Carc001870.4
Basic Information
- Insect
- Coenonympha arcania
- Gene Symbol
- USP
- Assembly
- GCA_036785405.1
- Location
- CM072056.1:12541688-12567052[+]
Transcription Factor Domain
- TF Family
- THR-like
- Domain
- zf-C4|THR-like
- PFAM
- AnimalTFDB
- TF Group
- Zinc-Coordinating Group
- Description
- DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. TR interacts with the thyroid response element, which is a DNA site with direct repeats of the consensus sequence 5'-AGGTCA-3' separated by one to five base pairs, upstream of target genes and modulates the rate of transcriptional initiation. Thyroid hormone receptor (TR) mediates the actions of thyroid hormones, which play critical roles in growth, development, and homeostasis in mammals. They regulate overall metabolic rate, cholesterol and triglyceride levels, and heart rate, and affect mood. TRs are expressed from two separate genes (alpha and beta) in human and each gene generates two isoforms of the receptor through differential promoter usage or splicing. TRalpha functions in the heart to regulate heart rate and rhythm and TRbeta is active in the liver and other tissues. The unliganded TRs function as transcription repressors, by binding to thyroid hormone response elements (TRE) predominantly as homodimers, or as heterodimers with retinoid X-receptors (RXR), and being associated with a complex of proteins containing corepressor proteins. Ligand binding promotes corepressor dissociation and binding of a coactivator to activate transcription. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, TR has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [4, 3, 5, 2, 7, 1, 6]
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 18 1.9e-09 2.4e-06 28.0 0.0 13 124 576 700 570 722 0.76 2 18 0.028 36 4.6 0.0 97 124 723 750 702 764 0.82 3 18 0.027 36 4.6 0.0 97 124 773 800 752 814 0.82 4 18 0.027 35 4.7 0.0 97 124 823 850 802 866 0.82 5 18 0.025 33 4.8 0.0 97 124 873 900 851 917 0.81 6 18 0.027 35 4.7 0.0 97 124 923 950 902 966 0.82 7 18 0.027 36 4.6 0.0 97 124 973 1000 952 1014 0.82 8 18 0.023 30 4.9 0.0 97 124 1023 1050 1001 1074 0.81 9 18 0.028 36 4.6 0.0 97 124 1073 1100 1053 1116 0.83 10 18 0.029 38 4.6 0.0 97 124 1123 1150 1103 1164 0.83 11 18 0.024 32 4.8 0.0 97 124 1173 1200 1152 1223 0.82 12 18 0.03 39 4.5 0.0 97 124 1223 1250 1204 1264 0.83 13 18 0.028 36 4.6 0.1 97 124 1273 1300 1252 1314 0.82 14 18 0.025 33 4.8 0.0 97 124 1323 1350 1301 1366 0.81 15 18 0.024 31 4.8 0.0 97 124 1373 1400 1350 1417 0.80 16 18 0.025 32 4.8 0.0 97 124 1423 1450 1403 1475 0.82 17 18 0.027 36 4.6 0.0 97 124 1473 1500 1452 1514 0.82 18 18 0.03 40 4.5 0.0 97 124 1523 1550 1504 1555 0.85
Sequence Information
- Coding Sequence
