Basic Information

Gene Symbol
-
Assembly
GCA_031163375.1
Location
CM062105.1:4100691-4107379[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 24 1.2 93 4.4 0.7 2 23 88 110 87 110 0.96
2 24 0.00035 0.028 15.5 0.7 1 23 115 138 115 138 0.96
3 24 9e-05 0.007 17.4 1.3 1 23 141 164 141 164 0.96
4 24 0.0088 0.69 11.1 0.8 1 23 170 193 170 193 0.93
5 24 0.0031 0.24 12.6 0.9 2 23 201 223 200 223 0.95
6 24 0.26 20 6.5 0.5 1 23 228 250 228 250 0.98
7 24 4.7e-07 3.6e-05 24.6 0.3 1 23 256 278 256 278 0.99
8 24 0.12 9.1 7.6 1.4 1 23 354 376 354 376 0.98
9 24 0.63 49 5.3 0.2 2 23 402 424 401 424 0.93
10 24 0.36 28 6.1 0.4 3 23 448 469 446 469 0.93
11 24 0.011 0.82 10.9 0.6 3 23 477 498 476 498 0.94
12 24 7.2e-05 0.0056 17.7 1.6 3 23 505 526 504 526 0.97
13 24 0.024 1.8 9.8 1.9 1 23 532 555 532 555 0.97
14 24 0.078 6.1 8.1 2.8 2 23 562 584 561 584 0.95
15 24 0.019 1.5 10.1 1.9 1 23 590 612 590 612 0.94
16 24 0.0017 0.13 13.4 0.9 1 23 618 641 618 641 0.90
17 24 0.061 4.8 8.5 1.1 1 23 711 733 711 733 0.98
18 24 0.15 12 7.3 0.2 2 23 759 781 758 781 0.91
19 24 0.01 0.79 10.9 1.5 2 23 804 826 803 826 0.96
20 24 0.00039 0.031 15.4 4.8 3 23 834 855 833 855 0.97
21 24 0.0093 0.72 11.1 1.8 1 23 887 910 887 910 0.98
22 24 0.00041 0.032 15.3 2.6 2 23 917 939 916 939 0.96
23 24 0.032 2.5 9.4 0.0 2 23 946 967 946 967 0.96
24 24 0.00085 0.067 14.3 4.5 1 23 973 996 973 996 0.95

