Basic Information

Transcription Factor Domain

TF Family: AP-2
Domain: TF_AP-2 domain
PFAM: PF03299
TF Group: Basic Domians group
Description: Activator protein-2 (AP-2) transcription factors constitute a family of closely related and evolutionarily conserved proteins that bind to the DNA consensus sequence GCCNNNGGC and stimulate target gene transcription [PMID: 2010091, PMID: 1998122]. Four different isoforms of AP-2 have been identified in mammals, termed AP-2 alpha, beta, gamma and delta. Each family member shares a common structure, possessing a proline/glutamine-rich domain in the N-terminal region, which is responsible for transcriptional activation [PMID: 2010091], and a helix-span-helix domain in the C-terminal region, which mediates dimerisation and site-specific DNA binding [PMID: 199812]. http://www.ebi.ac.uk/interpro/entry/IPR013854
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 1.9e-62 9.2e-58 196.8 0.1 1 145 35 176 35 187 0.91

2 3 3e-07 0.014 16.6 0.0 95 145 187 234 184 245 0.76

3 3 1.6e-21 8e-17 63.2 0.0 95 191 245 334 241 334 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	1.9e-62	9.2e-58	196.8	0.1	1	145	35	176	35	187	0.91
2	3	3e-07	0.014	16.6	0.0	95	145	187	234	184	245	0.76
3	3	1.6e-21	8e-17	63.2	0.0	95	191	245	334	241	334	0.90

Coding Sequence: ATGGACGACACGACGGGCTTCATGACTGATCTCCCCTTATTGAAAACGATGAAAGGCCGCGACGGCCTCGGCGGCGCCGGGTCCTGCGCACCGAACGACGTGTTCTGCTCGGTGCCGGGACGACTGTCGCTGTTGTCCTCCACCAGCAAGTACAAAGTGACCGTCGCCGAGGTGCAGAGGCGGCTGTCGCCGCCGGAGTGTCTGAACGCGTCGCTGCTCGGGGGCGTTTTGCGGAGAGCGAAGAGCAAAAACGGCGGCCGCCTGCTCCGGGAGAAATTGGAGAAAATTGGCCTCAACCTTCCCGCGGGCAGGAGAAAAGCCGCCAACGTGACTCTGCTCACTTCCCTCGTAGAAGCGGAAGCAGTGCACCTGGCCCGCGACTTCGGCTACGTGTGCGAGACAGAGTTCCCTGCGCGCGCGCTCGCCGAGTACCTCGCGAGGCAGTACGCCGAGCACGACGCGAGGAGACGCAGGGACCTGCTGCAGGCCACTAAGCAGGTTAGTGCACTAGTGTACGTCATAGTGCAGTCTAGATCTCTGGTCCGACGTCGCAGAGAAGACTACGTGTGCGAGACAGAGTTCCCTGCGCGGGCGCTCGCCGAGTACCTCGCGAGGCAGTACGCCGAGCACGACGCGAGGAGACGCAGGGACCTGCTGCAGGCCACTAAGCAGGTTAGTGCACTAGTGTACGTCATAGTGCAGTCTAGATCTCTGGTCCGACGTCGCAGAGAAGACTACGTGTGCGAGACAGAGTTCCCTGCGCGCGCGCTCGCCGAGTACCTCGCGAGGCAGTACACCGAGAAGAAGAAGACGCAGGGACCTGCTGCAGGACAGGTGACCAAGGAGTTGATGGACCTTCTGAACCAGGACCGGTCTCCGCTGTGCAACACGCGGCCCCCGCATCTCCTGGAGCCGGCCATCCAGCGGCATCTGACACATTTCTCGCTAATATCTCACGGGTTTGGGGGACCGGCGATTGTCGCCGCACTCACTGCTATACAG
Protein Sequence: MDDTTGFMTDLPLLKTMKGRDGLGGAGSCAPNDVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEAEAVHLARDFGYVCETEFPARALAEYLARQYAEHDARRRRDLLQATKQVSALVYVIVQSRSLVRRRREDYVCETEFPARALAEYLARQYAEHDARRRRDLLQATKQVSALVYVIVQSRSLVRRRREDYVCETEFPARALAEYLARQYTEKKKTQGPAAGQVTKELMDLLNQDRSPLCNTRPPHLLEPAIQRHLTHFSLISHGFGGPAIVAALTAIQ

Sequence clustering based on sequence similarity using MMseqs2