Basic Information

Gene Symbol
-
Assembly
GCA_963573255.1
Location
OY754303.1:22842430-22845497[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.03 1.6 9.6 1.6 2 23 28 50 27 50 0.94
2 16 0.033 1.7 9.4 0.8 2 23 254 278 253 278 0.93
3 16 8 4.2e+02 1.9 0.5 9 23 317 331 310 331 0.75
4 16 2.3 1.2e+02 3.6 2.1 2 23 469 491 468 491 0.91
5 16 5.6 2.9e+02 2.4 0.1 12 23 535 547 534 547 0.89
6 16 0.081 4.3 8.2 1.1 1 23 559 582 559 582 0.94
7 16 2.4 1.3e+02 3.6 3.5 1 19 620 638 620 643 0.83
8 16 0.097 5.1 7.9 2.9 1 23 654 679 654 679 0.91
9 16 0.00088 0.047 14.4 0.7 1 23 685 707 685 707 0.94
10 16 0.013 0.69 10.7 1.6 2 23 713 734 713 734 0.97
11 16 5e-05 0.0027 18.3 0.9 2 23 740 761 739 761 0.97
12 16 0.0013 0.07 13.8 1.6 1 23 767 791 767 791 0.97
13 16 1.8e-05 0.00097 19.7 3.0 3 23 799 819 797 819 0.97
14 16 0.004 0.21 12.3 0.4 5 23 828 846 826 846 0.96
15 16 0.00081 0.043 14.5 2.4 2 23 854 875 853 875 0.96
16 16 6 3.2e+02 2.3 0.8 2 23 892 914 891 914 0.87

Sequence Information

Coding Sequence
ATGGACGCTGAAGAGCTGGCAGAATCTGATCCGTGCGATATATTTGATACTGGGAAATGGCTGccaaattgcaataaattgaCTTGCGATATTTGCGATCAAAAATTCAGTAATAAgcTGAAAATCGTACTTCATTGGTGCACATCTCATGGATACAAATTGTGCAGTTTCTGTACAAACTATGCATTCAAGTATGATTCCGATAGGATACAGCACGAATTGCAGCATATTCCTTTTGGATGTTCGAATTGTACTCACGAATTTACAAGTATTAATGAAACGAATATTAGTGAGCATTATAAGGAAGCCCATCAGTCATTTCTATGTTCATACTGCTCATCTGTCATCCAGCCATTCTCAAAATATCCCGAACATGTTGAGAAGAAACATAGCGTAATTAACTATTTGGAGTTTTCAAGGAATAACAAGTTGTTTAGTTTGGATAGTGACGAAGAAATTAATCGTGATTCATTCTTCAATTGTTTAATGTGTAACAAACGAAAACGAATTGACTTGCTCTTTGGACATTACGTCTTTTACCATAATATATCAATTCATTCGCTCAAGAAGTTTTTACACAAAGTACcagaaatttctattaatGGTTCTGTGTTGAGTGCTGATGATAGAGAGTCGGGGGCTACAGAAATCGAAGAGActggaaataatttgaaagatATGTGCTCTGTATGtgaaaatccatttaaattcGATGAAATTGCCAAGGAACTTCACAGTGTATTTTGTCAGGGATATATTGTATGCAATTTAAAGGACTGTGCACAAGTTTTCGAGAATAAGAATGAGTTAAGTCAGCATTTACATTCAAAACATTCCTCATTGAGCTGCAAATATGGTTGTAAGGAGAGTACATTATTAAATCCACAGGAAATTAATGATCACATGCAAAATTTACATGACATTGTCGAATGCTTTCTATGCAACATCGTCAATAGTTCTGGGAATTTCAAAAACCATCTGAGAGATAAGCACAGTGTCAATTTGTTGACATATGAGAAAGCAATGAACACAACAACCTCGAAGCTCTATCGCGTGGAAAATTCTCCAGATGATTCGAAGCAAGTGCTGTGTAATTTTTGTGATCATGATTTGACggatgaaattaaagaattttcgtTCATTAATCATTATCAAAATGAGCACGAAATTAgttcaatagaaattttaagaaacttGGATAAGAATCCAATAATTGATGTCATATTAGATGACAAGAAATCCAAGATTGATGAAGAGTGCTTAAGTAACTTTAGCATCATCAAGTCACTGGATAGACTAATTGAAACAGATTTTGATACAAGTAAAGTTTGGTGTATTGGAATTGAGCACATAGAAGAGAAGCCAGTGTTGGACgaagatgatgaaattttaaaggctatattgaaatgtgaattttgtAACAGCTCTTTTGTAGACAACTGCGTCTATTATGAACATCTCAAGGATTATCATGGCTTTAAACTAATTAATCTCGATTCTTGCGATAAgtgcaaaattcaaaactctGAAACATTAGTTAATGAGGAcaacaaaaactttaatttggCGTTAATCTGTCCTCTCGATTCATCATATCATGTCACGAAAGATAACTTTAAGAACCACATGATCTATGAGCactttgacaaaaatttaacatctgATTCAGTATTTTATAAATGCTATGTATGTAGTTTTGCTTATAAAAATCTCAAGGAAGTTCGTGCTCATTTCAACGAAAGTCATCCTGAcgtaaaaatgaattattgcaAATTGTGCCGTTATCGACTGACTTCAAGCGAAAATGTCGATCATTTTGCTCGAAATCATGCTGAAGACTTGAAGCgtgttgagaaattttgttgcAATCTCTgtaaaaaggaatttaagaAAATGGGAACGGCTAAAATGCATTTTGTCAATTCTCATCGAAAGAAGgatttgaagaagaaatcGTCATTCAAATGTCAGTTTACTCTGTGTAATAAAGTCTTTGACAATAAGGAGGATCGTAAAATGCATCACATTTTTGCTCATCCAGACGAAAAAATGTTTGCCTGCAAATCATGTCCTTTAAAGTTCTCAACAAAGAGCAGTTTAAGCAGTCATaatattattcacaaaaatgtcGTCAATACTTGTGAATTTTGTAGCAAGACATTTTTAAGACGCGACAGTTTCAAGGAACATCTTCTCATTCATTCAGACACGAGACTCAAATGTAGTTTCTGTGAAAAACTATTCGTCCAGCGGAGCAATCTAGTGAGGCACGAACGGATTCATTTACAGGAAAAGCCATATCAGTGTACATTTGAGGGTTGTGGGAAGACATTTAGTGATAAGGGTGCTTGCACTTCGCATGAAAAAGTACACACAAAAGAAGAAAGCTCTAATTGTGAAGTGTGTGGAAAGCATTTTGCTCGAAAGCAGAAACTCAAGTATCATATGAGACTGCATACATTGGAAAATGTCTTGACTTGCGAATGTGGAAAAATCTTTCCCGAAAGTTATTCATTCAGAAAGCATCAGGAAAGCCATCAAAATAAAAGTCGTTGCTTGAAGtgcGAATATTGTACGAAAACCTTTCGATCGGCTAAATCGAAAGAGAAGCATGAGCAGTCTCATAATGTTGGGGAGCCATCAGAATCTAATGCTTTTAGCGATGCAGAAATCCAGTGCCACCTGTGTGATTCCAAGGATTTGAAGCCGTCAAATATCAAAAATCACTTGATGACAGCTCATGCTATCGTAGATGACAATTTACATGAGAGTATTAGCACAGAAAATTCGACAATGGAAACCTCTAACGAATTCATTTtaccttaa
Protein Sequence
MDAEELAESDPCDIFDTGKWLPNCNKLTCDICDQKFSNKLKIVLHWCTSHGYKLCSFCTNYAFKYDSDRIQHELQHIPFGCSNCTHEFTSINETNISEHYKEAHQSFLCSYCSSVIQPFSKYPEHVEKKHSVINYLEFSRNNKLFSLDSDEEINRDSFFNCLMCNKRKRIDLLFGHYVFYHNISIHSLKKFLHKVPEISINGSVLSADDRESGATEIEETGNNLKDMCSVCENPFKFDEIAKELHSVFCQGYIVCNLKDCAQVFENKNELSQHLHSKHSSLSCKYGCKESTLLNPQEINDHMQNLHDIVECFLCNIVNSSGNFKNHLRDKHSVNLLTYEKAMNTTTSKLYRVENSPDDSKQVLCNFCDHDLTDEIKEFSFINHYQNEHEISSIEILRNLDKNPIIDVILDDKKSKIDEECLSNFSIIKSLDRLIETDFDTSKVWCIGIEHIEEKPVLDEDDEILKAILKCEFCNSSFVDNCVYYEHLKDYHGFKLINLDSCDKCKIQNSETLVNEDNKNFNLALICPLDSSYHVTKDNFKNHMIYEHFDKNLTSDSVFYKCYVCSFAYKNLKEVRAHFNESHPDVKMNYCKLCRYRLTSSENVDHFARNHAEDLKRVEKFCCNLCKKEFKKMGTAKMHFVNSHRKKDLKKKSSFKCQFTLCNKVFDNKEDRKMHHIFAHPDEKMFACKSCPLKFSTKSSLSSHNIIHKNVVNTCEFCSKTFLRRDSFKEHLLIHSDTRLKCSFCEKLFVQRSNLVRHERIHLQEKPYQCTFEGCGKTFSDKGACTSHEKVHTKEESSNCEVCGKHFARKQKLKYHMRLHTLENVLTCECGKIFPESYSFRKHQESHQNKSRCLKCEYCTKTFRSAKSKEKHEQSHNVGEPSESNAFSDAEIQCHLCDSKDLKPSNIKNHLMTAHAIVDDNLHESISTENSTMETSNEFILP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-