Basic Information

Transcription Factor Domain

TF Family: TEA
Domain: TEA domain
PFAM: PF01285
TF Group: Helix-turn-helix
Description: The TEA domain is a DNA-binding region of about 66 to 68 amino acids that has been named after the two proteins that originally defined the domain: TEF-1 and AbaA. The TEA domain is located toward the N terminus of eukaryotic transcription factors of the TEA/ATTS family. It shows a three-helix bundle with a homeodomain fold [3, 1]. Two α-helices are nearly anti-parallel and pack on either side of the third one, which is the DNA-recognition helix of the TEA domain. Phosphorylation of one or both of the two conserved serines found on the DNA-binding surface could interfere with DNA-binding activity, by introducing electrostatic repulsion and/or steric hindrance, and help regulate the transcription factor activity of the proteins [2, 1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 7.8e-19 1.5e-14 54.1 1.0 35 66 2 33 1 36 0.94

2 2 1.4e-19 2.6e-15 56.5 1.2 27 66 48 87 33 89 0.83

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	7.8e-19	1.5e-14	54.1	1.0	35	66	2	33	1	36	0.94
2	2	1.4e-19	2.6e-15	56.5	1.2	27	66	48	87	33	89	0.83

Coding Sequence: ATGCTCGGACGAAATGAGTTAATAGCGCGCTACATTAAGCTCAGAACTGGTAAAACGAGAACGCGAAAGCAAGTCAGCTCACACATACAAGTTTTAGCTAGAAGAAAATTACGCGAATTTCAAGCAAAAATGAAGGTGGTAAGTATCTCATTTAATNTGCCAATTTCAGGACGAAATGAGTTAATAGCGCGCTACATTAAGCTCAGAACTGGTAAAACGAGAACGCGAAAGCAAGTCAGCTCACACATACAAGTTTTAGCTAGAAGAAAATTACGCGAATTTCAAGCAAAAATGAAGGTG
Protein Sequence: MLGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREFQAKMKVVSISFNXPISGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREFQAKMKV

Sequence clustering based on sequence similarity using MMseqs2