Basic Information

Transcription Factor Domain

TF Family: TEA
Domain: TEA domain
PFAM: PF01285
TF Group: Helix-turn-helix
Description: The TEA domain is a DNA-binding region of about 66 to 68 amino acids that has been named after the two proteins that originally defined the domain: TEF-1 and AbaA. The TEA domain is located toward the N terminus of eukaryotic transcription factors of the TEA/ATTS family. It shows a three-helix bundle with a homeodomain fold [3, 1]. Two α-helices are nearly anti-parallel and pack on either side of the third one, which is the DNA-recognition helix of the TEA domain. Phosphorylation of one or both of the two conserved serines found on the DNA-binding surface could interfere with DNA-binding activity, by introducing electrostatic repulsion and/or steric hindrance, and help regulate the transcription factor activity of the proteins [2, 1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 0.42 3.9e+03 -1.7 0.0 33 49 59 75 34 78 0.63

2 2 1.2e-10 1.1e-06 28.9 0.0 2 36 152 188 151 191 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	0.42	3.9e+03	-1.7	0.0	33	49	59	75	34	78	0.63
2	2	1.2e-10	1.1e-06	28.9	0.0	2	36	152	188	151	191	0.90

Coding Sequence: ATGTGTTCAAATTGCGTCGACGTTGGCGTTGACGTTATCTTGGCTGTGGCTGTCAACAGCGCCAAAGCAGCGCATCCCATTCTCGAAATCAAACTAAAACTAAAAGCTCTGCAAATAGTCAATGTTAGTGAAGCGGGTGAGCAGCAGCTGCTGCTGCTACATTGGTGGAGCAAGGAGGGGGCCAGGCGGGCACCTGTTATCAACATTTATTTAAAAAACGATACAGAAGACGGCACCAAAGTGGCGCCGTTCTCCAAACATTTGGATTCCCTTGAGGAATTTAAGGGATTGTCGGTTGGACCCGGCACCATACCATCCCCGTGGACACCAGTGAATGCCGGTCCGCCGGGTCCACTCGGATCGGCAGACACAAATGGCAGCATGGTGGATAGCAAAAATTTGGATGTGGGCGATATGAGCGATGATGAAAAAGATCTATCATCAGCCGATGCCGAAGGTGTTTGGAGTCCAGACATTGAACAAAGCTTTCAAGAGGCATTATCAATATATCCGCCATGTGGACGCAGGAAAATTATTTTATCCGATGAGGGTAAAATGTATGGTAAGTTGAACAAATAA
Protein Sequence: MCSNCVDVGVDVILAVAVNSAKAAHPILEIKLKLKALQIVNVSEAGEQQLLLLHWWSKEGARRAPVINIYLKNDTEDGTKVAPFSKHLDSLEEFKGLSVGPGTIPSPWTPVNAGPPGPLGSADTNGSMVDSKNLDVGDMSDDEKDLSSADAEGVWSPDIEQSFQEALSIYPPCGRRKIILSDEGKMYGKLNK

Sequence clustering based on sequence similarity using MMseqs2