Basic Information

Gene Symbol
-
Assembly
GCA_036417725.1
Location
CM071158.1:20353217-20359168[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 3.5 2.4e+02 3.0 0.1 2 23 19 41 18 41 0.91
2 18 0.0097 0.66 11.1 0.3 2 23 64 85 63 85 0.97
3 18 0.00032 0.022 15.7 1.5 1 23 89 111 89 111 0.94
4 18 0.011 0.73 10.9 1.7 1 23 116 139 116 139 0.90
5 18 0.051 3.5 8.8 1.9 2 23 147 169 146 169 0.94
6 18 0.00066 0.045 14.8 3.2 2 23 177 199 176 199 0.95
7 18 0.003 0.2 12.7 2.1 1 23 205 227 205 227 0.97
8 18 4.7e-06 0.00032 21.5 1.5 1 23 233 255 233 255 0.98
9 18 0.0015 0.1 13.6 0.8 1 23 323 346 323 346 0.96
10 18 0.012 0.79 10.8 1.3 2 23 373 394 372 394 0.97
11 18 0.032 2.2 9.5 4.3 1 23 451 474 451 474 0.95
12 18 0.00038 0.026 15.5 0.3 1 23 571 593 571 593 0.98
13 18 0.011 0.72 11.0 1.3 1 23 598 621 598 621 0.97
14 18 3.3 2.3e+02 3.1 3.0 1 23 628 651 628 651 0.92
15 18 3e-05 0.002 19.0 0.9 2 23 659 681 659 681 0.97
16 18 0.00063 0.043 14.8 3.1 1 23 687 709 687 709 0.97
17 18 1.3e-05 0.00086 20.2 1.5 1 23 715 737 715 737 0.99
18 18 5.2e-05 0.0035 18.2 3.5 1 23 743 766 743 766 0.98

