Basic Information

Gene Symbol
ZFY
Assembly
GCA_949628265.1
Location
OX451262.1:2032575-2035828[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.0013 0.095 13.3 0.1 2 21 30 49 29 50 0.94
2 13 0.00048 0.034 14.6 0.3 1 23 57 79 57 79 0.97
3 13 0.0063 0.46 11.1 5.9 2 23 85 106 84 106 0.97
4 13 0.00016 0.012 16.1 1.6 1 23 112 135 112 135 0.97
5 13 3.6e-06 0.00026 21.3 4.4 1 23 143 165 143 165 0.97
6 13 4.4e-05 0.0032 17.9 0.2 1 23 171 194 171 194 0.96
7 13 4.1e-06 0.00029 21.2 0.4 2 23 226 247 225 247 0.96
8 13 0.0021 0.15 12.6 0.4 3 23 261 281 260 281 0.96
9 13 0.00041 0.03 14.8 4.3 1 23 288 310 288 310 0.99
10 13 1.6e-05 0.0011 19.3 5.4 1 23 316 338 316 339 0.96
11 13 6.1e-05 0.0044 17.5 0.7 1 23 348 370 348 370 0.98
12 13 0.02 1.4 9.6 1.7 1 23 376 399 376 399 0.95
13 13 0.17 12 6.6 0.0 1 21 404 424 404 427 0.88

Sequence Information

Coding Sequence
ATGAGCGCCggggccagGTGCCCGACGTCCGCCGAGAAGACGCGCGAGGCAAATAGCGAggcgggcggcggcgccgAACCGGGCCTCAAGTGTCCGCACTGCGGCCTGGCGGCGGCCACGCGGGAGCAGCTGCAGCTGCACGTGCGCCAGGGCTGCTCGGCGTGCACGTTCATTTGCGAGTTGTGCGGCAAGCACGTGCGCAGCGTCAAGGCGCTCGTGCGCCACCGCATCGTGCACTTTCCGAAAACGCTCGAGTGCGACTTCTGCAAACGCACCTTCCATCACAAGGAAACCATCTCGAAGCACGTGCGCACGCACATGAACGTGCGGCCCTACCAGTGCACCTACTGCACCAAGAACTTCAAGCACGCCAACATCCTGAACGACCACATCAACGTCGTCCACATGGGCATTACCAAGGACGCGTTTCCGTGCGTCGCCTGCTCGCGCACCTTCTGCCGCCGCAGCCACCTCGAGCGCCACATGCGCGTGCACACGGGCGAACGCCCTTACGAATGCACCGTGTGCAACGCCAAGTTCGCGTCCAGCTACAATATGCGCGCGCACCGCGCCTCCGTGCACAAAATCATGCCACACGTGTGCTACGTCTGCCGGTTCGGCGCGCGCACGCGCCAGGCGCTCGCCGACCACTGCCTCGAGGCGCACGGCATATGGCAGTGCCCGCGATGCTGGCGCACGTTCAGCACGCGGAGTCTGCTGCGCGAGCACCAACTGGGCCACAAGTCGGGCgacgcggccgcggcggccggcaACGCCATGTGCGACGTGTGCGGCAAGCAGTTCTCGGCGCGGCGCCTCGTGCTGCAGCACCGGCGGGCGCACTTCGCGTCCGAGCGGCGCTACACGTGCCACTTCTGCGGCGTGGCCTACCTGCACAAGTACCAACTGCGCGACCACATGATGACGCACCTCGACCTGCGCACCTTCCAGTGCGAGGTGTGCGCCGAGACGTTCTCGCACCCGGCCAACCTGCGCCACCACTACAAGCGCCACCACCTGGCGGCGCCGCTGCAGAAGCGCCACAAGTGTCCCTACTGTCCGAAGCGCTTCCAGGCGCCGGCGTCCGTGCGCCGCCACTTGGTCACGCACACCGGCGAGCGGCCGTACGCGTGCACGCAGTGCGACAAGTATTACCAGCACGTGGACAAGCTCAACGACCACAACATGCGCGTGCACAAGCGCATGCCCTACGTGTGTCCCGTCTGCGCGGCCGGCTTCCGGCTGCTCAAGGAGCTGGCCGTGCACTCGTACCAAGAGCACCAGGTGCAGACCGTCGACCTGCAGCGCGCCCGCACCACCAACGCTACCTAA
Protein Sequence
MSAGARCPTSAEKTREANSEAGGGAEPGLKCPHCGLAAATREQLQLHVRQGCSACTFICELCGKHVRSVKALVRHRIVHFPKTLECDFCKRTFHHKETISKHVRTHMNVRPYQCTYCTKNFKHANILNDHINVVHMGITKDAFPCVACSRTFCRRSHLERHMRVHTGERPYECTVCNAKFASSYNMRAHRASVHKIMPHVCYVCRFGARTRQALADHCLEAHGIWQCPRCWRTFSTRSLLREHQLGHKSGDAAAAAGNAMCDVCGKQFSARRLVLQHRRAHFASERRYTCHFCGVAYLHKYQLRDHMMTHLDLRTFQCEVCAETFSHPANLRHHYKRHHLAAPLQKRHKCPYCPKRFQAPASVRRHLVTHTGERPYACTQCDKYYQHVDKLNDHNMRVHKRMPYVCPVCAAGFRLLKELAVHSYQEHQVQTVDLQRARTTNAT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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