Basic Information

Gene Symbol
-
Assembly
GCA_951394395.1
Location
OX596376.1:3852624-3862006[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 23 2.9 1.7e+02 3.4 0.3 1 20 15 34 15 38 0.72
2 23 2.4 1.4e+02 3.7 1.1 1 23 91 113 91 113 0.93
3 23 7.3e-05 0.0042 17.9 0.3 1 23 185 207 185 207 0.98
4 23 0.0001 0.0058 17.4 0.2 1 23 211 233 211 233 0.98
5 23 7.1e-05 0.0041 17.9 0.7 1 23 238 261 238 261 0.96
6 23 2 1.2e+02 3.9 0.8 1 23 382 404 382 404 0.91
7 23 0.028 1.6 9.8 0.1 2 23 433 455 432 455 0.93
8 23 4.2e-05 0.0024 18.6 2.4 1 23 477 499 477 499 0.98
9 23 0.0096 0.55 11.2 0.1 1 23 503 525 503 525 0.97
10 23 0.00016 0.0094 16.8 1.7 1 23 530 553 530 553 0.96
11 23 2.5 1.4e+02 3.6 3.6 1 23 559 582 559 582 0.95
12 23 0.0001 0.0058 17.4 0.4 1 23 589 612 589 612 0.97
13 23 0.00067 0.039 14.8 3.6 1 23 618 640 618 640 0.97
14 23 0.96 55 4.9 0.1 1 23 704 726 704 726 0.88
15 23 0.46 27 5.9 0.0 2 23 755 777 754 777 0.92
16 23 0.00011 0.0062 17.3 1.9 1 23 799 821 799 821 0.99
17 23 0.026 1.5 9.8 0.1 1 23 825 847 825 847 0.95
18 23 0.00061 0.035 15.0 0.1 2 23 853 875 852 875 0.94
19 23 2.9 1.7e+02 3.4 3.6 1 23 881 904 881 904 0.94
20 23 0.00088 0.05 14.5 2.8 1 23 911 934 911 934 0.97
21 23 0.0025 0.14 13.1 0.6 3 23 942 962 940 962 0.97
22 23 3.5e-06 0.0002 22.0 2.6 1 23 968 990 968 990 0.98
23 23 0.00099 0.057 14.3 0.5 1 23 996 1018 996 1019 0.95

