Basic Information

Gene Symbol
ZFX
Assembly
GCA_907165205.1
Location
OU015573.1:52785264-52790146[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 3.5e-07 5.9e-05 24.5 2.4 1 23 11 33 11 33 0.98
2 11 1e-05 0.0017 19.9 0.2 1 20 39 58 39 59 0.96
3 11 5.2e-06 0.00088 20.8 0.5 1 23 72 94 72 94 0.98
4 11 1.5e-06 0.00025 22.5 0.3 1 23 100 122 100 122 0.98
5 11 5.7e-08 9.7e-06 27.0 1.4 1 23 128 150 128 150 0.98
6 11 0.00038 0.064 14.9 2.7 1 21 156 176 156 179 0.95
7 11 0.18 30 6.5 2.3 1 23 185 205 185 205 0.96
8 11 3.4e-06 0.00057 21.4 0.6 3 23 213 233 212 233 0.99
9 11 0.0012 0.21 13.3 1.8 1 19 239 257 239 259 0.97
10 11 0.00056 0.095 14.4 3.7 1 21 267 287 267 290 0.94
11 11 2.5 4.2e+02 2.9 1.1 1 22 296 317 296 317 0.92

Sequence Information

Coding Sequence
ATGACGTTTTCCAAAGAAAAAGCTCGCAACCACGAGTGCGAAATATGCAAGAAGAAATTTTCAACCAAGACCGACCTCATCAAACATGTCAGGATACACACTAACGAACGACCGTTCACTTGTAAATTCTGCGGTCAGGCTTTCAGACAGGCTGGTTCCCTGAAGAATCACATCGCCTGTCGACACTCTACGACACTGCAGAGTTCGGAAATTTTCATTTGCAGCTATTGCGGAAAATCCTTTCCTATAAAGGAAAGGCTGAAATTGCACCTTAGGATTCATACCGGTCTGAAGCCGTACGCTTGTAAGCTGTGCCCGAAGACCTTCGCTCGTGGTGGTCAGTTGGTGCAACATCAGAGAACACACGACGGCTCCAGACCGTTCGTATGTAGGATTTGCGACACAACATTCACCACATCGGCAAATCTGCGGTCGCACATGAAACGGCATTTGGAAATCCGTGATTACATTTGCGACCTATGCGGCAAGTTGTTCTTCAGGAGAGACGCCCTAAGGAAACATTTAAACTGTTACCACGCCAATTTGAAGGCCTATTATTGCGAGATTTGCAAGAAGGAATTGAAAGGCCACTTACCACAACACATGAGAACCCACGCCAAAGATAAACCACATGGTTGTGCCCATTGCGGGGCCAGGTTTGCACAAAGATCTCAACTAACCGTACACCAAAGAGTCCATTCCGGCGAAAAGCCGTACAGGTGTCAAGTGTGCTGGAAAGCTTTCGCTCATTCTACAGCGCTCAAGCTGCACTGCCGTTGCCACACCGGGGAAAAACCTTTCGCTTGCAAATTGTGCAATAATTCCTTCTCGCAACTACCTCACCTGAAAAAACACATGCTGTGCGTGCACAAATCCAGCAAACCGTACGTTTGCGGAAACTGCAAGAGCTTTCATAAAACGAAAAAGGAACTCGAGTTACACGCTAAAACGTGTCAGTCGAACGAGGATAAACCGGAGGTTGTCGCTAAAAAAGAGGTTGAAGTACTGAAAATCGGGGCAGCTATGCCAATTGGGAAAATGAGATTTCTGCTTGCCATTTTAATCAAGAAGATTTCATCGGCTGAAAGACTGAAGGAAATAGGATTCAATAAGAGGCTGATCGATGATGTTTTGATTGATTCCATCAAGATGTCCGGAAGGGTTCCTTGTCAAGATTGCACTCTGACTCCTGCCGAACAGTTAAAGCTCAACGTGCAGATTCTGTTAGAATGGACTGTTCCAAAGAAATACATGGAAAAGTTCAAACTGGAACAGCGTTCTACGGAAGAACTGTTGGAAGAGTTGACTTCCTAA
Protein Sequence
MTFSKEKARNHECEICKKKFSTKTDLIKHVRIHTNERPFTCKFCGQAFRQAGSLKNHIACRHSTTLQSSEIFICSYCGKSFPIKERLKLHLRIHTGLKPYACKLCPKTFARGGQLVQHQRTHDGSRPFVCRICDTTFTTSANLRSHMKRHLEIRDYICDLCGKLFFRRDALRKHLNCYHANLKAYYCEICKKELKGHLPQHMRTHAKDKPHGCAHCGARFAQRSQLTVHQRVHSGEKPYRCQVCWKAFAHSTALKLHCRCHTGEKPFACKLCNNSFSQLPHLKKHMLCVHKSSKPYVCGNCKSFHKTKKELELHAKTCQSNEDKPEVVAKKEVEVLKIGAAMPIGKMRFLLAILIKKISSAERLKEIGFNKRLIDDVLIDSIKMSGRVPCQDCTLTPAEQLKLNVQILLEWTVPKKYMEKFKLEQRSTEELLEELTS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00130758;
90% Identity
iTF_00130758;
80% Identity
-