Basic Information

Gene Symbol
-
Assembly
GCA_951394395.1
Location
OX596359.1:10684190-10691324[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 19 0.011 0.63 11.0 1.9 1 23 14 36 14 36 0.93
2 19 0.045 2.6 9.1 4.0 1 23 64 86 64 86 0.98
3 19 0.00025 0.014 16.2 0.2 2 23 111 132 110 132 0.98
4 19 1.9 1.1e+02 4.0 0.1 6 23 141 159 139 159 0.89
5 19 0.00022 0.013 16.3 0.2 1 23 236 258 236 258 0.99
6 19 0.0017 0.096 13.6 0.4 1 23 264 286 264 286 0.95
7 19 0.0053 0.31 12.0 0.0 2 23 295 316 294 316 0.97
8 19 3.7e-05 0.0021 18.8 0.1 1 23 322 344 322 344 0.98
9 19 1.3e-06 7.6e-05 23.3 0.5 1 23 350 372 350 372 0.99
10 19 6e-09 3.4e-07 30.7 1.2 1 23 378 400 378 400 0.99
11 19 1.3e-06 7.3e-05 23.4 0.1 1 23 406 428 406 428 0.99
12 19 9.9 5.7e+02 1.7 6.3 1 23 433 456 433 456 0.93
13 19 0.021 1.2 10.1 0.1 1 23 463 486 463 486 0.97
14 19 0.0054 0.31 12.0 7.2 1 23 493 515 493 515 0.95
15 19 0.00069 0.04 14.8 3.2 1 23 551 574 551 574 0.93
16 19 0.01 0.58 11.1 3.7 2 23 597 618 593 618 0.94
17 19 0.0098 0.57 11.2 0.1 3 23 631 652 630 652 0.94
18 19 0.019 1.1 10.2 2.2 3 20 657 674 656 678 0.96
19 19 6.5 3.8e+02 2.3 0.6 2 21 683 702 682 703 0.89

