Basic Information

Insect: Cloeon dipterum
Gene Symbol: ZEB2
Assembly: GCA_949628265.1
Location: OX451262.1:2144524-2151552[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 31 0.2 14 6.4 3.2 1 23 204 227 204 227 0.93

2 31 0.0056 0.4 11.3 0.2 2 23 242 263 242 263 0.97

3 31 0.00033 0.024 15.2 0.1 1 23 269 291 269 291 0.97

4 31 6.7e-06 0.00048 20.5 0.2 1 23 297 319 297 319 0.98

5 31 0.39 28 5.5 0.2 1 23 325 348 325 348 0.94

6 31 0.0006 0.043 14.3 3.0 1 23 354 376 354 376 0.99

7 31 6.6e-05 0.0047 17.4 0.3 1 23 381 403 381 403 0.96

8 31 0.0011 0.078 13.5 0.2 2 23 411 433 410 433 0.91

9 31 2.6e-05 0.0018 18.6 0.5 1 23 439 461 439 461 0.98

10 31 1.2e-05 0.00088 19.7 2.3 1 23 467 489 467 489 0.98

11 31 0.17 12 6.7 1.0 1 23 517 540 517 540 0.94

12 31 0.0012 0.088 13.4 0.6 1 23 542 564 542 564 0.98

13 31 0.23 16 6.2 6.8 1 23 574 596 574 596 0.97

14 31 0.00081 0.058 13.9 0.3 1 23 602 624 602 624 0.98

15 31 0.048 3.5 8.3 4.3 1 23 656 679 656 679 0.97

16 31 0.086 6.2 7.5 0.1 6 23 723 741 723 741 0.96

17 31 0.0036 0.26 11.9 0.4 1 23 746 769 746 769 0.94

18 31 0.73 52 4.6 0.2 1 20 774 793 774 795 0.89

19 31 0.0096 0.69 10.5 0.1 1 23 813 835 813 835 0.97

20 31 0.12 8.9 7.1 0.6 2 23 904 925 904 925 0.98

21 31 0.11 8.2 7.2 1.9 1 23 932 955 932 955 0.92

22 31 0.0022 0.16 12.6 0.1 3 23 984 1004 983 1004 0.96

23 31 1.9 1.4e+02 3.3 2.2 2 23 1012 1034 1011 1034 0.93

24 31 0.063 4.5 8.0 0.6 2 23 1043 1065 1042 1065 0.94

25 31 0.57 41 5.0 0.4 2 23 1067 1089 1067 1089 0.95

26 31 0.2 15 6.4 2.4 2 23 1230 1252 1230 1252 0.86

27 31 0.0013 0.096 13.2 0.4 2 23 1254 1275 1254 1275 0.96

28 31 0.091 6.6 7.5 1.4 3 23 1307 1328 1306 1328 0.92

29 31 0.014 1 10.0 3.8 1 23 1360 1382 1360 1382 0.97

30 31 0.072 5.2 7.8 0.2 1 23 1388 1411 1388 1411 0.92

31 31 2.1 1.5e+02 3.2 0.1 2 20 1421 1439 1420 1441 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	31	0.2	14	6.4	3.2	1	23	204	227	204	227	0.93
2	31	0.0056	0.4	11.3	0.2	2	23	242	263	242	263	0.97
3	31	0.00033	0.024	15.2	0.1	1	23	269	291	269	291	0.97
4	31	6.7e-06	0.00048	20.5	0.2	1	23	297	319	297	319	0.98
5	31	0.39	28	5.5	0.2	1	23	325	348	325	348	0.94
6	31	0.0006	0.043	14.3	3.0	1	23	354	376	354	376	0.99
7	31	6.6e-05	0.0047	17.4	0.3	1	23	381	403	381	403	0.96
8	31	0.0011	0.078	13.5	0.2	2	23	411	433	410	433	0.91
9	31	2.6e-05	0.0018	18.6	0.5	1	23	439	461	439	461	0.98
10	31	1.2e-05	0.00088	19.7	2.3	1	23	467	489	467	489	0.98
11	31	0.17	12	6.7	1.0	1	23	517	540	517	540	0.94
12	31	0.0012	0.088	13.4	0.6	1	23	542	564	542	564	0.98
13	31	0.23	16	6.2	6.8	1	23	574	596	574	596	0.97
14	31	0.00081	0.058	13.9	0.3	1	23	602	624	602	624	0.98
15	31	0.048	3.5	8.3	4.3	1	23	656	679	656	679	0.97
16	31	0.086	6.2	7.5	0.1	6	23	723	741	723	741	0.96
17	31	0.0036	0.26	11.9	0.4	1	23	746	769	746	769	0.94
18	31	0.73	52	4.6	0.2	1	20	774	793	774	795	0.89
19	31	0.0096	0.69	10.5	0.1	1	23	813	835	813	835	0.97
20	31	0.12	8.9	7.1	0.6	2	23	904	925	904	925	0.98
21	31	0.11	8.2	7.2	1.9	1	23	932	955	932	955	0.92
22	31	0.0022	0.16	12.6	0.1	3	23	984	1004	983	1004	0.96
23	31	1.9	1.4e+02	3.3	2.2	2	23	1012	1034	1011	1034	0.93
24	31	0.063	4.5	8.0	0.6	2	23	1043	1065	1042	1065	0.94
25	31	0.57	41	5.0	0.4	2	23	1067	1089	1067	1089	0.95
26	31	0.2	15	6.4	2.4	2	23	1230	1252	1230	1252	0.86
27	31	0.0013	0.096	13.2	0.4	2	23	1254	1275	1254	1275	0.96
28	31	0.091	6.6	7.5	1.4	3	23	1307	1328	1306	1328	0.92
29	31	0.014	1	10.0	3.8	1	23	1360	1382	1360	1382	0.97
30	31	0.072	5.2	7.8	0.2	1	23	1388	1411	1388	1411	0.92
31	31	2.1	1.5e+02	3.2	0.1	2	20	1421	1439	1420	1441	0.90

