Basic Information

Gene Symbol
-
Assembly
GCA_014851415.1
Location
Chr27:5742251-5748187[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.0032 0.21 12.0 3.4 1 23 200 223 200 223 0.98
2 10 0.00055 0.036 14.3 0.2 1 23 244 266 244 266 0.98
3 10 0.00033 0.021 15.1 0.1 1 23 272 294 272 294 0.97
4 10 0.18 12 6.5 0.6 3 23 301 322 300 322 0.94
5 10 6e-05 0.004 17.4 0.7 1 23 328 350 328 350 0.99
6 10 0.0067 0.44 10.9 0.3 1 23 356 379 356 379 0.95
7 10 0.0011 0.071 13.4 2.5 1 23 388 410 388 410 0.98
8 10 0.00077 0.05 13.9 1.3 1 23 416 438 416 438 0.95
9 10 2.7e-06 0.00018 21.6 2.9 1 23 444 466 444 466 0.98
10 10 0.024 1.5 9.2 1.4 1 16 472 487 472 489 0.87

Sequence Information

Coding Sequence
ATGACTGAAAATGATAACCGCGGTATCTGTCGACTGTGTCTACTTGTTGAATCTCAAAATATGCACTCATTGACCGATCATCCGGAGATTTTGCGAAAAATACAGGAATGTTTTTCTATTAATATTGTCATAGAAGACTCATATCCAAAACAAATCTGCGGAGACTGTAAAATAAAAATCGAAGATATTCATGACTACCACTGTAAAGTGAATGCAATTGAAAAACTTCTCAAACATTATGCAATTATGGGGCAGAATTACTTAAACCAATTCTATTTGAGTTTAAAAATACCAGAGGTAAAAGTTAAAGAAGAAAATGAAAGTGTAGGTAGTTCTGGTAAAAGGAAAGAGACTTTAAAAGAAGAGAGCAAAGGATTGGAACCAAATCATAATGTTAGTAATGTAAAATCAAATATTTGTTCCAAAAATGAAATTAAGGTCAAAGCATTGGAATGTCCTGATAATCATGATGATGGAGAATGTTATTCACCAATAGAGACACTAAATACTGAGTCAAACACTATTAATTCTCACGATAGCAAAACCGTAAACAAACCTGACAAAGAAATATTTACAAACGAAGAAGACCTTCCAAAATTCAAATGCCTTACTTGTTTCAAAGTATGCGATGATAAGAAACTCCTGCTTTCCCACTATAACACTATACACAAGCCGATAGAAAAGACTAAAGCGGACTTCGTAATGCTGGAGATTGATGGTAATGTTACATACAAATGTAAAGTTTGTGAGAAAGTGTCAGTGAGAAGAATAGCTGCAATGTCGCATATGCGAGAGCATAATGTAGGAAGACCCTTTACATGTAAAGTATGCGGTAGAACATACCAAACAGCAGCAGAGATTGTCCGGCACGGCCGTGCTCATGACGGGTCCAAAATGTTCTGCAGCCACAACTGCGGGTACAGCACAGCGTACATGGGAGCCCTCATTGAGCATGAGAAGAGGCACAGCGGGGACCATAAGTATAAATGCGAGCAGTGCGGGAAAGGTTTCCAAGTGAAGACCTGGTATCTTCAGCACCAGAACATACATAAAGGTTTGAAGCCGTTCGTATGTGATATTTGCGGGGTCGCGTTCCATATGGACAGGTACCTAACAGCGCACAAGAGCTCTGTACACCCGCAGTCGTCGCATGTGAAGCGATACGTCTGTCCGCACTGCTCGCTGCCCTGCGACTCCAGGAAAACATTAACTGATCATTTGAAGGAGCATGGGATCAGAAGCAGTTTCCTCTGTGATCTATGCGGCAAGACTCTCTCCAATTCCGAACAGCTCAAGTTTCACAAGAGAATGCATCTTGGAGTCAAGCCGTTCTCATGCAGCACATGTAACAAGTCATTCGCAAAGAAGTTTAACCTTCAACTTCATGAACGAACCCACAGCGGGGAGAAGTCTCACGCATGCGCGCTGTGCGGCAAGTGTTACACACAGCGGAGCAACACTCAGAAACAAAACAGCACCACTGTACTAGGTGCACCAAGACATTCTCGTCATCAAGCCAATTGA
Protein Sequence
MTENDNRGICRLCLLVESQNMHSLTDHPEILRKIQECFSINIVIEDSYPKQICGDCKIKIEDIHDYHCKVNAIEKLLKHYAIMGQNYLNQFYLSLKIPEVKVKEENESVGSSGKRKETLKEESKGLEPNHNVSNVKSNICSKNEIKVKALECPDNHDDGECYSPIETLNTESNTINSHDSKTVNKPDKEIFTNEEDLPKFKCLTCFKVCDDKKLLLSHYNTIHKPIEKTKADFVMLEIDGNVTYKCKVCEKVSVRRIAAMSHMREHNVGRPFTCKVCGRTYQTAAEIVRHGRAHDGSKMFCSHNCGYSTAYMGALIEHEKRHSGDHKYKCEQCGKGFQVKTWYLQHQNIHKGLKPFVCDICGVAFHMDRYLTAHKSSVHPQSSHVKRYVCPHCSLPCDSRKTLTDHLKEHGIRSSFLCDLCGKTLSNSEQLKFHKRMHLGVKPFSCSTCNKSFAKKFNLQLHERTHSGEKSHACALCGKCYTQRSNTQKQNSTTVLGAPRHSRHQAN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-