Basic Information

Gene Symbol
-
Assembly
GCA_947507545.1
Location
OX382187.1:3759652-3760638[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 5.4e-05 0.0057 17.4 2.8 1 23 26 49 26 49 0.91
2 9 0.00011 0.011 16.4 3.1 1 23 55 77 55 77 0.98
3 9 0.002 0.21 12.5 0.4 1 23 83 105 83 105 0.98
4 9 0.00013 0.013 16.2 0.5 1 23 111 133 111 133 0.97
5 9 6.8e-06 0.00073 20.2 2.8 3 23 146 166 144 166 0.96
6 9 2.1e-07 2.2e-05 25.0 1.6 1 23 175 197 175 197 0.99
7 9 1.7e-05 0.0018 19.0 0.9 1 23 203 225 203 225 0.98
8 9 1e-05 0.0011 19.6 4.8 1 23 231 253 231 253 0.98
9 9 1.7e-06 0.00018 22.1 3.8 1 23 259 281 259 281 0.98

Sequence Information

Coding Sequence
ATGCTGTCGCAGGGACAGTGCGGCGTCAATGATATGAAGGTTATTTGCGAGGAGCCGCTGGATGAGAAGTTAGTGCACGCGTGCGATCATTGCGGTCGGAGCTTCACGTCGCCGACGGTGCTGAGGAAGCATAATCAGCagatgcatccagtggagaagagtcacacctgcgaaacgtgcggttacgcgtcggcccatcgtcagaatcttgtgagtcatcagaggcgtcacaatctcgagtacaagtatcactgcgaggtttgcggggctggtttctacgcccgcaacagttatcaggagcatcagttggtgcattcgagggagaaaccctttcagtgtgcgatatgcaacgccacgtttcgttatcgtcagggtttgcgattgcacgccaagctccatcagccggattacgttccaccgcagaagaagcatctctgcgaattgtgcaacaagaggttctctcgcaagcaagtacttctcgtgcacatgcgaactcacggcaccggaggaccgcagacggattatgtttgtcacatttgtggaaaatccgtctcaagcaaaacctaccttacggtccacgtgcgcaagcacacgggcgaaaaacctcacgtttgcgacatatgcgccaagggtttcatctcccaaaactacctcagcgttcacaggcgtacgcacaccggagagcgaccgcatcagtgcactcactgcgagaaacgcttcactcagcgcacgactttggtcgttcatctccgcggtcacaccggcgatcgtccctacccctgcaccttctgtcacaagtctttcgcctctaaaacaatgcttaacagccaccttaagacccacgcGAAACAAAACGCCAGGGCTCAACAGGCGCAACAGCATCAGCAGAATCAAATTCACATGCAGCAGCAGCAGCAGCCGGAAATGCAACAAACGGAGGAACGCTCGCAGCCTCTGGAAACCGTCGCCGTCCTACTTTCCGGTTGA
Protein Sequence
MLSQGQCGVNDMKVICEEPLDEKLVHACDHCGRSFTSPTVLRKHNQQMHPVEKSHTCETCGYASAHRQNLVSHQRRHNLEYKYHCEVCGAGFYARNSYQEHQLVHSREKPFQCAICNATFRYRQGLRLHAKLHQPDYVPPQKKHLCELCNKRFSRKQVLLVHMRTHGTGGPQTDYVCHICGKSVSSKTYLTVHVRKHTGEKPHVCDICAKGFISQNYLSVHRRTHTGERPHQCTHCEKRFTQRTTLVVHLRGHTGDRPYPCTFCHKSFASKTMLNSHLKTHAKQNARAQQAQQHQQNQIHMQQQQQPEMQQTEERSQPLETVAVLLSG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00263745;
90% Identity
iTF_01497676;
80% Identity
-