Basic Information

Gene Symbol
ZFX
Assembly
GCA_947284805.1
Location
OX369278.1:10886923-10943763[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.34 32 6.6 2.5 1 23 212 235 212 235 0.96
2 11 0.036 3.4 9.7 0.2 1 23 242 264 242 264 0.98
3 11 0.21 20 7.3 0.5 1 23 268 291 268 291 0.94
4 11 0.46 43 6.2 4.4 1 23 298 320 298 321 0.93
5 11 0.00083 0.079 14.8 1.8 2 23 326 348 325 348 0.96
6 11 0.013 1.2 11.1 1.4 3 23 356 376 354 377 0.93
7 11 0.016 1.5 10.8 0.5 3 21 407 425 406 430 0.93
8 11 0.00015 0.014 17.2 0.3 1 23 438 461 438 461 0.94
9 11 2.7 2.6e+02 3.8 0.3 1 9 466 474 466 476 0.88
10 11 2.5e-06 0.00023 22.8 1.5 2 23 717 738 716 738 0.97
11 11 8.1e-06 0.00076 21.2 1.3 1 23 744 767 744 767 0.95

Sequence Information

Coding Sequence
ATGAATTGTGCTAACAAAATTATTTGCGTGGCCTGTCTCAGGTCAAAGAAAACAGTCAAAAAGATCACAGACAAGCAGCTGCTACAATGCTTTAACAGCATTTTGGATGAGATTCCTGCGTCACTTCCAACCTCACAGCCCAGCTTGTGTTCCAAATGCATAAATTTGCTCAAAAAGTATTCAGCCTTCAAGCAAAAGGTCAAGGAGTCCTACAGGAGTCTGCATTCCTATACAAATGAGAATGTCCAAAAGTACGAGTTCGAAATCGACGATGGTAAAAAGTGTCATAGTATGTTGGCAAAACCGGAAGCTATTGACATACCTGGCGGCGTTGAAATGTTTGTCAAGGAGGAGGTCAAAGTGGAATTTGACCATGGTGGCCCAAAGATTGAAATGAACGCTCTAGGAGACTCCCGGGATGACAACTTGGATATGTCCACAACAGATGATGACAATGACAAAACTAATAATGATGCTATTGAGAAGGAACATAAGACAAAGAAAAAGAAAAAGCGCCAACAAAACGCAGTTAAAAAGGAACCCAAAATTTTTAAGACCATCGAGCTCTCCTACGAAGAGATGCTGCAGGAGCGACAGCAGGACGCAGCCAGGGAATGTTTCCTGAACGCCAAGCATCGCTGTGATAGCTGCCATCTGGTGTTCGCCTCTCAGAGGAGTGCGGATGTACATGTGAAGACTAAACATGATGCCAATATCGGCGACTACTTCTGCCCAGTGTGTAAAGTCGTCATTACGTCCGTGGACGCGTTCACCGCACACTATAAAAGGCATATGAGAAGATACGAATGCAGCGTGTGCCAGAAGAGGTCGGCGGATGTGAAGATGATACAGCGGCACTACTTCTCCGTGCACGAGACCTCCGTTAGAGATTACAAGTGCAACGTTTGCGCCAAAGTGTTCAAATCCATGGACGCACACAGATACCACAGAGACACGCATCACAAAGGGAGGGTGCAGTGCGGCTCGTGTGACAAAACTTTCAGACATCGCAACGGACTCATCACCCATCGCACGACAGTCCACGAGTCGAACCGCAAGATAATATGCGCGCAGTGCGGCAAGGAGTTCCGGTGGAAGACCAGCTTGAAGCGGCACGAGGACCGCCACCACAGCACCGTGAGTCCACCACCATCCAATGCCAATGCATTTGCGTCTATAACAGACGATTTAAAACAACAATCAACTGCGGTGCCCTCGTGCGAATCGTGCGACATCACCTTCGCGTCCGTGTCCTCTTACTTGCGGCATATGAAGAACAGTTTGAAGCACGTGTCGCAGGACCAGTTGAGGTACATATGCGATGAGTGCGGCAGACGGTACGCCAATAAAACCAAGTTGCGGGACCATATCGAGGAGAAACATCTGCACAGGAAGTTCTCCTGCCACATTTGTAACAAGGTAACTGTGTGCGCTCCAGTTCAAGTTCACTTATTATTAATAAAAACCGACTTCAAAAAAAGGAGTTCAGTCAGTTGCCGCCGCGCTGCCGTGAGTGACAGTCGAGTCGACTCTCGCTCAGTGACCTCTGCGCCACGCTTACGCATCGCCGTTGGCGCCGTCACGCCGCCGCCGTGCAAAATGACGGAAAACTTTTCGAATGTGGAGTTAGTGGAGATGGTGCGCTTGTACGCTATTAGTGGTAACAGTTTGCGACAAGCCTGTGAAATGTTCGTGGAAATGTTTCCGAACAGTCCGAGACCGACCCGGGACATAATGCTAGCTGCCACGCAAAGACTGCGGGATCATCGTCAGTTCGACGTCCCCGTCCATGCTCAAGGAAGAGGCAGCGTGGGCATTTCTGTAGCTTTACAAGAGGCTATTTTGGACTATTTTGAAAGAGAGCCACGAGCAAGTACTCGTGATGCAGAGCATGTCTTCGACGTGAATCACATGACGGTGTGGAACCTTTTAAAAAGTGAACAAAAGCATCCTTTTCACTTCCGTAAAGTTCAAAACCTTTGCCTGCAAGACAACGCCGCGCGGAGTACTTTTTGTCGTTGGCTTCTTCAAAACCAAAACGCCAACATTCTATGGACTGACGAATGCATGTTTACGAGGCCGTCGAAGAACAGAGTAGCTTTGGACCAGCACATCAGGAACGTGCACAAAGGCAGGCCCAACAACAAGATGTGCCATCAGTGCGGGAAGGGGTTCCCGACTAAAGTGCAGCTGGAGTCGCACATACGGACGCACACGGGCGAAAGGCCGTTCATCTGCGAGTACTGCCCCACCACGTTCTCCCAGCAGTCCAACCTCTACAAGCACAATAGACAGGTCCACATGAACATGAAGAAGCAACCCAGGAAGACCGACGGGACTCAAACCCGGGAGCCCAGCAAGCCGGGCGGGCCCTCCATATCTCTTACACTAACTCAATCACCCGGGTTTTTTTCAGCTAAAACCAAAATCAAGCCGAACGCTGTCAATCTAGCTGTGGAAACGTCTCTGATCTTTGGTGATGAGAACATAAAGAACGACTTAACTATCATTGATAACCTTCAGGACTTCCTCAATAAACTTAAAAGCTACCTCAATCAACGCGAAGAGACTAATTTCAGAAGCGAAGACCCGAAACAGGGGATATTCACGACATTCTTCAAAGATTTTAGTAGAATAATCATTAACTATGACAATGAGAGCCTAAGGAACCTTACAGATGTACTAGCTTTAGTTATGGAACCGTATTACTATCAAGGCACGGCGTTTCATAATATTATTGAAGATGAAAACTTGAAATCGTACATAAAAGATAAGCTGCATAATTGGGCTGATACAGATCCGAAAGTTTTGAAATATCAAATGGCTAACGCAGTAATGTCAAAGGAAGATACTCCAATAACGCGATTCGGGAATTATATTAACAAATTTTTCAGTGAAGATGATTCAAAAAGGCTTAAGAAGTTATTAAAAAAGTTCAATAATCATCACGAAAAAGGCATTGATATGCATAAGTTAGTTAAAAAGACTTTACAGTTTGTAATTTTTCATCGCTACAATGAATTAGAACAAACAGCCAAACATGACTTGTCGAATGCCCTTAAAAACCTTACTGCATTCATTACAAATATGCATGATACATCGAATCTTGGAAGTTCGAAAAAATATTTCCTTAATGATAAACACAATAGAACAGATAAAATTAACATTCGGAGAGCCCAAGTTAAAGCTAACCCGCTACTACCTGAGAAAATTATTTTACAAAAAGACGTAGAATTGAATGTAAAGGCACCCGAAAAGGAAAAGACAAAAGACACACGAATAAAGAATGATGAAGCTGATAAACTGACTACAAATCATACTAAGTTGCAAAAACTTCCATATATATCAGAGCAATCTCCGTATATGTCAATGGAAGTGAAATTGGATAATAATAAGCACATCGCTATAGAAACTCACGAGCATGCAGTAGACTCTAAAATAAATAGTACACATTCAGTTCATGAAGGCAGGGAAAACGAAGAAGTTGTGGAACAAACAACGCTTACTGAAATAAATAAAACTGCAACTGAAAAAATTACAACTACCATAGATACTTCAATATCAACTACAGAAATTAGTACCCAGATAGACCTCTACAAACAAATTATGGCAATTAACATAGAGGACGAGAAAGAAGCAGCAAATACAGATACAGAACATAATAAAGAGACAGAAAATGAAAATCACGACACCAGACAACCGATGACCCTGGCTTTGATACAGAATTCAGAAACTGAAGCTAACATTACCAATAAGATCGTCATTACTGCACAAAACGAAACCATTTCACCCAAAAATAAAAGCAAAGGCATTGAAAGAAGAATGGGGTTATTAGTTCATCAAGTTCTCCCAGAGGCTGTAGCTGATTCGAACTTGGATACAGATGAATTAAAGATAAAAGTGGATATGACTCCGCAATATAGTGCAACTGTTGGCTACGTAGATGAGTCAAATTCTAATGAAAACGAAGAAACTGGAACTGAAACTAATGGGGATGACGTTATAAATAGTGATAAAGAGGACTACCAAAACAAGATCAGTGATGGTGCGAATAAGATTAGGGATTTGTTGGATGATGCAATAGCCATGAAGTTGTTAGGTGTTGTATAG
Protein Sequence
MNCANKIICVACLRSKKTVKKITDKQLLQCFNSILDEIPASLPTSQPSLCSKCINLLKKYSAFKQKVKESYRSLHSYTNENVQKYEFEIDDGKKCHSMLAKPEAIDIPGGVEMFVKEEVKVEFDHGGPKIEMNALGDSRDDNLDMSTTDDDNDKTNNDAIEKEHKTKKKKKRQQNAVKKEPKIFKTIELSYEEMLQERQQDAARECFLNAKHRCDSCHLVFASQRSADVHVKTKHDANIGDYFCPVCKVVITSVDAFTAHYKRHMRRYECSVCQKRSADVKMIQRHYFSVHETSVRDYKCNVCAKVFKSMDAHRYHRDTHHKGRVQCGSCDKTFRHRNGLITHRTTVHESNRKIICAQCGKEFRWKTSLKRHEDRHHSTVSPPPSNANAFASITDDLKQQSTAVPSCESCDITFASVSSYLRHMKNSLKHVSQDQLRYICDECGRRYANKTKLRDHIEEKHLHRKFSCHICNKVTVCAPVQVHLLLIKTDFKKRSSVSCRRAAVSDSRVDSRSVTSAPRLRIAVGAVTPPPCKMTENFSNVELVEMVRLYAISGNSLRQACEMFVEMFPNSPRPTRDIMLAATQRLRDHRQFDVPVHAQGRGSVGISVALQEAILDYFEREPRASTRDAEHVFDVNHMTVWNLLKSEQKHPFHFRKVQNLCLQDNAARSTFCRWLLQNQNANILWTDECMFTRPSKNRVALDQHIRNVHKGRPNNKMCHQCGKGFPTKVQLESHIRTHTGERPFICEYCPTTFSQQSNLYKHNRQVHMNMKKQPRKTDGTQTREPSKPGGPSISLTLTQSPGFFSAKTKIKPNAVNLAVETSLIFGDENIKNDLTIIDNLQDFLNKLKSYLNQREETNFRSEDPKQGIFTTFFKDFSRIIINYDNESLRNLTDVLALVMEPYYYQGTAFHNIIEDENLKSYIKDKLHNWADTDPKVLKYQMANAVMSKEDTPITRFGNYINKFFSEDDSKRLKKLLKKFNNHHEKGIDMHKLVKKTLQFVIFHRYNELEQTAKHDLSNALKNLTAFITNMHDTSNLGSSKKYFLNDKHNRTDKINIRRAQVKANPLLPEKIILQKDVELNVKAPEKEKTKDTRIKNDEADKLTTNHTKLQKLPYISEQSPYMSMEVKLDNNKHIAIETHEHAVDSKINSTHSVHEGRENEEVVEQTTLTEINKTATEKITTTIDTSISTTEISTQIDLYKQIMAINIEDEKEAANTDTEHNKETENENHDTRQPMTLALIQNSETEANITNKIVITAQNETISPKNKSKGIERRMGLLVHQVLPEAVADSNLDTDELKIKVDMTPQYSATVGYVDESNSNENEETGTETNGDDVINSDKEDYQNKISDGANKIRDLLDDAIAMKLLGVV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-