Basic Information

Gene Symbol
zfh1
Assembly
GCA_900005825.1
Location
CVRI01000066.1:1467520-1482093[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.0017 0.13 13.1 1.4 3 23 45 66 43 66 0.94
2 9 0.032 2.4 9.0 0.1 2 23 125 149 124 149 0.91
3 9 0.0012 0.088 13.5 4.4 3 23 158 178 156 178 0.95
4 9 2e-06 0.00015 22.3 6.3 1 23 187 209 187 209 0.99
5 9 0.00012 0.0089 16.7 0.7 3 21 217 235 215 236 0.94
6 9 0.014 1.1 10.1 0.6 2 17 457 472 456 477 0.81
7 9 8.1e-06 0.0006 20.4 0.9 1 23 757 779 757 779 0.94
8 9 4.8e-05 0.0036 17.9 8.2 1 23 785 807 785 807 0.98
9 9 0.0025 0.18 12.5 3.5 1 21 813 833 813 834 0.96

Sequence Information

Coding Sequence
ATGTTGTCCTGTCTGGTGCCTCGTTTTGGACAAGAAGATATGCCGTCATCAACAAAATTTGACATACAATTTCAGCCATTGGCGATTGCACGTAATGACGACGACTCTTcacatcaaaatgaatttattaactGCACTCATTGTCAACTTGAGTTCTCTAACTTTCAATCGTTAAAAGATCATATAATGCAAGTACACCAACCAACATCCGAAGCACCGAATATGTCAATAAATGGAATGACACaccaacagcaacaacatttCTCACCACCACCTTCGTTACTATCGCCTGGACAATTCTCATACAATGTAACTACAGGTGTAAACGAAGGTGGGCGTCAATCGAACAGTCCAAATAATTTGAATACTCACGCATGCTCTTACAATCAGTGCTCCGCCTCATTCCCAACATTAGAATTATTAGAGAAGCACGAAATGATCCAACATTCATCAGGTGCTACAAATGTGtgtTGTCGATTGTGTCACAAAACATTTGCAAATGTTTATCGACTACAACGTCATATGATTTCACATGATGAATCAGCGTTattaaggaaatttaaatgcaCCGATTGTGATAAGGCTTTCAAGTTTAAGCATCATTTAAAGGAACATCTTCGTATTCACAGCGGAGAGAAACCTTTTGGATGTCCAAATTGTGGCAAACGATTCTCACATTCGGGATCATATTCCAGTCACATGACCTCTAAGAAATGCATCAGTATGGGATTAAAAATGAACGGTGGTGCAGGAATGGCGCCAAATGGTAACAACATTATGATGAATGGTTcgaaaatgaaatcagaaaagaaacaacaacttTCGATGGCATCGACATTAAATCAATCACATTTGTCGAATGCAGGAAAGTTCTTAAgcaattcaaattcttttcttccaaTGCTTCCAAACATCCCAAAATATGAGGGTTACGATGTGATGAATGCAGCATTTCTTGCAACGCTTTCGCATCCATTCTACTCAATGGGATTAAATCCAAATCTTAATCCTTATCACATTCAAAACTTACTCAAACTCACCGGTGTTCACAATCTTAATCCACCGATGGATGAAGAGAAGACAAATGAAGAACATAAAAGTCCAAATCAACATTCTAATCCCGaagatttaattgaagaagTGAATGAGAATGACGAATCTAAACTTGTCATGGATTTAAAggacgaagaagaaaaaattgcgaagattcaaagagaaaagtttgatgatggaaatgatgatgaagacaaTGATGATCCGATGaataatgaagaaactttattaACACATGAATCACGTGAAAAATCTCAATCACCGATTATTAAACAAGAACatcaaaattttgatgattcgGGGAACGACTCACTACGCTGTCAGCATTgtgataaagttttcaatcatCCGGCTGAACATTTGCAACATGAGAAGATTTTGTGTAATGcgatgttgatgaaaaatcatGAAGGAATCATGGCTCATATGAATGAGTCACTGAATTCATCAAATAATAATGGTTGCAGTGAAGATGATAACGATGATCGTGACTCAAAAATTTCCACAGAATCTGATCGTAAAGTTCGAGTTCGGACAGCAATTTCCGATGAACAGCAAGcaattttgaaagaattctATGCGATTAATGCACGACCAAATCGTGATGATTTCAGGAACATTGCACAACGATTGATGTTGGATCCACGTGTTGTTCAGGTTTGGTTTCAAAACAATCGATCGCGTGAAAGAAAACAGAATGGAAATCGCGATTGTCAGTTTAAAGTGAGTGATGAACAGCCTTTAGATTTATCGATGAAGAAAGAGATGAAAACGGAAACGCCAACAACTTCACCACGTTACGGAATTGTTCCTCATCAACATTCTTCCGAAGATGATCAAGTTCTTAATTTGAGTCGTAAAATGACGCCATTCTCACCAATCTTCCAACCAACTTACAACGCTGATTTCTTGACGCGACAAATTCCATCACCAAACGAGGCTGTGCCTCGAATGACAAACATTCGCAACGGGTACCATTTGCCACTTGGCTTACCACTCGAACGTCTGCTTCAATTTACACCAGAAATGATTATGATGAAACAAGATCAACGTGGAAATAGTTTGAGTCCCGGAAGTTCTGAAAAGCGTTCATggaaagatgaagaaagtcGTTCTTTCGACGAAGCCTTGAATCAATCACACCAACATTATCAAACACAACGCCGAATGCCTAAAATGAAATCGGAAATTCCACCCGATTCTGATGAATTCAATTTCGTTTGTGATCTTTGTGATAAGGCTTTTCGAAAGCAGAGTTCATTGGCTCGTCATAAATATGAACATTCTGGTCAGCGACCATTCAAATGCACCGAGTGCCCCAAAGCCTTTAAGCATCGTCATCACCTTaCTGAACACAAACGTTTACACTCAGGTGAAAAGCCTTTCCAATGCGGCAAATGCTTAAAACGATTCTCTCATTCCGGCTCATACAGTCAGCACATGAACCACAGGTATAGTTATTGCAAACCTTATCGAGATTAG
Protein Sequence
MLSCLVPRFGQEDMPSSTKFDIQFQPLAIARNDDDSSHQNEFINCTHCQLEFSNFQSLKDHIMQVHQPTSEAPNMSINGMTHQQQQHFSPPPSLLSPGQFSYNVTTGVNEGGRQSNSPNNLNTHACSYNQCSASFPTLELLEKHEMIQHSSGATNVCCRLCHKTFANVYRLQRHMISHDESALLRKFKCTDCDKAFKFKHHLKEHLRIHSGEKPFGCPNCGKRFSHSGSYSSHMTSKKCISMGLKMNGGAGMAPNGNNIMMNGSKMKSEKKQQLSMASTLNQSHLSNAGKFLSNSNSFLPMLPNIPKYEGYDVMNAAFLATLSHPFYSMGLNPNLNPYHIQNLLKLTGVHNLNPPMDEEKTNEEHKSPNQHSNPEDLIEEVNENDESKLVMDLKDEEEKIAKIQREKFDDGNDDEDNDDPMNNEETLLTHESREKSQSPIIKQEHQNFDDSGNDSLRCQHCDKVFNHPAEHLQHEKILCNAMLMKNHEGIMAHMNESLNSSNNNGCSEDDNDDRDSKISTESDRKVRVRTAISDEQQAILKEFYAINARPNRDDFRNIAQRLMLDPRVVQVWFQNNRSRERKQNGNRDCQFKVSDEQPLDLSMKKEMKTETPTTSPRYGIVPHQHSSEDDQVLNLSRKMTPFSPIFQPTYNADFLTRQIPSPNEAVPRMTNIRNGYHLPLGLPLERLLQFTPEMIMMKQDQRGNSLSPGSSEKRSWKDEESRSFDEALNQSHQHYQTQRRMPKMKSEIPPDSDEFNFVCDLCDKAFRKQSSLARHKYEHSGQRPFKCTECPKAFKHRHHLTEHKRLHSGEKPFQCGKCLKRFSHSGSYSQHMNHRYSYCKPYRD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01352532;
90% Identity
iTF_00346637;
80% Identity
iTF_00346637;