Basic Information

Gene Symbol
L
Assembly
None
Location
chr4:14552384-14689222[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 1.2e-06 7.2e-05 22.8 1.7 1 23 150 172 150 172 0.99
2 17 0.53 31 5.1 5.8 1 23 178 200 178 200 0.97
3 17 5.3e-07 3.1e-05 23.9 2.7 1 23 206 228 206 228 0.99
4 17 2.2e-05 0.0013 18.8 0.1 1 23 234 256 234 256 0.98
5 17 0.00056 0.032 14.4 0.0 2 23 272 294 271 294 0.95
6 17 2.3 1.4e+02 3.0 0.2 3 23 318 340 316 340 0.79
7 17 0.25 15 6.1 0.1 3 23 392 412 391 412 0.97
8 17 0.55 32 5.0 0.0 3 20 427 444 426 445 0.86
9 17 0.00025 0.015 15.5 0.6 1 23 455 478 455 478 0.94
10 17 0.027 1.6 9.1 0.1 1 23 483 506 483 506 0.92
11 17 0.068 3.9 7.9 0.9 1 23 569 593 569 594 0.94
12 17 0.00017 0.0096 16.1 0.1 2 23 651 672 650 672 0.96
13 17 0.049 2.8 8.3 0.0 1 23 680 702 680 702 0.97
14 17 1.4 82 3.7 0.7 2 23 710 731 709 732 0.93
15 17 0.39 22 5.5 0.6 1 23 806 828 806 828 0.94
16 17 0.0029 0.17 12.2 0.1 1 20 836 855 836 858 0.95
17 17 0.084 4.9 7.6 0.4 1 23 865 887 865 887 0.94

