Cv-a011587.1
Basic Information
- Insect
- Chloroclystis v-ata
- Gene Symbol
- ewg
- Assembly
- GCA_963691955.1
- Location
- OY829903.1:962772-970515[-]
Transcription Factor Domain
- TF Family
- Nrf1
- Domain
- Nrf1_DNA-bind domain
- PFAM
- PF10491
- TF Group
- Basic Domians group
- Description
- In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 11 2.2e-50 2.7e-46 158.4 0.7 1 101 78 178 78 181 0.98 2 11 5.4e-23 6.5e-19 68.9 0.0 40 101 177 238 174 241 0.94 3 11 8.6e-23 1e-18 68.2 0.0 41 101 238 298 236 301 0.95 4 11 8.6e-23 1e-18 68.2 0.0 41 101 298 358 296 361 0.95 5 11 8.2e-23 9.9e-19 68.3 0.1 41 101 358 418 356 422 0.95 6 11 5.4e-23 6.5e-19 68.9 0.0 40 101 417 478 414 481 0.94 7 11 5.4e-23 6.5e-19 68.9 0.0 40 101 477 538 474 541 0.94 8 11 7.8e-23 9.4e-19 68.4 0.0 41 101 538 598 535 601 0.95 9 11 8.6e-23 1e-18 68.2 0.0 41 101 598 658 596 661 0.95 10 11 1.1e-22 1.3e-18 67.9 0.0 42 101 659 718 657 721 0.95 11 11 1e-78 1.2e-74 251.0 0.0 41 212 718 896 716 897 0.95
Sequence Information
- Coding Sequence
- ATGGTCCGTGAAAGGGGCACCAAGCACAACATGAACTCCGCAGTCAGCACAGAGTCCATGGATATTGGGGATGAGGTTGAGGAGATGTCCCAAGTGGAAGGCTGCGGCCTGAGCGGCGGCTCGGAGGACGAGGACGAGTGCGTGTCGTCCCCGGCCGCCTCCAACTACGGCGACGGAGAGATCATGAAGTCTGCCATGAACGATGACGTCACCAAGACGCTCGCTGCCGCCGGTCCAATTGGCATGGCAGCAGCGGCGGCAATCGCCTCTTCCAAGAAACGCAAGAGACCGCACTCCTTCGAGACCAACCCCTCGGTCAGAAAGCGCCATCAGAACCGACTGCTTAGGAAATTGAGACAAACCATAGAAGAGTTCGCGACGCGCGTCGGGCAGCAAGCCGTGGTGCTGATCGCCACCCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCAAGCCGCTCGAGGACGTGGTGCGCAACCTGCGCTGCATGATCATGGAGGAGCTGGAGAACGCGCTGGCACAGCAGGTATATCATTGTATAGAAGAGTTCGCGACGCGCGTCGGGCAGCAAGCCGTGGTGCTGATCGCCACCCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCAAGCCGCTCGAGGACGTGGTGCGCAACCTGCGCTGCATGATCATGGAGGAGCTGGAGAACGCGCTGGCACAGCAGGTATATCATTGTATAGAAGAGTTCGCGACGCGCGTCGGGCAGCAAGCCGTGGTGCTGATCGCCACCCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCAAGCCGCTCGAGGACGTGGTGCGCAACCTGCGCTGCATGATCATGGAGGAGCTGGAGAACGCGCTGGCACAGCAGGTATATCATTGTATAGAAGAGTTCGCGACGCGCGTCGGGCAGCAAGCCGTGGTGCTGATCGCCACCCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCAAGCCGCTCGAGGACGTGGTGCGCAACCTGCGCTGCATGATCATGGAGGAGCTGGAGAACGCGCTGGCACAGCAGGTATATCATTGTATAGAAGAGTTCGCGACGCGCGTCGGGCAGCAAGCCGTGGTGCTGATCGCCACCCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCAAGCCGCTCGAGGACGTGGTGCGCAACCTGCGCTGCATGATCATGGAGGAGCTGGAGAACGCGCTGGCACAGCAGGTATATCATTGTATAGAAGAGTTCGCGACGCGCGTCGGGCAGCAAGCCGTGGTGCTGATCGCCACCCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCAAGCCGCTCGAGGACGTGGTGCGCAACCTGCGCTGCATGATCATGGAGGAGCTGGAGAACGCGCTGGCACAGCAGGTATATCATTGTATAGAAGAGTTCGCGACGCGCGTCGGGCAGCAAGCCGTGGTGCTGATCGCCACCCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCAAGCCGCTCGAGGACGTGGTGCGCAACCTGCGCTGCATGATCATGGAGGAGCTGGAGAACGCGCTGGCACAGCAGGTATATCATTGTATAGAAGAGTTCGCGACGCGCGTCGGGCAGCAAGCCGTGGTGCTGATCGCCACCCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCAAGCCGCTCGAGGACGTGGTGCGCAACCTGCGCTGCATGATCATGGAGGAGCTGGAGAACGCGCTGGCACAGCAGGTATATCATTGTATAGAAGAGTTCGCGACGCGCGTCGGGCAGCAAGCCGTGGTGCTGATCGCCACCCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCAAGCCGCTCGAGGACGTGGTGCGCAACCTGCGCTGCATGATCATGGAGGAGCTGGAGAACGCGCTGGCACAGCAGGTATATCATTGTATAGAAGAGTTCGCGACGCGCGTCGGGCAGCAAGCCGTGGTGCTGATCGCCACCCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCAAGCCGCTCGAGGACGTGGTGCGCAACCTGCGCTGCATGATCATGGAGGAGCTGGAGAACGCGCTGGCACAGCAGGTATATCATTGTATAGAAGAGTTCGCGACGCGCGTCGGGCAGCAAGCCGTGGTGCTGATCGCCACCCCGGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCCAAGCCGCTCGAGGACGTGGTGCGCAACCTGCGCTGCATGATCATGGAGGAGCTGGAGAACGCGCTGGCACAGCAGTTCGGTCTGGGCGGTcacggcgcggcgccgccccCGCCGGCGGAGGACCCCTCGCTGTTCGAGCTGCCGCCGCTCATCATCGACGGCATCCCCACGCCCGTCGAGAAGATGACGCAGGCGCAGCTGCGCGCCTTCATACCCCTCATGCTCAAGTACTCCATGGTTCGCGGCAAGCCGGGCTGGGGCCGCGAGTCGACGCGGCCGCCGTGGTGGCCCAAGGACCTGCCCTGGGCCAACGTGCGGATGGACGCGCGCACCGACGACGAGAAACAGAAGATGTCGTGGACGCACGCGCTGCGCCAGATAGTGGTGAACTGCTACAAGTTCCACGGGCGCGAGGACCTGCTGCCCGCCTTCAACGAGGACGACGACAAGCCCGCCGCCACCTCCATGTGTTCGTCCCCGGTGGGCGGGGCGTCCCCGCGCGGGGGGcacgggggcgggggcgggggacACGAGCACGAGCACGAGGTGCAGCAGCAGGCCGTGCTGAGCGCGCAGCAGGTCTGCATCGACCAGATGACGCTCACCGATGTCGAAAACATGCAGTACGCGCCGGCGGTGCTGCACTCCATCACGAACCCCGACGGGTCCGTGTCCATCCTCAACCTGGACCCCAACAACCCCATCATCACGCTGCCCGACGGCACCACGGCGCAGGTGATCCACACGGGCGACGTGGGCGCGGGCAGCGTGGTGCAGACGCTGGACGCGGACGGCAACGCGGTGGCGCTCGACATCAACTCCGTGGAGGCGCTCGCAGACAACCAGATCATCATCACCGGCGAGGACGGGGAGTGCCGGCCGCTGTCGCAGGTGGTGACGCTGCCCATGTACCAGCAGATGATGGCGCAGATGGCGGCGGGCGAGGCCGTCAGCGTCATGCCGCTCGTGCAGGTCCGCGTCAAGCGAGAGCGCCGCTACTACTGA
- Protein Sequence
- MVRERGTKHNMNSAVSTESMDIGDEVEEMSQVEGCGLSGGSEDEDECVSSPAASNYGDGEIMKSAMNDDVTKTLAAAGPIGMAAAAAIASSKKRKRPHSFETNPSVRKRHQNRLLRKLRQTIEEFATRVGQQAVVLIATPGKPNTSYRVFGAKPLEDVVRNLRCMIMEELENALAQQVYHCIEEFATRVGQQAVVLIATPGKPNTSYRVFGAKPLEDVVRNLRCMIMEELENALAQQVYHCIEEFATRVGQQAVVLIATPGKPNTSYRVFGAKPLEDVVRNLRCMIMEELENALAQQVYHCIEEFATRVGQQAVVLIATPGKPNTSYRVFGAKPLEDVVRNLRCMIMEELENALAQQVYHCIEEFATRVGQQAVVLIATPGKPNTSYRVFGAKPLEDVVRNLRCMIMEELENALAQQVYHCIEEFATRVGQQAVVLIATPGKPNTSYRVFGAKPLEDVVRNLRCMIMEELENALAQQVYHCIEEFATRVGQQAVVLIATPGKPNTSYRVFGAKPLEDVVRNLRCMIMEELENALAQQVYHCIEEFATRVGQQAVVLIATPGKPNTSYRVFGAKPLEDVVRNLRCMIMEELENALAQQVYHCIEEFATRVGQQAVVLIATPGKPNTSYRVFGAKPLEDVVRNLRCMIMEELENALAQQVYHCIEEFATRVGQQAVVLIATPGKPNTSYRVFGAKPLEDVVRNLRCMIMEELENALAQQVYHCIEEFATRVGQQAVVLIATPGKPNTSYRVFGAKPLEDVVRNLRCMIMEELENALAQQFGLGGHGAAPPPPAEDPSLFELPPLIIDGIPTPVEKMTQAQLRAFIPLMLKYSMVRGKPGWGRESTRPPWWPKDLPWANVRMDARTDDEKQKMSWTHALRQIVVNCYKFHGREDLLPAFNEDDDKPAATSMCSSPVGGASPRGGHGGGGGGHEHEHEVQQQAVLSAQQVCIDQMTLTDVENMQYAPAVLHSITNPDGSVSILNLDPNNPIITLPDGTTAQVIHTGDVGAGSVVQTLDADGNAVALDINSVEALADNQIIITGEDGECRPLSQVVTLPMYQQMMAQMAAGEAVSVMPLVQVRVKRERRYY
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -