Basic Information

Insect: Columbicola columbae
Gene Symbol: Thap12
Assembly: GCA_016920875.1
Location: JADMLL010000008.1:1460193-1465226[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 17 0.0033 0.26 11.8 0.3 1 23 491 513 491 513 0.93

2 17 0.6 46 4.7 1.3 2 21 530 549 529 550 0.90

3 17 0.48 37 5.0 4.2 2 23 565 586 564 586 0.90

4 17 0.13 10 6.7 0.2 2 23 593 615 592 615 0.91

5 17 2.2 1.7e+02 2.9 4.5 2 23 622 643 621 643 0.93

6 17 5.9e-05 0.0045 17.3 0.5 1 23 648 670 648 670 0.97

7 17 0.0057 0.43 11.0 3.2 2 23 684 706 683 706 0.93

8 17 0.002 0.15 12.5 0.4 1 23 722 744 722 744 0.97

9 17 0.0013 0.1 13.0 0.5 1 23 754 777 754 777 0.97

10 17 0.0012 0.091 13.2 0.8 1 23 783 805 783 805 0.99

11 17 0.0099 0.76 10.3 0.7 1 23 820 842 820 842 0.98

12 17 0.00035 0.027 14.8 2.4 1 23 848 870 848 870 0.98

13 17 0.00065 0.049 14.0 0.2 1 23 876 898 876 898 0.95

14 17 0.0022 0.17 12.3 3.5 1 23 904 926 904 926 0.97

15 17 0.00083 0.064 13.7 2.4 1 23 932 954 932 954 0.96

16 17 0.0002 0.015 15.6 3.2 1 23 960 982 960 982 0.97

17 17 9.7e-05 0.0074 16.6 0.8 3 23 990 1011 989 1011 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	17	0.0033	0.26	11.8	0.3	1	23	491	513	491	513	0.93
2	17	0.6	46	4.7	1.3	2	21	530	549	529	550	0.90
3	17	0.48	37	5.0	4.2	2	23	565	586	564	586	0.90
4	17	0.13	10	6.7	0.2	2	23	593	615	592	615	0.91
5	17	2.2	1.7e+02	2.9	4.5	2	23	622	643	621	643	0.93
6	17	5.9e-05	0.0045	17.3	0.5	1	23	648	670	648	670	0.97
7	17	0.0057	0.43	11.0	3.2	2	23	684	706	683	706	0.93
8	17	0.002	0.15	12.5	0.4	1	23	722	744	722	744	0.97
9	17	0.0013	0.1	13.0	0.5	1	23	754	777	754	777	0.97
10	17	0.0012	0.091	13.2	0.8	1	23	783	805	783	805	0.99
11	17	0.0099	0.76	10.3	0.7	1	23	820	842	820	842	0.98
12	17	0.00035	0.027	14.8	2.4	1	23	848	870	848	870	0.98
13	17	0.00065	0.049	14.0	0.2	1	23	876	898	876	898	0.95
14	17	0.0022	0.17	12.3	3.5	1	23	904	926	904	926	0.97
15	17	0.00083	0.064	13.7	2.4	1	23	932	954	932	954	0.96
16	17	0.0002	0.015	15.6	3.2	1	23	960	982	960	982	0.97
17	17	9.7e-05	0.0074	16.6	0.8	3	23	990	1011	989	1011	0.94

Sequence Information

Coding Sequence: ATGGAGGAGGATAAAAACTTTATAATTGTCCTGAAAAGTGGGAACGGAGAATCAATAAGTGTTGAGGTCTTCCCAGAAGATACAGTTAAAGACCTCAAGCAAAGGATAGAAACACAAGTTGGGATCCCACTTGATTTTGATCAACTCAAAATCGATGGAAAGACATTTAATGATGATACGAATATAATTGAATACTTCTCCTCAGAAATCATTCAAAATGATGATCAATTTGAAGAGGGTGAGGGTTTTGAAACAAGTGTTATAGAAGATGAAGAAATGATGGAGAGTCCGAAAGCAGAAGATGGTGGTGTTTCAAATCCTTCTACAAGTTCTGGTGAAACAAGAGTCAAAATGGAAAATGTGACCACTGATCTGTTTTGTGCTGCTATTGGTTGCCAGTCAAACAAATTTGACAATCCAGATGTTCAGCTTTTTAAATTCCCAGCTCAGAAGAAAAGGTGTCAGCAATGGCTTCAAGCAGCTCAACGCAGCGATCTCACCAATCAGTCCCTCGGATTCCTTAGTCACCATTTAGCTTTGTGCGGTAATCACTTCACCAAGGATCAGTTCACATCAAAGGATCGTCGCATCCTCAAACAAAACGCCATTCCGACTATTTTCGATGGATCTCAACAAAACGAAGATGAGAATATCGTAACCATTCTAGATGGTGACTCCAATCGGGAAATGGGAAAGTCCTTGGAGAGAAGACTGATGGAAGAAGACGAGGAGGAAGAGGAAGAAGGAGAGCCTGAACATCCGGGGACTTTATGCAGACTCTGTGGTAATACACTCATGACCTCCGATTCCATTTTCATATTCAGTGAAGATGGTGAAAAGAAAAGTTTGGCGGAAAAAATCAATTCGTGTTTACCCATATCCGTTAAGAAAACAGATCCACTTCCTAAACAGATTTGTTCTGAGTGTACAAAGAACCTGGAAATTGTTCACCTATTTGCAGAAGCTTGCATCAAAGCGGAAATCAAACTAAAGGCTCTTACTAAAAAATTTCTAGTTCACAAACTAAAGAAAAAACCGACGGGAGTCAAATCAAATCAAAAATCATTCTGTTGTCCTCTCTGTCGGGATGGAGCCATGAGATACCATGGAAATCACGAAGAATCCAAAGTTCAGAACGTGATTTGTATCAAGAAACAGTCGGATGATGATGTCTTGCAAATCCCGACGGGATTCCTACCCGTGACCAAGTTCGAGCCGGAGGATTCAAGTCATGATTTCCTCAAAGATCTGTACAGTGACGAGGACGATGGATCCTCCGATGCGGACAACATACTCGGAGAAGACAAAGAGATTTTCTTTGAGGCTTCTGACAAGTCTGAAGTTTCCGACACCCTATACCTCCAAGAAGACAAAGTCGAGATGGTGTTCGATTGTGGTATCTGCGAGGAGAACTTCCTCACTCCGTACGAGTGCTACGAACATTGCAAGACCCACGCGTCTCGAGACAATTTCCCCTGTTTGGTTTGTGGTTTAAGTTTTCAGTCGGAGGACAAGCTCAAAGTGCATTTTACCGAACACAAAAACAAAATCAATTCTACGCGAAGAACTCAGTACAAACCGATCTTGGAGTGCGGCGCCTGTAAGGTGAAATTCACTACGCGGAAAGACTTCATTCTCCACAAGTGTAGCAAACCCATCTTAAAGATTCTCCAGAACGACTCTGTCAATCTGTACTGTCACTCCTGCGACAAACACTTCAAGACACTGGAGAGAGCGGAGTTACATCGGTCCTACCACGGTGGAGCGGAGAAACTCGTTTGCGACCAATGTCACGGAGAGTTCGAAACGGAAAAGGCTCTCAAGTATCACGTGGTCGTTCAGCACGAGAACCAAGAACCGTGGACATGTCAGCACTGCGGTTTGAAGTTTTTCCTCAAAGAAAACTGCGACAAACACGAAAAGGTTCACGAGTCGACGACCTATCAGTGTTCGTTGTGCAACAAGACTTTCAAAGATTTGGAAAAGGTCACTAGTCACATAGAAGCTCATGGGATCAGCGGTGTCGAAGGTTTACCCAAACTCAATCTGAAGTGTCCTAAATGCGATCTTCAGTTCAGCAAAAAGACTCACTACCTCTACCATCTGGAGAATTTCCACGAGGGAGACCTGAACAGCATGAAACGCATGCCGTCTCTCATACAGTATCAGTGTAAGATCTGTTCGGAACGGTTTACGCTCTCTCAGGATGTGATCATACACAGAACGGTTCATTGGAAAAGTTACGACTCGTGCCTCCCGCACGTCTGTGAGTATTGCGGAGAGGCTCATTCTAGTCCGAACGCCCTGGCCAGGCATCGGAGGATATTACACCCGGACGAACAGCCCTACGTGTGCACGATATGCGAAACGACGACGAGGACTCTCTACGAGGCTCGCGTCCATCGGAAGACTCACACGGGTTATGTGAACGCTCCGCAGAAACCTCCCTCGAAAATCTACATCTGCGACAACTGTCCCAGTCTGTTCTCGGACAAAGCTTCTTTTCTCTCGCACAAGAAGTCGCATAAAGTCACTAAAGGATTCCAGTGCGAGTATTGTCAGAAAATATTTCCCGAAAGGCATCGGCTCATAGTTCACAGGCGTCAGCACACGGGAGAGAAACCGTTCTCATGTGGGGTCTGCGGTAAGAAGTTCGCTCAAACCTCTGCCATGTACACGCACGCGTTGCTCCACACCGGAGAAACCCCACACTCGTGCGATCTGTGCGGAAGAAGATTCAGGATCAAATCCGATCGGGACAATCACAGGAGAACGCACACTGGTGAAAAGCCTTACAAGTGTCAGTATTGCGATAAAAGCTTTCGAACGGGACAAGTCTACTATCAGCATAGAATGATACACACGGGTGAGAGGAGGTTTCCCTGTGACATATGCGGGCGGGCGTTCAAACGTTCACACACGCTTGTCTGTCACAGGCGGATACACACAGGAGAAAAGCCAAACATATGCGACGTTTGCGGAAAAGGTTTCAGACAGAGAACGGACATGAGGAAACACAAAATGAACCTCCACGGAGTACCTGCTTAA
Protein Sequence: MEEDKNFIIVLKSGNGESISVEVFPEDTVKDLKQRIETQVGIPLDFDQLKIDGKTFNDDTNIIEYFSSEIIQNDDQFEEGEGFETSVIEDEEMMESPKAEDGGVSNPSTSSGETRVKMENVTTDLFCAAIGCQSNKFDNPDVQLFKFPAQKKRCQQWLQAAQRSDLTNQSLGFLSHHLALCGNHFTKDQFTSKDRRILKQNAIPTIFDGSQQNEDENIVTILDGDSNREMGKSLERRLMEEDEEEEEEGEPEHPGTLCRLCGNTLMTSDSIFIFSEDGEKKSLAEKINSCLPISVKKTDPLPKQICSECTKNLEIVHLFAEACIKAEIKLKALTKKFLVHKLKKKPTGVKSNQKSFCCPLCRDGAMRYHGNHEESKVQNVICIKKQSDDDVLQIPTGFLPVTKFEPEDSSHDFLKDLYSDEDDGSSDADNILGEDKEIFFEASDKSEVSDTLYLQEDKVEMVFDCGICEENFLTPYECYEHCKTHASRDNFPCLVCGLSFQSEDKLKVHFTEHKNKINSTRRTQYKPILECGACKVKFTTRKDFILHKCSKPILKILQNDSVNLYCHSCDKHFKTLERAELHRSYHGGAEKLVCDQCHGEFETEKALKYHVVVQHENQEPWTCQHCGLKFFLKENCDKHEKVHESTTYQCSLCNKTFKDLEKVTSHIEAHGISGVEGLPKLNLKCPKCDLQFSKKTHYLYHLENFHEGDLNSMKRMPSLIQYQCKICSERFTLSQDVIIHRTVHWKSYDSCLPHVCEYCGEAHSSPNALARHRRILHPDEQPYVCTICETTTRTLYEARVHRKTHTGYVNAPQKPPSKIYICDNCPSLFSDKASFLSHKKSHKVTKGFQCEYCQKIFPERHRLIVHRRQHTGEKPFSCGVCGKKFAQTSAMYTHALLHTGETPHSCDLCGRRFRIKSDRDNHRRTHTGEKPYKCQYCDKSFRTGQVYYQHRMIHTGERRFPCDICGRAFKRSHTLVCHRRIHTGEKPNICDVCGKGFRQRTDMRKHKMNLHGVPA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01251123;
90% Identity: iTF_00362579;
80% Identity: iTF_00362579;