Basic Information

Gene Symbol
topi
Assembly
GCA_958295455.1
Location
OY282408.1:2015091-2033340[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.024 2.8 9.8 2.3 1 23 302 324 302 324 0.96
2 12 0.0075 0.87 11.4 1.4 2 23 332 353 332 353 0.94
3 12 0.23 27 6.7 1.0 1 23 357 379 357 379 0.98
4 12 0.0015 0.17 13.6 0.6 1 23 384 407 384 407 0.98
5 12 0.001 0.12 14.1 0.2 1 23 411 434 411 434 0.94
6 12 0.018 2 10.2 0.1 3 21 455 473 454 478 0.91
7 12 0.00017 0.019 16.6 1.2 3 23 488 509 488 509 0.98
8 12 1.5 1.7e+02 4.2 0.4 3 23 530 551 528 551 0.95
9 12 5.7e-06 0.00066 21.2 0.5 1 23 562 584 562 584 0.99
10 12 2.2e-05 0.0025 19.4 3.5 1 23 590 612 590 612 0.99
11 12 0.45 52 5.8 3.9 1 23 618 640 618 640 0.98
12 12 5.2e-05 0.006 18.2 0.2 1 23 646 669 646 669 0.98

Sequence Information

Coding Sequence
ATGGGGGACTTGGAAGTGTGCAGAATATGCCTCGCCATGGAAGTAAAAATGTATCATTTGCATTTAGACAGGCTGAACCACTACTATGAGTCAGTAATGGGACTGAATCTACAAAACTCAACAGACCTGCCACTGTATGTTTGCTTTGAATGTGCAGCTTTGTTGAAAAAATGCTCCAACTTCCGCGACAGATGTGTCTTCGGACAGTCCGTTTTATACACCATACTTCCAAGTCATGGAAAGaTAACCGCCCAAGCTATACAACAACTAGATCGGTACCAACTGAACCTGGTCTCCCACCTCAAACCACACAGTATTACAGAAGACAACACCATCTTCTTCACTCACCAGGAAAGAAAAGAAGAAGGAGAAATAAAACATGAACCATACGATGACTTCATCATACAAGTAGACTGCGTTAAGCAAGAAGAGTTCACAGAAAATATTCTAGGTTTATCCAGCGATGATGACGAACCATTGTCTCTGCATAAAAGTAATAAAGACAAACAAATGACTGAAAAGACTGAAAAGAAGAAGGGGAAAAGAGGGAGAAAGAAGAAGGAAAAAGAAGTAGAAGTTAAGGTAGATGAAGTCAAAGATGAAGAGGATTTGGGAATAGAGGAAGCCGACACCCTACCCTTCGAAGCAGAAGAACCACCATCACCCAACCAGGACCTACTGCAGCCTGCCAAAAGAAAGAGGGGTCGCCCAAGAAAGACGGATATGCCGACCAATCCCGAggcgaagaagaagaagaaaatgcGACGCACCACGAACACGGGGGGTGTGGCTGATGATGACGTCAATATTGAGGAGTACTGCACGGTTGTTAAGTTGACGCTAGACCAGCAGCTAGAAGACATAAACAAGCGGCAGCACTCGTCCAACTACGTGAACGCGCCGTTCCAGTGCGATCTGTGCTTCAAGGGGTTCATAGACACGCACGCGTGGACGCACCACGTGGGGAAGCATGACCCGAGCGCGGGCTCGGAGCAGTGCGCGGTGTGCAAGTTCCGCTTCCCCTCCAAGCGCGCGCTGCAGAAGCACGCGGCGCACCACGAGAGGCAGTACCGCTGCCGCGCCTGCCCCTACATCTCCAAGACCACAACGCAAGCCAAACAGCATCAGAGATGGCACAAAGGGGTCACCTATAAATGCCAGTACTGTGACGAAGTGTCCGACAAATGGACGTCGTACCTGAGCCACGTGCGCATAAAGCACCCCTCGGACTTCATCTGCGGCGTGTGCGGCTACTCGTTCGTCAGCAAGCTCGGCCTCACCATGCACAAGACGATGATGCACAAGGACGTCGCGGAACCAAAAGAGACGGAAGGCGACAGCAAACAGTTCCTGGGCCCGTACTGCGCGGAGTGCGACGTGAAGTTTATCTCGGCGGAGGCCTACAAGCGGCACCTGGTCACCTCCGTCAAACACACGCTCTCCAAGAACTTCAACAAGGGCTGTCGTGTGTGCGGCGAGACATTCAACTCGGCGGAGGAGCTGCGGCTGCACCACCGCAAGGAGCACGCCAGGAAGCGGCCCAAGAACTACGGGAAAAAGCCCTCCAACATGACCTGGCCCACCAACTGCGAACAGTGCTCGGAAGAGATAGAGAACGCGCGCGAGTACTGGACCCACTTCCGCCGCTTCCACCCCGACAAGCCCTACCCCATCCAGAAGAACTACGTGTGCGACATATGCGGCAAGAGCTTCCGGGGCAACGCGTTCCTGGTATACCACAAGCGCACGCACTCGGGCGAGCGCGCGTTCCAGTGCACGCAGTGTCCCAAAGCGTTCCACAACCGCACCAACCTGCAGATGCACGAGAAGACGCACTCCGACGCGCGCCCCTACCCCTGCGACGTCTGCTGCAAGGGGTTCAAGTGCAAGGGAGCCCTGGACCGGCACTACCGGAGCCACACCGGCGTCCGCCCGTACGAGTGCGAGGTGTGCGGCAAGGCGTTCGGCCAGTCCAACAGCCGCAAGCTGCATGTCCGCACGGTGCACCTGAAGCTGCCGGCGCCCTACGTCAGCCGCAACCGGCAAGATCGCCGCAAGCAACACGCTCTGTTCTGA
Protein Sequence
MGDLEVCRICLAMEVKMYHLHLDRLNHYYESVMGLNLQNSTDLPLYVCFECAALLKKCSNFRDRCVFGQSVLYTILPSHGKITAQAIQQLDRYQLNLVSHLKPHSITEDNTIFFTHQERKEEGEIKHEPYDDFIIQVDCVKQEEFTENILGLSSDDDEPLSLHKSNKDKQMTEKTEKKKGKRGRKKKEKEVEVKVDEVKDEEDLGIEEADTLPFEAEEPPSPNQDLLQPAKRKRGRPRKTDMPTNPEAKKKKKMRRTTNTGGVADDDVNIEEYCTVVKLTLDQQLEDINKRQHSSNYVNAPFQCDLCFKGFIDTHAWTHHVGKHDPSAGSEQCAVCKFRFPSKRALQKHAAHHERQYRCRACPYISKTTTQAKQHQRWHKGVTYKCQYCDEVSDKWTSYLSHVRIKHPSDFICGVCGYSFVSKLGLTMHKTMMHKDVAEPKETEGDSKQFLGPYCAECDVKFISAEAYKRHLVTSVKHTLSKNFNKGCRVCGETFNSAEELRLHHRKEHARKRPKNYGKKPSNMTWPTNCEQCSEEIENAREYWTHFRRFHPDKPYPIQKNYVCDICGKSFRGNAFLVYHKRTHSGERAFQCTQCPKAFHNRTNLQMHEKTHSDARPYPCDVCCKGFKCKGALDRHYRSHTGVRPYECEVCGKAFGQSNSRKLHVRTVHLKLPAPYVSRNRQDRRKQHALF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-