Basic Information

Gene Symbol
ZFX
Assembly
GCA_963691955.1
Location
OY829898.1:15868763-15874784[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.32 22 6.1 1.5 1 23 87 111 87 111 0.96
2 11 0.00075 0.052 14.4 1.8 2 23 119 140 118 140 0.96
3 11 9.9e-05 0.0068 17.2 1.3 2 20 146 164 145 166 0.94
4 11 1.6e-07 1.1e-05 26.0 0.8 1 23 176 199 176 199 0.98
5 11 0.64 44 5.2 4.6 1 23 205 228 205 228 0.92
6 11 0.0033 0.23 12.4 0.1 1 23 235 257 235 257 0.95
7 11 0.074 5.1 8.2 0.3 1 23 262 284 262 284 0.97
8 11 2.1e-06 0.00015 22.5 0.7 1 23 290 312 290 312 0.99
9 11 0.0056 0.39 11.7 2.5 1 23 315 337 315 337 0.97
10 11 3.9 2.7e+02 2.7 0.2 3 23 345 370 343 370 0.81
11 11 0.00024 0.016 16.0 2.2 1 23 377 399 377 399 0.98

Sequence Information

Coding Sequence
ATGGCCCCTAAAAGAAGAGGACGCCCCCCAGGGTCAACAAAGCTGAAAACTACAACAACAAAACCGACTTTAAAAGAAAAGTTGCTTAGAATGATTGGAGGTGATGATGTAAATGAAAACATGATCAAGGTAGAGTGTTTGAGTAATGACGATAGCAGCAGCTTTACAAATGGAGATGATGATGGACTTATAGAAATTACTATTCCACCTCACCCAGATATTCAGACCCCAATTACAGCTAAAGAAAAACGGAAGGTTTATAATTGCTCTGTAtgtcaaaacaaaaactttaaaatgaaAGAAAAGTATGAGCTACATTTGCTGAAGGAACATTCAGTGACACCAGGCAGtgttccttgtaaaaaatgcCATGTTGTATGTCCTGATAAGGAGACTTTGGAAGAACATATGAAAAATCACAATCTACCTACGATTAAATGTGAGCATTGTTCTAAACAGTTCACTCGTCAGGCTCATGTTCTGAGACATATGGCTCAGAGAGGCTGTGGAAAGAAAATGGCAAAGTTTCCATGTGAAaTATGTCATGCAAGTTTCTCTAGAAAAGACAACCTGATTGTTCATCTTCGTACAACCCATATAATGAGCAACAGATTTTCCTGTAAAAGCTGTACGTTTACAACtaaaaactttacaaaacTCACTAGACATTGGCATGCACTACATgcagaGACTCCTAATCAGTTTGTTTGTGATCTTTGTGGTAAGATCACATCTTCTCGAGCTGCAATGTCTAAACACAATGAAATTCATGGAGAAAAGAAGTATGCTTGTGATGTGTGTGGCTACAGCACCCACACAGTGGAGGTGATCCGCCGGCACGTGCTGACCCACGTCTCGGACAAGCCGTACAAGTGCAACCTGTGCCCGCAGTCCTACATCCAGCGCTCGCAGCTGCTGCGCCACCTCGAGACGCACTCCGGCTTCGTGTGCTTCCACTGCGATGCCCGCTTCCCGAACAGACTCagTTTGTTAAATCATAACAAAAAGCACACGGAAGATGTCAAGTTATTCTGCCCGTACAAGGATTGCGAGTTCTCGTCAACGGTGTTCAAGAGCGAGTCCAGCTATGATGAACATTTACAACTTCATTGCGGTGATGAAAAATTATTCTCGTGCGAGGTGTGCCGCAAGCAGTTCCTGAGCGAGACCAACATGCGGCGGCACATGCGCACGCACACGCTGGACCGGCCGCGCCGCTGCATGTACTGCGTCAGCGCGCGCGCCTACATCCGCGGCATGCACCTCGTGCGCCACGTGCGCAACTACCACAAGGACGTGTTCCAGGGGCATCTCACGCACGTGCGCACCGTGCTCATGAATTCCTCGCAAAAGATAAGTGTGAACGACAAGCGAGTCACCGGATCGGAACTGGAGTCGATCCTTAATCTCTTGGACGCGGAGGCCGACCGCATCCTCGAGGGCTGCAGCGATGGATCCGTGCTGTACGGCGGCATGCAGGAGAACATGGACGAAGCAGCGCCGCAGGAGCAAGTGGACGAGACTAACGGAGAGCCCAAAATCAGTCCATTGATGTCAGAAGAAGTACTTGCTGAGAACTTGACCAAGTTACTCGTGAAGCTGATTGACACTGAGACGCTTGAGTGCTTTGGATGGCCTTATGATGACGTCATTACGGTCCTGGAAAAAGTGATACAGGAATGCGGAGTTAAACCAGCGGCGCAAGACTGGACGCGTGTGCAACGTCTGCGCGAAAACGCCAAGCATCTGTTCATCCACGTCGTGGACGACAAGAACGTGGCGCGCATGCTCGACACACACACCATCGACCAGATCATCAAGCACATGCTCAACCAGTTCAACGACCGGCCCGTGGAGGACGAACAGCTGTTTGTAGAGACCTAG
Protein Sequence
MAPKRRGRPPGSTKLKTTTTKPTLKEKLLRMIGGDDVNENMIKVECLSNDDSSSFTNGDDDGLIEITIPPHPDIQTPITAKEKRKVYNCSVCQNKNFKMKEKYELHLLKEHSVTPGSVPCKKCHVVCPDKETLEEHMKNHNLPTIKCEHCSKQFTRQAHVLRHMAQRGCGKKMAKFPCEICHASFSRKDNLIVHLRTTHIMSNRFSCKSCTFTTKNFTKLTRHWHALHAETPNQFVCDLCGKITSSRAAMSKHNEIHGEKKYACDVCGYSTHTVEVIRRHVLTHVSDKPYKCNLCPQSYIQRSQLLRHLETHSGFVCFHCDARFPNRLSLLNHNKKHTEDVKLFCPYKDCEFSSTVFKSESSYDEHLQLHCGDEKLFSCEVCRKQFLSETNMRRHMRTHTLDRPRRCMYCVSARAYIRGMHLVRHVRNYHKDVFQGHLTHVRTVLMNSSQKISVNDKRVTGSELESILNLLDAEADRILEGCSDGSVLYGGMQENMDEAAPQEQVDETNGEPKISPLMSEEVLAENLTKLLVKLIDTETLECFGWPYDDVITVLEKVIQECGVKPAAQDWTRVQRLRENAKHLFIHVVDDKNVARMLDTHTIDQIIKHMLNQFNDRPVEDEQLFVET

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00706387;
90% Identity
-
80% Identity
-