Sequence Information

Coding Sequence
atgaaAGGACATCCTATCAGCGCTTACGTTGTTAAACTAGACATCACAGCGCTGACATGCCAGATATGTTCAATTGATATCGACACCTTGGAGAAGTTTATGCAACATCTGCAAGACGATCACGGAAAAGTTTTATATAGTGATATCAAGAACCACATACTACCGTTCAGGTTTTATGGAGACGTGTTACAATGCGCGGTTTGCTCAAAGAACTACGAAAGCTTCAAAGTTCTACAAGAGCATATGAATATTCATTACAGAAATTACACTTGCAATGTTTGTCATGCAACTTTCGTTAACAGCAGAACACTCCGAGCCCACAGCGGCAGACATAAACAAGGTGACTTCGAGTGCCAGTTTTGCGGAAAAGTATTCGATACGCGCACGAAAAAAGTCAACCACGAAAAGTTCGTTCACATAGGAGACCACAGGAGAAATAAGTGCCCCCATTGTTCAGAGAAGTTTGTAAGCTACAAAAAGAGAATGGAGCATATGGTAGTGCAGCACGGCGTGCAGCCTCTCGTGTTACGTTGTATGGCCTGCGATCAGACGTTCTGCAGCCGTGGTCAGCTAACAAAACACACGAGGAAGGATCACTTGTTGGAGAGAAGGCATGAATGTGATCGTTGTGATATGAAGTTCTTCGGTAGGAAGGACTTATTGAACCACATGATCAAACACACTGGAGTCAGGAAGCATCAATGCGACGTATGTAGTAAAGCCTTTGCCAGAAAGCAGACGTTGCGGGAACATCTGCGTATACATGCTGATGATAGGAGGTTCAAATGCATGCGTTGTGAGCACCAAAAACAAAGTGGATACAAATATCGGAAAGCTACAGTGAAAACTGAAGATAATCAACTTGATGTGCCTTTTAAAAGCGAGCTAGATTTGCAGCGGCGAAATTTATTAGAGATATTGATGCACTCAAACGCGACGCCGATCCGTCGATACAGCGGCATCGGTTACATGTGTTCTTATTGCGACGAACAGTACGCGCTGGCGGCTCATCTCAAGCAGCACACCCTTAGCTCGCACACCGATGTGTGGGGTGCTAATTTTATGACCAATATGAGCTTATACGAATTCGTAGTAAAGTTCAAAGAGGAGATTCTACAATGCGACATATGCCTCAGCGAGTTTAACAACTTGAAGCTTCTTCTCACTCACATGCACACCCACTATAAAAACTACATGTGCAAGGCATGTGAGCGACAAAAAGTGGAATGTAAAAAAGatataacaacaaaaataacGCCAAAAACCGAATTGGTGAAGCATCGAAGTAATATAAGAGAGATTTTGCTGAGTTCAAATGCAACGCCGATTCGGAGGTACGGTGGCATCGGATACACTTGCTGCTACTGTGAAGAGCAGTACCAGCAGCCAGCGCAACTTAAACACCATACACTACAAACGCACACGGATATATCTGAAGCTAATTTTATGAAGAACATGAATATGTCGGAGTATGTCGTCAAACTGGATATTTCTAATCTGCGTTGCAAGCTTTGTAGTAGCGATATTGATACATTAGAAAAATTTAATGAACATTTGATGAAAACACACGATAAAAATTTATTCACAGATATAAAAAGCCATATCTTCCCATTCAAATTTGATGGCGATTTATTAAGATGCTTGATTTGttcaagtaattttaataaattcagaATTTTAGTAAACCATATGCATAAACATTATAGAAACTATATATGTTCCacttgtgatattggatttgttaaTAGGAATGGGCTTACTCAGCATGCCAAGAAACATATAACAGGAACATACCCATGCGAGTACTGTCCAAAGGTATACGATACTcacttaaagaaaaaaatacatgaaCGAACCATCCACACACACTCTGAAGTATTATACAAATGCGCCTATTGCTGTGAAACATTTAAAGATTATAGGAAAAAGGAAGCTCATGTGTCACAGGTCCACGGTGTTATAGCTCCGAGAGCAAAGTGTCAGGCGTGCGACAAAGTTTTCAGCAAtcgtaaattattaaatattcacaTAAAGAGAGATCACTTGATGGAACGCCCTCACAAATGCACAGACTGTGACATGAAATTCTTTACGACAACTGCGTTAAAGAATCATATAGTCAAACACACAAAGTCGAGAGCCTTTCAGTGCGATGTGTGTATGAAATCTTTTGGACGGAAGAAGACTTTAAATAGTCATATGAGAATCCACGATGATACGCGGAGATACAAATGCGAACATTGTGGACAAGCTTTCGTACAAAAATGTAGTTGGCGAGGGCATATGAGAATCAAACACGGCGAAATTATTTAA
Protein Sequence
MKGHPISAYVVKLDITALTCQICSIDIDTLEKFMQHLQDDHGKVLYSDIKNHILPFRFYGDVLQCAVCSKNYESFKVLQEHMNIHYRNYTCNVCHATFVNSRTLRAHSGRHKQGDFECQFCGKVFDTRTKKVNHEKFVHIGDHRRNKCPHCSEKFVSYKKRMEHMVVQHGVQPLVLRCMACDQTFCSRGQLTKHTRKDHLLERRHECDRCDMKFFGRKDLLNHMIKHTGVRKHQCDVCSKAFARKQTLREHLRIHADDRRFKCMRCEHQKQSGYKYRKATVKTEDNQLDVPFKSELDLQRRNLLEILMHSNATPIRRYSGIGYMCSYCDEQYALAAHLKQHTLSSHTDVWGANFMTNMSLYEFVVKFKEEILQCDICLSEFNNLKLLLTHMHTHYKNYMCKACERQKVECKKDITTKITPKTELVKHRSNIREILLSSNATPIRRYGGIGYTCCYCEEQYQQPAQLKHHTLQTHTDISEANFMKNMNMSEYVVKLDISNLRCKLCSSDIDTLEKFNEHLMKTHDKNLFTDIKSHIFPFKFDGDLLRCLICSSNFNKFRILVNHMHKHYRNYICSTCDIGFVNRNGLTQHAKKHITGTYPCEYCPKVYDTHLKKKIHERTIHTHSEVLYKCAYCCETFKDYRKKEAHVSQVHGVIAPRAKCQACDKVFSNRKLLNIHIKRDHLMERPHKCTDCDMKFFTTTALKNHIVKHTKSRAFQCDVCMKSFGRKKTLNSHMRIHDDTRRYKCEHCGQAFVQKCSWRGHMRIKHGEII

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-