Sequence Information

Coding Sequence: ATGGCCGCGTCCACGAAAGTTAGCGACATGTGTCGCTTATGCGGCACGGACACACTTAATGTGGTTCGACATCACATTTTCGAGGGTGAAGGGCAAGTCAAGAAGTCTGCCCAGAAGATTTCCGAGTGCCTTCCTCTGCATATTGCTGCAGAAGACCCGcttcccaaaaatatttgtggggAGTGCTCCTACAAACTGGACCTTATGAGTGACTTCAGAGAAAAAGCTGTGAAAACAGATGTTATGCTCGTTTCCCTGGTGGAAGGAGTGAAACCTGAGATTCCAGACGACGATGACGATGGTCCAGACCACGAAATTGACAATGACTTTCGCTCCGACACTCCAGTCGAGCAACCTGAGCAGCAGACTGAGCCTGAGGTACTGATCAAAGAGGAAGAGGCACAACAGCCTCAGCAGCCGGAGAAAAGGCCCGGCAGAAAAGCGGCCAACAAACGGCCCATCCAAGAGTCTGAcatggaggaggaggaggaggaggcgccCGCCAAGAAGCGCGGCCGCAAACCCAAGGAAAAGGAGACTGCACCAGCGGCGTCGGCTACGACATCGGCATCAACCAACCCGCCTAAGGAGAACACAGGGGGTCCGTTGTTCGAATGCTCTCACTGCCACCACATGACGGCCACTCTGGGCCAGATGCGCGTTCACGTGGCAAACCGGCACTTGCCGCGGGCGGACATTCCGCCGCTGAACGGTCGGCGGGCGCAGTGCGTCGAGTGCGAGCGCACCTTCGGCAGCGCCAAAAAGCTAGCAGACCACCTGGCGCGCCACACAGGTGCTCGGCCCTTTGAGTGTGGCCTGTGCGACCGCGGATTCAGCACCCAGGGACGCCTGGACGCGCACATGACCTTGCACACCTCCGTCTGGACGCACGAGTGCACTGAATGCGGCGCCGCCTTCGCCACTAAGGCCGATTTGACGGCCCACGAGCGACGCCACACGGGGGCCACGCCCTTTTCGTGCTTGTTGTGCGCGGCCGCCTTTGCCTCGCGAGACCTGCTCGCAGACCATAACGCGACTTGCCACCTTGACGAAAGCCTGTTCACATGCCAGCACTGCGCCAAGCGCTTCGGCGTCGCCTCCAAATTCAGAGAGCACCTCCGCACGCACGCTGAGCGCCGACACGCTTGCGTTTACTGCGACGCCAAATTCGCGACGCCGTCCAGACTAAATGCTCACATTCAGACGCACACGCGCGGCGAGCGTCATTTTCTATGTGACGCGTGCGGCAAACGCTTCCCTAGCGCCAAGGATTTAACGCAGCACGAGACCATGTCGCACTCTGAAGAAAAGCGCTTCATATGCGAGCATTGCGCCCGTCCTTTTTCCCGACGAGAGGGCCTTGTCGTGCATCTACGCACGCACACGGGCGAACGCCCGTTCGAGTGTGCTGAATGTGGACACGCGTTCACGCAGAGGCACGCGCTACAGACGCACGAGCGCACGCACACAGGCGAGAGGCCATTCCGGCCGCTGCCGGTGATTGTGCGACCCGAACCTGGCCCCCAGCCCGTGATTGGAGAAATCGCCTACCAATGTAGTCACTGCTTTGAACTGTTCAAGATGAGCCGCGACGCAAAATTACACATCATAGAAGCGCACAAGTACAAATGCTCCACCTGCAGATATCGAGGGAGTACAGAAGCGGATCTCGAGAAGCACATGGAGAATCATCCAGCGCAGGTAGAGAAGGAAAACCTGCATCGctgttgcatttgcttacggTCTTGTATCTCCCGAGAAGCGTATACAAACCACATGAAGTTGCACGTCGGCTCTTTGCCTTATGAGTGCGAAAAATGCGACTTGCTATTTCCTAACAAACCTAGATTGGAAAATCACATGACAAGGCACGTGTGTCTGCCGCGCAAGCAAGGCGGCGTCTACGTGCGAAAAGCTCTCAAGCAGAGGGTAGCTTACCAGAAAAAGACTGTTCAATATAAAGGACACGAGTGCAGCATCTGTCAGCAAAGATTCTTGCGCAGAGATGACATGAGAAACCACAAGAGAAGATTCCACGCTCGGGCCAAAGAAATCGCAAGGAGCGAACGCGTGGCGAGGAATTCAAATCTGGCCAAGAAGAAACTGAATGCAAATAGACGTGGTTCGCTGCTATCAGCAAAGAAGCCTCGCAAGTTTGACTGCCCGTGCGGCGAGACTTTTACGCAGTTGGATGTGTTGTTGCGGCATCGGGCTAAATCTCATCCCGACTGGATACACGCATGCCAGCGTTGTGAAAGGATGTACACTACGCCCATGCAGTTGGCATCGCACATCGACAGAGCACACCCTGCATCCTCTTACGAATGCAATGAGTGCAAAGAAAAGCTGAAGACCATGGTGGGAATGCTCAACCACAGGGAGAAGCGGTGTCCACTTAGGAAAGGGCAGGTTAATGCTCCAACCAGTCTGGGAAAGTTTACTTGCGACATTTGCATGAAAGTGTTTGAGAGCAAGGCTGAAATCGAGGTGCACGTCATGCTGCatttacacaaaataaaaaatatcatgaaaGAAATTTCCAAGATTGAAGGGAAAAACATGCTATTAGCAACTACCCcgccaaaagcagcagcgcaaAACCAAGGCAAAAAGAAGTCCAACTTTGTGCAGTGCCCATCGTGCGACATGAACGTCCCCGCGTTCCAGTGGAAAATGCATCAAGTCCTGCACGACAACCCAAACCGTCCTAAGTGCGCCAAGTGCAACTTTGTCACAGTCACGCAAGGCAAGATGTTGGCGCACACCAACAGCCACTTGGACACCGAGGCGCCATTCTCTTGCAGCGTGTGTCACCTCAACTTCAGGGAGAAGTACTGGGCCGAAAAGCACACCAGTGCGTACCACGGAAACAAAGCCAGGGTGAAGAACAACTTCGAAGTGACTGACCCAGCGGCAAAACAGCAGAATAAACTGGCTAAAGTCAAAGCGTGCCCCATGTGCACCGAATCCTTTAGCGATCCTCTCTCCTACCAGACACACCTTCTGGCCCATAAGCAAGTGCAAAGCTTCCAGAAATGCAAACACTGCGACACTCGCATCCGCGGTTTCGACATGATGGTAACTCACTTGAAACTGCAGCACTGCCTCCACGTCACAGTCCCGCTCAACTGTCCAATGTGCAACTTGCTGCTGAATAACAGATTCAGCCTGAACCGCCATCTCACTAGCATGCATCCTTCTTGCTCGTACTGCAGACAAATGCAGTCGAGCAAAGCTGCACTCGTGTCTCACATCAGCATGAGGCATCCGGACATGCTGCCGTTCAGCCCACTCGAGGATGACACCACCGTAAAGGTTGAGCCCCCTGAAACGAGTCCCCCTGCAGTAGAAGTGAAGGATGCTGAACCCCCCAGTCGCAATACAATTGATGCACTGAAAAATTTTGTCGCGACAAAGGGCAACATCGCAAGCAACAGTGTTGGTAACGGAGTGGAACAGAACTCAGCCGCGGCCAGCCAACAACTCCCTGCTCTGGTGCCCATCTCTGATCAGAAGCAAACAAAGGCGAAGAGGCCCTCGAAACCTAAAATCCCTAAGCAAGCTGTACCACCAGAATCTAACGTCGCGGAAACTCAGAACATCGTCAAAATCGAGTCTGCCCAAGATGAGGGTTCTGATTTGAACGGAGCTGGACTTTTCCTTAAGTCGAACTCTCGCAATAGAAATACTTGCCACATTTGCGGAATGAGGTTTAAAACGATCGGTGAATGCTCTAATCACTTGATCAACGAGCACAATGTGTGCCGCTATTGCAGTAAGAACTTTGAAACTGCGGCTGAGATGCAGACCCACATGGATAATCATCCAACCCTTAGTTGCCCTTGCTGTTCAATAAAGCACACCGATCCCAATAAAATGCATATTCACATATTGCGGAGTCATCAAGACGGAAATGCCTGTTGCAGATGCTTTAAAGTGTTAAAAAACCGTGAAGACCTGAAAGCCCACTATGAACTCGAGCATGATTCTATCGTGCAGTGCCCTACCTGCGACCACTTCATGCACAAGAACAATATCACATCTCACGTTAGAACGAAACATGGCAGTATAGCAAATTATAAATGCGCTCATTGTTCCAGAGTTTTCAAAACTAAAGCTAGCCACGATTTGCATATCCGAATCCACACAGGAGAAACGCCATATGAGTGCCCAATTTGCGTTCAAAAGTTTATTGCCTCACACAAAATGGCAAAACATGTTGTAGTCAGTCACAAGTTTGATGAAAAGCGCCCGATACAAACTTGCCCCTGGTGCAACACCAAGTTGCGGACCATTATTGAGCTGGGCAAACACGTCACTTCCTCTAAAGCTTGTAGTGAAATGCGTGATTCTCAATCTCGTGCGTCTGGCTCGGACGTTTCTAACGAGACAGTAGATACTGGCTCGTCTTCAACAGCAGATGTCAATTGA
Protein Sequence: MAASTKVSDMCRLCGTDTLNVVRHHIFEGEGQVKKSAQKISECLPLHIAAEDPLPKNICGECSYKLDLMSDFREKAVKTDVMLVSLVEGVKPEIPDDDDDGPDHEIDNDFRSDTPVEQPEQQTEPEVLIKEEEAQQPQQPEKRPGRKAANKRPIQESDMEEEEEEAPAKKRGRKPKEKETAPAASATTSASTNPPKENTGGPLFECSHCHHMTATLGQMRVHVANRHLPRADIPPLNGRRAQCVECERTFGSAKKLADHLARHTGARPFECGLCDRGFSTQGRLDAHMTLHTSVWTHECTECGAAFATKADLTAHERRHTGATPFSCLLCAAAFASRDLLADHNATCHLDESLFTCQHCAKRFGVASKFREHLRTHAERRHACVYCDAKFATPSRLNAHIQTHTRGERHFLCDACGKRFPSAKDLTQHETMSHSEEKRFICEHCARPFSRREGLVVHLRTHTGERPFECAECGHAFTQRHALQTHERTHTGERPFRPLPVIVRPEPGPQPVIGEIAYQCSHCFELFKMSRDAKLHIIEAHKYKCSTCRYRGSTEADLEKHMENHPAQVEKENLHRCCICLRSCISREAYTNHMKLHVGSLPYECEKCDLLFPNKPRLENHMTRHVCLPRKQGGVYVRKALKQRVAYQKKTVQYKGHECSICQQRFLRRDDMRNHKRRFHARAKEIARSERVARNSNLAKKKLNANRRGSLLSAKKPRKFDCPCGETFTQLDVLLRHRAKSHPDWIHACQRCERMYTTPMQLASHIDRAHPASSYECNECKEKLKTMVGMLNHREKRCPLRKGQVNAPTSLGKFTCDICMKVFESKAEIEVHVMLHLHKIKNIMKEISKIEGKNMLLATTPPKAAAQNQGKKKSNFVQCPSCDMNVPAFQWKMHQVLHDNPNRPKCAKCNFVTVTQGKMLAHTNSHLDTEAPFSCSVCHLNFREKYWAEKHTSAYHGNKARVKNNFEVTDPAAKQQNKLAKVKACPMCTESFSDPLSYQTHLLAHKQVQSFQKCKHCDTRIRGFDMMVTHLKLQHCLHVTVPLNCPMCNLLLNNRFSLNRHLTSMHPSCSYCRQMQSSKAALVSHISMRHPDMLPFSPLEDDTTVKVEPPETSPPAVEVKDAEPPSRNTIDALKNFVATKGNIASNSVGNGVEQNSAAASQQLPALVPISDQKQTKAKRPSKPKIPKQAVPPESNVAETQNIVKIESAQDEGSDLNGAGLFLKSNSRNRNTCHICGMRFKTIGECSNHLINEHNVCRYCSKNFETAAEMQTHMDNHPTLSCPCCSIKHTDPNKMHIHILRSHQDGNACCRCFKVLKNREDLKAHYELEHDSIVQCPTCDHFMHKNNITSHVRTKHGSIANYKCAHCSRVFKTKASHDLHIRIHTGETPYECPICVQKFIASHKMAKHVVVSHKFDEKRPIQTCPWCNTKLRTIIELGKHVTSSKACSEMRDSQSRASGSDVSNETVDTGSSSTADVN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -