Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 5.7 4.2e+02 2.0 0.1 6 23 98 116 96 116 0.85

2 6 3.3e-07 2.4e-05 24.7 1.8 1 23 154 176 154 176 0.95

3 6 0.00038 0.028 15.1 1.6 1 23 182 207 182 207 0.97

4 6 0.33 25 5.8 1.0 1 23 213 235 213 235 0.82

5 6 1.7e-05 0.0012 19.4 0.1 3 20 243 260 241 262 0.95

6 6 0.00011 0.0078 16.8 0.6 1 23 277 300 277 300 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	5.7	4.2e+02	2.0	0.1	6	23	98	116	96	116	0.85
2	6	3.3e-07	2.4e-05	24.7	1.8	1	23	154	176	154	176	0.95
3	6	0.00038	0.028	15.1	1.6	1	23	182	207	182	207	0.97
4	6	0.33	25	5.8	1.0	1	23	213	235	213	235	0.82
5	6	1.7e-05	0.0012	19.4	0.1	3	20	243	260	241	262	0.95
6	6	0.00011	0.0078	16.8	0.6	1	23	277	300	277	300	0.95

Coding Sequence: ATGCCTTTCGTGGCGTATTTGAGCCTTACAAGCGACTATGCAGCCATTTTAAGGAAAAATAGTCGAGGTATGGTCACAAAACACAAGAATAGAATAAATCTAAACGTTTTGATTTTAGAAGAAGTTTCTGATACTGAAGAATTTGctcaagaaattaaaagaatgaagttGGATAATACAGGAAAGAACAATgAGAAGAATGATCAAGTTGAAGTATCATTTATGAAAGATGTTGAAACTGTGCCTGAACGTAATTTAATCATCAATGATTACCTGAAACAAGTTCAATTATGTGCATCGACATTTAAAACGGCACCAGAGCTTGTTGAACATTTCAATGCAAAGCATAATAAACAACCAAAACCTGGTGAAGTTCCTTCAACTTCTGATCGTATTCCCAGAAAAGCTGATGAACAACGAAAAGGTGGCGTTCATCAAACATCTACAAAATCTCGTCAATATCTTTGCGAAGTTTGTGGTAAATCATACACACAATCTTCTCATTTGTGGCAACATTTAAGATTCCATCAAGGTGTGAAACCATTTGAATGTTCTTATGAAGGTTGTAATCGTCGATTTACAATCCGACCTGATCTAAACGACCACATCCGAAAATGTCACACTGGTGAACGACCTTTTTTGTGCACCACTTGTGATAAACGTTTTTTGACCGGATCTGTTTATTACCAACATCGATTGATTCATCGTAATGAACGTCGTTATGGATGTGAAGAATGTGGAAGACGATTTTATCGTGCAGATGCTTTAAAAAATCACATgTCTTTTAATTTGGcatttttaaagcttattCATACTGGTACGAAACCTTATACTTGCGCTGAATGTGGCAGAATGTTTCGTCAACGTGGAGATCGCGATAAACACCTTAAAGCACGTCATCCACATGCTGGAGCTGCAAACTCACCAAAGAAAGAACGAATCAAATCATTTGGTCGTGGAAGAACAAAAGACAACACGAGTTTGTATGAAGCGAAACCAGATTTTTCTTTGtag
Protein Sequence: MPFVAYLSLTSDYAAILRKNSRGMVTKHKNRINLNVLILEEVSDTEEFAQEIKRMKLDNTGKNNEKNDQVEVSFMKDVETVPERNLIINDYLKQVQLCASTFKTAPELVEHFNAKHNKQPKPGEVPSTSDRIPRKADEQRKGGVHQTSTKSRQYLCEVCGKSYTQSSHLWQHLRFHQGVKPFECSYEGCNRRFTIRPDLNDHIRKCHTGERPFLCTTCDKRFLTGSVYYQHRLIHRNERRYGCEECGRRFYRADALKNHMSFNLAFLKLIHTGTKPYTCAECGRMFRQRGDRDKHLKARHPHAGAANSPKKERIKSFGRGRTKDNTSLYEAKPDFSL

Sequence clustering based on sequence similarity using MMseqs2