Basic Information

Gene Symbol
ZFHX3
Assembly
GCA_905475395.1
Location
FR997757.1:22974922-23002828[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.0031 0.067 14.1 0.1 1 23 78 101 78 101 0.96
2 14 0.53 11 7.0 1.9 2 22 214 234 214 237 0.90
3 14 9.1 2e+02 3.2 0.5 3 23 251 274 249 274 0.86
4 14 0.017 0.37 11.7 1.6 1 23 292 314 292 314 0.97
5 14 0.067 1.5 9.9 0.6 2 23 321 343 320 343 0.94
6 14 0.01 0.22 12.4 3.1 1 23 467 491 467 491 0.92
7 14 0.029 0.63 11.0 0.6 1 22 511 532 511 535 0.89
8 14 0.0059 0.13 13.2 0.2 1 23 629 653 629 653 0.93
9 14 0.0072 0.16 12.9 0.2 2 20 729 747 728 749 0.93
10 14 2.7 58 4.8 2.5 2 19 928 945 927 950 0.90
11 14 0.00063 0.014 16.2 2.5 1 23 1575 1597 1575 1597 0.99
12 14 0.0027 0.059 14.2 0.3 1 23 1700 1722 1700 1722 0.98
13 14 0.013 0.27 12.1 0.4 2 23 1879 1901 1878 1901 0.97
14 14 0.84 18 6.4 3.2 3 23 2163 2185 2161 2185 0.89

Sequence Information

Coding Sequence
ATGTCCTCATCAGATGATCTCAATACATCAATAGAATCCACGACACCATCCTCCAATCATATATGCCCATTTTGTAACTATAGTAGTAATTCAGAGATGCGAATACAAGCGCATGTTTTAGCCCAACATAGTAATCTTGCTCAACAACAATCCGTAACTACCCCGCAACAACAACAAGCAGAACCGATATCAACTCCAACAGTGCCACAATCACCACCTCAACAATACACCTTTCAATGTCCTTTGTGTCAAGATGCATTTAAAGATCGTATTAATTTAGAACGTCATGTCATGCAAATCCATTCGGTTAATTCAGAAGGATTACAAAGACTGTTGATGCTTGTCGATCAAAGTCATTGGTTAAATCAAGTTGCTCGAAACAATCAAACTCCTCCAAGTTCGAATATTAACAATACCACGATAACTGCATCACATATGATGGCAGCAGCCACGGCTCAACAACAAGCCTCACCTAATTCTGTAACATCATCCTCGGGTGATCGAGATCGTAAAGATCTAATTAAAACCGAACGTGACGATTTAATTATCATAGAGTCGTCATCAACACCAAATAACGAACTTATGTCACCAGTTAACAATGACAACGATGTCGTTATCAATGACACAATCGAATCAGAACGTTGTCAACAATGTTTACAAACATTTAAAAATATCGATGAATTATGTTTACATCAAAATGAATCAGGCCATATTGAAATTAAACAAACACCCAGTGGTCCTGGTTACTTATGTTGGAAAAAAGGGTGTAATCAATTTTTCCCCACGGTTTTATCATTACAAACACATTTTAAGGAAGTACACGCAAAAAATTCAATATCACAAATGTCCGTTTCAGAGAAACATGTTTACAAATATCGTTGTAATCAATGTTCGTTGGCATTTAAAACGTTAGAAAAATTACAACTGCATTCGCAATATCATTTAATACGAGACGCAACGAAATGTGTCCTCTGTGGACGTAATTTTCGATCGGTTATTGCATTACATAAACATGTGGAATCCGTTCATTCAGAATTATCTGATGATGAATTACAAGCTTATAAGAATAGTTTATTAAATAATCCATTATTATTGGCTGGATTACAAGGTCATGTTTTGGATCCGTCAACAACAAATGACTTGTTAAAGCGAGAAACAATGCGTGATGTATCTGGAAGTGAAAATGATTTACGTAACGCTTCTGGCGGACCAAATGAATTTAATAAAACTAATTCTGATTCATCCTCATTATTAGAAAATGATGAATCCAAAGAATTAATTGATAATGACGGAGAAAATTCTGATGATAGTATCGTTTACAAAGAACAACAATTCCTAGAAGAGTATTTAAATTCGCAAGCGGTAGCCGAAGATAATTATGCGGATCCAACACGTAAATATAAATGCCATCGATGTCGTGTTGCATTCACCCGACAAAATTATTTAACCGCACATAATAAAACAATACAACATCGTAAAGGGGAAAAATTAAATTATCCAATGGAAAAATATTTAGATCCAAATCGTCCATATAAATGTGATGTTTGTAAGGAGAGCTTTACCCAAAAGAATATTTTACTTGTACATTATAATTCTGTAAGTCATTTACATAAATTAAAGAGGGCAATGCAAGAACAACAAAACAATAATAATCCAGTTTCACCAACACAAGGTCAACAGCAAACAAGTACGTCAGCGAACATTACATCAACAGCATCCACAGGGGTAGTTGTTAGTACTGGCGGGGGTAATAATAATAATAATAACAATACAAATAATAATAATACGCTTACATTAACACCAAAAAGTACGACAAGTTCAAGTTCAACCACGTCATCTTCATCAACGGCGAATAATGATGAAATGATGGATGAGAAAAAACGTTATCGTTGTAATATATGTAAAGTTGCTTACACGCAAGGTAGCACGCTTGATATACATATGCGAAGCGTTTTACATCAAACACGTGCAAGTAAGCTACAAGATTTAGCAATCAGTGGACAAATCGATTTATCTAGACCACTAGTTGAACAACCATCAATGAATGATTTAATAAACAACCCCTCACCACCTGGAGGGGTTGTTACACAACCAATATTACCTCAAACTCCGCCTGTACCATCTACCTCCCCTCCAAGTAACAATAATACTGTTCAGGTAGTACAAACACCTCAAGGGATGATTTCATGTCCTAAATGTGGTGTTCTTTTTGCAAATCAAGATCAGTTAACTACTCACCAGCATTTATATTGTATGTTTGCAATAACTAGTAGTGGTATACCGACTAGTGTTGCAACATCTATGGCTGTAGCTGCAGCCCAACAACAATTAGCAAATAGTAATAATAATAACAGTGTGGTGGACAATGTTGTGACAAGACCATCTCCAAGTGCTACCCCAAATAGTGTTGTGACAATAAATGATCAAAGCTCAAACGATATGAATAAATTAAATATACCGCGTAAAACTGGATCACATATTTATAAACATTTGTTAGAAAGTTATGGATTTGACTTAGTGATGCAATTTAATGAAAACCATCAACGACGTCAACGTTTAGCTGCAGCTCAACAACTTCAACAATTGGAGGAATTACGTAATAGTGTTGCACCAAATAAAACACCAAGTCCATTACCACAGCAACAAGCACCGGATGTACCTAGTAACAACAATACAATTGGAACAACACCAAGTGGAATTGATAATGAAAATGGTTCTGGTGTACCACGAAGTGAGGATGCATCTTCAACACCACATCATTTGCCAGAGGTCAGTAAATCCACGTGCCAACATTGTAATAAAGACTTTTCAAGTGTGTGGGTGTTAAAATCACATTGTGAAGAAATTCACAAAGATTTAGTGCCATTAGAATTCTTAGAAAAATATGCGCAACAAATTAAAAACGAATATGAAAAGAAGGCAGTTGTAGTGTGTAGTACTACGGCGGGGGGAGGAACATCATCGTCGATAGTTACGACAACACCACGTGCCACAACACCTGGTGGTGTATCGACAAATGCGACGACGTTGACTATACCTCCGTTGTGTACCACAACTACCACCCCAAGTCTTGTTGAGAATTCTGATTTAAGTGAAGACAATAAAGAAGTGTTGCATACAAAATTGAACATTCAACAGAACACTACGACAACAACACCACCGGCTGCTTCCGGGGATGGTGCTATCACTGGTGCGGCTGCTACATCCACAGCACCCTCGACACCAACATCTTCCTCAACGCCTGTTTCGTGCAGCAACGATAATGGTGGTAGTGCCAACAACGGAGGAGCACCACCAGGTGGTCCAACGATACCGGCAAATATCCAAGCGATGTTGGCTCAAACTATGGCCCAAAATCCAATGGCGTTTGCACAACAAATGTCGGAAATGCAAGCGGCGTTGAATGTCATGCAATTACAACAGCAATTCCAAAATTTCAATCCAATGATGATGAGCCAAATGATGTCAATGGGTTTGCCACTTGGTTTAAATGCATTGGCTGCAATGAATTTACAACCACCATTGGTTGCAAATGCTGCGGCAAACCAGAAGAGAGCACGTACCCGTATTACTGATGATCAATTAAAAATATTACGCGCCCATTTCGACATAAATAATTCACCCTCAGAGGATCAAATTCATGAAATGGCGGCCCAATCTGGATTACCACCCAAAGTGATCAAACATTGGTTCCGTAACACATTGTTCAAAGAACGACAACGTAATAAAGATAGTCCGTACAATTTTAATAATCCACCATCGACGACATTAAATTTAGAAGAATATGAGAAAACTGGTGAAGCTAAAGTGTTACCATTAAATACGTCAGGCTCGTCGGGGTCGTCTGGTGATGATTTACAAAAATCAACTTCATCACAACCACAATCATGCCCTAGCGATAATGAAAACAAATTAGGCCCAATGGGTATGTTACAATCCACATCGCCGAGTATAAATGATTATCCAAATAGTGATATTGTTAAAACTGAACCAAAAGAGGAACAAAATGATGAGACTGATAAATTATTACCAGATACCCCAATCGATGAGAAACCAAATATATTTAATTTGCCATTTAATTTACATCATCCACCCCAAAGTCCAGTGCCATCATTAGCGGAATCAGAAAATCAAAGTTTGATGCATTCAAGAAATAGTAGTCGGCCATCAACGCCGACGAACTTAAATCTTTCGTCTTTAATGAATCAACAACTTAATGATGTGATTTCATCGGTTTCTCAATTGCCTGTTTCTATGGCCCAAGTAATGACACCGACATCATTGTCTAGTACAATGTTACCACCACCAAAATTGACGCCACAAAATTTTGCTAGCCCTAATAACGTGGGTGGACAACAAAATATGCTATCATTAACGCCAAATCGTAGCATTAGTCCAACACGAGTAGAATTTGGTGGCAACAGTAATGGATCAAATAGTTCCAGTGGATCAACTGGCAAACGAGCAAATCGTACACGATTCACTGATTATCAAATAAAAGTTTTACAAGAATTTTTTGAAAATAATGCATACCCAAAAGACGATGATTTAGAGTATTTATCAAAATTATTAAGTTTAAGCCCACGAGTGATAGTTGTTTGGTTTCAAAATGCACGGCAAAAAGCTCGAAAAGTATATGAAAATCAACCAGCTGTAGAACCCGCACCAGGTGTCGCTGAAGAAGCCGGTGCAAATCGTTTTCAAAGAACACCTGGTTTAAATTATCAATGTAAAAAATGTTTGTTAGTATTCCAACGATATTATGAGCTTATTCGCCATCAAAAGACACACTGTTTTAAAGAAGAAGATGCTAAAAGATCAGCTCAAGCTCAAGCTGCTGCAGCACAAATTGCCGCAGTTTTGAGTTCAGAAGATTCAAATTCAAGTACAATCATTGAACAAAGTCAACAAAGTCAACCACCCGTACCACAAAGTCCACAAATACAAAATATTCCACCACAAAGTCCGATCAGTCAACCAACACAACCCACAACACCAACACCGTGTGGGTCGAATTTTCCCAATTCGCCAGCAACAACCCCAACACCAAGCCAACAAGGAGGTAATAACAGCAACAACGATACTAAGGAAGGTACATTTCAATGTGATAAGTGTAACTTAGTATTTCCACGGTTTGATTTATGGCGTGAACATCAATTGGTTCATATCATGAATCCAAACTTATTTCCATCTTATCCACCTGACTCCCCGTTTGGCATATTACAACAACATGCGCAGTTACAACAAATGAATGCGGCCGCAGCTGCAGCAGCGGGCAATTTAAATGTATCAGAACTGAGTAACAGTACTGGCAACTCACCAATACCGCATCCATTAATGGGATTGTTAACAAATGCTGGCGGACAAGTGAAACGAAAATATGATGAATATGATCTGGAAAGTGATATGTCCGATCAACCAAAAGATAAACGACTGCGCACAACAATACTACCCGAACAATTGGATTATTTATATCAAAAATATCAAATTGAATCGAATCCATCTCGAAAAATGTTAGAAAACATTGCTCGAGAGGTGGGTTTAAAAAAACGTGTAGTCCAGGTGTGGTTTCAGAACACTCGGGCGCGTGAACGTAAAGGACAATTCCGAGCACACGCCCAGGTAATCAATAAACGTTGTCCATTCTGCCCAGCATTGTTCAAAGTTAAATCTGCATTAGAATCACATTTACAAACTAAACATGCAGATCAATGCGCACGCGGAGAAATCAATATTGATGCGTTGCCAGATGAAGAATTAAGTATGGAATCGGCGCCAAGCTTCAGTTCAGGTGGTGATAATAAAAGTTTTTCATCAAATAATCCAAATATGATTCCACCACTTTTCCCACCATTTAATACTCCTGACATGGAAAATTCAATAAAAAAATACTACGAAGAAAGTATGAAGCGATATATTAGTGAGTTGCAAGCACATGCAGCTGCGACGAATGGTGATAAAAGTGAAATAATGCTTAAATCGGGTAAAGAAGAAGGTGACTCACCATTAGATCTATCTAAGCCTGTTGATTTATCACGACCAATGAAAGTCACATTGGATCATGAAAAATCATTTATAGACCCAGGTCCATTAACGGATTTAAGTGAACGTTCCTTATGTGATGATGATTCCATGTCAGAAACAACGGAATTCTATGATGATGAAAGTAATCCAACATCTCCAGCAAGTTCGACACAAAGTACTAATAATAATCAACAACGTACAATGACTTCGACGGGCTCAAATTCGGGTGGCAATAAACGTTATCGTACTCAAATGTCTTCGTTACAAATCAAAGTAATGAAATCATTATTTAACGATTATAAGACACCCACAATGGCGGAATGTGAAATGTTAGGTCGTGAAATTGGTCTTCCAAAACGTGTTGTACAAGTATGGTTTCAAAATGCTCGTGCAAAAGAAAAGAAGAATAAAGGTTCATCGACAAAACCTGGAAGTGAACTAGTGGAAAAAACACCGGACGATTGTAAATATTGTAATTTTAAATATTCACATAAATTTTCCGTGCAAGATCATATATTTACAAAATCACATATTGCAAATGTGAAAATGCATTTAGAAGCGTTAAGTAAAGACTCATCGGGTAATTTAAGTGATAATGGTGAATTTCAAGTGCCCCCTGTACCGGGTGGTAGTACAAACAATAATAATAATAGTGCGGTAAATGCGGATTCTACAACACAAAATTTATTGGCAACATTAAATAATAATGGCAATAATAATCAGCATTTAGCGCAAATGCAATTATTACAAATGGCTGGTCTACAAATGGCGGCTGTTGCACAACAACAGAAACAAAACTCTGGTGGCGGTGATGATAGTAAAAATAATGACAATGACAATGCGAATAATGTGACGGAATCATTATTTCAACAATTGTATGCGTTAAGTAGTGCTAGCGGTGGTCCAAATTCAAGTGGGTTCCCTGGCGCGAATCAGTTCCTACACCCTGCAATGTTTGGTGCAAATGGTGAGTGA
Protein Sequence
MSSSDDLNTSIESTTPSSNHICPFCNYSSNSEMRIQAHVLAQHSNLAQQQSVTTPQQQQAEPISTPTVPQSPPQQYTFQCPLCQDAFKDRINLERHVMQIHSVNSEGLQRLLMLVDQSHWLNQVARNNQTPPSSNINNTTITASHMMAAATAQQQASPNSVTSSSGDRDRKDLIKTERDDLIIIESSSTPNNELMSPVNNDNDVVINDTIESERCQQCLQTFKNIDELCLHQNESGHIEIKQTPSGPGYLCWKKGCNQFFPTVLSLQTHFKEVHAKNSISQMSVSEKHVYKYRCNQCSLAFKTLEKLQLHSQYHLIRDATKCVLCGRNFRSVIALHKHVESVHSELSDDELQAYKNSLLNNPLLLAGLQGHVLDPSTTNDLLKRETMRDVSGSENDLRNASGGPNEFNKTNSDSSSLLENDESKELIDNDGENSDDSIVYKEQQFLEEYLNSQAVAEDNYADPTRKYKCHRCRVAFTRQNYLTAHNKTIQHRKGEKLNYPMEKYLDPNRPYKCDVCKESFTQKNILLVHYNSVSHLHKLKRAMQEQQNNNNPVSPTQGQQQTSTSANITSTASTGVVVSTGGGNNNNNNNTNNNNTLTLTPKSTTSSSSTTSSSSTANNDEMMDEKKRYRCNICKVAYTQGSTLDIHMRSVLHQTRASKLQDLAISGQIDLSRPLVEQPSMNDLINNPSPPGGVVTQPILPQTPPVPSTSPPSNNNTVQVVQTPQGMISCPKCGVLFANQDQLTTHQHLYCMFAITSSGIPTSVATSMAVAAAQQQLANSNNNNSVVDNVVTRPSPSATPNSVVTINDQSSNDMNKLNIPRKTGSHIYKHLLESYGFDLVMQFNENHQRRQRLAAAQQLQQLEELRNSVAPNKTPSPLPQQQAPDVPSNNNTIGTTPSGIDNENGSGVPRSEDASSTPHHLPEVSKSTCQHCNKDFSSVWVLKSHCEEIHKDLVPLEFLEKYAQQIKNEYEKKAVVVCSTTAGGGTSSSIVTTTPRATTPGGVSTNATTLTIPPLCTTTTTPSLVENSDLSEDNKEVLHTKLNIQQNTTTTTPPAASGDGAITGAAATSTAPSTPTSSSTPVSCSNDNGGSANNGGAPPGGPTIPANIQAMLAQTMAQNPMAFAQQMSEMQAALNVMQLQQQFQNFNPMMMSQMMSMGLPLGLNALAAMNLQPPLVANAAANQKRARTRITDDQLKILRAHFDINNSPSEDQIHEMAAQSGLPPKVIKHWFRNTLFKERQRNKDSPYNFNNPPSTTLNLEEYEKTGEAKVLPLNTSGSSGSSGDDLQKSTSSQPQSCPSDNENKLGPMGMLQSTSPSINDYPNSDIVKTEPKEEQNDETDKLLPDTPIDEKPNIFNLPFNLHHPPQSPVPSLAESENQSLMHSRNSSRPSTPTNLNLSSLMNQQLNDVISSVSQLPVSMAQVMTPTSLSSTMLPPPKLTPQNFASPNNVGGQQNMLSLTPNRSISPTRVEFGGNSNGSNSSSGSTGKRANRTRFTDYQIKVLQEFFENNAYPKDDDLEYLSKLLSLSPRVIVVWFQNARQKARKVYENQPAVEPAPGVAEEAGANRFQRTPGLNYQCKKCLLVFQRYYELIRHQKTHCFKEEDAKRSAQAQAAAAQIAAVLSSEDSNSSTIIEQSQQSQPPVPQSPQIQNIPPQSPISQPTQPTTPTPCGSNFPNSPATTPTPSQQGGNNSNNDTKEGTFQCDKCNLVFPRFDLWREHQLVHIMNPNLFPSYPPDSPFGILQQHAQLQQMNAAAAAAAGNLNVSELSNSTGNSPIPHPLMGLLTNAGGQVKRKYDEYDLESDMSDQPKDKRLRTTILPEQLDYLYQKYQIESNPSRKMLENIAREVGLKKRVVQVWFQNTRARERKGQFRAHAQVINKRCPFCPALFKVKSALESHLQTKHADQCARGEINIDALPDEELSMESAPSFSSGGDNKSFSSNNPNMIPPLFPPFNTPDMENSIKKYYEESMKRYISELQAHAAATNGDKSEIMLKSGKEEGDSPLDLSKPVDLSRPMKVTLDHEKSFIDPGPLTDLSERSLCDDDSMSETTEFYDDESNPTSPASSTQSTNNNQQRTMTSTGSNSGGNKRYRTQMSSLQIKVMKSLFNDYKTPTMAECEMLGREIGLPKRVVQVWFQNARAKEKKNKGSSTKPGSELVEKTPDDCKYCNFKYSHKFSVQDHIFTKSHIANVKMHLEALSKDSSGNLSDNGEFQVPPVPGGSTNNNNNSAVNADSTTQNLLATLNNNGNNNQHLAQMQLLQMAGLQMAAVAQQQKQNSGGGDDSKNNDNDNANNVTESLFQQLYALSSASGGPNSSGFPGANQFLHPAMFGANGE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00332163;
90% Identity
iTF_00332163;
80% Identity
iTF_00332163;