Sequence Information

Coding Sequence
ATGAAAGACTGCAATGCAATCAAGGAGCACCATAGCGCAAAGCACAGCCTCTCTCCGAACTCCTTCAATGTTAAAACTATCGTATCTAAAGATTTGCCAGTTAAGATCGATATTAGTGAACTTGCGTGCAAGCTCTGTTCTGACGTTGAAATACAAACGTTTGATGAGTTGGTAGCCCATATCGTGACTGCACACAATGAAGAGTATCACTACGACGCCGGAGTTTGCTTACTACCATTCGTTCTGGACAAGGAGTTGATGCAATGCGTCCTCTGTGAGAGCACGTTCGATAATTTCACTTCAATGATGATGCATACAAATAAAGAGCATATAGCACATTCGCATGTTTGCCAAATATGCGGTTTGAGCTTCATAAACATGATCAGATTGAACAGGCATATCAACAGCCGCCATATCGGATACCGTTGTACGATCTGCAGTAAGTCTTTCGTCGGTAACAACAAATTGGAGCGGCACAAGTCTAGGATTCACGGCTTGAATAAGAACCACGATTGCAGTCTCTGCAGCGCTACTTTCGAGAACAGTTATCTGATGAAAGTGCATATGGGGAAGGTGCATAACGTTGAGAAGTATAGGATTCAGTGCGAGCACTGTCCTAAGGTCTGCAACACTAAAGGCGCTATGGTCTTGCATGTGCAGTCTGTGCATTCTGCTTTGAGGTACGAGTGCGATCTCTGCGAGTACAAGACTGCTGTTAAGTGGATGATTAAATTGCATAAGCGCAAGCATTTCGGTGAGAAACCTTATGAGTGCAGCGTTTGTGGGAGGAAATTTGGTAGGTCTAGTAACGTTCGGGCTCATATGAAGGTGCATACCGGAGAACTTAGAGGTGGCCAGAAAGTGAGAAAGTCTTCAGACCCCGCGCAAAACGTCGAAACTCCAGTCAAAAGTGACAAACCGACACAAGATGAATTCTTCAGCGCACAAGCCGTAAAACCAGCATTGTCTGCGAAGGAAAAACGGAGAATCATGCGCGAGAACGTGGTACAAGTCCTTATAAAGTCAACCGTGATGCCGTTTCGATGGCTGAGGAGTTCATACAGATGTTTCTACTGCTACGACATATTCCAAGAAGCGACAGATTTGAAGAGTCATCAGCAATCGCACGAGGGTGACGAATTAAAGGAGCAAGCAATGAGCAAATATTGGGAGCCGGTAGTCTACGTGGATATATCGGAAATGTCTTGTAAGCTGTGCCCGGAAATAGTGCACGATTTATACGATTTGATAGACCACTTGGTATCTAAACATGATGTGGTTTACAATAAAGACGTTGGCATCTGTATGGTAGCTTTCAAACTAGGCAATATGAACGTCAGTTGCTTAGCTTGCGGCGCCAGCTTCTATACATTTGGCCCTTTATTGCATCATACGAATAAGGACCACAAAGGAACTTCGGCTATTCTCTGCGACGTATGCGGACAACATTTTAAAGATGTGAATTTGCTGAAAATTCACTTTAAAGCAGTTCATGATAGTACTGGTTTGTTATGCACGGAATGTGGGGAGAAGTTTGAGACGAAATATAAGCTAAAGACGCATCAGAAGAATATGCATGAATCGGACAATAAGTATAAGTGTTTGATGTGTTCCTTGACCTTTCAGAGTAATTATAAGCGGTCGAGGCATATGGCGTCTGAGCATAAGAACAAGCAGGAGATAAAATGCTTGCATTGTCCGAAGACATTTCTTTTTAGGAGTACGATGATGACGCATTTGAGGGATACGCATTTGAAGCTCCGGAATCATGTGTGTAGTGTCTGCGGGTGGAAGGCTTTTAACAACAATCGGTTGAAGAACCACATGTACAAACACAGTGGCGAGAAGAAATTTAAATGCGATGTTTGTGATAAAGCGTTCACTACGAAGAAGATTATGAAGGCGCATTTTGCTCGGATGCACAAAAGTGTACAGGCGCCAGTGGATATCGGTTTCGACGGAAAGACGCGCGCCAAGAAACAGGAGACAGTCAGAACGAAGGCGACATCGAACCGGGAAACGAAACAGGAAGCGAAAAAGACTCTGAACAAACAGATGGTGATGAGAGAGAACGTTCTGCAAGTACTCCTCAAGTCAACAGTGATGCCTTTCAGATGGCTCAAGAGTTCATACAGATGTTTCTACTGTTACGACGTCTTCCAAGAGCCTAAGGACTTGAAATCCCACCAGATTAACCATACTACTGAAGAAGATATATTCAAAGCCATGAAAAACTATTGGGAGATGACTGTCTATGTGGACGTCTCCGCTCTGTCCTGTACAGTCTGCTCCACAAGTCTAACCGACTTCTACAAACTCATAGATCACTTGATCGACTCCCACGGGATTGCCTTTGATAAAGACATAGGAATATGCATGGTGCCGTTCAGACTGAACAACATTTCAGTTACATGCGTTCAATGCGAGCGGGAGTTCAGAACATTCGGGCATCTGTTGCTGCACACTAATAAAGAACATAAAGGGTTCTCGCAAATTCTGTGCGAATTCTGCGGTCAGCATTTTAAGAGTAATCAGCATTTGAAGGATCATATGAACAAGGAGCATAGTAGTAGATCTGTGCTGTGCACTCTCTGCGGTGAGGAGATACACAGCGTTACGAGAATGAGGACTCATATGCAGAATGTACATAATAAGAGATATAAGTGTTTGGTGTGTCCGGAGATGTTCGATACTCATTATAAGCGGTCCAGGCATGTCATGACTGTTCATAAGACGAGGGAGGAGGTGAAGTGCCAGCATTGTCCTAGGACTTTTGTGTTCAGGAGTACAATGATGAGGCACGTTAGGGAGACTCACTTGCAGGAGCGGAATGCTGTTTGCGGAATTTGCGGGTGGAGAGCTTTCGGTCCGGGGAGACTGACCAGACATATGTTGAAGCATAGCAATGAGAGGAACTTCAAGTGTCATGCGTGCGATAAGGCTTTTAAGACTAAGAAGACTATGAAGCAACATTACAGCAATATACATGAAAAGGGCGCCAGGCAGGATATGTTGCCAGGAATATCAGTGGATGCGCTTGTACAGAATTCTATATGA
Protein Sequence
MKDCNAIKEHHSAKHSLSPNSFNVKTIVSKDLPVKIDISELACKLCSDVEIQTFDELVAHIVTAHNEEYHYDAGVCLLPFVLDKELMQCVLCESTFDNFTSMMMHTNKEHIAHSHVCQICGLSFINMIRLNRHINSRHIGYRCTICSKSFVGNNKLERHKSRIHGLNKNHDCSLCSATFENSYLMKVHMGKVHNVEKYRIQCEHCPKVCNTKGAMVLHVQSVHSALRYECDLCEYKTAVKWMIKLHKRKHFGEKPYECSVCGRKFGRSSNVRAHMKVHTGELRGGQKVRKSSDPAQNVETPVKSDKPTQDEFFSAQAVKPALSAKEKRRIMRENVVQVLIKSTVMPFRWLRSSYRCFYCYDIFQEATDLKSHQQSHEGDELKEQAMSKYWEPVVYVDISEMSCKLCPEIVHDLYDLIDHLVSKHDVVYNKDVGICMVAFKLGNMNVSCLACGASFYTFGPLLHHTNKDHKGTSAILCDVCGQHFKDVNLLKIHFKAVHDSTGLLCTECGEKFETKYKLKTHQKNMHESDNKYKCLMCSLTFQSNYKRSRHMASEHKNKQEIKCLHCPKTFLFRSTMMTHLRDTHLKLRNHVCSVCGWKAFNNNRLKNHMYKHSGEKKFKCDVCDKAFTTKKIMKAHFARMHKSVQAPVDIGFDGKTRAKKQETVRTKATSNRETKQEAKKTLNKQMVMRENVLQVLLKSTVMPFRWLKSSYRCFYCYDVFQEPKDLKSHQINHTTEEDIFKAMKNYWEMTVYVDVSALSCTVCSTSLTDFYKLIDHLIDSHGIAFDKDIGICMVPFRLNNISVTCVQCEREFRTFGHLLLHTNKEHKGFSQILCEFCGQHFKSNQHLKDHMNKEHSSRSVLCTLCGEEIHSVTRMRTHMQNVHNKRYKCLVCPEMFDTHYKRSRHVMTVHKTREEVKCQHCPRTFVFRSTMMRHVRETHLQERNAVCGICGWRAFGPGRLTRHMLKHSNERNFKCHACDKAFKTKKTMKQHYSNIHEKGARQDMLPGISVDALVQNSI*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-