Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_035041775.1
Location
JAWNKW010000047.1:5938883-5944838[-]

Transcription Factor Domain

TF Family
THAP
Domain
THAP domain
PFAM
PF05485
TF Group
Zinc-Coordinating Group
Description
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1e-15 8.3e-13 49.0 0.2 1 87 5 84 5 84 0.90
2 2 1.1e-05 0.0087 16.9 0.1 25 87 1034 1089 1016 1089 0.81

Sequence Information

Coding Sequence
ATGGGTCGTCGTTGCTGCGTAGCCAACTGCCCTTCCACATCTCGGCTGGTGGAACATAATGGCGTTACCTATCATTTATATCCCTCGGGCACCGTCATTCGCAATATTTGGATCAAGAACACGCGCATTGACTTGGAACGTCAGATAACTAAAAGCGTGCTTGTTTGTTCTCGACACTTCCATCATTCGGACTTTCACACTATACGCAATGGCAAGTATTTGCTTGAGCCAGGCGCCTTTCCTACGGTATTTCCTTGgggtaaaatggaaaattctGAAATCGAGGCTGACCAACGCGCTTTGCAGCAAGGTGCGCTCGATGGTGCTTCAGTTGCCCAAGTAGCTGCAATTGACGACGATGCAGCTACAGCTGAAATAAGCGAAGAAGCGGCTGCGCCGAAATATGGACCACTTACCAATATCATCATTGGAGCACGTCTGGAAGCTCTGAACAGCGAAGAGGCATGGATGCCGGCGCGCATAGTGGAAATTGATGATCAGCGGCAAACCGTACTCGTACGTTTTGAgcgaaacaacaaacagagaGTGCCACTCCCACCAGGAGTCAGCAATCAAAAATGGATGAGCATAAAGTCGGAGCGCCTGCGTCAGCGCGTTAGTGCGCGTGTGCTGTCCATATTTGAGTTGCACGAAAAGTGCATGGCGCGTTGGTCGGGACCGCGCAAGTTTCCAGGCACCACTAAGAAGCTGCTGGGCAACGATACCTACGAGGTGCTCTTTGATAATGGCTATAGCAAGAATGTGCACGCTCTACATATGGATAAACTGCCCAAACAGCTGGATGCAATTGACGGTGTGGCTATGCCGGCAAAACGTGCATGTTTGCctagcaacagcagcaaaaagaagagcaagtCGGCAGCGCAACGCAAGGATTGGCCTTTGCAGGATATGTCATCTTTGGATTTGGATTCACTTGGTCTTCCCGACATACCCCGTGATGGAGAATGGACATGTCACTGGGTAAACGATCAACCCATTGGCAGTGAGGGTTTTTTAATTGTTGGCGAGCAACGCAAGCCCACAGTTATTGTGCAGGACTGGCGTCTGCCTGCGGGTTGGATAAAACACATGTGTCAGCGCACCAATGTCTTAGGCAAATGGGACGTCATCTTGGTCTCACCTAGCGGCAGGCGTTTTCGTTCGAAATCTGATCTTAAGCTTTTTCTTGAGTCTCAAGGCTTCGATTATGATCCGGAAGTGTACGATTTTAGCATTCATCGTAGACGGGCCAAGGACATTAATGCCTATGTCTATACAAACAACTATAGCCCACAAGAGCCACATAAGCCCAAACATTTAAATCCGGCCCCGCTGGATCCTACTACTGACAAATTAGCGGCAGCTGTAGCTGTGCCGGTTAGTCAGTATATGGAAATGCCAGTTGTCTCTTTGATGCCGCCAGCAGAGCTATTGTCTTCACAGGAAAGCGCAGCAGAGGACATAAAGTCTTTTTCAGTCTTATATGCAGAAGCTACCGTCGGCATAGAGCGTCTCCCAACGGGCATTGACAAAGATGGCGCCGAAGAGTTGCATAATGATTACGCTTACATTGGAGGTCTGAAGGTTCAAATAACtaacaatttgtttgtgtgcccCAACGAGAGCTGCGGAAAGACCTATCGCAAGGAGGACTTTCTACAAATACACATACGCCACTACCATAAGGAGTTTGCAGAgcATGTTAGCCGCTGTCCCAAAATGCAAGAACTTGCTGTCAAACGTACGCATCCTTCCTCAAAAGTACAAGGCGAGAGCACGCCTAAAAACCAGATACcaaatcagctgttctttGCCAAACTGCACCAGCAAGATTTAAAGCAAACGCGTTCCGTTCGACGCAAAGCTGCTGCCACAAAATTATCCGTTATCCCAACTACACACACGTCTCCTGCCAAGGCAGCGCATTCATCGCCCAAAATGGAAGAGGCAGCAGTGTCAACATTGACATCAATTCCCGTTTTACCTAGCGTTCCGAATATTGTCGCTGCCGCACCCGTGCCTCATAGCATGGTGGCCGCAAAACCGTTAAAGACGGTCGTATGTGATCGCTCCAAGAAACCACGTTCATCGCGCAAAATCAGTCGCCAGCGCACACAACGACGCTACACCAAACCAACACCAAGCAGCTTTGAAAAGCAAGATTTTCAGTCCACAGATGACGAGCAGACTCCGACACTGGACAACCGCGATCCCAACGAGTCAAAGAGACGACGCTTAGAAGTCGTAGACACACCCAACGAGCTGACGATTGATTCGACAGCTACGTTCGATTCCATTTACACCGCTTCGGTTAACGAGCAGGACGATGTAAATGCACCATTGGTGCCAACGCCGCCAATCAGTCAGCTGTCGCAGTTTATTAAGGAGGAGATCATAAACTGTATTTGCAAGAATGGCAAAGAGTCTGGCCTTATGATACAGTGCGAGTTGTGTCTCTGCTGGCAGCACGGTGCCTGCAATGGCATTTACCAGGAGTCGTACGTACCAGAAAAATATGTCTGCTACATTTGCCACAATCCGCCGCGTGTACGTGAATCGATGCGCTTCAAACATGATCAAGATTGGCTGTTCGAAGGCAAGCTTCCAACTGCAAGCTATCATACGGCTAATCCTCAGGCTGAAAAGGAGTCTTCTCTATTAGAACGCTCGCACGCGATCACGGGCAATCTTTTGGATCTCAAGCACTCAATGCACTCACAGCAAGTAAAGATTAACATTTGCAAGGAACCCTGCCATCCCGAGTTGTTTTTATGGGCCAAAAAGTgggatgaagatgaagaaacCCCCGAACAACTGAACACACCACATCTACCACAGCAAGAAGCCGCAATCGATCCAGAAGAATGCCACTATAATTTGATCGAGCATATAAGTCATCAGCAGGAATTGACTTCAGATCGACTTAATGACATTGAAGCCGCGATAAGCCAACTCGAAGAATTGGATGACTTGGCCGACTTAAAAGATGCACCTGATGTGGCAGTCAAAGAAGCCTTGtccatttatataaaagatgtGGAGCAGCTTCAACGTCTGGCTAACTTTAACTATGTGGCCAATATGAAGAAGGCCCAAGAAGAGAAGCatctaaaaatTATTTGGATCAAGAACACGCGCATTGGCTTGGAACGCCAGATAACTAAGAGCGTGCTTGTTTCTTCTCGACACTTCCATCGCTCGGACTTTCACACTATACGCAATGGCAAGTATTTGCTTGAGCCAAGTGTCTTTCCTACGGTATTTCCTTGGGGTAAAATGGACAATTCTGAAATCGAAGCTAACCAACGGGCTTTGCAGCAAGCTGCGCTCGATGGTACTTCACTTGGCCAAGGAGCTGCGACTGCTTATAGCGAGGAAGATACAGCCAAGGATGTCGTGAACAATTGA
Protein Sequence
MGRRCCVANCPSTSRLVEHNGVTYHLYPSGTVIRNIWIKNTRIDLERQITKSVLVCSRHFHHSDFHTIRNGKYLLEPGAFPTVFPWGKMENSEIEADQRALQQGALDGASVAQVAAIDDDAATAEISEEAAAPKYGPLTNIIIGARLEALNSEEAWMPARIVEIDDQRQTVLVRFERNNKQRVPLPPGVSNQKWMSIKSERLRQRVSARVLSIFELHEKCMARWSGPRKFPGTTKKLLGNDTYEVLFDNGYSKNVHALHMDKLPKQLDAIDGVAMPAKRACLPSNSSKKKSKSAAQRKDWPLQDMSSLDLDSLGLPDIPRDGEWTCHWVNDQPIGSEGFLIVGEQRKPTVIVQDWRLPAGWIKHMCQRTNVLGKWDVILVSPSGRRFRSKSDLKLFLESQGFDYDPEVYDFSIHRRRAKDINAYVYTNNYSPQEPHKPKHLNPAPLDPTTDKLAAAVAVPVSQYMEMPVVSLMPPAELLSSQESAAEDIKSFSVLYAEATVGIERLPTGIDKDGAEELHNDYAYIGGLKVQITNNLFVCPNESCGKTYRKEDFLQIHIRHYHKEFAEHVSRCPKMQELAVKRTHPSSKVQGESTPKNQIPNQLFFAKLHQQDLKQTRSVRRKAAATKLSVIPTTHTSPAKAAHSSPKMEEAAVSTLTSIPVLPSVPNIVAAAPVPHSMVAAKPLKTVVCDRSKKPRSSRKISRQRTQRRYTKPTPSSFEKQDFQSTDDEQTPTLDNRDPNESKRRRLEVVDTPNELTIDSTATFDSIYTASVNEQDDVNAPLVPTPPISQLSQFIKEEIINCICKNGKESGLMIQCELCLCWQHGACNGIYQESYVPEKYVCYICHNPPRVRESMRFKHDQDWLFEGKLPTASYHTANPQAEKESSLLERSHAITGNLLDLKHSMHSQQVKINICKEPCHPELFLWAKKWDEDEETPEQLNTPHLPQQEAAIDPEECHYNLIEHISHQQELTSDRLNDIEAAISQLEELDDLADLKDAPDVAVKEALSIYIKDVEQLQRLANFNYVANMKKAQEEKHLKIIWIKNTRIGLERQITKSVLVSSRHFHRSDFHTIRNGKYLLEPSVFPTVFPWGKMDNSEIEANQRALQQAALDGTSLGQGAATAYSEEDTAKDVVNN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00336730;
90% Identity
iTF_00336728;
80% Identity
iTF_00336728;