATAAGTTAATAGAAGCTGCTCAGACATATTCGCGTGGTGATGTTCCGGAGCCATGTCGAAAATTAGTGTGGAAAGAGTTTAACGCTCGCTACAGTAGTCacgattttttgttaaattcaatAATACACCCGTTTGCTACGATATATGCGTTCTATTGTTCCGTATCCGAGTTACTTAGTATTAatgtattatttccttttatatatgcCATAATGCCTCAATTACAAGTCATTTGTCTTTTTCTACTCTTACCCAATATTAAGATAGCCGACTTTACACCGATATTTCCaccgatattttattatttctcgctGACTATTATTATCAGTGCTAGTTGTCAAATTTTATGTTATAAACGCAATTTTCGTCAGTTTCGTTCGTGGTCTAATCTTTTTATATTGTACAGCGAGGGTAGCTTTACTCCGACACGATCAGAAAGTCAGTACGGGAAAAAAACAGTGAGaatatatttttggtttttctttGGATTCCTTTTTCATTTGGCAGTTCCTATATTCGGCGAATTTCAGCCTACACATCATTCGGAGTGTGCTGTTGTGGCATTTCTTTTTACATTCTTATTGCTGTATTCATCTTCcGTATCTGGAACTCGTTATTCATCGCGAACGGGCCGTGTCGATATTTTAAGCGTTCTTTCTTTCATGTTATATGTGATTGCGAAGTACCCTTACGAGACCGATTCTGTCGTTAATTTAGGTTGGAGATTTGTCGACATTCATTTTCCAACTTGTTTGACGTATATTATTGGAACCGGAATAAACTTGTGTTCCAATTATCGTTCGTTTTTTTACATCTCGATAAttccgataataataaaaatggcaAGTAGAACGAAGTGGTCCGGAATATATACAGATGTTATACCTCATTGTGTGGTCCTAACCTGGTGGCAGTTAACACTTTTATATTCAGAAGGCGCAACGTGGTACGGATTAACGCGCAGTGCTCTAATGTTAGCGggatttttcatgtttttaccGTTGATGTGCGTTTTTAGCGTGATGTTTCCAATATACGTGgcttttgaattattaaaaacgcATGAAAATTATATCGCTACttcgatttttatcattttcacaGTAACACTAGCGTTCGTTACATTATACGCTAACCGATTTCGGTCGTCAGTAGCTAAGTTTTTTACTGTGCTACAGATAATCATCGCTATTCTAGTTCTCGTGGTCTTCGTTTCGCGTAATAAATTAACGGTCAACGATGTTAGCACTACGGAAATTTCAGAATTGGAATGGGacgattttgtaaaatattgcaGGGATAATCGTATAGACcgtataaaaggaaataacgtAGATTTTCAATTAGAATGTTCCACTTTGATCGGCGCAGAAGTTAATTGGAAGGGATACGTAAAAGATGTTAAAATTGCGAAGATAGATAATCCAATTCTTTATATAACGGGCGATTTATACCCggaAATTTCAACATTAATACATTGTATATTAGGAGAAAAGTATGAGTTATGTGACGAAGACACCGATGCATGTAGAAAATTTTCAAGTATATGTCATGTGAACAATTGGAATAGATATCAGTATAATATCGATGTAGAGATTAATGTAAATACTGGGCTTTGGAAAATGTCTAATTCTGAACGTTTACAATTAATTGCCGACGATGCTTTTTATAACTTCACTCGCTATTTAACCACTGGCGATTATATATGGTTCAGAGGCATCATGGTTGGCGACTCGAATGGTTTGTTACAATCTGAATTACCTTCTATAAAATTGCTAGCAGCTAATTGTCTGTTGTGCACAAATCAAATTGAGCCTGAAGCTGTAAAGTTTGTAACGGTAACTTATGAGGATGTAACACGAAcgGTATGCGAGAAGCTATGTATAGTCACTTTGACCTTTAAGTGGATAAATTGTAAAGCTACCAATGCGGACTTGGTACACGATCTTACTATGGAACCTCCGGGAATGGACCTATCAAGAGGGATATGGTGCAGAGTAAACAGGTTTAGTACGGGACAAGGTAGGTGTGCGTACACTTTAAACAAGTGGAAAATGATCTCGGGTCCTAGGCACTCTAATGATGAAAATCCTAATGTTATACCAGGAAAGTCCACCTGTCTCTGGTTTGTTCTGGTTAATAATTGTGACATGGAATGCTATTGGTTCATATTGTTTCGAAAGCACATTTGA
Protein Sequence
MASGNHSIQLVALNPNVDDDSSENLVEPEYIIHRPAELTKDLTISSFSTELLSQNIIELTSTTNFAPHALTTTQYYDTDFLTQTFTDEDRKLAAALVAVQLSHNRANVSVGSELINTKLNTSSQQLSLIQNEKPVTTSIVTNYIPSIEQTQIKTEHAMDLPIQDQNNISDDQSEHCEVEQVTLKLYHPLREHAPDSDIEDNAEHISLNETDGVVGHEFETEYDNEMQTSRRSLPHKKRIPNKLKRSQPLTSGRYFHSKCYKCTKCGEQFLSQTSLSEHKLTHSIKRNDFSCELCGNTFNNQLNFFEHLKFHYEPQPRIVDTITLSEDETKNIKAESPHHEQEKQEIPYENDHISIATDEMNDDRSSNSIKDSQIKSVTLRGSDPGFAIRLFPPSEFHTVEGTGELDRPCLIHPFEHIPRVQHIYSYLATYQTFSEQKTSVDVVREPREHVAEVNPITCGICRKVFRRKKAFDCHMSVIHPKKEDIEEFSEPEDMMEGIRHVVNLVPSYDDEDRSDIEWHPDNRNEFKIVPNMSDSTVSSTNHSILTPRGPCNILEGKPKKQFNCTECDRTFLHRNSLFYHIRSHTGNRPFQCQTCGKSFYAQGALKIHMRYHSGERPYKCEFCEKRFRQWGDLKYHITSLHTDTKMFQCEFCGKDFARKYSLVVHRRIHTGEKNYICEYCSKTFRAASYLQNHRRIHTVVNDLQSTVINQINNILPLKIIRELISKRRNARKEWQHYRYPSNHQIYNKLSKRLREAIAAYHNACHDYYLSTLNSTDCSVWKAANYLMKKSITPYHIKKPDGSWSKTENQKEDTFAEYLENVFQPHSIGEKPHTCEVCKKPFRVRSDLKRHMKTHGEISNAMIKSIQVINGQSDSGQLTNCKNELVKTSNNNNNNVVGSDSRNSAEQMKLEENSDSAIREEDEDDPPPAVICNEIISNNPNTTTVISRTPSETIPLNLHMKPENDNDLVVTVTTTSTENTTDIVTINTTNPNTDITTDTNTTSVSTENIYQAYRQAVSNAERKSSVPFHRNGSHLAEDGCPESQVLLAKQLLEQNDSSDLDAEENAQQGVYWLIKASKQGYSEATELLRQCVESGRGINDHNYPDVQECLETPDDEKQAVKIARDIFSVLSADDDFITTDQLRNALKLADRVTAGLSEETSKKLKRDLLAGSVGNSGHNYRFDECGSKITEDKLIEAAQTYSRGDVPEPCRKLVWKEFNARYSSHDFLLNSIIHPFATIYAFYCSVSELLSINVLFPFIYAIMPQLQVICLFLLLPNIKIADFTPIFPPIFYYFSLTIIISASCQILCYKRNFRQFRSWSNLFILYSEGSFTPTRSESQYGKKTVRIYFWFFFGFLFHLAVPIFGEFQPTHHSECAVVAFLFTFLLLYSSSVSGTRYSSRTGRVDILSVLSFMLYVIAKYPYETDSVVNLGWRFVDIHFPTCLTYIIGTGINLCSNYRSFFYISIIPIIIKMASRTKWSGIYTDVIPHCVVLTWWQLTLLYSEGATWYGLTRSALMLAGFFMFLPLMCVFSVMFPIYVAFELLKTHENYIATSIFIIFTVTLAFVTLYANRFRSSVAKFFTVLQIIIAILVLVVFVSRNKLTVNDVSTTEISELEWDDFVKYCRDNRIDRIKGNNVDFQLECSTLIGAEVNWKGYVKDVKIAKIDNPILYITGDLYPEISTLIHCILGEKYELCDEDTDACRKFSSICHVNNWNRYQYNIDVEINVNTGLWKMSNSERLQLIADDAFYNFTRYLTTGDYIWFRGIMVGDSNGLLQSELPSIKLLAANCLLCTNQIEPEAVKFVTVTYEDVTRTVCEKLCIVTLTFKWINCKATNADLVHDLTMEPPGMDLSRGIWCRVNRFSTGQGRCAYTLNKWKMISGPRHSNDENPNVIPGKSTCLWFVLVNNCDMECYWFILFRKHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-