Basic Information

Gene Symbol
zfh1
Assembly
GCA_949987675.1
Location
OX465088.1:138475485-138520068[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.0029 0.3 12.2 1.9 2 23 78 100 77 100 0.95
2 9 0.018 1.9 9.6 0.1 1 23 289 311 289 311 0.96
3 9 3.2e-05 0.0034 18.3 1.8 2 23 325 346 324 346 0.97
4 9 1.1e-05 0.0012 19.7 6.4 1 23 355 377 355 377 0.99
5 9 0.00033 0.035 15.1 1.2 3 21 385 403 383 404 0.94
6 9 0.0018 0.19 12.8 0.5 2 21 672 691 671 692 0.92
7 9 1.5e-05 0.0015 19.4 0.5 1 23 1079 1101 1079 1101 0.94
8 9 5.5e-05 0.0058 17.6 7.4 1 23 1107 1129 1107 1129 0.98
9 9 0.0028 0.29 12.2 4.3 1 21 1135 1155 1135 1156 0.96

Sequence Information

Coding Sequence
ATGTTGTCCTGTTTGGCGCCGTCGTCTACACGTTTTGGCCAAGAGGATAATATTATACAACAAAGTATGCCATCGTCAACAGCCTTTACCATGCAgtTTCCCTCTTTGGCCTCCAGtctacatcatcatcatatGCACAGCAAGGCTAGTAATGCGGCAGCCAGCCAGGAGCATGTGGAGCATGCAGCAAGTGCCACAGATTTGACGGGCAATGCCGAGGACTATCTGGTCAAGTGCACGCAATGCCACAAACGCTTTACAGAGTTTCAGTCCCTCAGCGAGCACATTGCCAGCGAGCATCCGCATGATAAGCTTAACTTTGAGTCCAGCCGTGGCGCCAACTTAGGCGCCGCCGCTCAGCCGGAAAGCGATGCTGAGGATGCCGAGCAGCTGGACGAATGCGATCAaagcaatagcagcagcagtCGGAAATATGCCAAGACACCGCCCAATGCCAGCTccagcaataacaataacaacaatgagACGGCCAagaatcacaacaacaacaataataataacagcagcagcagtattAACAAGCACTCGCCCATGTGCTCGCCCAGCTCAGCGCCACATAGCGCTAGCGAGCTTTTTGCTCACTTGCCACATGCCGCAGCCGGCTCACATCCGCCACATTTGCCCGCCCAATTGCATGCCCAATTCATGGCCGCCGCCTTGGCCATGCAATCCGCACGTACCGCCAGCTCACCCAGCAATCAGCTGGTACCGCCGCCACATCATCCACAGCTGAATggtggcagcaacagcagcgttGGTAGCAATTCCGCCTACGATTTGGATTTGACTGCAGCACGTTCCACCTCCAGTCCCGGCTCGATTACGGGCGATCTCAATGCCAGCTATCCGTGTATGCAGTGTACGGCTGCGTTTGGTTCACGCGAGCAGCTGGAGCAGCACGAGCTGCTGCACTCACCCGGCGCACAGCAGTCCACACAGAATGTGACACAGACCTGCAAAATCTGCCACAAAGCCTTTGCCAATGTCTATCGCCTGCAGCGTCATATGATCAGCCATGATGAGTCCGCTCTGCTGCGCAAGTTCAAGTGTAATCAGTGCGACAAGGCTTTCAAGTTTAAGCATCACCTCAAGGAACATGTACGCATTCATTCCGGCGAGAAGCCCTTTGGCTGTGACAACTGCGGCAAGCGTTTCTCGCACTCGGGCTCCTTTAGCTCGCATATGACCTCCAAAAAGTGCATTAGCATGGGCATTAAGCTGAACAACAATCGCGCCATGCTTAAAACGCTGGAGAAAAGCGTCAGCGTTGGTTTGGGCAGTGGTCGCACCTTGGtcgaacagcaacaacaacagcagcagcaactgcagCACAGCAAGCGCCCCAGCAATAATGGCCTTAAACTGCCGGAACAGTCGCCCGCCTTGCCTGCTTTGCCGCCAACTTTGCACAATCCCATGAACTACTTTGCTGGCGATACACAGGCCAAtggtgtgcccaacaatgcacCCGCGCCCTTTTATCCCAACTATAGTGCCATGAATGCCGCTTTATTGGCCACAAATGCCTTTTATAGCATGGCAATGGATCCACGCATACATCCTTATAGCATACAGCGTCTGCTAGAGCTGACGGCTGCgggacagcagcagcaacatcagcagcaaCGTGAGGAGGAAGAACAGCTGTATGCTGAGCTTAAGCCCAGCGTCAAGGACGAGGAGGAAGCCCACGATGAGCCCAAGTTGGTGATGGACTTAGATGAGGCAGAGGAACGCGCCAAGGAGCTGGAGCAAATTGCTGCCACGCCGCAGCTAGCGCACTCACCTATTATAGAAACAGCAGCCGATGCAGCGTCTGTCAAACAAGAGCCCAGTCGTGAAGCCACACCTGTTACAAACATTGGCAGCGCACCAGCCACGCCCAAACCCATAAAACAAGAGCAATTAGAGTCAACAGCCATTGTCATGGATTCACAGCCCGTAGCAGAGGAAGCACGTCCCAGTTCAGCCATAGATGTAGACGCTGAGCTGCGCTGCAGCCGCTGTGACAAGCAATTCAATCATCCCACAGAGTTGGTGCAGCATGAAAAGGTGCTTTGTGGTTTGATTAAGGAAGAGCTGGAGCAGCACTAccagctgcaacagcagcaacaacagcagcagctgcgttTGAACGATGAGCCTAGCAACAACTCTTTTTCGTTGCTGCCCTCCGCCAGCGAGGCTGACGAAGAAGAAGAGCATGTGGATGCTGACGAGGATCGCATTGACTTGGAGAATCGTCAGGACTTTAATGGCAGCGACAGCAGCGAACGCAAAGTGCGCGTGCGTACAGCCATAAatgaggagcagcagcagcaactgaaGCAACACTATACTGTCAATGCGCGTCCCAGCCGCGATGAATTCCGCATGATTGCAGCACGCCTGCAGTTAGATCCACGTGTAGTGCAGGTCTGGTTCCAAAATAATCGCTCACGTGAGCGCAAGCTGCAAAGCTATGCTGTCAATGCTTCGAATTCCAACTCCAGCGAGCCGGCAGTGGCTACAGTTGGACTACGCGAAGATCAGCCTTTGGATTTGTCTGTCAAGCGTGATGCCTTGTTATCCAAGCGCAATGGCGCTCAGCTGCATTCGCCCTTGTATGGCCTGGCACCACAGCAGGCGGGTCAAGCGTTGGCCAACAATGCCGCTGATTTCCAAGAGGCCATTAATCTCAGTCGCAAGCTGTCCAGCACGGCGTCGCTTTCGCCATCTTCGCTGTCGCCTTCCTCAGGCGCCTCTGTACCGGTTTTCAAGCAGCAAGCGGCTgccgctgcagctgcagctttaTACTTTGGTGCACCACAGCACCAGACGCCTTCACCACCTATGCTGGATGCAAGCGCTAATACAGTGCTGCCGCCACAGCACAGCTCCACGCCTAGATCCGCCGCTGGCGCCTTTACCAGACTAGCCGATCACTTGCCGCCCTACATGCTGCCTGGCGCCATGCAGCGCGGCCTGGTGCCCATGGAGGCGCTCTTCCAGATGACGCCCAGCGAGTATGCGCGTAATCCGCTCATGAACAGTATTAAATTGCCCGACTATCGCGGCACTAGCCTTAGTCCAGGCGGCTCGGAGAAACGCTCTTGGCGCGATGATGACTCGCGCATTAGCCATGAGGATGACTATAGCGGTGGACTATTGCCGCCCAAGCCCAAGCGCGCCAAGGCCGAAACGCATGGTCATGCAGGTGATCCTGATTTGCCTTTTGTTTGCGATCAATGCGACAAGGCCTTTGCCAAGCAAAGTTCGCTGGCGCGTCACAAATACGAGCATTCCGGTCAGCGGCCCTATCAATGCATGGACTGTCCCAAGGCTTTCAAGCACAAGCATCACTTGACGGAGCACAAGCGTCTGCACAGCGGCGAAAAGCCCTTTCAGTGCTCCAAGTGCCTCAAACGTTTCTCTCATTCGGGCAGCTATAGCCAGCACATGAACCACCGTTACTCCTACTGCAAACCCTACAGGGAATAG
Protein Sequence
MLSCLAPSSTRFGQEDNIIQQSMPSSTAFTMQFPSLASSLHHHHMHSKASNAAASQEHVEHAASATDLTGNAEDYLVKCTQCHKRFTEFQSLSEHIASEHPHDKLNFESSRGANLGAAAQPESDAEDAEQLDECDQSNSSSSRKYAKTPPNASSSNNNNNNETAKNHNNNNNNNSSSSINKHSPMCSPSSAPHSASELFAHLPHAAAGSHPPHLPAQLHAQFMAAALAMQSARTASSPSNQLVPPPHHPQLNGGSNSSVGSNSAYDLDLTAARSTSSPGSITGDLNASYPCMQCTAAFGSREQLEQHELLHSPGAQQSTQNVTQTCKICHKAFANVYRLQRHMISHDESALLRKFKCNQCDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGIKLNNNRAMLKTLEKSVSVGLGSGRTLVEQQQQQQQQLQHSKRPSNNGLKLPEQSPALPALPPTLHNPMNYFAGDTQANGVPNNAPAPFYPNYSAMNAALLATNAFYSMAMDPRIHPYSIQRLLELTAAGQQQQHQQQREEEEQLYAELKPSVKDEEEAHDEPKLVMDLDEAEERAKELEQIAATPQLAHSPIIETAADAASVKQEPSREATPVTNIGSAPATPKPIKQEQLESTAIVMDSQPVAEEARPSSAIDVDAELRCSRCDKQFNHPTELVQHEKVLCGLIKEELEQHYQLQQQQQQQQLRLNDEPSNNSFSLLPSASEADEEEEHVDADEDRIDLENRQDFNGSDSSERKVRVRTAINEEQQQQLKQHYTVNARPSRDEFRMIAARLQLDPRVVQVWFQNNRSRERKLQSYAVNASNSNSSEPAVATVGLREDQPLDLSVKRDALLSKRNGAQLHSPLYGLAPQQAGQALANNAADFQEAINLSRKLSSTASLSPSSLSPSSGASVPVFKQQAAAAAAAALYFGAPQHQTPSPPMLDASANTVLPPQHSSTPRSAAGAFTRLADHLPPYMLPGAMQRGLVPMEALFQMTPSEYARNPLMNSIKLPDYRGTSLSPGGSEKRSWRDDDSRISHEDDYSGGLLPPKPKRAKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00339039;
90% Identity
iTF_00338228;
80% Identity
iTF_00338228;