Sequence Information

Coding Sequence
ATGTCTCGAAGGAAGCAAGCGAAACCGCGATCGTTGAAACCGGAAGACGAAGAATGGAACGAAGGTACACCACGTGATGAAAACGAGATGGCAGCTACCGAAGAACAAGAAGATGACGACTCCGGAGACAAGGAAAAGAATGATGAAGTTGATGAACCTAACGCGAGTGAAGGACCAGAAGATGGTGAGGATATACAAACAAATGGAAATAAGCCGGCCGATGACTACGACGTCGATGACACGGCTGATATGGCGGACATCAAAACCGAGAGCATGGACAGTTTCGAATCAGAAGCCCTGGGAAGTGTGGGCAGCACGGCGGGAAGCTCATGGCCGTCTTCAACGCCTGAGCCGTCCCCATCGCCCGCATCCACGCCCACCTCCGCTGACGCAGCCGATGCTGACGCCGAACCACCGTTCACGCTGGGCGCCACCGAGCACACGCCCTACCAGTGCCAGTTCTGCGACAAGGCCTTCCCTAGGTTGTCTTACTTGAAGAAACATGAACAGACGCATTCGGACCAAATGCCTTTCCGGTGCGAGTTCTGTTCCCGGCTGTTCAAGCACAAGCGTTCACGGGATAGACACGTGAAGCTGCATACCGGAGATAGGAAATACCGCTGTGCGCATTGTCCTGCTGCTTTTTCTAGAAGCGACCATTTGAAGATCCATATGAAGACGCATGATAATCAGAAGCCGTTCCAGTGTACGGTGTGCAACCGAGGGTACAACACAGCAGCGGCGCTGACGTCACACATGCAGGGACACAAAAGGGACAGGGAGGGACGTGAGCCTGACCGCCGACGGGTGCTGCGCTGTTTACGTTGCGGGGATGCGTTTAGGCGCCCTGACTTATTACAAGCTCACATGGCCAGTGCACATGGAGTGGAGACTCCTGCGCTAACGCCACCGCGGCGAGTTGCATCGCAGCCACCGCCGACGCTACTCGCTTGCATGTACTGCACTCGCGACACTTTTACGAGTATGGAACAACTGCAACTCCACGTACGTGCAGCACACTCCGCATTACTCAACGGGGAGACGCCCATGCAGGTCGACCAACCGAAACCCACGGATCTCAGCAGACGAGCGGCAGAAGACGCGCCGTTAGCGAAGCGACCTAGGTCCGGATCTGGGACGCCGCATACAACCTTATCTCCCAGCACTCTTTTGTGCAACCAGTGCGACGCGGCACTCCCTGACTTTGAAGCTTTCCGGAATCACTTAAAAGGACATTTAGAAGAAGGAGGAGAATTGGGGAGATCAAGTCCCGCTCCGTGCTTGCATTGCGGGGCTACATTCGCTGATGCGGCGGCGTCTGAACGACATCTCGCCGCATTCTATTTGGCTGTGTCGTGCGAATACACCTGCCACAGCTGTGCCAGGAGCTTTTCCGCACCAGACGATTTGCAGAAGCATCTTCTAGATTTACATGCTCATCATCTGTATCGGTGTTCGCTGTGCAAAGAAATCTTCGACTCCAAAGTAGCTATTCAGGTGCACTTCGCCGTGGCCCATAGCGGTGAGAACAAGGTGTGGATGTGCCGAGGGTGCGGGGGCGGCGCGGGTCCGTTGCGGTCGGAAGCGGAGGGCGCAGCGCACGTGCGTGCACGACACGCGGCGGGTGCGGCACGGTGCACGTGCGGCGCGGTACTGGGCGGGCCCGGCGCTGGACCCGGCCGTCTGCCGCGCGCCGCCCGCGCTTACCGCTGCCCCGCGCCCGCCTGCACCGACACATTCGCCGTGCACTACCTGCTGGAGCGACACGTGCAGACGCACCACGCGCCACAACACCCGGCGATAAACGGTGACATGTCGAGAGTAAAGCGTATGGACAACAACAACATCTCTGATGGCGTCGACGGGAACTGTTCACCGCGCACGCCCGGCTCGGACGGGAACGGGCCCGTGGTGGAGGAACGAAGGCGGAAAAACGGCGCAGTAGCACTGCAATGTGCGTACTGCGGCGAACGTACCCGCAGTCGCGCCGAACTAGAGGCTCATACGCGCGCTCACTCGGGCGCTGCCGCTGCGAGGCATAAGTGTCTGATATGCGATGAAGTGCTCCCCTCAGCGGCGGTGCTTGCCGAACACAAGCTTACACATTGCAAGGTTGTTGCTGGCGACACATGTGCTCGATGCCGTGCTAGGCTGCCGTCCGAAGAATCATTCCTAACCCACATGGCGCGACATCATCCCACGCTGCCGGCACCATGCGTTGTTTGCCGGCAAACTCTCGCGTCAGAGGCGGAGGCAAGGCTTCACGCTCGTTTCCATTTGCGACCGGCAGAAGACGAACAACGGTGCGCGATATGTTTGAGGGCATTGACAGAAAGTGAGACAGGCGAAGGGGCTCGCGCTTGTTCTTCGTGCTACGCTCGGCACGCCGCCCCTCACCCCCCTCCACCAGCAGATCACGACTGCCGCCTTTGTAGACGCACTCTCGGTTCTCCTACGAGACTTCAAGCGCACCTCATAGAACACACGTTCGCCGGAATAAGCGCGTTCACCTGCTACCTCTGCTCGGCAGTTTTCACCAGCGCAGCCGGACTGCAACGTCACCTCCCCGAACACGCAGCAGCGCCGAAACCGTTCGACTGCGGACGGTGCGGTATGAAATTCTTCTTCCGGGCCGAGTTGGATAATCACGCTTTCGTACATCTAGAGGAGGCGGAAATAGCACAGAGAGCGTTCTATGAGGCCTACGCGAGAGGAGCAGCATCGGCGTGGGCTGCGTTGGCACCACCGGAAGCGGTACCTCAAGCTGCACAGATTCCACCTCCCGTGCCACCATTGGCCGAAGTTAAACGAGAGCCAGACATAAAAGAAGAGCGCAACACCGACGAGTATATTGAGGTAGCTTCTCCTCCACCAGCCCCTCCGCCAGAAGTTCCGAATCCTTCACCTCCCCTTGTAGTGAAAGAAGAGAAACCCGACGAAGACTGA
Protein Sequence
MSRRKQAKPRSLKPEDEEWNEGTPRDENEMAATEEQEDDDSGDKEKNDEVDEPNASEGPEDGEDIQTNGNKPADDYDVDDTADMADIKTESMDSFESEALGSVGSTAGSSWPSSTPEPSPSPASTPTSADAADADAEPPFTLGATEHTPYQCQFCDKAFPRLSYLKKHEQTHSDQMPFRCEFCSRLFKHKRSRDRHVKLHTGDRKYRCAHCPAAFSRSDHLKIHMKTHDNQKPFQCTVCNRGYNTAAALTSHMQGHKRDREGREPDRRRVLRCLRCGDAFRRPDLLQAHMASAHGVETPALTPPRRVASQPPPTLLACMYCTRDTFTSMEQLQLHVRAAHSALLNGETPMQVDQPKPTDLSRRAAEDAPLAKRPRSGSGTPHTTLSPSTLLCNQCDAALPDFEAFRNHLKGHLEEGGELGRSSPAPCLHCGATFADAAASERHLAAFYLAVSCEYTCHSCARSFSAPDDLQKHLLDLHAHHLYRCSLCKEIFDSKVAIQVHFAVAHSGENKVWMCRGCGGGAGPLRSEAEGAAHVRARHAAGAARCTCGAVLGGPGAGPGRLPRAARAYRCPAPACTDTFAVHYLLERHVQTHHAPQHPAINGDMSRVKRMDNNNISDGVDGNCSPRTPGSDGNGPVVEERRRKNGAVALQCAYCGERTRSRAELEAHTRAHSGAAAARHKCLICDEVLPSAAVLAEHKLTHCKVVAGDTCARCRARLPSEESFLTHMARHHPTLPAPCVVCRQTLASEAEARLHARFHLRPAEDEQRCAICLRALTESETGEGARACSSCYARHAAPHPPPPADHDCRLCRRTLGSPTRLQAHLIEHTFAGISAFTCYLCSAVFTSAAGLQRHLPEHAAAPKPFDCGRCGMKFFFRAELDNHAFVHLEEAEIAQRAFYEAYARGAASAWAALAPPEAVPQAAQIPPPVPPLAEVKREPDIKEERNTDEYIEVASPPPAPPPEVPNPSPPLVVKEEKPDED

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01437318;
90% Identity
iTF_00448363;
80% Identity
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