Basic Information

Gene Symbol
ZFX
Assembly
GCA_032883995.1
Location
CM065053.1:2052072-2058935[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 19 4.8e-05 0.013 17.4 2.0 2 23 351 372 350 372 0.96
2 19 3.4e-06 0.00095 21.0 0.2 3 23 382 402 381 402 0.97
3 19 4.4e-07 0.00012 23.8 0.5 1 23 408 430 408 430 0.97
4 19 8.2e-08 2.2e-05 26.1 1.5 1 23 436 458 436 458 0.98
5 19 5.1e-05 0.014 17.3 0.5 1 23 464 486 464 486 0.98
6 19 1.3e-06 0.00034 22.4 0.4 1 23 492 514 492 514 0.94
7 19 2.1e-07 5.9e-05 24.8 0.9 1 23 520 542 520 542 0.99
8 19 2.1e-07 5.8e-05 24.8 3.4 1 23 548 570 548 570 0.97
9 19 2.5e-06 0.00068 21.4 0.6 1 23 576 598 576 598 0.98
10 19 5.9e-07 0.00016 23.4 0.5 1 19 604 622 604 626 0.93
11 19 7.3e-07 0.0002 23.1 1.6 1 23 632 654 632 654 0.99
12 19 5e-07 0.00014 23.6 0.3 1 23 660 682 660 682 0.98
13 19 9.8e-06 0.0027 19.6 0.1 1 23 688 710 688 710 0.93
14 19 0.00016 0.045 15.7 0.3 1 23 783 805 783 805 0.98
15 19 0.00038 0.11 14.6 0.1 1 23 988 1011 988 1011 0.94
16 19 2.7e-06 0.00075 21.3 0.8 2 23 1019 1040 1018 1040 0.97
17 19 6.2e-06 0.0017 20.2 2.2 1 20 1046 1065 1046 1068 0.93
18 19 0.00094 0.26 13.3 3.7 1 23 1074 1096 1074 1096 0.97
19 19 0.0069 1.9 10.6 2.0 3 23 1104 1124 1103 1124 0.95

Sequence Information

Coding Sequence
ATGGATCAACAAATTCAGACCGATCCTGTTCCTAGGAAAGATAACATAATAAACATACAACTTGCTGAAGTTACAGGAGTTGATACGGAGAATTTTGCAGATGCGTTTTATAGAAGGATCCCGGACGGTGTTGGATATGGAATTTTGTTTCCATCTTTACAAGTTAATCAGGAAGATACTTTGAACGGGGTCAACATGGAATCGTTAACAAAAGTGATTAATAATAGCGATTTATCGAATATTCAGTTTAACGGTCAATTTCAAATGATGACATTCAAAATGAATTCTTCATCGTTATCGGATAATAGAAACGAATTTACTAATACTTATACATTGGTATCGAATACTTCGCCGAATACGTTAACTACCGACTCGCAATCGACGCCAACGATATCTATCGAACATATACAACAACAAGATCAGCAAGATCATTCTCAATCGCAGTCACCTTTATCCCAACATCAGCAACTTCAACATCAATCGCAGCAACAAACACAAATGCAACATCAACAATTACAATCTAATCAACAGCAACAGTTACATATTCAACAGTCGAATAATCAGCAACAGTTGCATCCTCAACAAAGTGTTCAATCTTTACCGAATCAACCTTTAACAACAACGCGACATAGCGTGAACACTCAGTCAGTTGGTCAGCAAACTATAGACGAGaaagatataatatttattaaatgcgaACAGCCACCCGATGTCGAAGCGGTTTATTCGGACGACGAAGATAAAAATcacgaaaaaagaaatattaccaATAAtagtcacaataataataataataataataataataataacgttataagtaataataagaaaaatagtatgaataataatattaaaaatcatataattatcgttaataataatataaacaacatcGGTAAGATACCTTTGTTAGATATGTTACCGAATTGCGACGATCTTCCGCCTCACGAACACCCAAAcggtcatcatcatcatcattatcatcaaaaTCAAAATCGcgtcgtaaatattttaaataataaagtatgtACCGCGAACGACGGTGTACGGTGTTTAGTATGCGGTAAGAAATTCGCCAATAggcataatttaaaaattcattcttaCACGCATAACGGAGATAATCGGCCGAAATCTTTTTGTCCTACCTGCGAAAAAGGTTTCGTCAAACCGTCCGACTTGCGCAGACACATGATAATTCATACGGGCGTTAAACCGTTCGATTGTAAAGATTGCGGTATGACGTTCGCCGATCCGAGCACTTTGAAGCAGCATTCGCGAACTCATAGCGGTAAAAAACCGTACAGTTGCACCGATTGCGATAAATCGTTCACGTCGAATTATTCGCTACAAAGGCACGTACTAAGTCATACCGGAAATTCTTTGTTTACTTGCGACGAATGCGGCGTATCTTTGAATACTAGATACGATTTGAAAATTCACACGATGAAACACAGCGGCTGTTTACCGTATCCGTGTAGCGTTTGTAATAAAAGTTTCAGTAAACCGTCCGATTTAACGCGTCACAGCGTCGTACATACGGGCGAACGACCGTTTCAATGTACCATATGCGATAGTACGTTTACGAATTCGAGTAATTTACGAATGCACATTATAACTCATTCGAAAATTAAACCGCATCCGTGCGATATGTGCGGTAAATCTTTTCGACGACCGTCCGATTTACATCGACATCGATTAACGCATACCGGGGAAAGACCGTTCGTATGCGATCTGTGTAATATGGCGTTTACGactaattacaatttaaaaatacatctaTTGAAACATTCCAACGATTTACCGTATCGTTGTACGGTCTGCGGTAAATCGTTTAGTAAACCGTCCGAATTGCAACGGCACGATTTAGTACATTCGGGAGTGCGTCCGTTTCAATGCGAAAGTTGCGATATGCGTTTTACCAATAACAGTAATTTAAAATCGCATCTGTTAACGCATACCGGTAAAAAACCGTATCCTTGCAGTATGTGCGAAAAAACTTTTTCCAGACCTTCCGACGTTAAACGTCACATAGTTACGCATACCGGAGCGCGACCGTTCGCCTGTCAAGTTTGCGGTATGGCGTTCGCCGATTCGTCTAATTTGAAAAAACATTCTTTGGCTCATATCAAAAATAAcagtagtaacaataataataataatagtaacaatattaataacggtaataataatcttaatatcgttaataataataataataataacttagtCGTCGAAGATACTAATAATAACGCGAACGTAATTCATCAACAAACGCAAGAAGCTACTGATAACAACGGTAAGGAGAATCAAGAAGAAACAATTAATAGCGAAGAATATACGTTCGTTTGTTCCatctgttttatttcattttattcgaacGAAGATTTAAATATGCACGCTTTGACGCACGTTTGTAACGGAGACATTATCAATTCGACCGAAGAATTTGTCTGCAAGACAAACGACGAAACGGATCAGGTAATAAATAGCGTCGTCATGATAAGCAATCGTTCGAATAGTAacgaaaattcgaataatattttattaagcgATAATACTACTACAACCActattactaatactactaatattattactactagtagtagtaataacagTAACGTTAGTAACTATAATAACAGCGACGTTAGTATAAATTGCGAGACTATATTAGGAACCGatgttaaaaacgaaaataacgatATCAATAATCAGCaccgtaataataacaataatgaaaataataacaataataataataataataacggtagtCAATTTAACGAcggtagtaatattaataataataataacggtagtCAATTTAACGAcggtagtaatattaatattaataataataataacggtagtCAATTTAACGAcgttagtaatattaatattaatattaataataataataataacgttgttaataacgacaataataataagaattacatTTGTCCGATGTGCGGATGCGCTTTCGCTCACGCTGTCGCTTTACAAGAACACGCCGGTACCGAACACAGCGATATGACTCCGATGTGGCGATGcgaaatttgtaataaaactTTCATCGAAAAATCTTTTCTAAAAACTCACATGGCCACCCATACCGAAGCCAGACCGCACGTATGTACGATTTGTAATAAAGGCTTCAAAAGTTCGTCGCATTTGAAAAATCACATACCGATTCATTCCGGCGTTAAACCGTTTATATGCAGCGTGTGCGGTAAGACGTTTTTGAAACACGCCTCCCTAAGACGACATCACGCGACACACGAACGAGTAAATCCGGTCGCTTGTACTTTGTGCGGTAAAACGTTTTTAAATCACGAATATTTGAGAAAACACAGCGTTACTCACGCCCCTTCataa
Protein Sequence
MDQQIQTDPVPRKDNIINIQLAEVTGVDTENFADAFYRRIPDGVGYGILFPSLQVNQEDTLNGVNMESLTKVINNSDLSNIQFNGQFQMMTFKMNSSSLSDNRNEFTNTYTLVSNTSPNTLTTDSQSTPTISIEHIQQQDQQDHSQSQSPLSQHQQLQHQSQQQTQMQHQQLQSNQQQQLHIQQSNNQQQLHPQQSVQSLPNQPLTTTRHSVNTQSVGQQTIDEKDIIFIKCEQPPDVEAVYSDDEDKNHEKRNITNNSHNNNNNNNNNNNVISNNKKNSMNNNIKNHIIIVNNNINNIGKIPLLDMLPNCDDLPPHEHPNGHHHHHYHQNQNRVVNILNNKVCTANDGVRCLVCGKKFANRHNLKIHSYTHNGDNRPKSFCPTCEKGFVKPSDLRRHMIIHTGVKPFDCKDCGMTFADPSTLKQHSRTHSGKKPYSCTDCDKSFTSNYSLQRHVLSHTGNSLFTCDECGVSLNTRYDLKIHTMKHSGCLPYPCSVCNKSFSKPSDLTRHSVVHTGERPFQCTICDSTFTNSSNLRMHIITHSKIKPHPCDMCGKSFRRPSDLHRHRLTHTGERPFVCDLCNMAFTTNYNLKIHLLKHSNDLPYRCTVCGKSFSKPSELQRHDLVHSGVRPFQCESCDMRFTNNSNLKSHLLTHTGKKPYPCSMCEKTFSRPSDVKRHIVTHTGARPFACQVCGMAFADSSNLKKHSLAHIKNNSSNNNNNNSNNINNGNNNLNIVNNNNNNNLVVEDTNNNANVIHQQTQEATDNNGKENQEETINSEEYTFVCSICFISFYSNEDLNMHALTHVCNGDIINSTEEFVCKTNDETDQVINSVVMISNRSNSNENSNNILLSDNTTTTTITNTTNIITTSSSNNSNVSNYNNSDVSINCETILGTDVKNENNDINNQHRNNNNNENNNNNNNNNNGSQFNDGSNINNNNNGSQFNDGSNININNNNNGSQFNDVSNINININNNNNNVVNNDNNNKNYICPMCGCAFAHAVALQEHAGTEHSDMTPMWRCEICNKTFIEKSFLKTHMATHTEARPHVCTICNKGFKSSSHLKNHIPIHSGVKPFICSVCGKTFLKHASLRRHHATHERVNPVACTLCGKTFLNHEYLRKHSVTHAPS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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