Basic Information

Gene Symbol
-
Assembly
GCA_947284805.1
Location
OX369303.1:11972390-11980505[+]

Transcription Factor Domain

TF Family
HPD
Domain
HPD domain
PFAM
PF05044
TF Group
Helix-turn-helix
Description
Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. Homologues of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here [1]. This homeo-prospero domain binds to DNA.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.029 4.7e+02 1.9 0.0 21 53 37 69 29 77 0.88
2 9 0.027 4.4e+02 2.0 0.0 21 53 80 112 71 121 0.88
3 9 0.033 5.3e+02 1.8 0.0 21 53 123 155 115 164 0.88
4 9 0.0067 1.1e+02 4.0 0.0 22 54 167 199 159 241 0.82
5 9 0.028 4.5e+02 2.0 0.0 21 53 250 282 243 292 0.88
6 9 0.037 5.9e+02 1.6 0.0 21 53 293 325 285 329 0.88
7 9 0.012 2e+02 3.1 0.0 22 53 337 368 328 373 0.89
8 9 0.043 7e+02 1.4 0.0 22 53 380 411 372 415 0.89
9 9 0.57 9.3e+03 -2.2 0.0 22 48 423 449 415 452 0.83

Sequence Information

Coding Sequence
ATGGcttggtgtgacgtgcggtcgaagtcaggaagtcggcaccttatttggcaccacgacaacgtcGCGGAGCACTACTCCGCACCTTATTTGGCACTACGACAACGTCGCGGAGCACTACTCCGCACCTTATTTGGCACCACGACAACGTCGCAGAGCACTACTCCGCACCTTATTTGGCACTACGACAACGTCGCGGAGCACTACTCCGCACCTTATTTGGCACTACGACAACGTCGCGGAGCACTACTCCGCACCTTATTTGGCACCACGACAACGTCGCAGAGCACTACTCCGCACCTTATTTGGCACTACGACAACGTCGCGGAGCACTACTCCGCACCTTATTTGGCACTACGACAACGTCGCGGAGCACTACTCCGCACCTTATTTGGCACCACGACAACGTCGCGGAGCACTACTCCGCACCTTATTTGGCACCACGACAACGTCGCAGAGCACTACTCCGCACCTTATTTGGCACCACGACAACGTCGCGGAGCACTACTCCGCACCTTGTTTGGCACCACGACAACGTCGCGGAGCACTACTCCGCACCTTATTTGGCACTACGACAACGTCGCGGAGCACTACTCCGCACCTTATTTGGCACCACGACAACGTCGCAGAGCACTACTCCGCACCTTATTTGGCACCACGACAACGTCGCGGAGCACTACTCCGCACCTTGTTTGGCACAACGTCGCGGAGCACTACTCGGCACCTTATTTGGCACTACGACAACGTCGCGGAGCACTACTCCGCACCTTATTTGGCACCACGACAACGTCGCAGAGCACTACTCCGCACCTTATTTGGCACTACGACAACGTCGCGGAGCACTACTCCGCACCTTATTTGGCACTACGACAACGTCGCGGAGCACTACTCCGCACCTTATTTGGCACCACGACAACGTCGCGGAGCACTACTCCGCACCTTATTTGGCACCACGACAACGTCGCAGAGCACTACTCCGCACCTTATTTGGCACCACGACAACGTCGCGGAGCACTACTCCGCACCTTGTTTGGCACCACGACAACGTCGCGGAGCACTACTCCGCACCTTATTTGGCACTACGACAACGTCGCGGAGCACTACTCCGCACCTTATTTGGCACCACGACAACGTCGCAGAGCACTACTCCGCACCTTATTTGGCACCACGACAACGTCGCGGAGCACTACTCCGCACCTTATTTGGCACCACGACAACGTCGCGGAGCACTACTCCGCACCTTGTTTGGCACCACGACAACGTCGCGGAGCACTACTCCGCACCTTATTTGGCACTACGACAACGTCGCGGAGCACTACTCCGCACCTTATTTGGCACCACGACAACGTCGCGACTAAGATATTAATCAATAATGTGTTGTTGTTGCTCGAGGCGACGCCTGCGCAGTTGTTGTTGCTATGGCTGTAG
Protein Sequence
MAWCDVRSKSGSRHLIWHHDNVAEHYSAPYLALRQRRGALLRTLFGTTTTSQSTTPHLIWHYDNVAEHYSAPYLALRQRRGALLRTLFGTTTTSQSTTPHLIWHYDNVAEHYSAPYLALRQRRGALLRTLFGTTTTSRSTTPHLIWHHDNVAEHYSAPYLAPRQRRGALLRTLFGTTTTSRSTTPHLIWHYDNVAEHYSAPYLAPRQRRRALLRTLFGTTTTSRSTTPHLVWHNVAEHYSAPYLALRQRRGALLRTLFGTTTTSQSTTPHLIWHYDNVAEHYSAPYLALRQRRGALLRTLFGTTTTSRSTTPHLIWHHDNVAEHYSAPYLAPRQRRGALLRTLFGTTTTSRSTTPHLIWHYDNVAEHYSAPYLAPRQRRRALLRTLFGTTTTSRSTTPHLIWHHDNVAEHYSAPCLAPRQRRGALLRTLFGTTTTSRSTTPHLIWHHDNVATKILINNVLLLLEATPAQLLLLWL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-