- ATGAAAATGCTTACTCTGAACTTAAGGAGATTAAAGCTGGAGTACCACAAGGAAGTGTCCTGGGGCCTGTCTTATACCTTCTCTATACATGTGATATTCCAGAACTCGAACATAACACTATCGCTACCTTTGCCGATGACACTGCCATCATCGCTGTGGGGAATACTCATGAAGAGGCAGTGGGAAAGAATGGATTCCAAGAAACAGGAAAAGGAAGAAAGGAAGACAAAGGAGAAGATGGAGAGATATCTTCAATCAAATTGTGGGACCAAACTGGATGACGGGCTGAACTTAGAGGCGGGCTTCATGTCGCCCATGTCGCCGCCGGAGATGAAGCCCGACACGGCCATGCTGGACGGCATGCGGGACGACGCCACGTCTCCGCCGGCGATGAGGAACTACCCGCCGAACCATCCCCTCAGCGGCTCCAAGCACCTCTGCTCCATATGCGGCGACAGGGCGTCGGGGAAGCATTACGGAGTTTATAGGTTAGTCAACATAGAGACGAGCTTCATGTCGCCCATGTCGCCGCCGGAGATGAAGCCCGACACGGCCATGCTGGACGGCATGCGGGACGACGCCACGTCTCCGCCGGCGATGAGGAACTACCCGCCGAACCATCCCCTCAGCGGCTCCAAGCACCTCTGCTCCATATGCGGCGACAGGGCGTCGGGGAAGCATTACGGAGTTTATAGGTTAGTCAACATAGAGACGAGCTTCATGTCGCCCATGTCGCCGCCGGAGATGAAGCCCGACACGGCCATGCTGGACGGCATGCGGGACGACGCCACGTCTCCGCCGGCGATGAGGAACTACCCGCCGAACCATCCCCTCAGCGGCTCCAAGCACCTCTGCTCCATATGCGGCGACAGGGCGTCGGGGAAGCATTACGGAGTTTATAGGTTAGTCAACATAGAGACGAGCTTCATGTCGCCCATGTCGCCGCCGGAGATGAAGCCCGACACGGCCATGCTGGACGGCATGCGGGACGACGCCACGTCTCCGCCGGCGATGAGGAACTACCCGCCGAACCATCCCCTCAGCGGCTCCAAGCACCTCTGCTCCATATGCGGCGACAGGGCGTCGGGGAAGCATTACGGAGTTTATAGTTGCGAAGGCTGCAAGGGTTTCTTCAAGCGGACCGTGAGGAAGGACCTCACGTACGCGTGTCGTGAGGAGAGGAATTGCATAATCGACAAGCGACAGCGGAACCGATGCCAGTACTGTCGATATCAGAAGTGCCTCGCGTGCGGCATGAAGCGCGAGGCCGTGCAGGAGGAgcggcagcgggcggcgcgcggcgcggaggATGCTCATCCCAGCAGTTCTGTTCAGGAGCTGTCGATCGAGCGGCTGCTGGAGATGGAGTCGCTGGTGGCGGACCCCAGCGAGGAGTTCCAGTTCCTGCGCGTGGGGCCCGACAGCAACGTgcccgcgcggtaccgcgcgccCGTCTCCAGCCTGTGCCAGATAGGTAACGTGCCGCGACCTGGAGCGCTTTATGTATCGAAGCAGAGCGAGGAGTTCCAGTTCCTGCGCGTGGGGCCCGACAGCAACATgcccgcgcggtaccgcgcgccCGTCTCCAGCCTGTGCCAGATAGGTAACGTGCCGCGACCTGGAGCGCTTAATGTATCGAAGCAGAGCGAGGAGTTCCAGTTCCTGCGCGTGGGGCCCGACAGCAACGTgcccgcgcggtaccgcgcgccCGTCTCCAGCCTGTGCCAGATAGGCAACAAGCAGATCGCGGCGCTGGTGGTGTGGGCGCGCGACATCCCCCACTTCAGCCAGCTGGAGCTCGACGACCAGGTGGTGCTCATCAAGGCGTCCTGGAACGAGCTGCTGCTCTTCGCCATCGCCTGGCGCTCCATGGAGTACCTGGAAGATGAGCGGGAGAACATGGACGGCACGcgaagcgccgcgccgccgcagctcATGTGTCTAATGCCTGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGTAACACTCGGCAGGCATGA
- Protein Sequence
- MKMLTLNLRRLKLEYHKEVSWGLSYTFSIHVIFQNSNITLSLPLPMTLPSSLWGILMKRQWERMDSKKQEKEERKTKEKMERYLQSNCGTKLDDGLNLEAGFMSPMSPPEMKPDTAMLDGMRDDATSPPAMRNYPPNHPLSGSKHLCSICGDRASGKHYGVYRLVNIETSFMSPMSPPEMKPDTAMLDGMRDDATSPPAMRNYPPNHPLSGSKHLCSICGDRASGKHYGVYRLVNIETSFMSPMSPPEMKPDTAMLDGMRDDATSPPAMRNYPPNHPLSGSKHLCSICGDRASGKHYGVYRLVNIETSFMSPMSPPEMKPDTAMLDGMRDDATSPPAMRNYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACREERNCIIDKRQRNRCQYCRYQKCLACGMKREAVQEERQRAARGAEDAHPSSSVQELSIERLLEMESLVADPSEEFQFLRVGPDSNVPARYRAPVSSLCQIGNVPRPGALYVSKQSEEFQFLRVGPDSNMPARYRAPVSSLCQIGNVPRPGALNVSKQSEEFQFLRVGPDSNVPARYRAPVSSLCQIGNKQIAALVVWARDIPHFSQLELDDQVVLIKASWNELLLFAIAWRSMEYLEDERENMDGTRSAAPPQLMCLMPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGNTRQA
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00353122;
- 90% Identity
- iTF_00353122;
- 80% Identity
- iTF_00353122;