Basic Information

Gene Symbol
-
Assembly
GCA_905475355.1
Location
FR997815.1:1052001-1056215[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 7.7e-06 0.00078 20.7 1.9 1 23 80 102 80 102 0.98
2 12 6.9e-06 0.0007 20.9 1.8 1 23 108 130 108 130 0.99
3 12 0.0025 0.25 12.8 1.1 1 23 136 159 136 159 0.96
4 12 0.0005 0.05 15.0 6.3 1 23 165 187 165 187 0.99
5 12 0.00024 0.025 16.0 5.0 1 23 193 215 193 215 0.96
6 12 1.2e-07 1.3e-05 26.4 2.2 1 23 225 247 225 247 0.99
7 12 3.8e-06 0.00039 21.7 5.9 1 23 253 276 253 276 0.98
8 12 1.1e-06 0.00012 23.3 1.3 1 23 282 304 282 304 0.99
9 12 5.9e-05 0.006 18.0 0.5 1 23 310 332 310 332 0.99
10 12 2.6e-06 0.00026 22.2 5.8 1 23 338 360 338 360 0.98
11 12 9.1e-06 0.00092 20.5 3.1 1 23 366 388 366 388 0.99
12 12 3.5e-05 0.0036 18.6 2.6 1 23 394 417 394 417 0.96

Sequence Information

Coding Sequence
ATGGAGACTCAGGTCCACGTGGAGTTGGTTCGCATGGAGAATGCAAACCCTCCCTCGTTCATGGAGAACGAAGAACAGTCGAACCTTAACCCGCTGGAACTGGTCATCGTGAAACAAGAGATCGTGTCAGATGAGGAACCTCACGAGGCGGTCGAACCACCGCCCACACCGCCAAAGCCCAAGAAGAAGAAGAAGCTGGTGAAAAAAAAGGCATTGAAAGACCCGAACGAGAGGCCCCATAAATGCCAGGAGTGCCCTAAGGCGTTCAAAACGCGTCGTGCAATCCGCCTTCACATGCGAATACACACGGGAGAAAGGCCTTATGAATGCGAAATTTGCCACAAAACTTACGCCAAGCGGTGGAGTCTGAAGGGCCATTTACGAACGCACACTGGCGAAAAGCCCTACATATGCGACGCCTGTCAACGCCCCTTCGGGAGCAGATGCAACCTAAAGCTCCACATCATCAGAAAGCACCTTCCAGACAAGCCGTTCCGGTGCAAAATGTGTTCTAGAAACTTCTCGAGCATGTGCTCCTTAAAGAAACACGTGAAGACTCATACCGAAGAGAAACCTTACTTGTGTACGGTCTGCAAGAAGACCTTTAGGGAGCATTATCATTTAAAAGACCATGCTAGGATACATTTGGACGATATGGATAAGGGCAAGCCGTATAAGTGTCAGACTTGTGGCAAACCGTTTGCAAGGCAGTGTGACCTGAACAAGCACATCAGGATTCATACCGGAGAAAAACCTTATAAGTGTGAAGTGTGTTCTAAATCGTTCAGGCAGTGCGGACACTTGAAAGACCATATGAAACGGCTGCATATATTCGAGAAACCATTTAAGTGCAAGTACTGTGATAAAACGTTCATCGAGGAACGGGATCTGGGGAAACATATCCGGACGCACACCGGAGAGAAACCATACAAGTGTGATAAGTGTGATAGTACCTTTACTGTGCTGGGGTCTTTAGTCCGCCATACTATAACGCACACTGGTGACAAGCCACACAGCTGTCACCTATGTCCAAAGACATTTAGACAGACGTCAGAACTGAAAAGTCACCTCAGAACTCACTCCGGAGACAAACCGTTCAAGTGTGACCTGTGTCAGAAATGCTTCCGAGCTCAGGGTGACTTGATGAAGCATTACAGAATACACACAGGGGAGAAACCATACCAATGCGAGGTCTGCCAAGCGAACTTTAGGCAGCAGAGCCATTTGAAGACCCATAACCAACGAGTGCACGGCATCGCTAAGCCTAAACGGATCCGTGGGAAGAAAGCTGAAGTCTCAATGGAAGGGTTGAAAGCGGACGGGGATAACTTGGTTCTGGATAAACCGGAGAAGGAAAATGGACCTAATTACAGCCTAGCAAGCCATGCAATGCCTCAGCAAGATTATGGGCTGACTGATCATGGGTTGATAGGAAACGGGTTTGGCTTGCCCAGTGTTTTGCCTCCGCATATGATGGCTCAGGAAGTTAATTATGGCTTACCTGTGCCTGGTATGAAGCCAGATGGGGACGGATATGGCTTGAGCCACGGCATGAAGAATGAGGCCCACAATTTTGGCTTGCATGCGCCCAGCATGAAGCAGGAGGTTCATAACTATGGCCTGACCGGTCCGGACATGAAACACGAGGTGCAGAATTTTGGACTCAGTCTTCCAACTCATCATATTCAAATGAATGCCCCAGATCTTCAGAGTTATGGTCTTAGCGCTCCTTTAATGAGCTTATCCCATGACATTGGGTCTTCGTAA
Protein Sequence
METQVHVELVRMENANPPSFMENEEQSNLNPLELVIVKQEIVSDEEPHEAVEPPPTPPKPKKKKKLVKKKALKDPNERPHKCQECPKAFKTRRAIRLHMRIHTGERPYECEICHKTYAKRWSLKGHLRTHTGEKPYICDACQRPFGSRCNLKLHIIRKHLPDKPFRCKMCSRNFSSMCSLKKHVKTHTEEKPYLCTVCKKTFREHYHLKDHARIHLDDMDKGKPYKCQTCGKPFARQCDLNKHIRIHTGEKPYKCEVCSKSFRQCGHLKDHMKRLHIFEKPFKCKYCDKTFIEERDLGKHIRTHTGEKPYKCDKCDSTFTVLGSLVRHTITHTGDKPHSCHLCPKTFRQTSELKSHLRTHSGDKPFKCDLCQKCFRAQGDLMKHYRIHTGEKPYQCEVCQANFRQQSHLKTHNQRVHGIAKPKRIRGKKAEVSMEGLKADGDNLVLDKPEKENGPNYSLASHAMPQQDYGLTDHGLIGNGFGLPSVLPPHMMAQEVNYGLPVPGMKPDGDGYGLSHGMKNEAHNFGLHAPSMKQEVHNYGLTGPDMKHEVQNFGLSLPTHHIQMNAPDLQSYGLSAPLMSLSHDIGSS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-