Sequence Information

Coding Sequence
ATGAAAGGACACAACGAGTATGCTCACAAAAAGGTTAAAAGACACATTTGCCCTCAATGCCCTGAGACATTCTTGATCTATTACGATAAATCAAAACATATGGCTGCTGCTCacgGTGTGCGTCCCGGTGAGACTCAAGAAGATAATTTACGCAAGATGTATGCAAATGCGAAGACTCAAGTAATCCTAGCTAACCGTGCCAGAAGGCAACGCATCAGTACGCTACTTCAGTTTTCCAGAATGTGCCTTTTTAAACAAAAAGCGACATTATTCATGTGCATATATTGCGATCAGAATTACCTGAATCTTGCGCAATTGAGACAACATTACACTAAACACAATGATGTTACACCTATGGGGATCGAAAAAGCAATCAAAGGGATGCATTCTCCACAACTATTTAAAGCTGATGTCACTGATGTCAGTTGCAAACTTTGCGACTCCAAACCAGACAAATTAGATGATCTCATCAAACACTTAGTTGAAAAACACAACAAGAAAATCGATAATCTTGATCTCGGAAtcctttcttttaaaacaaACCTTGAAGATTACATATGCGGAATTTGTGATGCAAGTTACACCGATTTCGTGTCTCTTAATCATCACATGAACGTGCATTACCCAAAGTTTGTTTGCGAACAATGTGGGACTGGGTTTGTTTCTGCAATGAGATTGAATCGACACTTATTAACCCACGCAAAAGGTTCGTTCCCATGCACCACTTGCAACAAAGTGTTCACCTCTGCTGACGCAATGAAAAGCCACTTTAGATACGCTCACATGAAGGTCAAAAAACATGTGTCGATACGCCTTCAGACGAGACTCACGAAGGCACGGTCACAAGTACGAAGACACAACGAGTTCTTGCAAATCATTCAAACAGAGCCAGAAGGCAGCGTGTCCGGTTACTTCTGGAATGTTCTAGAATATGCCTCTTCAAACGAAAAGGGCCCTTATATATTTGCATATACTGCATTCAAGGGTGTCGATACGCCTTCAGACGAGACTCACGAAGGCACGGTCACAAGTACGAAGACACAACGAGTTCTAGCAAGTCATTCAAACAGAGCCAGAAGGCAGCGTGTCCGGGTACTTCTGGAATGTTCTAGAATATGCCTCTTTAAACGAAAAAAGTCTTTATATGTTTGCATATATTGCCATCAAGAGTACGAAGACCCTGCCAAATTTAGAGAACACAATTCTGAACATGAAAATGTTAAACCTGTGGAGATAGAAAGAGCGATCGCTAGAATGCGCACAACGGAGTTATTTCAAGCAGATATCACAGACGTTAGCTGTAAACTTTGCGATACCCCAGTAAACAGATTAGACGATCTAATAACACATTTGTCTGAAAAACATAATAGGAAAATCGACTGCAATCCAGACATTGGAATCCTACCTTTCAAATTGAACATAGATGACTTTAAATGCGCTATTTGTAACGAAAAATACACGGATTACAAGTCACTCAATCATCATATGAATGTACATTACCCAAGATTCGTTTGCGAACAATGTGGGTCTGGGTTTGTCACGGCAATGAGGTTGAAGTCACATGTTGTCACGCACGAAACTGGGTCCTTCCCGTGCAACTCTTGTGACAAAGTGTTTTGCTCAAAAGAAGCAATGAGAGCACATTACAAATACGCTCAcatgaaagttaaaaaacacAGTTGTACTCAATGTCCCGagacttttttgttttacagcCAGAAGCTAAAGCATATTACCACTTTCCATGGGATAAACTTAGAGAAGTTTAAATGCAATTATTGTTCGAGAACTTTTCCAGCCAGGGGGCTTCTTGCTAGGCATGTGCGCGAACTGCATTTGAGAGATTGGCGCCACGTGTGTACTGTTTGTGATGCAAAGTTCTACGGTAAAAGTTGTCTAACGAAACACATGGTCACACATACCGGAGAAAGGAAGCATCAGTGTAGTGTATGTATCGATGAGACTACGAACAAGACTCGAGAAGGTATCCTACAAAACGATACTCAAACTAAAAAGGCACAGCAGATTGAAATCAAAGCGCGACAGCAACGAGTCTTGATTCTCCTAGAGTGCTCCAGAATATGTCCCTTTAAATGGAAAAGGCATACATTCATATGCATTTACTGCAATCAGGGATACGTAGATCCTGCTAAATTAAGAGAACATAATACTGAACATCAAGATATTAAACCTCGAGAAATAAAAACAGCCGTGGCTAAAATTAGTTCAAAGGAATTATTAAAAGCTGATATCACAGACGTCAGCTGTAAACTATGTGACGCTTCGATTGATAGATTGGATTATCTCATAATGCACTTAGCTGAAAAGCACAAAAAGAATATTGAGCTGACTTCAGACCTGGGCCTAATTCCCTTTAAAGTAACGCTAGACGATTACAAATGCACGATTTGTGATAAACAGTATGCAGAATACATCACTCTTAAACATCACATGAACATTCATTACCCAAATTTTATCTGCGAACAGTGTGGATCAGGTTTTGTTAATGCAGGAAGGTTGAAAGTGCATGCTTTTTCACACGAAACCGGGTCCATTCCATGCGAAACTTGCGGCAAGGTCTTTCGCTCTACTGCTTCAATGAAATTGCACTACGAAATCGTACACAAGAAACTTAAAAGGCACAGTTGCACTCAATGCTCCGAGACATTCTTGTACTACTATCAGAAACAGAAGCACATATCGTCAGTCCACGGGATGAAGGTTAAGGAGTTTAAGTGCAGCTGGTGCccgaaattattttataatagtggaAAATTATACCACCACCAGCGTGCTACACATCTGAAAGAAAAGCGCTATGGTTGCAGTGTTTGTGACGCAAAGTTCTTTACGACAAACTTATTGAAGAACCATATGCTTTCGCATTCAGAAGAGAAGAACCATCAGTGCGGCGTTTGCCAGAAAGCTTTTAAGAAGAAGTATACCTTGGTGATACACATGAGGACTCATACGGATGTTAGGCGATTCGCTTGTAATGTTTGTGGCAACTCGTTTGCGCAGATAAGCGTGTTGAAGCAACATGGCAACACTCATCATCCTCGTTATCCAAACCCAGCAGTTCAATACGACAATACATCGCAGCcgtag
Protein Sequence
MKGHNEYAHKKVKRHICPQCPETFLIYYDKSKHMAAAHGVRPGETQEDNLRKMYANAKTQVILANRARRQRISTLLQFSRMCLFKQKATLFMCIYCDQNYLNLAQLRQHYTKHNDVTPMGIEKAIKGMHSPQLFKADVTDVSCKLCDSKPDKLDDLIKHLVEKHNKKIDNLDLGILSFKTNLEDYICGICDASYTDFVSLNHHMNVHYPKFVCEQCGTGFVSAMRLNRHLLTHAKGSFPCTTCNKVFTSADAMKSHFRYAHMKVKKHVSIRLQTRLTKARSQVRRHNEFLQIIQTEPEGSVSGYFWNVLEYASSNEKGPYIFAYTAFKGVDTPSDETHEGTVTSTKTQRVLASHSNRARRQRVRVLLECSRICLFKRKKSLYVCIYCHQEYEDPAKFREHNSEHENVKPVEIERAIARMRTTELFQADITDVSCKLCDTPVNRLDDLITHLSEKHNRKIDCNPDIGILPFKLNIDDFKCAICNEKYTDYKSLNHHMNVHYPRFVCEQCGSGFVTAMRLKSHVVTHETGSFPCNSCDKVFCSKEAMRAHYKYAHMKVKKHSCTQCPETFLFYSQKLKHITTFHGINLEKFKCNYCSRTFPARGLLARHVRELHLRDWRHVCTVCDAKFYGKSCLTKHMVTHTGERKHQCSVCIDETTNKTREGILQNDTQTKKAQQIEIKARQQRVLILLECSRICPFKWKRHTFICIYCNQGYVDPAKLREHNTEHQDIKPREIKTAVAKISSKELLKADITDVSCKLCDASIDRLDYLIMHLAEKHKKNIELTSDLGLIPFKVTLDDYKCTICDKQYAEYITLKHHMNIHYPNFICEQCGSGFVNAGRLKVHAFSHETGSIPCETCGKVFRSTASMKLHYEIVHKKLKRHSCTQCSETFLYYYQKQKHISSVHGMKVKEFKCSWCPKLFYNSGKLYHHQRATHLKEKRYGCSVCDAKFFTTNLLKNHMLSHSEEKNHQCGVCQKAFKKKYTLVIHMRTHTDVRRFACNVCGNSFAQISVLKQHGNTHHPRYPNPAVQYDNTSQP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-