Basic Information

Gene Symbol
-
Assembly
GCA_027574865.2
Location
JAODAH020029462.1:1-3708[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.016 1.6 9.8 0.3 2 23 5 27 4 27 0.95
2 14 1.8e-05 0.0017 19.1 1.4 1 21 35 55 35 56 0.94
3 14 0.00019 0.018 15.8 1.4 1 23 64 86 64 86 0.99
4 14 0.53 50 5.0 0.3 3 23 94 114 93 114 0.95
5 14 4.1e-05 0.0039 18.0 3.9 1 23 120 142 120 142 0.94
6 14 0.0024 0.23 12.4 3.4 1 23 148 170 148 170 0.98
7 14 2.4e-05 0.0023 18.7 1.3 1 23 297 319 297 319 0.97
8 14 0.4 38 5.4 7.3 1 23 327 350 327 350 0.94
9 14 2.3e-06 0.00022 21.9 0.5 2 23 355 377 354 377 0.95
10 14 0.00034 0.032 15.1 0.4 1 19 387 405 387 408 0.94
11 14 6.7e-05 0.0063 17.3 2.2 2 23 417 438 416 438 0.97
12 14 0.00087 0.082 13.8 1.8 1 23 444 466 444 466 0.95
13 14 7.9e-05 0.0075 17.1 1.2 1 23 472 494 472 494 0.94
14 14 2.5 2.4e+02 2.9 3.9 1 23 500 522 500 522 0.93

Sequence Information

Coding Sequence
attaaaaagattaaatgtagaatttgtttggaattttttgaaaatcaggAATATTACTTCTtacatataaatgaaatacatAAAGGGAAAACTACCGATTATCATATGTGTAGCGAATGTGGGAGAGAGTACAAAACTAAACACGAACTAACAAAtcatattaattcaaaatgtggGACTCTTAAACTTTATAAGTGCGAGatttgcaataaagaattaatgtCTAAAGGTTCTTTGTATAATCACACCAAAAAGCATCGAGATGAAAGAACGAATATGTGCAGATTttgtgcaaaattatttttaacagcAGGTCAGTTAGAAATACATGAAAGAAGTCACACTCAAGATAAACCATTTATCTGCAATatttgtgGTAAAAGTTTTTGCCATCGACAAAGTTTAATCACTCATAATACCATCCATACTGGAATAAAACCGTTTTCATgtgaaaattgtgtaaaatctTTTAGTTGTATCGgcaatttaatgaaacatcGAAAAACTCATTCTTCTACATGCGGACTAATTCCGTCAAATTCGCATAGCGTTAAAAAtccaaatacaaaattaaaacttaaatgtaataccccagaaatttcaaaattaaaaactataattaaatctaaagaaataaaaaataaaataattaaaatcaaagaaaaattaaatgagaaaagcatagaaaaaaatgaagataatgaGTTTCAATTAGAAGAACTTAATAAagattggaatttaaataatgaaattaaagaaaatgaggaaataatagaaaataaagagAGATTAAAAGGAATTCATTCcaagaataaaattagcaaaatgGATCTCAAGAACTTTTTAGCAAACAGAGGACACGgtgatcaaaataaaaatcgtggaaattataaatgtcaaaaatgtgaaaaatcttttcaaaatcCAAGGTGGTTGATGAAACATGAATTAAAtcacgatttaaaaatttccaaaatatttaaatgtaatttttgcaaagaattttttaattcgaaaGAGGAATGCAGGAAACatcatgaaaatattcatCGGGAATTATTGACTTGTAATTATTGTGAAAAAGTTTTTGCAAATCGTGATTCGTTAAATAACCACAAGAAAATCGTCCATGAAGGTGCCCCccgaaaaatttatgtttacatctgtcaaaaatgtggaaaacaatttaaagaacaTTCATTACTAATAATTCACGAAAGCAACAATTGCCTCAATAAACCTTTAATAGAATGTGaaacatgcaataaaaaatttaatcgtttACATGCAAAAAAAGCTCATATGAGAGTACATAATTcggaaaaaaagtttctttgtaattattgTGGAAAAAGTTATCATTGGAAAGGACAGTTACAGATACACGAAAGGAGCCATACCGGAGAAAAGCCTTACACTTGTTTATATTGCccgaaaagttttaattacagaGAAAGTTTAATTACTCATAGCACTTTACATACTGGAATGAAACCGTATCTATGCGAGGCTTGTGGATCTCGGTTTTCTTGCataggaaatttaaagaaacatcATTTTAGTCATGTCAACACTTGTTTGGTTTGGtgtaaaaagaataaaagtgACGggacaaaatataaatggttGATAAATACTTAG
Protein Sequence
IKKIKCRICLEFFENQEYYFLHINEIHKGKTTDYHMCSECGREYKTKHELTNHINSKCGTLKLYKCEICNKELMSKGSLYNHTKKHRDERTNMCRFCAKLFLTAGQLEIHERSHTQDKPFICNICGKSFCHRQSLITHNTIHTGIKPFSCENCVKSFSCIGNLMKHRKTHSSTCGLIPSNSHSVKNPNTKLKLKCNTPEISKLKTIIKSKEIKNKIIKIKEKLNEKSIEKNEDNEFQLEELNKDWNLNNEIKENEEIIENKERLKGIHSKNKISKMDLKNFLANRGHGDQNKNRGNYKCQKCEKSFQNPRWLMKHELNHDLKISKIFKCNFCKEFFNSKEECRKHHENIHRELLTCNYCEKVFANRDSLNNHKKIVHEGAPRKIYVYICQKCGKQFKEHSLLIIHESNNCLNKPLIECETCNKKFNRLHAKKAHMRVHNSEKKFLCNYCGKSYHWKGQLQIHERSHTGEKPYTCLYCPKSFNYRESLITHSTLHTGMKPYLCEACGSRFSCIGNLKKHHFSHVNTCLVWCKKNKSDGTKYKWLINT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-