Basic Information

Gene Symbol
USP_2
Assembly
GCA_036785405.1
Location
CM072056.1:12541688-12567052[+]

Transcription Factor Domain

TF Family
RXR-like
Domain
zf-C4|RXR-like
PFAM
AnimalTFDB
TF Group
Zinc-Coordinating Group
Description
DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. RXR functions as a DNA binding partner by forming heterodimers with other nuclear receptors including CAR, FXR, LXR, PPAR, PXR, RAR, TR, and VDR. All RXR heterodimers preferentially bind response elements composed of direct repeats of two AGGTCA sites with a 1-5 bp spacer. RXRs can play different roles in these heterodimers. RXR acts either as a structural component of the heterodimer complex, required for DNA binding but not acting as a receptor, or as both a structural and a functional component of the heterodimer, allowing 9-cis RA to signal through the corresponding heterodimer. In addition, RXR can also form homodimers, functioning as a receptor for 9-cis RA, independently of other nuclear receptors. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, RXR has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [cite:PUB00121610], [cite:PUB00121611], [cite:PUB00121612], [cite:PUB00025660], [cite:PUB00121613], [cite:PUB00092048], [cite:PUB00092725], [cite:PUB00092726], [cite:PUB00016724], [cite:PUB00059514PMID:18971932
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 2.5e-32 5.4e-29 102.3 0.2 1 115 574 700 574 704 0.96
2 18 1e-11 2.2e-08 35.0 0.0 59 115 697 750 697 753 0.95
3 18 4.1e-12 8.9e-09 36.3 0.0 58 115 746 800 746 803 0.96
4 18 4.1e-12 8.9e-09 36.3 0.0 58 115 796 850 796 853 0.96
5 18 4.1e-12 8.9e-09 36.3 0.0 58 115 846 900 846 903 0.96
6 18 4.1e-12 8.9e-09 36.3 0.0 58 115 896 950 896 953 0.96
7 18 4.1e-12 8.9e-09 36.3 0.0 58 115 946 1000 946 1003 0.96
8 18 4.1e-12 8.9e-09 36.3 0.0 58 115 996 1050 996 1053 0.96
9 18 4.1e-12 8.9e-09 36.3 0.0 58 115 1046 1100 1046 1103 0.96
10 18 3.9e-12 8.5e-09 36.4 0.0 58 115 1096 1150 1096 1154 0.96
11 18 4.1e-12 8.9e-09 36.3 0.0 58 115 1146 1200 1146 1203 0.96
12 18 4.1e-12 8.9e-09 36.3 0.0 58 115 1196 1250 1196 1253 0.96
13 18 4.5e-12 9.9e-09 36.1 0.0 58 115 1246 1300 1246 1302 0.96
14 18 1e-11 2.2e-08 35.0 0.0 59 115 1297 1350 1297 1353 0.95
15 18 1e-11 2.2e-08 35.0 0.0 59 115 1347 1400 1347 1403 0.95
16 18 4.5e-12 9.9e-09 36.1 0.0 58 115 1396 1450 1396 1452 0.96
17 18 4.1e-12 8.9e-09 36.3 0.0 58 115 1446 1500 1446 1503 0.96
18 18 9.3e-12 2e-08 35.1 0.0 59 115 1497 1550 1497 1555 0.95

Sequence Information

Coding Sequence
ATGAAAATGCTTACTCTGAACTTAAGGAGATTAAAGCTGGAGTACCACAAGGAAGTGTCCTGGGGCCTGTCTTATACCTTCTCTATACATGTGATATTCCAGAACTCGAACATAACACTATCGCTACCTTTGCCGATGACACTGCCATCATCGCTGTGGGGAATACTCATGAAGAGGCAGTGGGAAAGAATGGATTCCAAGAAACAGGAAAAGGAAGAAAGGAAGACAAAGGAGAAGATGGAGAGATATCTTCAATCAAATTGTGGGACCAAACTGGATGACGGGCTGAACTTAGAGGCGGGCTTCATGTCGCCCATGTCGCCGCCGGAGATGAAGCCCGACACGGCCATGCTGGACGGCATGCGGGACGACGCCACGTCTCCGCCGGCGATGAGGAACTACCCGCCGAACCATCCCCTCAGCGGCTCCAAGCACCTCTGCTCCATATGCGGCGACAGGGCGTCGGGGAAGCATTACGGAGTTTATAGGTTAGTCAACATAGAGACGAGCTTCATGTCGCCCATGTCGCCGCCGGAGATGAAGCCCGACACGGCCATGCTGGACGGCATGCGGGACGACGCCACGTCTCCGCCGGCGATGAGGAACTACCCGCCGAACCATCCCCTCAGCGGCTCCAAGCACCTCTGCTCCATATGCGGCGACAGGGCGTCGGGGAAGCATTACGGAGTTTATAGGTTAGTCAACATAGAGACGAGCTTCATGTCGCCCATGTCGCCGCCGGAGATGAAGCCCGACACGGCCATGCTGGACGGCATGCGGGACGACGCCACGTCTCCGCCGGCGATGAGGAACTACCCGCCGAACCATCCCCTCAGCGGCTCCAAGCACCTCTGCTCCATATGCGGCGACAGGGCGTCGGGGAAGCATTACGGAGTTTATAGGTTAGTCAACATAGAGACGAGCTTCATGTCGCCCATGTCGCCGCCGGAGATGAAGCCCGACACGGCCATGCTGGACGGCATGCGGGACGACGCCACGTCTCCGCCGGCGATGAGGAACTACCCGCCGAACCATCCCCTCAGCGGCTCCAAGCACCTCTGCTCCATATGCGGCGACAGGGCGTCGGGGAAGCATTACGGAGTTTATAGTTGCGAAGGCTGCAAGGGTTTCTTCAAGCGGACCGTGAGGAAGGACCTCACGTACGCGTGTCGTGAGGAGAGGAATTGCATAATCGACAAGCGACAGCGGAACCGATGCCAGTACTGTCGATATCAGAAGTGCCTCGCGTGCGGCATGAAGCGCGAGGCCGTGCAGGAGGAgcggcagcgggcggcgcgcggcgcggaggATGCTCATCCCAGCAGTTCTGTTCAGGAGCTGTCGATCGAGCGGCTGCTGGAGATGGAGTCGCTGGTGGCGGACCCCAGCGAGGAGTTCCAGTTCCTGCGCGTGGGGCCCGACAGCAACGTgcccgcgcggtaccgcgcgccCGTCTCCAGCCTGTGCCAGATAGGTAACGTGCCGCGACCTGGAGCGCTTTATGTATCGAAGCAGAGCGAGGAGTTCCAGTTCCTGCGCGTGGGGCCCGACAGCAACATgcccgcgcggtaccgcgcgccCGTCTCCAGCCTGTGCCAGATAGGTAACGTGCCGCGACCTGGAGCGCTTAATGTATCGAAGCAGAGCGAGGAGTTCCAGTTCCTGCGCGTGGGGCCCGACAGCAACGTgcccgcgcggtaccgcgcgccCGTCTCCAGCCTGTGCCAGATAGGCAACAAGCAGATCGCGGCGCTGGTGGTGTGGGCGCGCGACATCCCCCACTTCAGCCAGCTGGAGCTCGACGACCAGGTGGTGCTCATCAAGGCGTCCTGGAACGAGCTGCTGCTCTTCGCCATCGCCTGGCGCTCCATGGAGTACCTGGAAGATGAGCGGGAGAACATGGACGGCACGcgaagcgccgcgccgccgcagctcATGTGTCTAATGCCTGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGCATGACGCTGCACCGCAACTCGGCGCTGCAGGCGGGCGTGGGGCAGATCTTCGACCGCGTGCTGTCGGAGCTGTCGCTCAAGATGCGCGCGCTGCGCATGGACCAGGCCGAGTACGTCGCGCTCAAGGCCATCATCCTGCTCAACCCAGGTAACACTCGGCAGGCATGA
Protein Sequence
MKMLTLNLRRLKLEYHKEVSWGLSYTFSIHVIFQNSNITLSLPLPMTLPSSLWGILMKRQWERMDSKKQEKEERKTKEKMERYLQSNCGTKLDDGLNLEAGFMSPMSPPEMKPDTAMLDGMRDDATSPPAMRNYPPNHPLSGSKHLCSICGDRASGKHYGVYRLVNIETSFMSPMSPPEMKPDTAMLDGMRDDATSPPAMRNYPPNHPLSGSKHLCSICGDRASGKHYGVYRLVNIETSFMSPMSPPEMKPDTAMLDGMRDDATSPPAMRNYPPNHPLSGSKHLCSICGDRASGKHYGVYRLVNIETSFMSPMSPPEMKPDTAMLDGMRDDATSPPAMRNYPPNHPLSGSKHLCSICGDRASGKHYGVYSCEGCKGFFKRTVRKDLTYACREERNCIIDKRQRNRCQYCRYQKCLACGMKREAVQEERQRAARGAEDAHPSSSVQELSIERLLEMESLVADPSEEFQFLRVGPDSNVPARYRAPVSSLCQIGNVPRPGALYVSKQSEEFQFLRVGPDSNMPARYRAPVSSLCQIGNVPRPGALNVSKQSEEFQFLRVGPDSNVPARYRAPVSSLCQIGNKQIAALVVWARDIPHFSQLELDDQVVLIKASWNELLLFAIAWRSMEYLEDERENMDGTRSAAPPQLMCLMPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGMTLHRNSALQAGVGQIFDRVLSELSLKMRALRMDQAEYVALKAIILLNPGNTRQA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00353122;
90% Identity
iTF_00353122;
80% Identity
iTF_00353122;