Basic Information

Gene Symbol
-
Assembly
GCA_947507545.1
Location
OX382189.1:8363668-8366948[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 5 5.4e+02 1.7 0.1 2 20 35 53 34 56 0.71
2 9 0.08 8.5 7.4 0.2 2 23 345 367 345 367 0.89
3 9 3.7e-06 0.0004 21.0 2.6 2 23 386 408 385 408 0.95
4 9 3.4e-05 0.0036 18.0 3.6 1 23 431 453 431 453 0.98
5 9 1.2e-05 0.0012 19.5 2.2 2 23 459 480 458 480 0.96
6 9 0.00015 0.016 15.9 6.5 1 23 486 508 486 508 0.98
7 9 0.00016 0.017 15.9 3.5 1 23 514 536 514 536 0.97
8 9 6.5e-06 0.00069 20.3 2.7 1 23 542 564 542 564 0.98
9 9 0.0015 0.16 12.8 4.0 1 20 570 589 570 590 0.94

Sequence Information

Coding Sequence
ATGTGTGCTCGACTACTCGCATGTCCGCTGTGTTCGCAACCTGCTTTCGTGACGCTCGACGCACTGCGAGCGGGACTCGTGAGCGTCGCGACGCGACCCTTGACCTGTCCGGTCTGCAACGAGACTCTCCTGGGCATCGACAAGCTCACCATTCATCTCTTCGGTCACACTATCAGCCCCAACGACAAACACGTCAATCGCAAAAATGCCACTGGCGGCGTCGTCGACTGCACAACCGTTTTCACCCAAAAATGGGAAATTTGTGGCACGCAGGACGCAGCCCGCCAGGAACAACCGCCCGGGGAGGAAGTGGCTTTCGTTCCCCTCGCCAGTGTCAACGGAGCGACCGGCGCTAATCCGGAGCCTCCGGATGCCCAAGCGTGTCAGAGACTCTCCGCGACAGCCACAAAAGACAATCAAACCCACCTAACGTTCGGTCAACGCCACAAATTTCCATCCCCGATATCCATCGATTTGGACAATTCCACCGGTGCTATTTCCAATGCCAAAGTTTACAGAGTTCCCGTAACGCTGGACTCTCCGCCGGGGAACGAGAGAACGGCGTTGTCCGGGTCGCCGCGCGATTCGCACGAGCAAAACTGTTTGCGGTCCAATGGCTCCAACGGGCGAGGGGTTTCCTCTAAAAGCGGGGAAAAAAGTAGCGACGTCACTGTCCGGAGAGAGGAAATTATAAGCGATTTTGGGGATACTTGGATAGAGAATTTGTTGCACGAAGACGGTAGAAAATGTTCCGAAAGATTGGTATCCGGAGAAGAAAAGCCAAGATATTCCATCGATTCCCAAGGAATTTCAGACGGGGAAGACAAGTATCGTCCCGGTACGTCAGCCGGAATAAATTCAGATATTCGGAGCAATGGGCGAGCGTCCGATGAATTAAATTCGAGCGATTCTATCGTCCGAACGGCGGAGGAAATATTCGATTCGAATCAGCGGAGCGATTTGAATTCCAAAGGAGCGTTGTTGCCACAGTGGAAGGCCTTCAGGCTTCTCGCTATGAAGGAGAAAAGCGAACGCTGCGACATTTGTGGTATTCATTTTCCTGACGTCAATTTTTTAGTCCTGCACAAAGAGCTAGCTCACATGATATCCGAAAAAGATGTCGACGCTTCGCCCGAAGAACCGTTGAAAAATTGTCCGTGCCACCTGTGCACAAAAGTATTCAAAACCCGAGGTACTCTCATGGTTCACATGAGAGTAGCGCACATGGGATACAATCTTGGTTTTTTATCCAAGGACAATGACGGCGAATCCGTCTCTTGCGAAAATGGTTTCAACTGCCCAACTTGCGGAAAGAACTTCAAAAAGGAACAGCACGTAACGCAACATCTGAAGACACACGAGGGAAAGCAGTGGGAATGCGACGTGTGCAGTAAAATGTTCACCACCAAATATTTCCTGAAGAAGCACAAACGTCTGCATTCCGGTGAAATGCCCTACAAATGCACCATTTGCGACAAGACTTTTACTTTCCAACAATCTTATCACAAGCACAGATTGTACCACAAAGACGATAAGCCTCACACGTGCGCGACTTGCGGAAGATCATTCAAGGAGCTTTCGACGCTTCACAATCACGAGCGAATTCACACCGGCGAAAAGCCCTTCGTCTGTGAAACCTGCGGAAAGTGTTTTCGTCAGCGTGTTTCTTATTTGGTGCATCGTCGAATTCACACGGGCGTAATGCCCTACAAATGCAGCGTATGTGGAAAGAGTTTCCGGTACAAAGTCAGTCAGAGAACGCACAAGTGTCCGGCTCAGCCGGAAGAAGCGGAAATTCCAGGAGGGCCGGAGATTCCAGCAGGAGAAAGAGACTTATCTTCGATTCGTCGAGCCGATCGCTCGGCCAACGCGAACACGGAAATTTTACTGCAAAATTATTCGAGCGAGCCGAACGAAAGCAACAAATTTATTCTCATCGTGAATACGCAAGGCCAGCCGATATTGACGAGGGAAACTGACGTTAATTCGGCGAGTGGCTACCTCAACGAGAAGCGAATCATCGAACCACCAGTGGAACGCCGCAAAGAAAATCGGCGAGACGAAAGCGATTTGTGGAACGATAATTCAACGAAAGACGATCTCTCGAGGAGCGGCGAAAAAATGGGAAGCAGCAACGTGAACGATTTTTTTTCACTCGTCATGTCGCCGATGGAAAATGATTTGTCCTCGCCATCCACGGAAATGGAACATTTGCGGCTCTCCTCGCCCCAAAACGAAACTCGTGAAACGCCCGAGAATTCCAGCGAAGACTCGAGACTTCAGAGGGACTTGAACAACGCGATCGAAGGAATATTTCAGGAGAATTGCGCCAACAACAGTCCGCTACAGACTATAAACGAAGAGTCTCTAAAGCAGTTACTTTACGGTATAGACAGAAAAGTGTGA
Protein Sequence
MCARLLACPLCSQPAFVTLDALRAGLVSVATRPLTCPVCNETLLGIDKLTIHLFGHTISPNDKHVNRKNATGGVVDCTTVFTQKWEICGTQDAARQEQPPGEEVAFVPLASVNGATGANPEPPDAQACQRLSATATKDNQTHLTFGQRHKFPSPISIDLDNSTGAISNAKVYRVPVTLDSPPGNERTALSGSPRDSHEQNCLRSNGSNGRGVSSKSGEKSSDVTVRREEIISDFGDTWIENLLHEDGRKCSERLVSGEEKPRYSIDSQGISDGEDKYRPGTSAGINSDIRSNGRASDELNSSDSIVRTAEEIFDSNQRSDLNSKGALLPQWKAFRLLAMKEKSERCDICGIHFPDVNFLVLHKELAHMISEKDVDASPEEPLKNCPCHLCTKVFKTRGTLMVHMRVAHMGYNLGFLSKDNDGESVSCENGFNCPTCGKNFKKEQHVTQHLKTHEGKQWECDVCSKMFTTKYFLKKHKRLHSGEMPYKCTICDKTFTFQQSYHKHRLYHKDDKPHTCATCGRSFKELSTLHNHERIHTGEKPFVCETCGKCFRQRVSYLVHRRIHTGVMPYKCSVCGKSFRYKVSQRTHKCPAQPEEAEIPGGPEIPAGERDLSSIRRADRSANANTEILLQNYSSEPNESNKFILIVNTQGQPILTRETDVNSASGYLNEKRIIEPPVERRKENRRDESDLWNDNSTKDDLSRSGEKMGSSNVNDFFSLVMSPMENDLSSPSTEMEHLRLSSPQNETRETPENSSEDSRLQRDLNNAIEGIFQENCANNSPLQTINEESLKQLLYGIDRKV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-