Sequence Information

Coding Sequence
ATGGAAGGGTTTATTGTCAAGCTAGATAAGGTGGAACTACATAAATGTATCAAATGCCCAAAAGCGTTCACCAACACTAAAGATCTTGAAACTCATAATGCAAGGCATGAGCTTAAGGAAGAGTTGTATCAAGCCAGACTTGCAGAGCATTATCTCAGCGCAAAAGTTTTACTGAAGCGTGTCCAAATATACCAATGCAAAGAGTGTCCCAGTTGTTTCCTGCACTATGCTTCCCTGAATGAACACCAGAAGGAACATTCCTGTATCGGAAAATCAAGCCCTAGTCTCGGAAAAAACCCTGAACAAAACAACAATGAATTGAAGCCAAATAAATGTGAAGAGTGTGGGTTAAGGTTCGTTGAAATCTCCACTTTGAACACACACTTGAAAGTCCATAAACCGTTCCGACACATCTGTCGCTGCGGCATTGGATTCTACCAGCTCAAGGATCTTGCCACTCATGAGGAATTGGTTCACCCAACGCAGATTAAAACGGTACTCAatgataaaaatacaaaatcagaTTTTATAGTCAAACCAAAGAAAAAACGAACCAAATCAAAAGGAAAGAACAAACCGAGACTGTCAGCCAAACTTGCATTCCCTAAACTAAAGttcaaatcaaaaaataaaaccaaagcGAAAAGTTATAGACTTCATGGTTGTAATAAGGAAAACAGGTTGTCCAAAAACAAGAATGGTGACTATGTATGTTCATTGTGTGGACAGATATACAGAGATGAAACTGAATTCTTTGCTCATGTCAACACTCACACTAATAAATGGCCGTATGTTTGTGACATATGTCCTTACGGTTGTAAAACGAAAGCTATGTTGATTGTCCATAAGACAGAACACGAAGGtggttacaataaaatatggaAATGCAACTTTTGCTCGAAAGTCATAAGCGACAGAGGTGGTTTAGCTATACACCTATTAGTGCACACAGGAGAAAAACCGTATGCGTGTAATATATGCCCTCAAAAGTTCACACAGATCGGTGCATTAAAAATTCACTTGAATCGGCATGCTGGGATCTATCTGTTCAAATGTGAGCAATGTGGGAAAAGTTTCGTAGATAAAGGTGCGTTAGATTTACACAAGCGCACGCATAGCGGATACAAGCCTTACAGTTGCAAGTACTGCGGGAAAGAGTTCTCGGACCCCTCAGCTTTCAAGCGCCACATTAGAACCCATACAGGAGAGAAGCCGTACGTCTGCCGCTACTGTCCAAAAGCTTTCAGCGATAACAGCGCTTGGATTGTACATATACGCCGCCACGAAGGTCACACTCATACTTGCAAGATCTGCTCTAAACAACTATCTTGTAACAACTCCTTGCGTTTGCATATTGCACATTTCCATGATAAATCATACCAGAAATACGAATGTGATTATTGCggaataataaagaataaaaaaccGAATTTGTACAATCACATTCAAATAGTTCATATGAAAAAGAAACCTCGCCATCAATGTAAATACTGTCCGAAAATGTTCTATTTTAAATGCCAGCTTCGCAATCACGAGAGCCTTCACGAGGGTAATGAATATTACGCCTGTCCGGTTTGTTGCCATAACTGTCACTCTGAAGCTTCTTTGAAAAGGCATATTGCTCAAAATCATAGCAATATTGAAGATAAGTATAAATGCGAACACTGCAAGGCTAGATTTAACAGTCCAGATAGCTTAGAGTCGCACGTAACCCTTTGCCATAACAGAAAGTTTTGCAAAAAGTGCAAAAGAAACCTCGACTCTTCACAGGAGCGACACAAATGCGTTACTTGCGCTGTTTGCGGGAGGTACTTTAAAACAGATTCAGATATGAGAATACATTACAAAAATCATgcttctaaaaatgtattacatAAGAAGAATCATGGGTGTTTAGAATGCCCTAAAAAGTTTTATGAAGCGACTGCACTAGAAAGACATGTCCTAGAACGGCATGGTACAACATTATGTGATCATTGCAAAGAGAATTTCAATGGAAAATCAAAGTTGAGGAATCATATTTGGAATAAGCATATGCTGAGTTTGTACTGTAACGTGTGTATGAAGCGCTTTTACGCTGAACACGAGTTTGAATACCATAAAAATATTGGCTGTGTAAAGAAAGCTAAATGCAGATTTTGTCTTagGGGTTGCCGTAGCGCCGGTTCTGCCGCGCCGCTCGATACGCGCGTCTCGTCCGTCGCCGCACCCTTCGCTTCCACCCCCAGTATTAAGCACACGTCCGGGAAGTGCGGCACTGCAAAATTAACAAGCAAAATATAtgtaattcattaa
Protein Sequence
MEGFIVKLDKVELHKCIKCPKAFTNTKDLETHNARHELKEELYQARLAEHYLSAKVLLKRVQIYQCKECPSCFLHYASLNEHQKEHSCIGKSSPSLGKNPEQNNNELKPNKCEECGLRFVEISTLNTHLKVHKPFRHICRCGIGFYQLKDLATHEELVHPTQIKTVLNDKNTKSDFIVKPKKKRTKSKGKNKPRLSAKLAFPKLKFKSKNKTKAKSYRLHGCNKENRLSKNKNGDYVCSLCGQIYRDETEFFAHVNTHTNKWPYVCDICPYGCKTKAMLIVHKTEHEGGYNKIWKCNFCSKVISDRGGLAIHLLVHTGEKPYACNICPQKFTQIGALKIHLNRHAGIYLFKCEQCGKSFVDKGALDLHKRTHSGYKPYSCKYCGKEFSDPSAFKRHIRTHTGEKPYVCRYCPKAFSDNSAWIVHIRRHEGHTHTCKICSKQLSCNNSLRLHIAHFHDKSYQKYECDYCGIIKNKKPNLYNHIQIVHMKKKPRHQCKYCPKMFYFKCQLRNHESLHEGNEYYACPVCCHNCHSEASLKRHIAQNHSNIEDKYKCEHCKARFNSPDSLESHVTLCHNRKFCKKCKRNLDSSQERHKCVTCAVCGRYFKTDSDMRIHYKNHASKNVLHKKNHGCLECPKKFYEATALERHVLERHGTTLCDHCKENFNGKSKLRNHIWNKHMLSLYCNVCMKRFYAEHEFEYHKNIGCVKKAKCRFCLRGCRSAGSAAPLDTRVSSVAAPFASTPSIKHTSGKCGTAKLTSKIYVIH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-