Basic Information

Transcription Factor Domain

TF Family: THAP
Domain: THAP domain
PFAM: PF05485
TF Group: Zinc-Coordinating Group
Description: The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 1e-16 2.9e-14 54.4 5.8 1 86 4 84 4 85 0.88

2 8 3.1 8.6e+02 1.6 0.0 71 86 96 111 90 112 0.82

3 8 7e-06 0.002 19.7 0.1 51 86 119 149 112 150 0.82

4 8 3.1 8.6e+02 1.6 0.0 71 86 161 176 155 177 0.82

5 8 2.9 8.3e+02 1.7 0.0 71 86 188 203 181 204 0.82

6 8 2.9 8.3e+02 1.7 0.0 71 86 215 230 208 231 0.82

7 8 2.9 8.3e+02 1.7 0.0 71 86 242 257 235 258 0.82

8 8 2.2 6.3e+02 2.1 0.0 69 86 267 284 262 285 0.82

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	1e-16	2.9e-14	54.4	5.8	1	86	4	84	4	85	0.88
2	8	3.1	8.6e+02	1.6	0.0	71	86	96	111	90	112	0.82
3	8	7e-06	0.002	19.7	0.1	51	86	119	149	112	150	0.82
4	8	3.1	8.6e+02	1.6	0.0	71	86	161	176	155	177	0.82
5	8	2.9	8.3e+02	1.7	0.0	71	86	188	203	181	204	0.82
6	8	2.9	8.3e+02	1.7	0.0	71	86	215	230	208	231	0.82
7	8	2.9	8.3e+02	1.7	0.0	71	86	242	257	235	258	0.82
8	8	2.2	6.3e+02	2.1	0.0	69	86	267	284	262	285	0.82

Coding Sequence: ATGCCAAACTGTTCTGTGGCTTGTTGCAAAAAAAGATCCCAATCTTCGAGTTTGAAAAGAGGCGGGATCAGCTATCATACGTTCCCCAAGAACCCGCACCTGTGGGAGATCTGGAAGAAGTTCTGCAACAACAAGCGCACCTGGACACCGACGCGCAGCAGCGTCATCTGCTCCGAACACTTCTCCCCCAAGGACTTCCGCGTGCTCAAGGAGAACCGGCGCAGGCTGCTCAAGACCTCCGTGCCCAGCCTGGTGCCCGCCTGCATATGCCCGGACTTCCGCGTGCTCAAGGAGAACCGGCGCAGGCTGCTCAAGACCTCCGTGCCCAGCCTGGTGCCCGCGCCTGCATATGACCGCGTCATCTGCTCCGAACACTTCTCCCCCAAGGACTTCCGCGTGCTCAAGGAGAACCGGCGCAGGCTGCTCAAGACCTCCGTGCCCAGCCTGGTGCCCGCCTGCATATGCCCGGACTTCCGCGTGCTCAAGGAGAACCGGCGCAGGCTGCTCAAGACCTCCGTGCCCAGCCTGGTGCCCGCCTGCATATGCCCGGACTTCCGCGTGCTCAAGGAGAACCGGCGCAGGCTGCTCAAGACCTCCGTGCCCAGCCTGGTGCCCGCCTGCATATGCCCGGACTTCCGCGTGCTCAAGGAGAACCGGCGCAGGCTGCTCAAGACCTCCGTGCCCAGCCTGGTGCCCGCCTGCATATGCCCGGACTTCCGCGTGCTCAAGGAGAACCGGCGCAGGCTGCTCAAGACCTCCGTGCCCAGCCTGGTGCCCGCCTGCATATGCCCGGACTTCTGCGTGCTCAAGGAGAACCGGCGCAGGCTGCTCAAGACCTCCGTGCCCAGCCTGGTGCCCGCCTGCATATGCCCGGTAcacagccgtagccatatgacattatctgcgtag
Protein Sequence: MPNCSVACCKKRSQSSSLKRGGISYHTFPKNPHLWEIWKKFCNNKRTWTPTRSSVICSEHFSPKDFRVLKENRRRLLKTSVPSLVPACICPDFRVLKENRRRLLKTSVPSLVPAPAYDRVICSEHFSPKDFRVLKENRRRLLKTSVPSLVPACICPDFRVLKENRRRLLKTSVPSLVPACICPDFRVLKENRRRLLKTSVPSLVPACICPDFRVLKENRRRLLKTSVPSLVPACICPDFRVLKENRRRLLKTSVPSLVPACICPDFCVLKENRRRLLKTSVPSLVPACICPVHSRSHMTLSA

Sequence clustering based on sequence similarity using MMseqs2